All Posts
Improving lung health in low-income and middle-income countries: from challenges to solutions
28 Feb, 2021 | 21:23h | UTCImproving lung health in low-income and middle-income countries: from challenges to solutions – The Lancet (free registration required)
Commentary on Twitter
LMICs bear a high burden of global morbidity & mortality from chronic respiratory diseases (CRDs). Read this review on improving lung health in LMICs—challenges in prevention, diagnosis, management, & pathways to universal health coverage: https://t.co/u8ToWFzwUl pic.twitter.com/gJQbO8B0Zk
— The Lancet (@TheLancet) February 24, 2021
Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice
28 Feb, 2021 | 21:25h | UTCNews release: Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice – Wits University
Commentary on Twitter
New paper from @davidjbath @CatKPitt and colleagues
@LSHTM_CHIL @LSHTM_malariaTargeting spraying for malaria control is safe, less costly, and cost-effective compared with standard spraying
With low incidence, these funds could be spent elsewhere🦟https://t.co/OCb9qhqBCX https://t.co/a0sD4uhymo
— Global Health Economics Centre (@LSHTM_GHECO) February 26, 2021
Turning houses into ‘lethal mosquito lures’ nearly halves incidence of malaria in children
28 Feb, 2021 | 21:26h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/EDSternberg/status/1365083598538362882
RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay
28 Feb, 2021 | 21:09h | UTCEditorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU
Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder
Commentary on Twitter
In this phase 3 RCT, high-dose baclofen reduced agitation-related events vs placebo in patients with unhealthy alcohol use receiving mechanical ventilation; considering the modest effect & secondary endpoints & adverse events, further research is needed https://t.co/gHWEqZKfFv
— JAMA (@JAMA_current) February 23, 2021
RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia
28 Feb, 2021 | 21:03h | UTC
RCT: similar outcomes in patients with heart failure with preserved ejection fraction randomized to high-intensity interval training vs. moderate continuous training vs. guideline-based physical activity advice
28 Feb, 2021 | 21:06h | UTCEffect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Hold Off on HIIT for Patients with Heart Failure with Preserved EF – Physician’s Weekly
Commentary on Twitter
In this RCT, high-intensity interval training was no better at improving peak V̇O₂ at 3 months vs moderate continuous or guideline control training, in patients with #HFpEF https://t.co/CZzAcQESLg @TUMSportMedizin @jamacardiology @jamainternalmed #VisualAbstract
— JAMA Cardiology (@JAMACardio) February 22, 2021
RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates
28 Feb, 2021 | 20:59h | UTCSafety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Clinical Update: Enteric Fever
28 Feb, 2021 | 21:02h | UTCEnteric fever – The BMJ (free for a limited period)
Commentary on Twitter
Diagnosis of enteric fever is complicated as symptoms overlap with other causes of fever and early investigations are inconclusive. Here's what you need to know about its presentation, diagnosis, and treatment #BMJEducationhttps://t.co/1mvbNb7peS pic.twitter.com/Z7YxngHanl
— The BMJ (@bmj_latest) February 28, 2021
M-A: Risk predictors of progression to severe disease during the febrile phase of dengue
28 Feb, 2021 | 20:57h | UTC
Cognitive behavioral therapy for a variety of conditions: an overview of systematic reviews and panoramic meta-analysis
28 Feb, 2021 | 20:50h | UTC
Observational study suggests women have a lower range of ‘normal’ blood pressure than men
28 Feb, 2021 | 20:52h | UTCNews release: Women Have a Lower Range of ‘Normal’ Blood Pressure Than Men – Cedars-Sinai
Original study: Sex Differences in Blood Pressure Associations With Cardiovascular Outcomes – Circulation
Commentary: Women’s Risk for CVD Seen at Lower BP Thresholds Than Men – TCTMD
Commentary on Twitter
Sex differences in associations of systolic blood pressure with incident CVD: are sex-specific blood pressure goals needed? https://t.co/JibgGRh9uP #GoRedforWomen #AHAJournals @BP_Teemu pic.twitter.com/SWEWBjA2Nx
— Circulation (@CircAHA) February 17, 2021
RCT: Endoscopic surgery improves survival compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma
28 Feb, 2021 | 20:45h | UTC
Bioethics | Should clinical guidelines incorporate cost pathways for persons with financial hardship?
