All Posts
M-A: Not enough evidence there are individual differences in response to antidepressants
19 Feb, 2021 | 02:15h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)
Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly
Related studies: What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis – BMJ Open AND Individual response to antidepressants for depression in adults-a meta-analysis and simulation study – PLOS One
Commentary on Twitter (thread – click for more)
https://twitter.com/PloederlM/status/1362294365255852032
Defining the optimal total number of chemotherapy courses in younger patients with Acute Myeloid Leukemia: A comparison of 3 vs. 4 courses
19 Feb, 2021 | 02:06h | UTCDefining the Optimal Total Number of Chemotherapy Courses in Younger Patients With Acute Myeloid Leukemia: A Comparison of Three Versus Four Courses – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Optimal Number of Treatment Courses Explored in Younger Patients with AML – CancerNetwork
Commentary on Twitter
What is the optimal number of chemotherapy courses in younger patients with acute myeloid leukemia (AML)? This study evaluates 3 vs 4 courses https://t.co/peC7Xo3BbX #leusm #JCO pic.twitter.com/OGChNkYS0X
— Journal of Clinical Oncology (@JCO_ASCO) January 6, 2021
RCT: Treatment of uterine fibroid symptoms with Relugolix combination therapy
19 Feb, 2021 | 02:08h | UTC
Review: Diagnosis and treatment of metastatic colorectal cancer
19 Feb, 2021 | 02:07h | UTCDiagnosis and Treatment of Metastatic Colorectal Cancer: A Review – JAMA (free for a limited period)
Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO and OH (CCO) Joint Guideline Update
19 Feb, 2021 | 02:04h | UTC
BRUGADA-RISK: A primary prevention clinical risk score model for patients with Brugada Syndrome
18 Feb, 2021 | 02:57h | UTCCommentary: Risk Score Model for Brugada Syndrome – American College of Cardiology
RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism
18 Feb, 2021 | 02:46h | UTCRelated Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine
Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism
Commentary on Twitter
Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1
— JAMA Network Open (@JAMANetworkOpen) February 10, 2021
AAP: 2021 Recommendations for Preventive Pediatric Health Care
18 Feb, 2021 | 03:01h | UTCRecommendations: Periodicity Schedule
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
18 Feb, 2021 | 03:20h | UTCEditorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer
In this RCT a single high dose of #vitaminD3 (100K IU) raised mean serum 25OH D levels but had no effect on hospital LOS (primary outcome), in-hospital mortality, ICU admission, or need for mechanical ventilation (secondary outcomes) https://t.co/eozVaYnb25
— JAMA (@JAMA_current) February 17, 2021
Clinical decisions: Delayed second dose vs. standard regimen for Covid-19 vaccination
18 Feb, 2021 | 03:17h | UTC
World’s first coronavirus “Human Challenge” study receives ethics approval in the UK
18 Feb, 2021 | 03:14h | UTCWorld’s first coronavirus Human Challenge study receives ethics approval in the UK – GOV.UK
Commentaries: Covid-19: World’s first human trials given green light in UK – BBC AND UK to infect up to 90 healthy volunteers with Covid in world first trial – The Guardian
WHO Guidance on the subject: Feasibility, potential value and limitations of establishing a closely monitored challenge model of experimental COVID-19 infection and illness in healthy young adult volunteers – World Health Organization AND Key criteria for the ethical acceptability of COVID-19 human challenge studies – World Health Organization
See also: Challenge Trials—Could Deliberate Coronavirus Exposure Hasten Vaccine Development? – JAMA AND Ethical guidelines for deliberately infecting volunteers with COVID-19 – Journal of Medical Ethics AND Challenge trials can speed development of a Covid-19 vaccine. Planning for them needs to start now – STAT AND Accelerating Development of SARS-CoV-2 Vaccines — The Role for Controlled Human Infection Models – New England Journal of Medicine AND Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure – The Journal of Infectious Diseases AND Ethics of controlled human infection to address COVID-19 – Science AND Extraordinary diseases require extraordinary solutions – Vaccine
M-A: The effect of convalescent plasma therapy on COVID-19 patient mortality
18 Feb, 2021 | 03:07h | UTCRelated study (not published yet) with conflicting results: RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19 (news release and commentary)
Open schools in Sweden during the SARS-CoV-2 pandemic were associated with low incidence of severe Covid-19 among schoolchildren and children of preschool age
18 Feb, 2021 | 03:19h | UTCOpen Schools, Covid-19, and Child and Teacher Morbidity in Sweden – New England Journal of Medicine
Video: Emergency intubation in Covid-19
18 Feb, 2021 | 03:16h | UTCEmergency Intubation in Covid-19 – New England Journal of Medicine
India’s dramatic fall in virus cases leaves experts stumped
18 Feb, 2021 | 03:06h | UTCIndia’s dramatic fall in virus cases leaves experts stumped – Associated Press
What place should COVID-19 vaccine passports have in society?
