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Podcast | Obstetrics for the Internist: What to Expect.

16 Nov, 2021 | 08:18h | UTC

#305 OB for the Internist: What to Expect – The Curbsiders

 

Phase 4 RCT: Concomitant administration of COVID-19 vaccines (AstraZeneca or Pfizer) with seasonal influenza vaccines in adults is safe and preserves antibody responses to both vaccines.

14 Nov, 2021 | 20:14h | UTC

Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial – The Lancet

 

Large populational study finds prior SARS-CoV-2 infection reduces the risk of breakthrough infection following mRNA vaccination.

14 Nov, 2021 | 20:12h | UTC

Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar – JAMA

Commentaries:

Vaccine plus previous infection may offer enhanced COVID-19 protection – CIDRAP

Prior SARS-CoV-2 infection and risk of breakthrough infection following mRNA vaccination – News Medical

 

Commentary on Twitter

 

Populational study in Qatar showed the effectiveness against SARS-CoV-2 Delta-induced severe, critical or fatal disease was 93.4% for the Pfizer vaccine and 96.1% for Moderna.

14 Nov, 2021 | 20:11h | UTC

BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar – Nature Medicine

 

Commentary on Twitter

 

What influences people’s responses to public health messages for managing risks and preventing infectious diseases? A rapid systematic review of the evidence and recommendations.

14 Nov, 2021 | 20:06h | UTC

What influences people’s responses to public health messages for managing risks and preventing infectious diseases? A rapid systematic review of the evidence and recommendations – BMJ Open

 

Commentary on Twitter

 

SARS-CoV-2 vaccines are safe and immunogenic in most people with cancer, according to study.

14 Nov, 2021 | 20:05h | UTC

News Release: SARS-CoV-2 vaccines are safe and immunogenic in most people with cancer, according to study – Harvard Medical School

Original study: Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study – Journal of Clinical Oncology

 

Commentary from the author on Twitter (thread – click for more)

 

#AHA21 – RCT: Among children and adolescents who had screening echocardiograms and were identified as having latent rheumatic heart disease, secondary antibiotic prophylaxis with penicillin G benzathine for 2 years was associated with reduced echocardiographic progression (0.8 vs. 8.2% in the control group).

14 Nov, 2021 | 20:03h | UTC

Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Penicillin significantly reduces rheumatic heart disease progression in children – Murdoch Children’s Research Institute

Penicillin slows devastating impacts of rheumatic heart disease in children from Uganda – Children’s National Hospital

Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology

 

Commentaries on Twitter

 

#AHA21 – Pooled data from six prospective cohorts found higher sodium and lower potassium intakes were associated in a dose–response manner with a higher cardiovascular risk.

14 Nov, 2021 | 19:58h | UTC

24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Less sodium and more potassium could be key in lowering risk of cardiovascular disease – The Harvard Gazette

Related study: Cohort Study: Joint Association of Urinary Sodium and Potassium Excretion with Cardiovascular Events and Mortality

 

Commentary on Twitter

 

Editorial: COVID is disrupting scientific careers around the world.

14 Nov, 2021 | 20:08h | UTC

COVID is disrupting scientific careers around the world – Nature

See also:

Scientists count the career costs of COVID – Nature

Potentially long-lasting effects of the pandemic on scientists – Nature

 

#AHA21 – RCT: Concomitant tricuspid repair in patients undergoing surgery for degenerative mitral regurgitation reduced tricuspid regurgitation progression but increased the need for permanent pacemaker implantation.

14 Nov, 2021 | 20:00h | UTC

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Tricuspid Repair During Mitral Surgery Slows Disease Progression at 2 Years – TCTMD

Cardiothoracic Surgical Trials Network: Concomitant Tricuspid Valve Repair + Mitral Valve Surgery vs. Mitral Valve Surgery Alone – CTCR-MVS – American College of Cardiology

CTCR-MVS: Concomitant Tricuspid Repair in Patients With MR – American College of Cardiology

 

#AHA21 – RCT: In asymptomatic patients with severe aortic stenosis, early surgery improved outcomes compared to conservative treatment.

14 Nov, 2021 | 20:01h | UTC

Aortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis: The AVATAR Trial – Circulation (free for a limited period)

News release: Surgery to replace heart valve beneficial even with no symptoms of severe aortic stenosis – American Heart Association

Commentaries:

AVATAR Supports Early SAVR in Asymptomatic Severe AS Patients – TCTMD

Aortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis – AVATAR – American College of Cardiology

Related study: #AHA19 – Randomized Trial: Early Surgery Improves Outcomes in Asymptomatic Patients with Very Severe Aortic Stenosis

 

Commentary on Twitter

 

#AHA21 – RCT: Among patients undergoing cardiac surgery, routine posterior left pericardiotomy can prevent postoperative atrial fibrillation.

