All Posts
SR | Long‐acting muscarinic antagonist (LAMA) plus long‐acting beta‐agonist (LABA) vs. LABA plus inhaled corticosteroid (ICS) for COPD
20 Jun, 2023 | 12:26h | UTC
SR | Automated mandatory bolus vs. basal infusion for maintenance of epidural analgesia in labor
20 Jun, 2023 | 12:24h | UTC
ESICM guidelines on ARDS: definition, phenotyping and respiratory support strategies
19 Jun, 2023 | 14:18h | UTCSee also: Caring for Patients With Acute Respiratory Distress Syndrome: Summary of the 2023 ESICM Practice Guidelines – JAMA (free for a limited period)
Commentary on Twitter
#ARDS @ESICM guidelines
🫁 definition
🫁 phenotyping
🫁 #HFNO
🫁 CPAP/NIV
🫁 low tidal volume MV
🫁 PEEP & recruitment maneuvers
🫁 prone positioning
🫁 neuromuscular blocking agents
🫁 extracorporeal life support #ECMO #ECLS #ECCO2r#FOAMcc on @yourICM
🖇️ https://t.co/xGtI2y0vZw pic.twitter.com/H1z7EBxLLo— Intensive Care Medicine (@yourICM) June 16, 2023
RCT | High-dose hemodiafiltration reduces mortality risk in kidney failure patients compared to conventional high-flux hemodialysis
19 Jun, 2023 | 14:17h | UTCEffect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
#ERA23: In patients with kidney failure undergoing kidney-replacement therapy, the use of high-dose hemodiafiltration resulted in lower mortality than conventional high-flux hemodialysis. Full results of the CONVINCE trial: https://t.co/NRtQnHm9vo
— NEJM (@NEJM) June 16, 2023
RCT | Video laryngoscopy improves first-attempt intubation, severe complications unchanged
19 Jun, 2023 | 14:15h | UTCVideo versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Study shows video laryngoscope increases successful intubation on first attempt – Vanderbilt University Medical Center
RCT | Testosterone replacement does not appear to increase cardiovascular events in hypogonadal men at high risk
19 Jun, 2023 | 14:13h | UTCCardiovascular Safety of Testosterone-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Presented today at #ENDO2023: In the TRAVERSE study, a randomized trial involving men with hypogonadism and preexisting or a risk of cardiovascular disease, testosterone therapy was noninferior to placebo with respect to major adverse cardiac events. https://t.co/V3FTTsOLd1
— NEJM (@NEJM) June 16, 2023
RCT | Continuous vs. intermittent meropenem administration shows similar mortality and drug-resistance in sepsis patients
19 Jun, 2023 | 14:11h | UTCContinuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis? – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Trial finds no difference between continuous, intermittent meropenem for sepsis patients – CIDRAP
Commentary on Twitter
Continuous administration of meropenem, compared with intermittent administration, does not improve clinically relevant outcomes in critically ill patients with #sepsis. https://t.co/eJ9zdGI4k2 #CCR23 pic.twitter.com/8n2eR9qBPe
— JAMA (@JAMA_current) June 16, 2023
Practice advisory for preoperative and intraoperative pain management of thoracic surgical patients
19 Jun, 2023 | 14:05h | UTCPart 1: Practice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients – Anesthesia and Analgesia (free for a limited period)
Part 2: Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients – Anesthesia and Analgesia (free for a limited period)
See also: Prevalence and Characteristics of Persistent Postoperative Pain After Thoracic Surgery: A Systematic Review and Meta-Analysis – Anesthesia and Analgesia (free for a limited period)
Infographic: Persistent Pain After Thoracic Surgery—What Works, What Doesn’t – Anesthesia and Analgesia (free for a limited period)
RCT | Fruquintinib extends median survival to 7.4 months vs. 4.8 months with placebo in refractory metastatic colorectal cancer
19 Jun, 2023 | 14:02h | UTCFruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter questioning the control group (thread – click for more)
Disgusting, unethical PLACEBO control trial in colon cancer just so Fruquitinib can win
I will show you that placebo should not have been the control arm, & the IRBs & FDA failed 🧵
First, this trial tests a new drug vs. placebo (sugar pill) in patients dying of colon cancer pic.twitter.com/fa915vgUbp
— Vinay Prasad MD MPH (@VPrasadMDMPH) June 17, 2023
RCT | Adding bio-impedance to fluid management fails to enhance kidney function preservation in new hemodialysis patients
19 Jun, 2023 | 14:01h | UTC
Review | Necessity of antigen testing for Legionella in hospitalized patients with community-acquired pneumonia
19 Jun, 2023 | 13:56h | UTC
Review | Celiac disease: who should I test, and how?
