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Pfizer vaccine: What an ‘efficacy rate above 90%’ really means

11 Nov, 2020 | 09:23h | UTC

Pfizer vaccine: what an ‘efficacy rate above 90%’ really means – The Conversation

 

Cluster randomized trial: Mass distribution of azithromycin to preschool children in sub-Saharan Africa increases azithromycin resistance by 7-fold, also causing resistance to nonmacrolide antibiotics

12 Nov, 2020 | 09:13h | UTC

Macrolide and Nonmacrolide Resistance with Mass Azithromycin Distribution – New England Journal of Medicine

 

Pfizer’s ultra-cold vaccine could be difficult to distribute

11 Nov, 2020 | 09:22h | UTC

Pfizer’s ultra-cold vaccine could be difficult to distribute – The Conversation

 

Covid-19: Reopening places such as restaurants, gyms, hotels, cafes, and religious organizations are predicted to cause the largest increase in infections

11 Nov, 2020 | 09:26h | UTC

Mobility network models of COVID-19 explain inequities and inform reopening – Nature

Commentaries: Restaurants and gyms were spring ‘superspreader’ sites. Occupancy limits could control Covid, new study predicts  – STAT AND How to stop restaurants from driving COVID infections – Nature AND Covid Superspreader Risk Is Linked to Restaurants, Gyms, Hotels – Bloomberg AND Covid-19 modeling study suggests which places may have highest risk of spread — but occupancy limits can help – CNN

 

Commentary on Twitter

 

Randomized trial: vitamin D, omega-3 fatty acids, or a strength-training exercise program do not improve clinical outcomes in older adults

11 Nov, 2020 | 09:11h | UTC

Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial – JAMA (free for a limited period)

 

Study: N95 masks with exhalation valves do not work

11 Nov, 2020 | 09:20h | UTC

Flow visualization of an N95 respirator with and without an exhalation valve using schlieren imaging and light scattering – Physics of Fluids

Commentary: N95 Masks With Exhalation Valves Don’t Slow The Spread Of Covid-19 – Forbes

 

Commentary on Twitter

 

Derivation and validation of the HA2T2 (Hypoxia, Age, Troponin) COVID‐19 mortality risk score

11 Nov, 2020 | 09:18h | UTC

Troponin and Other Biomarker Levels and Outcomes Among Patients Hospitalized with COVID‐19: Derivation and Validation of the HA2T2 COVID‐19 Mortality Risk Score – Journal of the American Heart Association

 

Commentary on Twitter

 

[Not Published Yet] Randomized trial: Long-acting injectable drug every 8 weeks is highly effective in preventing HIV acquisition in women

11 Nov, 2020 | 09:17h | UTC

Trial results reveal that long-acting injectable cabotegravir as PrEP is highly effective in preventing HIV acquisition in women – World Health Organization

Commentary: NIH study finds long-acting injectable drug prevents HIV acquisition in cisgender women – NIH News Releases

 

USPSTF Statement: Insufficient evidence to recommend screening for high blood pressure in children and adolescents

11 Nov, 2020 | 09:14h | UTC

Screening for High Blood Pressure in Children and Adolescents – U.S. Preventive Services Task Force

Editorial: An Alternative View of Childhood Blood Pressure Screening: Reframing the Question – JAMA Network Open

Author interview: USPSTF Recommendation: Screening for Hypertension in Children and Adolescents

JAMA Patient Page: Screening for High Blood Pressure in Children and Adolescents

 

[Abstract Only] Randomized trial: Intravenous haloperidol more effective than ondansetron for cannabis hyperemesis syndrome

11 Nov, 2020 | 09:08h | UTC

Intravenous Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC): A Randomized, Controlled Trial – Annals of Emergency Medicine

 

Commentary on Twitter

 

KDIGO Guideline Synopsis: Diabetes management in chronic kidney disease. Use of ACE inhibitors or ARBs, glycemic monitoring and targets, and choice of antihyperglycemic drugs are covered

11 Nov, 2020 | 09:09h | UTC

Diabetes Management in Chronic Kidney Disease: Synopsis of the 2020 KDIGO Clinical Practice Guideline – Annals of Internal Medicine

Original guideline: Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease

 

Podcast on chronic cough. Don’t be afraid to try empiric therapies! PPIs for GERD, antihistamines and intranasal steroids for post-nasal drip, and inhaled corticosteroids for post-viral cough are generally low-risk and will treat many cases.

