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#AHA20 – In patients hospitalized for heart failure with iron deficiency, intravenous Ferric carboxymaltose at discharge reduced the risk of heart failure rehospitalizations
16 Nov, 2020 | 01:53h | UTCCommentaries: Intravenous iron reduced rehospitalization risk in people with heart failure – American Heart Association AND AFFIRM-AHF: IV Iron Supplementation Linked to Fewer Repeat Hospitalizations for HF – TCTMD
Commentary on Twitter
Latebreaker at #AHA20 @AHAMeetings—Ferric carboxymaltose for iron deficiency at discharge after acute #heartfailure: AFFIRM-AHF, a multicentre, double-blind, randomised, controlled trial https://t.co/gRKtbsxfba pic.twitter.com/k67HDJMW2b
— The Lancet (@TheLancet) November 14, 2020
Practice Pointer: Using antibiotics wisely for respiratory tract infection in the era of covid-19
16 Nov, 2020 | 01:48h | UTCUsing antibiotics wisely for respiratory tract infection in the era of covid-19 – The BMJ
Commentary on Twitter
When should patients with respiratory tract infections be assessed in person and when should you prescribe antibiotics based on best available evidence? This Practice Pointer offers guidance in the era of covid-19https://t.co/k6LoYPWmsv pic.twitter.com/rtIrjplyv0
— The BMJ (@bmj_latest) November 15, 2020
Sweden has admitted its coronavirus immunity predictions were wrong as cases soar across the country
16 Nov, 2020 | 01:44h | UTC
Perspective: The third surge is breaking health-care workers
16 Nov, 2020 | 01:46h | UTC
Commentary from the author (thread – click for more)
🚨I wrote about what health-care workers are going through, how exhausted & scared they are, and what this 3rd pandemic surge is doing to them.
It’s not like the first 2. It’s worse. How much slack is left in the system? Iowa nurse: “There is none” 1/ https://t.co/is2NGHdwRP
— Ed Yong is not here (@edyong209) November 13, 2020
World Diabetes Day 2020 (14 November 2020): Introducing the Global Diabetes Compact
16 Nov, 2020 | 01:43h | UTCWorld Diabetes Day 2020: Introducing the Global Diabetes Compact – World Health Organization
See also: WHO Global Diabetes Compact
Related: The Lancet Commission on diabetes: using data to transform diabetes care and patient lives (free registration required) AND Editorial: Turning evidence into action on diabetes – The Lancet
Commentary on Twitter (thread – click for more)
It's #WorldDiabetesDay #COVID19 causes fear & suffering for people with #diabetes:
1⃣ They have ↗️ risk of severe disease & death when infected with COVID-19
2⃣ Delay in diagnosis may result in more advanced disease & complications
3⃣ Delayed, incomplete, interrupted treatment pic.twitter.com/vlL9XAXVqq— World Health Organization (WHO) (@WHO) November 14, 2020
Covid-19: Inhaled Nebulized Interferon Beta-1a shows potential for hospitalized patients in preliminary trial
13 Nov, 2020 | 09:33h | UTC
Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19
13 Nov, 2020 | 09:35h | UTCEditorial: COVID-19 Infection—Preventing Clinical Deterioration
Long Covid: Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
13 Nov, 2020 | 09:27h | UTCCommentary: Half of recovered COVID-19 patients report lingering fatigue – CIDRAP
Long Covid: 2 months after being hospitalized for Covid-19, many patients persisted symptomatic and did not resume normal activities
13 Nov, 2020 | 09:28h | UTCSixty-Day Outcomes Among Patients Hospitalized With COVID-19 – Annals of Internal Medicine
Commentary on Twitter
New Mich. hospital data: Of people admitted with COVID, 70% were alive and home 60 days later.
Of those who'd been working, 40% either lost their job or were still too sick to work.
