All Posts
Eight months later: Researchers compare immune responses elicited by three COVID-19 vaccines.
17 Oct, 2021 | 21:27h | UTCOriginal study: Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines – New England Journal of Medicine
Commentary on Twitter
Just published @NEJM
Neutralizing antibody levels and T cells response out to 8 months for Pfizer, Moderna and J&J vaccines https://t.co/ghAgk3Y4kR
Moderna highest antibody response; J&J while lower doesn't fall off and best CD8 T-cell response at 8 months pic.twitter.com/uANSzAylMF— Eric Topol (@EricTopol) October 15, 2021
Viewpoint: Surgical overtreatment and shared decision-making—the limits of choice. – “Payment models further incentivize surgical intervention. Fee-for-service payment plans reward surgeons for operating, not for ensuring that surgery is right for a patient”.
17 Oct, 2021 | 21:17h | UTCSurgical Overtreatment and Shared Decision-making—The Limits of Choice – JAMA Surgery (free for a limited period)
Commentary on Twitter
“Adjusting payment models to mitigate financial incentives..to overtreat is a start. However..greater focus should be given to the myriad other causes of overtreatment,” such as triggers of care cascades, write Clapp, Schwarze & @LeeAFleisher. https://t.co/f4mPsnxyVB
— Ben Harder #BlackLivesMatter (@benharder) October 14, 2021
Guidelines for anesthesiologists on patient blood management in cardiac surgery.
17 Oct, 2021 | 21:22h | UTC
Commentary on Twitter
Please check out editorial on patient #blood management in #cardiacsurgery, a collaboration between Society of Thoracic Surgeons, Society of Cardiovascular Anestheisologists and SABM, AmSECT. https://t.co/HHA8SjxNot pic.twitter.com/DAj2TrGYC3
— Jiapeng Huang (@jiapenghuang) September 24, 2021
M-A: Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis – although Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be most effective treatments, topical diclofenac 70-81 mg/day is safer and should be considered as first line treatment.
17 Oct, 2021 | 21:14h | UTCNews release: Topical pain-killers more effective, safer than opioids for knee osteoarthritis pain – St. Michael’s Hospital
Commentary: Network meta-analysis compares analgesic regimens for osteoarthritis – medwire News
Commentary on Twitter
Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be the most effective oral NSAIDs for knee and hip osteoarthritis pain and physical function, but might not be appropriate in the presence of comorbidities or for long term use, concludes #BMJResearchhttps://t.co/rrtX3BnQE5
— The BMJ (@bmj_latest) October 16, 2021
RCT: After third molar surgery, Ibuprofen doses above 400 mg did not significantly increase the analgesic effect, and Paracetamol 1000/codeine 60 mg was not more effective than ibuprofen 400 mg.
17 Oct, 2021 | 21:16h | UTC
Review: Management of infectious emergencies for the inpatient dermatologist.
17 Oct, 2021 | 21:06h | UTCManagement of Infectious Emergencies for the Inpatient Dermatologist – Current Dermatology Reports (if this link is paywalled, try this one)
Serious injury risk higher for horse riding than for football, motor racing, or skiing – “Chest most common site of injury, but head and neck injuries most lethal”.
17 Oct, 2021 | 21:08h | UTCNews release: Serious injury risk higher for horse riding than for football, motor racing, or skiing – BMJ
Commentary: Horse Riding More Dangerous Than Skiis And Motorcycles, Injury Data Reveal – Science Alert
M-A: Psychosocial and psychological interventions for relapse prevention in schizophrenia.
17 Oct, 2021 | 21:12h | UTC
Commentary on Twitter
An excellent SR/Network MA on #Psychosocial interventions for relapse prevention in #schizophrenia
Family interventions, family psychoeducation, & CBT are effective & must be prioritised in the care systems for patients with schizophrenia @TheLancetPsych https://t.co/d6xRw14fbT— 🌈 Rajesh Mohan @raj-psyc.bsky.social (@raj_psyc) October 16, 2021
PHE Statement: The role of face coverings in mitigating the transmission of SARS-CoV-2 virus.
15 Oct, 2021 | 02:52h | UTC
Commentary on Twitter
https://twitter.com/OutbreakJake/status/1448651504563355657
What can masks do? The science behind COVID-19 protection.
15 Oct, 2021 | 02:51h | UTCCOMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection – CIDRAP
Review: Timing of antibiotic therapy in the ICU.
17 Oct, 2021 | 21:05h | UTCTiming of antibiotic therapy in the ICU – Critical Care
Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.
15 Oct, 2021 | 02:49h | UTCHeterologous SARS-CoV-2 Booster Vaccinations: Preliminary Report – medRxiv
Commentary: Study: Mixing and Matching COVID-19 Booster Shots Is Effective, Safe – U.S. News
Commentary on Twitter
So yes, mRNA vaccines are great at generating antibodies but what does that mean? Where is the efficacy data? How come JnJ gets really great efficacy at preventing symptomatic COVID and severe disease with low antibodies? T-cells? Still much to learn. https://t.co/YwKUyogAhQ
— Daniel Griffin MD PhD (@DanielGriffinMD) October 13, 2021
‘I hope you die’: how the COVID pandemic unleashed attacks on scientists.
15 Oct, 2021 | 02:46h | UTC‘I hope you die’: how the COVID pandemic unleashed attacks on scientists – Nature
Commentary on Twitter
#COVID19 has changed many things- one has been the way the public interacts with scientists.
Like many of my colleagues I was not prepared for the onslaught of harassment and it affected me deeply.
Thanks to @Nature for telling our stories https://t.co/PiVCREyc8A
— Krutika Kuppalli, MD FIDSA (@KrutikaKuppalli) October 13, 2021
Statins linked to reduced risk of death from COVID-19 in major population study – “Randomized studies will be needed to ascertain whether there is a causal relationship, note the researchers”.