19 Jun, 2023 | 13:54h | UTCCeliac disease: Who should I test, and how? – Cleveland Clinic Journal of Medicine
Review | mRNA-based cancer therapeutics
19 Jun, 2023 | 13:53h | UTCmRNA-based cancer therapeutics – Nature Reviews Cancer
Commentary on Twitter
Excited to share our paper entitled "mRNA-based cancer therapeutics" @NatureRevCancer. Congrats to all the group members @BrighamWomens @harvardmed on this paper! 👉https://t.co/1LB1M1Yl96https://t.co/QwmDZmyixB
— Wei Tao (@WeiTaoLab) June 13, 2023
M-A | Anticoagulation options for continuous renal replacement therapy in critically ill patients
19 Jun, 2023 | 13:51h | UTC
Review | The role of diet and nutrition in the management of COPD
19 Jun, 2023 | 13:47h | UTCThe role of diet and nutrition in the management of COPD – European Respiratory Review
Evidence Analysis | ADHD: evidence to help you decide how best to manage the condition
19 Jun, 2023 | 13:45h | UTCADHD: evidence to help you decide how best to manage the condition – Evidently Cochrane
Consensus Paper | Transition of patients with esophageal atresia–tracheoesophageal fistula
19 Jun, 2023 | 13:44h | UTCThe International Network on Oesophageal Atresia (INoEA) consensus guidelines on the transition of patients with oesophageal atresia–tracheoesophageal fistula – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Position Statement | Curriculum for training in endoscopic mucosal resection in the colon
19 Jun, 2023 | 13:42h | UTC
Review | Role of GLP1 receptor agonists in achieving weight loss and improving CV outcomes in people with overweight and obesity
19 Jun, 2023 | 13:40h | UTC
Triple trouble | Uncovering the risks and benefits of early fetal reduction in trichorionic triplets in a large national Danish cohort study
19 Jun, 2023 | 13:39h | UTC
M-A | HFNC, CPAP, BiPAP prove more effective than conventional oxygen therapy in minimizing pediatric extubation failure
19 Jun, 2023 | 13:35h | UTC
Commentary on Twitter
Study suggests that CPAP, HFNC, and BiPAP were more effective than conventional oxygen therapy for providing postextubation noninvasive respiratory support in a pediatric population. https://t.co/d56eNkP8QP @abusultaneh @RobyKhemaniMD @PALISInet
— JAMA Pediatrics (@JAMAPediatrics) June 5, 2023
RCT | Mild hypercapnia after cardiac arrest shows no improvement in neurological outcomes vs. normocapnia
16 Jun, 2023 | 14:15h | UTCMild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: New data supports current management of CO2 levels in cardiac arrest patients – UCD Dublin
Perspective | Benefits and pitfalls of social media in cardiology
16 Jun, 2023 | 14:13h | UTC
Commentary on Twitter
Medical #education has entered the #DigitalTransformation era 🤖
What is the role of #SoMe and multimedia platforms in #cardiology❓
Here is our view from the @JACCJournals #JACCCaseReports #SoMe Editors ❤️#CardioTwitter #MedEd #CardioEd
➡️Link to full paper below🧵 pic.twitter.com/0W77HzoJ6Q
— Alessandro Beneduce (@ABeneduceMD) June 9, 2023
Brief Review | Why is cuff size so important and other factors that affect accurate blood pressure measurement
16 Jun, 2023 | 14:12h | UTC
RCT | Multiple electrolytes solution reduces acute kidney injury in pediatric septic shock compared to saline
16 Jun, 2023 | 14:10h | UTCMultiple Electrolytes Solution Versus Saline as Bolus Fluid for Resuscitation in Pediatric Septic Shock: A Multicenter Randomized Clinical Trial – Critical Care Medicine (link to abstract – $ for full-text)