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[Abstract Only] Randomized trial: In patients with anorexia nervosa, a higher-calorie refeeding approach promotes earlier recovery with no increase in safety events during hospitalization
6 Nov, 2020 | 09:31h | UTCShort-term Outcomes of the Study of Refeeding to Optimize Inpatient Gains for Patients With Anorexia Nervosa: A Multicenter Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text0
Commentaries: Higher calorie treatment for people hospitalized with anorexia – NIH News Releases AND Higher-calorie diets for patients with anorexia nervosa shorten hospital stays – University of California – San Francisco
Commentary on Twitter
Great paper by @AndreaGarber2 showing that higher-calorie refeeding in #anorexia nervosa does not come at a higher risk of refeeding syndrome and can shorten hospital stays which is advantageous for both the patients/families and the medical system.https://t.co/aFQZKycpTX
— Jonas Steinhäuser (@JoSte95) October 30, 2020
Hot off the presses! Largest clinical trial of refeeding in #anorexianervosa shows that a higher-calorie approach is more efficacious & less costly than lower-calorie refeeding, with no increase in safety events & significant savings in healthcare costs. https://t.co/F0ciJAORdq
— UCSF EatingDisorders (@UCSF_EDP) October 20, 2020
[Abstract Only] New clinical prediction rule for distinguishing bacterial from aseptic meningitis in children
6 Nov, 2020 | 09:32h | UTCClinical Prediction Rule for Distinguishing Bacterial From Aseptic Meningitis – Pediatrics (link to abstract – $ for full-text)
Commentary: How to Tell Bacterial vs Viral Meningitis – Journal Feed
Commentary on Twitter
The MSE (Meningitis Score for Emergencies): a tool that distinguishes aseptic from bacterial meningitis in children aged 1 month to 14 years. An impressive collaborative work of @TSEUP . #AlDiaSEUP @MintegiSanti @JavierBenitoF https://t.co/r6QHjUka88
— riseup-sperg (@riseup_sperg) August 25, 2020
High prevalence of pericardial involvement in college student-athletes recovering from COVID-19
5 Nov, 2020 | 09:08h | UTC
Commentary on Twitter
The heart and #COVID19 in 54 consecutive college athletes @WVUHealth w/ echo, MRIhttps://t.co/76DvMNaeBL @JACCJournals todayhttps://t.co/hMyY8cQNln @ppsengupta1 @BritoCardio
>1/3 had resolving pericarditis with mild-moderate covid or no symptoms; no myocarditis, no controls pic.twitter.com/GTj3JZxL26— Eric Topol (@EricTopol) November 5, 2020
Challenges in creating herd immunity to SARS-CoV-2 infection by mass vaccination. Efficacy, duration of protection, and percentage of the population receiving the vaccine are key issues
5 Nov, 2020 | 09:09h | UTCChallenges in creating herd immunity to SARS-CoV-2 infection by mass vaccination – The Lancet
Commentary on Twitter
The real deal herd immunity, via a #SARSCoV2 vaccine, will be a formidable feat to achieve, with efficacy, coverage levels and duration of protection as key determinants https://t.co/3jeXkO5Yak @TheLancet pic.twitter.com/mXcDpHbHR6
— Eric Topol (@EricTopol) November 5, 2020
Opinion: Disagree on Covid-19, but don’t demonize other views
5 Nov, 2020 | 09:04h | UTCDisagree on Covid-19, but don’t demonise other views – Research Professional News
Postmortem lungs of COVID-19 patients show massive damage
5 Nov, 2020 | 09:06h | UTCPostmortem lungs of COVID-19 patients show massive damage- CIDRAP
Original article: Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology – EBioMedicine
NICE Guideline: Human and animal bites. Assessment, indications for antibiotic prophylaxis in uninfected bites, and choice of antibiotic are reviewed
5 Nov, 2020 | 09:02h | UTC
Meta-analysis: Increased mortality due to cancer treatment delay
5 Nov, 2020 | 09:03h | UTCMortality due to cancer treatment delay: systematic review and meta-analysis – The BMJ
Editorial: Prioritising research into cancer treatment delays – The BMJ
Commentary on Twitter
People whose treatment for cancer is delayed by even one month have in many cases a 6 to 13% higher risk of dying – a risk that keeps rising the longer their treatment does not begin, suggests new research @HannaRadOnc https://t.co/KAmY3vx9jy
— The BMJ (@bmj_latest) November 5, 2020
Review: Electrodiagnostic studies can help establish if a patient is likely to have a muscle disease, a disorder of neuromuscular junction transmission, axon loss, or demyelinating disease
5 Nov, 2020 | 08:56h | UTCUsing and interpreting electrodiagnostic tests – Cleveland Clinic Journal of Medicine
Review: Clinical Management of Hyperkalemia. Classification and monitoring, when to reinitiate RAASi therapy, use oral K+-binding agents, and more
5 Nov, 2020 | 08:58h | UTCClinical Management of Hyperkalemia – Mayo Clinic Proceedings
Review: Diagnosis and treatment of lower extremity venous thromboembolism. Role of pretest probability and D-Dimer on diagnosis + treatment issues such as postthrombotic syndrome and the role of new anticoagulants
5 Nov, 2020 | 09:00h | UTCDiagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review – JAMA (free for a limited period)
Summary: Diagnosis and Treatment of Lower Extremity Venous Thromboembolism – American College of Cardiology
Screening: earlier detection of disease is not necessarily better
5 Nov, 2020 | 08:53h | UTCScreening: earlier detection of disease is not necessarily better – Evidently Cochrane
