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WHO: Preliminary findings indicate that a SARS-CoV-2 mink-associated variant strain has moderately decreased sensitivity to neutralizing antibodies. The implications are not yet well understood.
9 Nov, 2020 | 01:34h | UTCSARS-CoV-2 mink-associated variant strain – Denmark – World Health Organization
Commentaries: Spread of mutated coronavirus in Danish mink ‘hits all the scary buttons,’ but fears may be overblown – STAT AND Six countries reported coronavirus on mink farms, WHO says – MedicalXpress AND What’s the science behind mink and coronavirus? – BBC
Review: Use of multiple period, cluster randomized, crossover trial designs for comparative effectiveness research
10 Nov, 2020 | 09:22h | UTC
This article outlines the key methodological and ethical requirements needed for the robust design of multiple period, cluster randomised, crossover trialshttps://t.co/CMky7icWhY
— The BMJ (@bmj_latest) November 6, 2020
Video: Herd immunity as a coronavirus pandemic strategy
9 Nov, 2020 | 01:32h | UTCHerd Immunity as a Coronavirus Pandemic Strategy – JAMA
Perioperative evaluation and management of patients with diabetes, thyroid disease, and adrenal insufficiency. Use of insulin and noninsulin diabetic medications, management of hyper and hypothyroidism, and use of stress-dose corticosteroids are some of the subjects reviewed
10 Nov, 2020 | 09:24h | UTCPerioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings
What can we expect from new SARS-CoV-2 rapid tests? They promise to aid public health responses to COVID-19, since they can deliver results in a matter of minutes in the field, rather than taking days in clinical diagnostic labs
9 Nov, 2020 | 01:30h | UTCCoronavirus testing finally gathers speed – Nature
Biden’s ready to start his pandemic response immediately. “He will reach out to Tony Fauci. He will declare his intent to be an active participant in the WHO and in the world”
9 Nov, 2020 | 01:29h | UTCBiden’s ready to start his pandemic response immediately – STAT
[Preprint] Covid-19 vs. Influenza in Kids: Despite negligible fatality, complications including pneumonia, acute respiratory distress syndrome and multi-system inflammatory syndrome were more frequent in children/adolescents with Covid-19 than with influenza
9 Nov, 2020 | 01:27h | UTC
Study shows preexisting cross-reactive antibodies against common cold coronaviruses may protect against SARS-CoV-2 and are more common in children
9 Nov, 2020 | 01:28h | UTCPreexisting and de novo humoral immunity to SARS-CoV-2 in humans – Science
Commentaries: Pre-existing coronavirus antibodies could help protect children against new pandemic strain – Francis Crick Institute AND Expert reaction to study looking at pre-existing coronavirus antibodies – Science Media Centre
Commentary on Twitter
Do some people have cross-reactive antibodies to #SARSCoV2? If so, who are they? And are these cross-reactive Abs protective against #COVID19? A fascinating study by @KevinWNg et al provides answers. Thread. (1/n)
https://t.co/U9UVrwztX5— Prof. Akiko Iwasaki (@VirusesImmunity) November 7, 2020
Global study shows poor nutrition in school years may have created a 20cm height gap across nations
9 Nov, 2020 | 01:24h | UTCCommentaries: Poor diet: Children 20cm shorter as a result, analysis says – BBC AND Poor nutrition in school years may have created 20cm height gap across nations – Imperial College London
Commentary on Twitter
NEW—Most comprehensive global study to date suggests concerning height and BMI trends among school-aged children and adolescents: a pooled analysis of 2181 population-based studies with 65 million participantshttps://t.co/CXlqcAvYHA pic.twitter.com/Nzj1krjuhH
— The Lancet (@TheLancet) November 5, 2020
JACC Focus Seminar: Advanced management of intermediate- and high-risk pulmonary embolism. Patients who deteriorate despite anticoagulation and those with high-risk PE should be considered for advanced therapies for pulmonary reperfusion, including systemic fibrinolysis, surgical embolectomy, and catheter-based therapies
9 Nov, 2020 | 01:20h | UTCAdvanced Management of Intermediate- and High-Risk Pulmonary Embolism: JACC Focus Seminar – Journal of the American College of Cardiology (free for a limited period)
Podcast: Advanced Management of Intermediate- and High-Risk Pulmonary Embolism: JACC Focus Seminar
New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children
9 Nov, 2020 | 01:25h | UTC
[Not published yet – presented at #ACR20] Randomized trial: Methotrexate improves function in people with knee osteoarthritis after 3 months
9 Nov, 2020 | 01:19h | UTC