18 Feb, 2021 | 03:12h | UTCWhat place should COVID-19 vaccine passports have in society? – Ada Lovelace Institute
Q&A: Does handwashing stem the transmission of Covid-19?
18 Feb, 2021 | 03:03h | UTCQ&A: Does handwashing stem the transmission of Covid-19?
Related: Coronavirus is in the air — there’s too much focus on surfaces – Nature AND COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature
Patient characteristics and clinical outcomes of Type 1 vs. Type 2 myocardial infarction
18 Feb, 2021 | 02:54h | UTCPatient Characteristics and Clinical Outcomes of Type 1 Versus Type 2 Myocardial Infarction – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)
Commentary on Twitter
What are the patient characteristics & clinical outcomes of type 1 vs type 2 #cvMI in the U.S.? Over 200K+ are analyzed. Find out in this week’s issue of #JACC: https://t.co/trgZtKgbOy @CianPMcCarthy @mvaduganathan @JJheart_doc #HFWeek2021 #HeartMonth #CardioTwitter pic.twitter.com/dCdinfeNwE
— JACC Journals (@JACCJournals) February 16, 2021
WHO: New Covid-19 cases around the world dropped 16% last week
18 Feb, 2021 | 03:04h | UTCNew Covid-19 Cases Around The World Dropped 16% Last Week, World Health Organization Says – Forbes
SR: Concomitant use of levothyroxine and proton pump inhibitors causes a significant increase in TSH concentration
18 Feb, 2021 | 02:48h | UTC
A small, randomized cross-over trial showed Ivabradine may be a useful medication for hyperadrenergic POTS (Postural orthostatic tachycardia syndrome)
18 Feb, 2021 | 02:56h | UTCRandomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome – Journal of the American Academy of Cardiology (link to abstract – $ for full-text)
Commentaries: Existing heart failure drug may treat potential COVID-19 long-hauler symptom, study suggests – University of California – San Diego AND Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome – Ivabradine in POTS – American College of Cardiology
Commentary on Twitter
Our study showing ivabradine's benefit for POTS patients is out @JACCJournals. Also has implications for post-COVID 19 POTS (part of long haulers syndrome). Congrats to my co-first author/mentee @AdenaZadourian and the rest of my research team. @Dysautonomia @NIH @UCSDHealth pic.twitter.com/KGtzFh9CnT
— Pam R. Taub, MD❤️💃🏻 (@PamTaubMD) February 15, 2021
M-A: Preventable medication harm across health care settings
18 Feb, 2021 | 02:43h | UTCCommentary: Preventable medication harm across health care settings: a systematic review and meta-analysis – PSNet
RCT: Avacopan for the treatment of ANCA-associated vasculitis
18 Feb, 2021 | 02:50h | UTCAvacopan for the Treatment of ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
Dieting may slow metabolism – but it doesn’t ruin it
18 Feb, 2021 | 02:44h | UTCDieting may slow metabolism – but it doesn’t ruin it – The Conversation
Sleep: the underhyped secret to success and safety in medicine
18 Feb, 2021 | 02:41h | UTCSleep: the underhyped secret to success and safety in medicine – The BMJ Opinion
Commentary on Twitter
“As medical students you feel guilty if you’re not up burning the midnight oil, but actually, from a learning point of view, you are much better in prioritising your sleep. Sleep is absolutely fundamental to learning.” @DrMikeFarquhar @BMJStudent https://t.co/MDxNWBCMVS
— The BMJ (@bmj_latest) February 17, 2021