Systematic Review: Little benefit from phlebotonics in patients with venous insufficiency
5 Nov, 2020 | 08:54h | UTCPhlebotonics for venous insufficiency – Cochrane Library
The neurological sequelae of pandemics and epidemics. A review of large and important epidemics of human history in which neurological manifestations are evident
5 Nov, 2020 | 08:51h | UTCThe neurological sequelae of pandemics and epidemics – Journal of Neurology
Review of clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort
5 Nov, 2020 | 08:46h | UTC
Commentary on Twitter
Protecting lung (vs excessive stress/strain) & diaphragm (vs atrophy/injury due to low/excessive efforts) bedside:
➡️ inspiratory/expiratory MV settings
➡️ monitoring & managing effort or drive
➡️ managing dyssynchrony
➡️ sedation
➡️ adjuvant strategieshttps://t.co/pdvKndwHYY pic.twitter.com/irvrX9WxTj— Intensive Care Medicine (@yourICM) November 2, 2020
[Abstract Only] Randomized, open-label trial: Olanzapine seems effective for the prevention of vomiting in children and adolescents receiving highly emetogenic chemotherapy
5 Nov, 2020 | 08:48h | UTCOlanzapine for Prevention of Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy: Investigator-Initiated, Randomized, Open-Label Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary on Twitter
RCT of adding Olanzapine to Nausea regimen (aprepitant, ondan, dex)
231 children, cycle 1 of highly emetogenic chemo
Primary endpoint: complete response= no vomiting + no rescue med use
78% v 59% day 1
74% v 47% days 1-5
64% v 38% overall#supponc https://t.co/cZFM8bLXKg— Arjun Gupta (@guptaarjun90) September 16, 2020
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS. Dosage, timing of initiation, mode of administration, duration of therapy, infection surveillance, tapering, and more
5 Nov, 2020 | 08:45h | UTC
Commentary on Twitter
Glucocorticoids in #ARDS… focus not only on molecule! Key elements to achieve optimal response to therapy:
➡️ dosage (initial, overtime, adjustments)
➡️ timing of initiation
➡️ mode of administration
➡️ duration of therapy
➡️ tapering
➡️ co-interventionshttps://t.co/4b9vtNXsb7 pic.twitter.com/X6UZyMSI1r— Intensive Care Medicine (@yourICM) November 4, 2020
SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts
4 Nov, 2020 | 09:51h | UTC
Commentary on Twitter
Important new study on #SARSCoV2 transmission of >1,100 cases with 7,700 close contacts
— 36% asymptomatic; require testing
— Household contact risk: sharing bedroom >5X; speaking w/ 1° case for ≥ 30 min: 7.9Xhttps://t.co/lSKebOzoNf @TheLancetInfDis pic.twitter.com/UTtkCUqlRn— Eric Topol (@EricTopol) November 3, 2020
Study: Strategies to prevent super-spreading events could have a significant impact on the overall transmission of Covid-19
4 Nov, 2020 | 09:56h | UTCOriginal study: Evidence that coronavirus superspreading is fat-tailed – Proceedings of the National Academy of Sciences
New CDC Report found that pregnant women with Covid-19 are more likely to have severe illness
4 Nov, 2020 | 09:47h | UTCCommentary: Pregnant women with Covid-19 face higher risk of severe illness and death, study says – CNN
Key populations for early COVID-19 immunization: Preliminary guidance for policy
4 Nov, 2020 | 09:46h | UTC
Commentary on Twitter
Preliminary guidance on key populations for early #COVID19 immunization: groups include those at high risk for severe illness and death, essential workers, #Indigenous communities. Read the evidence-based guideline https://t.co/Tc3vBdJxSV @CPHO_Canada @GovCanHealth @CaroQuach pic.twitter.com/3vyGkL87AD
— CMAJ (@CMAJ) November 3, 2020
The double threat of COVID-19 in Africa
4 Nov, 2020 | 09:43h | UTCThe Double Threat of COVID-19 in Africa – Think Global Health
Association between industry payments to physicians and device selection in ICD implantation
4 Nov, 2020 | 09:40h | UTCAssociation Between Industry Payments to Physicians and Device Selection in ICD Implantation – JAMA (free for a limited period)
Editorial: Reconsidering Health Care Fraud and Abuse Laws (free for a limited period)
Commentary on Twitter
More evidence that payments from industry to physicians influence clinical decisions. Great paper led by @AmarMD99 in @YaleCardiology shows that patients most likely to receive ICD/CRD made by manufacturer that provided largest payments to their physician https://t.co/P1Hh2VAxur
— Joseph Ross (@jsross119) November 3, 2020
Randomized trial: Vitamin C does not improve iron absorption in adult patients with iron deficiency anemia
4 Nov, 2020 | 09:42h | UTCCommentary: Study: Vitamin C Supplements Have No Effect on Iron-Deficiency Anemia – NEJM Journal Watch
Commentary on Twitter
RCT finds oral iron alone is equivalent to oral iron + #vitaminC in improving hemoglobin and iron absorption in patients with iron deficiency #anemia https://t.co/atSVVnGkEV #VisualAbstract
— JAMA Network Open (@JAMANetworkOpen) November 2, 2020
Analysis: Adversity in childhood is linked to mental and physical health throughout life
4 Nov, 2020 | 09:28h | UTCAdversity in childhood is linked to mental and physical health throughout life – The BMJ
Commentary on Twitter
Adversity in the first years of life may deleteriously affect the course of human development. This #BMJInfographic presents some of these challenges and the mechanisms by which they can affect health throughout childhood and into adulthoodhttps://t.co/9cJAgmhrcr @will_s_t pic.twitter.com/Qsfp0YR9fZ
— The BMJ (@bmj_latest) November 3, 2020