It's not just the deaths; it's the health and economic damage. https://t.co/wMGkJw5KSF pic.twitter.com/8EbHktTxRX
— Atul Gawande (@Atul_Gawande) November 12, 2020
Case report: Persistence and evolution of SARS-CoV-2 in an immunocompromised host
13 Nov, 2020 | 09:24h | UTC
Commentary on Twitter (thread – click for more)
This summer, we partnered with the clinical team of an immunosuppressed patient with recurrent COVID and multiple hospitalizations. His NP swab VL reached 1 billion copies 5 months after initial dx. The team's Q: is this pt being re-infected w/ COVID? 1/ https://t.co/vkVerBUUPg
— Jonathan Li (@DrJLi) November 12, 2020
How risky is air travel in the pandemic? Here’s what the science says
13 Nov, 2020 | 09:22h | UTCHow risky is air travel in the pandemic? Here’s what the science says – Vox
Tranexamic acid after traumatic brain injury: Exploratory analysis combining data from CRASH-2 and CRASH-3 trials suggests reduced mortality
13 Nov, 2020 | 09:21h | UTC
Commentary on Twitter
📊🔍 IPD meta-analysis of #CRASH2 and #CRASH3 trials show rapid #TXA (<3 hrs) reduces early deaths by >20% in both studies
Highly consistent results that #TXA reduces trauma deaths regardless of the location of the #bleeding 🩸
READ @Crit_Care 👉https://t.co/s3vkm6c6Tf pic.twitter.com/og9jYi5tqo
— Clinical Trials Unit – Global Health Trials Group (@CTU_LSHTM) November 11, 2020
Perspective: Many younger adults need to take Covid-19 more seriously as demographics shift
13 Nov, 2020 | 09:25h | UTCYounger Adults Caught in COVID-19 Crosshairs as Demographics Shift – JAMA
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/jenabbasi/status/1326909913805828100
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus
13 Nov, 2020 | 09:19h | UTC
Older age and frailty are frequently associated with atypical and unspecific COVID-19 presentations, including functional decline, acute mental change, and hypotension
12 Nov, 2020 | 09:22h | UTC
Commentary on Twitter
DIVERGENT: age, #frailty, and presentations of #COVID19
Typical symptoms were uncommon in frail and older
patients; they were more likely to experience functional decline and key features of delirium. #geriatrics @geronsociety @OxfordJournals #gerontolhttps://t.co/jRhwvacsVm pic.twitter.com/9zhHZjsSoy— Marlon Aliberti (@marlon_aliberti) November 5, 2020
Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality
12 Nov, 2020 | 09:24h | UTCCommentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business
[Abstract Only] Study: An automated predictive model can identify hospitalized adults outside the ICU at risk for clinical deterioration for whom interventions by rapid-response teams could be implemented
13 Nov, 2020 | 09:16h | UTCAutomated Identification of Adults at Risk for In-Hospital Clinical Deterioration – New England Journal of Medicine (link to abstract – $ for full-text)
Review for the public on the different kinds of COVID-19 tests. It covers the differences and similarities between molecular, antigen, and serologic tests.
12 Nov, 2020 | 09:19h | UTC
Wearing cloth or disposable surgical face masks has no effect on vigorous exercise performance in healthy individuals
12 Nov, 2020 | 09:21h | UTCCommentary: Face masks don’t hinder breathing during exercise, study finds – University of Saskatchewan
Why do COVID death rates seem to be falling? Correct use of corticosteroids, hard-won experience, younger patients, and reduced strain on hospitals are all possibilities
12 Nov, 2020 | 09:16h | UTCWhy do COVID death rates seem to be falling? – Nature
New Guideline on neonatal opioid withdrawal syndrome provides advice on monitoring the newborn for withdrawal symptoms, supportive care, and breastfeeding
12 Nov, 2020 | 09:14h | UTCNeonatal Opioid Withdrawal Syndrome – Pediatrics
Commentaries: Pediatrics Group Issues Recommendations on Neonatal Opioid Withdrawal Syndrome – NEJM Journal Watch AND New guidelines address rise in opioid use during pregnancy – Associated Press
[Preprint] Validation of home oxygen saturation as a marker of clinical deterioration in patients with suspected COVID-19: Even small deflections in oxygen saturations of 1-2% below 96% confer an increased mortality risk.
12 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
*BREAKING* First paper examining home oxygen saturation in COVID confirmed cases as a trigger for initial hospital assessment. We need to rapidly implement a hybrid community-hospital COVID Oximetry@home #COVIDvirtualward @richardhorton1 @bmj_latest https://t.co/0SjrUT0Tjw pic.twitter.com/0TgPPRUBqv
— Matt Inada-Kim (@mattinadakim) November 8, 2020
Prone position in ARDS patients: why, when, how and for whom
12 Nov, 2020 | 09:11h | UTCProne position in ARDS patients: why, when, how and for whom – Intensive Care Medicine
Commentary on Twitter
Prone position in #ARDS
➡️ effects: chest wall/lung mechanics, ventilation, perfusion, gas exchange
➡️ hemodynamics
➡️ whom & when? indications/contraindications
➡️ ventilator settings
➡️ how to perform bedside
➡️ impact on outcomes
➡️ unanswered questionshttps://t.co/rCU7QOQSlw pic.twitter.com/rpBK8kRE9W— Intensive Care Medicine (@yourICM) November 10, 2020
Opinion: “Why the Pfizer and BioNTech vaccine is a cause for optimism — and skepticism. Vaccine science by press release has to stop”
11 Nov, 2020 | 09:25h | UTCWhy the Pfizer and BioNTech vaccine is a cause for optimism — and skepticism – Vox
Related commentaries: Champagne and questions greet first data showing that a COVID-19 vaccine works – Science AND 90% efficacy for Pfizer’s COVID-19 mRNA vaccine is striking. But we need to wait for the full data – The Conversation
See also: Science by press release: When the story gets ahead of the science – CNN
[Preprint] A machine learning study of 534,023 Medicare beneficiaries with COVID-19: Implications for personalized risk prediction to identify candidates for early vaccine and therapeutics allocation.
12 Nov, 2020 | 09:15h | UTCCommentary: Largest-to-Date COVID Mortality Study Released – MedPage Today (free registration required)