11 Nov, 2020 | 09:04h | UTC

#241 Chronic Cough – The Curbsiders Internal Medicine Podcast

 

News Release [Not Published Yet]: Vaccine candidate 90% effective against Covid-19 according to manufacturer

10 Nov, 2020 | 09:41h | UTC

News Release: Pfizer and Biontech announce vaccine candidate against Covid-19 achieved success in first interim analysis from phase 3 study

Commentaries: What Pfizer’s landmark COVID vaccine results mean for the pandemic – Nature AND Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate – The BMJ AND Covid vaccine: First ‘milestone’ vaccine offers 90% protection – BBC AND Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective – The Guardian AND Four reasons for encouragement based on Pfizer’s Covid-19 vaccine results – STAT AND Expert reaction to Pfizer and BioNTech reporting interim results from phase 3 COVID-19 vaccine trial – Science Media Centre

 

Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths

11 Nov, 2020 | 09:06h | UTC

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)

 

Commentary on Twitter

 

Another study shows hydroxychloroquine does not benefit adults hospitalized with COVID-19

10 Nov, 2020 | 09:39h | UTC

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science

Commentary: Hydroxychloroquine does not benefit adults hospitalized with COVID-19 – NIH News Releases

 

Patients with Covid-19 and myocardial injury have increased in-hospital mortality, particularly if echocardiographic abnormalities are present

10 Nov, 2020 | 09:37h | UTC

Characterization of Myocardial Injury in Patients With COVID-19 – Journal of the American College of Cardiology

Commentary: Study identifies cardiac structural damage experienced by COVID-19 patients – Mount Sinai Health System / News Medical

 

Report: Large cluster of cases during a long flight shows seating proximity was strongly associated with infection risk

10 Nov, 2020 | 09:38h | UTC

Transmission of SARS-CoV 2 During Long-Haul Flight – Emerging Infectious Diseases

Related studies: In-Flight Transmission of SARS-CoV-2 – Emerging Infectious Diseases AND A large national outbreak of COVID-19 linked to air travel, Ireland, summer 2020 – Eurosurveillance

Commentaries: Coronavirus can spread on airline flights, two studies show – CNN AND Do Masks On Plane Flights Really Cut Your Risk Of Catching COVID-19? – NPR AND Is it worth the risk? A guide to navigating holiday travel during the pandemic University of Texas Health Science Center at Houston

 

Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients

10 Nov, 2020 | 09:33h | UTC

Multidrug-Resistant Candida auris Infections in Critically Ill Coronavirus Disease Patients, India, April–July 2020 – Emerging Infectious Diseases

Commentaries: Candida auris Infection in COVID-19 Patients – NEJM Journal Watch AND Drug-resistant superbug thriving in hospitals hit hard by COVID-19 – National Geographic

 

In patients hospitalized with COVID-19, right ventricular dilation or dysfunction was independently associated with a >2-fold increase in risk for mortality

10 Nov, 2020 | 09:36h | UTC

Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 – Journal of the American College of Cardiology

Commentaries: Utility of RV Remodeling Over Risk Stratification in COVID-19 – American College of Cardiology AND Damage to heart’s right ventricle predicts a greater chance of death from COVID-19 – Weill Cornell Medical College

 

Aspirin to be investigated as a possible treatment for COVID-19 in the RECOVERY trial

10 Nov, 2020 | 09:35h | UTC

Aspirin to be investigated as a possible treatment for COVID-19 in the RECOVERY trial – University of Oxford

Commentary: Aspirin to be tested as potential COVID-19 drug in UK study – Reuters

 

[Abstract Only] Randomized trial: In patients with persistent atrial fibrillation, treatment with catheter ablation + vein of Marshall ethanol infusion increased the likelihood of remaining free of AF, compared with catheter ablation alone

10 Nov, 2020 | 09:32h | UTC

Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Systematic review: Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. “At present, there are no convincing data supporting any specific inotropic or vasodilating therapy to reduce mortality in hemodynamically unstable patients with CS or LCOS.”

10 Nov, 2020 | 09:30h | UTC

Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome – Cochrane Library

 

Cohort study: Nighttime high blood pressure phenotype linked to worse cardiovascular prognosis

10 Nov, 2020 | 09:29h | UTC

Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis: Practitioner-Based Nationwide JAMP Study – Circulation

Commentaries: People who experience high blood pressure while sleeping have increased risk of heart attacks, strokes – News Medical / American Heart Association AND Sleeptime BP Spikes Tied to Heart Troubles – Physician’s Weekly

 

[Abstract Only]: Randomized trial: Drug-coated balloons non-inferior to drug-eluting stents for small coronary artery disease

10 Nov, 2020 | 09:27h | UTC

Long-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.

10 Nov, 2020 | 09:26h | UTC

Current and evolving standards of care for patients with ARDS – Annals of Intensive Care

 

Commentary on Twitter

 

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