Real-world data confirms Pfizer-BioNTech vaccine effectiveness

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting – New England Journal of Medicine

Audio Interview: The Real-World Effectiveness of Covid-19 Vaccination – New England Journal of Medicine

Commentaries: Real-world trial of Pfizer COVID vaccine finds high 2-dose, good 1-dose protection – CIDRAP AND Pfizer-BioNTech vaccine performs as well in the real world as in clinical trials, new study concludes – STAT AND In boost for COVID-19 battle, Pfizer vaccine found 94% effective in real world – Reuters AND Expert reaction to NEJM paper on Pfizer-BioNTech vaccine roll-out in Israel and COVID-19 outcomes – Science Media Centre

Commentary on Twitter (thread – click for more)

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We've just confirmed the effectiveness of the Pfizer-BioNTech vaccine outside of randomized trials.

Details @NEJM: https://t.co/POgXK8owvM

Yes, great news, but let's talk about methodological issues that arise when using #observational data to estimate vaccine effectiveness.

— Miguel Hernán (@_MiguelHernan) February 24, 2021