28 Feb, 2021 | 20:54h | UTC
Joint Statement: Hydroxychloroquine use with respect to retinal toxicity
28 Feb, 2021 | 20:41h | UTCCommentary: Societies Agree on Eye Safety for HCQ – MedPage Today (free registration required) AND ACR, medical societies reach consensus on hydroxychloroquine retinopathy – Healio (free registration required)
Commentary on Twitter
🆕 Joint statement on #Hydroxychloroquine use with respect to retinal toxicity 👀 by several #rheumatology and #opthtalmology societies. #ocular #toxicity relates to #HCQ dosage and duration of use and is seen in 4.3% to 13.8% of patients 🔎#Lupus #SLEhttps://t.co/ocFSCmgVsN
— Laurent ARNAUD (@Lupusreference) February 18, 2021
Systematic Review: Cardiovascular Effects of Medical Marijuana
28 Feb, 2021 | 20:48h | UTCCardiovascular Effects of Medical Marijuana: A Systematic Review – The American Journal of Medicine
M-A: Adjuvant corticosteroids are effective in lowering the risk of kidney scarring in children with acute pyelonephritis
28 Feb, 2021 | 20:38h | UTCAdjuvant corticosteroids for prevention of kidney scarring in children with acute pyelonephritis: a systematic review and meta-analysis – Archives of Disease in Childhood (link to abstract – $ for full-text)
U.S. Guidelines panel recommendation for long-acting injectable antiretroviral regimen in adults and adolescents with HIV
28 Feb, 2021 | 20:34h | UTCWhat’s New in the Guidelines? Panel’s Recommendation for Long-Acting Injectable Cabotegravir and Rilpivirine in Persons with HIV
Indian Guidelines for pediatric skin care in neonates, infants, and children
28 Feb, 2021 | 20:37h | UTCIndian Academy of Pediatrics Guidelines for Pediatric Skin Care
CDC studies on superspreading events at fitness facilities
26 Feb, 2021 | 08:44h | UTCCommentaries: Going maskless is a key factor in Covid-19 outbreaks at gyms, studies say – CNN AND A Chicago gym saw dozens of COVID-19 cases after infected people attended HIIT classes without masks – Insider
Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19
26 Feb, 2021 | 08:48h | UTC
Commentary on Twitter
Why do 2 randomized trials of tocilizumab, an interleukin-6 blocker, for severe covid-19, have opposite results?
Today @NEJMhttps://t.co/g8LCrhhpLyhttps://t.co/BcN3wOwsl0 pic.twitter.com/sLrQUYI1pf— Eric Topol (@EricTopol) February 25, 2021
PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?
28 Feb, 2021 | 20:43h | UTCEditorial: Navigating treatment approaches for presumed ESBL-producing infections
Commentary on Twitter (thread – click for more)
🔥NEW🔥 PRO-CON Debate on the role of carbapenems in infections caused by Enterobacterales resistant to ceftriaxone. #AMR @BSACandJAC @IDdocAdi @ABsteward
— JAC-AMR (@jac_amr) February 24, 2021
WHO Report: Preparing for Long COVID 2021
26 Feb, 2021 | 08:46h | UTCIn the wake of the pandemic: preparing for Long COVID (2021) – World Health Organization
Commentaries: Long COVID sufferer still has disease’s debilitating symptoms nearly a year after first falling ill – EuroNews AND Debilitating ‘long-COVID’ may have severe health, social impacts: WHO – Reuters
Related: Dr. Fauci says new data suggests ‘long’ Covid symptoms can last up to 9 months – CNBC
New protocol tested SARS-CoV-2 positivity on day 9 among quarantined student contacts of confirmed cases, resulting in safe reduction in loss of instructional time
26 Feb, 2021 | 08:42h | UTCCommentary: Is the CDC 10-day COVID-19 quarantine guideline enough? – News Medical
Commentary on Twitter
In this study of a 9-day testing protocol for student contacts of confirmed #COVID19 cases in 1 Florida county, a reduction in loss of instructional time was found that was less than what would have occurred with 14-day quarantine https://t.co/YPft2oAvYk
— JAMA (@JAMA_current) February 19, 2021
Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19
26 Feb, 2021 | 08:43h | UTCCommentary: Studies help discern severe COVID from related kids’ syndrome – CIDRAP
Commentary on Twitter
In this case series using national MIS-C registry data, kids w MIS-C were younger (6-12 y), more likely to be non-Hispanic Black, & have severe CV or mucocutaneous involvement and more extreme inflammation vs kids w severe #COVID19 https://t.co/jmCCDPXLmf @BostonChildrens
— JAMA (@JAMA_current) February 25, 2021
Real-world data confirms Pfizer-BioNTech vaccine effectiveness
25 Feb, 2021 | 09:09h | UTCAudio Interview: The Real-World Effectiveness of Covid-19 Vaccination – New England Journal of Medicine
Commentaries: Real-world trial of Pfizer COVID vaccine finds high 2-dose, good 1-dose protection – CIDRAP AND Pfizer-BioNTech vaccine performs as well in the real world as in clinical trials, new study concludes – STAT AND In boost for COVID-19 battle, Pfizer vaccine found 94% effective in real world – Reuters AND Expert reaction to NEJM paper on Pfizer-BioNTech vaccine roll-out in Israel and COVID-19 outcomes – Science Media Centre
Commentary on Twitter (thread – click for more)
1/
We've just confirmed the effectiveness of the Pfizer-BioNTech vaccine outside of randomized trials.Details @NEJM: https://t.co/POgXK8owvM
Yes, great news, but let's talk about methodological issues that arise when using #observational data to estimate vaccine effectiveness.
— Miguel Hernán (@_MiguelHernan) February 24, 2021