Safe surgery: A cluster randomized trial showed that the implementation of control charts with feedback on indicators to surgical teams was associated with concomitant reductions in major adverse events in patients
9 Nov, 2020 | 01:23h | UTC
Guideline synopsis for follow-up colonoscopy after polypectomy. Repeat Col in 7 to 10 y after 1 to 2 tubular adenomas (TA) < 10 mm; Repeat Col in 3 to 5 y after 3 to 4 TA < 10 mm; Repeat Col in 3 y after 5 to 10 TA < 10 mm; Repeat Col in 3 years after 1 or more TA > 10 mm
9 Nov, 2020 | 01:17h | UTCRecommendations for Follow-up Colonoscopy After Polypectomy – JAMA (free for a limited period)
Author interview: New Recommendations for How Often to Repeat Colonoscopy Following Polypectomy
Original guideline: Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology
Another study shows improved outcomes with dual antiplatelet therapy in the first weeks after an acute ischemic stroke or transient ischemic attack
9 Nov, 2020 | 01:16h | UTCRelated Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ
[Preprint] Research finds detectable but low-level SARS-CoV-2 contamination on public surfaces
6 Nov, 2020 | 09:56h | UTCResearch finds detectable but low-level SARS-CoV-2 contamination on public surfaces – News Medical
Original study (preprint): Longitudinal monitoring of SARS-CoV-2 RNA on high-touch surfaces in a community setting – medRxiv
Commentary on Twitter
Can you get COVID-19 from touching the grocery store door handle? Probably not – we estimate the risk at <5 in 10,000. But SARS-CoV-2 RNA on high-touch public surfaces may be a leading indicator of community case trends. New pre-print out! #1440funded https://t.co/x0IpYAlRuY
— Amy Pickering (@SeqH2O) November 2, 2020
Why scientists fear the “toxic” Covid-19 debate
6 Nov, 2020 | 09:57h | UTCWhy scientists fear the “toxic” Covid-19 debate – NewStatesman
Related: Disagree on Covid-19, but don’t demonise other views – Research Professional News
UNICEF and WHO call for emergency action to avert major measles and polio epidemics
9 Nov, 2020 | 01:15h | UTCCommentary: UN urges resumption of mass measles and polio vaccinations – The Guardian
Perspective: Rich countries reserve billions of Covid-19 vaccine doses even before there is one
6 Nov, 2020 | 09:52h | UTCRich Countries Reserve Billions Of Covid-19 Vaccine Doses Even Before There Is One – Forbes
Clots, strokes and rashes. Is COVID-19 a disease of the blood vessels?
6 Nov, 2020 | 09:54h | UTCClots, Strokes And Rashes. Is COVID-19 A Disease Of The Blood Vessels? – NPR
International consensus guidance for management of myasthenia gravis: The 2020 version includes updated recommendations for thymectomy, for early immunosuppression in ocular MG, and for the management of MG associated with immune checkpoint inhibitor treatment
6 Nov, 2020 | 09:46h | UTCInternational consensus guidance for management of myasthenia gravis: 2020 update – Neurology
[Abstract Only] Large randomized trial fails to show benefit from a multifactorial prevention strategy to prevent falls and fractures in older people
6 Nov, 2020 | 09:48h | UTCScreening and Intervention to Prevent Falls and Fractures in Older People – New England Journal of Medicine (link to abstract – $ for full-text)
Related study: A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries – New England Journal of Medicine
Randomized trial: Similar outcomes with goal-directed hemodynamic therapy vs. restrictive normovolemic therapy in major open abdominal surgery
6 Nov, 2020 | 09:34h | UTC
Commentary on Twitter
Goal-directed hemodynamic therapy versus restrictive normovolemic therapy in major open abdominal surgery: A randomized controlled trial #openaccess @SurgJournal @ELSSurgery #SoMe4Surgery https://t.co/pdOk0Z9iMC pic.twitter.com/orRmTnc6l5
— SURGERY Journal (@SurgJournal) November 1, 2020
[Abstract Only] More than a third of older adults are prescribed potentially inappropriate drugs, study finds
6 Nov, 2020 | 09:42h | UTCOriginal study: Potentially Inappropriate Medications Are Associated with Increased Healthcare Utilization and Costs – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
JACC Review: Evaluation and management of patients with stable angina. Based on large clinical trials, medical therapy rather than revascularization is the initial management strategy for most patients
6 Nov, 2020 | 09:43h | UTCEvaluation and Management of Patients With Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review – Journal of the American College of Cardiology (free for a limited period)
Summary: Evaluation and Management of Patients With Stable Angina – American College of Cardiology