15 Oct, 2021 | 02:47h | UTCNews release: Statins linked to reduced risk of death from COVID-19 in major population study – Karolinska Institutet
Original study: HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study – PLOS Medicine
Commentaries:
Expert reaction to study looking at statins and risk of death from COVID-19 – Science Media Centre
People taking statins less likely to die from Covid, study suggests – The Guardian
Perspective | Trying to Block SARS-CoV-2 Transmission With Intranasal Vaccines.
15 Oct, 2021 | 02:44h | UTCTrying to Block SARS-CoV-2 Transmission With Intranasal Vaccines – JAMA
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
15 Oct, 2021 | 02:41h | UTCCovid-19 treatments and vaccines must be evaluated in pregnancy – The BMJ
Related:
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter
Inconsistent messaging from authorities, driven by lack of trial data, has increased covid-19 vaccine hesitancy among pregnant women@DrAllyah and colleagues argue that pregnant women should be included in drug and vaccine development from the outsethttps://t.co/P3v1ouk8tQ
— The BMJ (@bmj_latest) October 14, 2021
FDA panel green-lights Moderna COVID boosters for risk groups.
15 Oct, 2021 | 02:43h | UTCFDA panel green-lights Moderna COVID boosters for risk groups – CIDRAP
FDA issues food industry guidance for reduction of sodium in processed and packaged foods.
15 Oct, 2021 | 02:29h | UTCGuidance for Industry: Voluntary Sodium Reduction Goals – U.S. Food & Drug Administration
Commentaries:
FDA Issues New Guidance on Sodium Targets for Food Industry – TCTMD
Reducing Sodium Intake in the US: Healthier Lives, Healthier Future – JAMA
FDA Reduces Recommended Salt Levels in Americans’ Food – HealthDay
FDA guidance to food industry aims to reduce sodium consumption – American Heart Association
New FDA guidance aims to drastically cut salt in food supply – NBC News
Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.
15 Oct, 2021 | 02:38h | UTCRelated:
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter (thread – click for more)
First dataset I have seen for vaccine efficacy in pregnant persons during #Delta era. Impressive aOR for both severe illness (0.11) and infection positivity in general (0.31)! #GetVaccinatedNow 🤰🏻💉 https://t.co/VhBHyeOWjz
— Lauren Hassen, MD MPH (@ljhassen) October 14, 2021
Systematic Review: “Formula milk trials have a high risk of bias, almost always report favorable conclusions, lack transparency, and selectively report findings”.
15 Oct, 2021 | 02:25h | UTCNews release: Formula milk trials are not reliable, warn researchers – Imperial College London
Original study: Conduct and reporting of formula milk trials: systematic review – The BMJ
WHO Report: Tuberculosis deaths rise for the first time in more than a decade due to the COVID-19 pandemic.
15 Oct, 2021 | 02:30h | UTCReport: Global tuberculosis report 2021
Commentary: Tuberculosis deaths rise for 1st time in years, due to COVID – Associated Press
Commentary on Twitter (thread – click for more)
🆕 WHO's Global TB Report reveals deaths from #tuberculosis rise for the first time in more than a decade due to the #COVID19 pandemic.
1.5 million people died in 2020 & the number will continue to rise unless urgent action is taken 👉https://t.co/RFmWYIelhq #EndTB pic.twitter.com/33G7sI8K2J
— World Health Organization (WHO) (@WHO) October 14, 2021
Former CDC director: Low sodium salt could save millions of lives.
15 Oct, 2021 | 02:27h | UTCFormer CDC director: Low sodium salt could save millions of lives – CNN
Related:
Is salt good for you after all? The evidence says no.
Systematic Review: Altered dietary salt intake for people with chronic kidney disease.
New WHO benchmarks help countries reduce salt intake and save lives.
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels
Systematic Review: There is not enough evidence from randomized trials to inform about the effects of additional antihypertensive drugs in patients with hypertension‐induced left ventricular hypertrophy.
15 Oct, 2021 | 02:20h | UTCPharmacotherapy for hypertension‐induced left ventricular hypertrophy – Cochrane Library
Commentary on Twitter
What are the effects of added #antihypertensive drug therapy on morbidity/mortality of people with #LVH and #hypertension? 💊
Our @CochraneLibrary @CochraneHTN systematic review looks at evidence from 3 RCTs w/ 930 participants with #highbloodpressure
👉🏾https://t.co/d3dakCPW0B pic.twitter.com/ppCqKBU7K0
— Cochrane Hypertension (@CochraneHTN) October 11, 2021
Meta-analysis of cohort studies: High intake of fatty acid in nuts, seeds and plant oils linked to lower risk of death.
15 Oct, 2021 | 02:22h | UTCNews release: High intake of fatty acid in nuts, seeds and plant oils linked to lower risk of death – The BMJ
Commentaries:
Current evidence on dietary intakes of fatty acids and mortality – The BMJ
Commentary on Twitter
NEW research: A high intake of alpha linolenic acid, found mainly in nuts, seeds, and plant oils, is associated with a lower risk of death from all causes, and specifically from diseases of the heart and blood vessels, finds a study https://t.co/HGvg8dBUUN
— The BMJ (@bmj_latest) October 14, 2021
Trends in use and outcomes of same-day discharge following elective percutaneous coronary intervention.
15 Oct, 2021 | 02:15h | UTCTrends in Use and Outcomes of Same-Day Discharge Following Elective Percutaneous Coronary Intervention – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentaries:
Trends in Same-Day Discharge for Elective PCI – American College of Cardiology