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Systematic Review | Tranexamic acid likely decreases red blood cell transfusion need in hip fracture surgery

16 Jun, 2023 | 14:09h | UTC

Interventions for reducing red blood cell transfusion in adults undergoing hip fracture surgery: an overview of systematic reviews – Cochrane Library

Summary: What treatments reduce the need for a blood transfusion in adults who have broken their hip? – Cochrane Library

SR | Analysis of postdischarge interventions for children treated for moderate or severe wasting, growth faltering or failure, or edema

16 Jun, 2023 | 14:07h | UTC

Analysis of Postdischarge Interventions for Children Treated for Moderate or Severe Wasting, Growth Faltering or Failure, or Edema: A Systematic Review – JAMA Network Open

RCT | Cisplatin–gemcitabine improves 3-year progression-free survival in N2–3 nasopharyngeal carcinoma compared to cisplatin–fluorouracil

16 Jun, 2023 | 14:05h | UTC

Concurrent chemoradiotherapy followed by adjuvant cisplatin–gemcitabine versus cisplatin–fluorouracil chemotherapy for N2–3 nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

News Release: Concurrent Chemoradiotherapy Followed by Adjuvant Cisplatin-Gemcitabine for the Treatment of Patients with Locoregionally Advanced Nasopharyngeal Carcinoma – ESMO

Commentary on Twitter

NOW OF: Concurrent chemoradiotherapy followed by adjuvant cisplatin–gemcitabine versus cisplatin–fluorouracil chemotherapy for N2–3 nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trialhttps://t.co/n6WalQiRfo pic.twitter.com/vE4VASUIgM

— The Lancet Oncology (@TheLancetOncol) June 5, 2023

M-A | Mechanical ventilation in patients with acute brain injury

16 Jun, 2023 | 14:03h | UTC

Mechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis – Critical Care

RCT | Increased detection of metastases via PET-CT alters treatment path in locally advanced breast cancer

16 Jun, 2023 | 14:02h | UTC

Impact of 18F-Labeled Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Versus Conventional Staging in Patients With Locally Advanced Breast Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)

M-A | Increased risk of cognitive toxic effects and fatigue in prostate cancer treatment with second-generation antiandrogens

16 Jun, 2023 | 14:00h | UTC

Association of Second-generation Antiandrogens With Cognitive and Functional Toxic Effects in Randomized Clinical Trials: A Systematic Review and Meta-analysis – JAMA Oncology (link to abstract – $ for full-text)

Commentary: Second-Generation Antiandrogens and Cognitive and Functional Toxicity in Patients With Prostate Cancer – The ASCO Post

Review | Point-of-care thoracic ultrasound in children: new advances in pediatric emergency setting

16 Jun, 2023 | 13:59h | UTC

Point-of-Care Thoracic Ultrasound in Children: New Advances in Pediatric Emergency Setting – Diagnostics

Review | Bloodstream infection and gram-negative resistance: the role for newer antibiotics

16 Jun, 2023 | 13:57h | UTC

Bloodstream Infection and Gram-Negative Resistance: The Role for Newer Antibiotics – Antibiotics

Cohort Study | Alcohol consumption and risks of more than 200 diseases in Chinese men

16 Jun, 2023 | 13:55h | UTC

Alcohol consumption and risks of more than 200 diseases in Chinese men – Nature Medicine

News Release: Alcohol consumption increases the risks of over 60 diseases – University of Oxford

Review | Aminoglycosides for the treatment of severe infection due to resistant gram-negative pathogens

16 Jun, 2023 | 13:56h | UTC

Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens – Antibiotics

Global Analysis | Disease burden linked to unsafe domestic water, sanitation, and hygiene

16 Jun, 2023 | 13:52h | UTC

Burden of disease attributable to unsafe drinking water, sanitation, and hygiene in domestic settings: a global analysis for selected adverse health outcomes – The Lancet

ATS Report | Rehabilitation for people with respiratory disease and frailty

16 Jun, 2023 | 13:51h | UTC

Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report – Annals of the American Thoracic Society

Single-center cohort study | Low-risk PE patients with concerning CT findings – increased hospitalization, but no increased risk of mortality

16 Jun, 2023 | 13:49h | UTC

Adverse Clinical Outcomes Among Patients With Acute Low-risk Pulmonary Embolism and Concerning Computed Tomography Imaging Findings – JAMA Network Open

Commentary: Acute Low-Risk Pulmonary Embolism and Concerning CT Findings – American College of Cardiology

Review | Antifungal stewardship interventions in patients with hematologic malignancies

16 Jun, 2023 | 13:47h | UTC

Antifungal Stewardship Interventions in Patients with Hematologic Malignancies

M-A | Post-surgery interventions for hip fracture

16 Jun, 2023 | 13:45h | UTC

Post-surgery interventions for hip fracture: a systematic review of randomized controlled trials – BMC Musculoskeletal Disorders

An integrative review on the acceptance of artificial intelligence among healthcare professionals in hospitals

16 Jun, 2023 | 13:46h | UTC

An integrative review on the acceptance of artificial intelligence among healthcare professionals in hospitals – npj Digital Medicine

RCT | Prehospital use of tranexamic acid in severe trauma cases shows no superiority over placebo

15 Jun, 2023 | 15:16h | UTC

Prehospital Tranexamic Acid for Severe Trauma – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Shining a new light on tranexamic acid for trauma care – Monash University

Commentary on Twitter

Late breaking at #CCR23: In the PATCH-Trauma trial involving adults with major trauma, treatment with tranexamic acid did not result in a greater number of patients surviving with a favorable functional outcome at 6 months than placebo. https://t.co/i8fu34ReCB pic.twitter.com/GEOtRphOBb

— NEJM (@NEJM) June 14, 2023

Consensus Statement | Concussion in sport

15 Jun, 2023 | 15:14h | UTC

Consensus statement on concussion in sport: the 6th International Conference on Concussion in Sport–Amsterdam, October 2022 – British Journal of Sports Medicine

News Release: International expert panel revises management of concussion in sport for optimal care of athletes at all levels of participation – BMJ

Perspective | Observational studies must be reformed before the next pandemic

15 Jun, 2023 | 15:12h | UTC

Observational studies must be reformed before the next pandemic – Nature Medicine

Evidence-based clinical practice guideline for deprescribing opioid analgesics

15 Jun, 2023 | 15:08h | UTC

Evidence-based clinical practice guideline for deprescribing opioid analgesics – University of Sidney

RCT | Cannabis-based medicines show no significant relief for moderate-to-severe cancer pain

15 Jun, 2023 | 15:10h | UTC

Cannabis‐based medicines and medical cannabis for adults with cancer pain – Cochrane Library

Summary: Cannabis-based medicines for cancer pain – Cochrane Library

Cohort Study | Identification of an optimal threshold to define oliguria in critically ill patients

15 Jun, 2023 | 15:05h | UTC

Identification of an optimal threshold to define oliguria in critically ill patients: an observational study – Critical Care

Commentary on Twitter

#CritCare #OpenAccess

Identification of an optimal threshold to define oliguria in critically ill patients

Read the full article: https://t.co/4msRdcWZYY @jlvincen @ISICEM #FOAMed #FOAMcc pic.twitter.com/5PfiXkE5FO

— Critical Care (@Crit_Care) June 9, 2023