14 Nov, 2021 | 19:53h | UTC

Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery: an adaptive, single-centre, single-blind, randomised, controlled trial – The Lancet (free registration required)

Commentaries:

A short cut to prevent postoperative atrial fibrillation – The Lancet (free registration required)

Posterior Left Pericardiotomy for the Prevention of Postoperative Atrial Fibrillation After Cardiac Surgery – PALACS – American College of Cardiology

 

#AHA21 – [Not published Yet] A small, randomized study showed stopping ticagrelor only 2-3 days before bypass surgery may be safe.

14 Nov, 2021 | 19:56h | UTC

News release: Ticaglelor may be stopped Time from stopping blood thinner to bypass surgery may be shortened for select patients – American Heart Association

Commentary: RAPID CABG: No Penalty to Early Surgery for ACS After Stopping Ticagrelor – TCTMD

 

Cohort study suggests low-dose vs. standard radiation dose CT have similar diagnostic accuracy in suspected acute appendicitis.

14 Nov, 2021 | 19:37h | UTC

News release: Doctors can use CT scans with less radiation to diagnose appendicitis – Oxford University

Original study: Diagnostic accuracy using low-dose versus standard radiation dose CT in suspected acute appendicitis: prospective cohort study – British Journal of Surgery (link to abstract – $ for full-text)

 

Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019.

14 Nov, 2021 | 19:45h | UTC

Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet

Commentary: Nearly two-thirds of those who died young in 2019 were male, research finds – The Guardian

 

Commentary on Twitter (thread – click for more)

 

Consensus practice guidelines on interventions for cervical spine (facet) joint pain.

14 Nov, 2021 | 19:34h | UTC

Consensus practice guidelines on interventions for cervical spine (facet) joint pain from a multispecialty international working group – Regional Anesthesia & Pain Medicine

News release: Only certain patients with chronic neck pain need invasive procedures to treat it – BMJ

 

Viewpoint | How to Measure Progress in Addressing Physician Well-being: Beyond Burnout.

14 Nov, 2021 | 19:40h | UTC

How to Measure Progress in Addressing Physician Well-being: Beyond Burnout – JAMA

Related:

Physician Well-being 2.0: Where Are We and Where Are We Going?

Consensus Study – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being – National Academies of Medicine

[Abstract Only] Assessment of Risk Factors for Suicide Among US Health Care Professionals

Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care

Perspective: Hospital Administration Response to Physician Stress and Burnout

Opinion: It’s Time to Talk About Physician Burnout and Moral Injury

Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout

Perspective: The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution)

Physician Burnout: A Global Crisis (several resources on the subject)

 

Assessment of arsenic trioxide and all-trans retinoic acid for the treatment of pediatric acute promyelocytic leukemia.

14 Nov, 2021 | 19:32h | UTC

Assessment of Arsenic Trioxide and All-trans Retinoic Acid for the Treatment of Pediatric Acute Promyelocytic Leukemia: A Report From the Children’s Oncology Group AAML1331 Trial – JAMA Oncology

News release: Drug combination helps children with acute promyelocytic leukemia avoid conventional chemotherapy – NIH News Releases

 

Commentary on Twitter

 

RCT: BBV152 (India’s COVAXIN) has an overall vaccine efficacy of 77.8% against symptomatic Covid-19 in adults.

12 Nov, 2021 | 10:43h | UTC

Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial – The Lancet

Invited Commentary: Inactivated SARS-CoV-2 vaccine (BBV152)-induced protection against symptomatic COVID-19 – The Lancet

Related: WHO issues emergency use approval for India’s Covaxin.

 

Commentary on Twitter

 

Observational Study: In patients with shockable in-hospital cardiac arrest, epinephrine before defibrillation was associated with worse survival.

14 Nov, 2021 | 19:33h | UTC

Epinephrine before defibrillation in patients with shockable in-hospital cardiac arrest: propensity matched analysis – The BMJ

 

Commentary on Twitter

 

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

12 Nov, 2021 | 10:39h | UTC

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – Nature

Related:

[Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.

Study: Children and young people remain at low risk of COVID-19 mortality

 

Commentaries on Twitter

 

Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method.

12 Nov, 2021 | 10:41h | UTC

Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method – The Lancet Infectious Diseases

 

Commentary from the author on Twitter (thread – click for more)

 

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

12 Nov, 2021 | 10:32h | UTC

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID – The Lancet

Related:

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

The COVID pandemic has harmed researcher productivity – and mental health – “Surveys show that women, parents of young children and people of color are most affected by pandemic-related disruptions and need more support”.

12 Nov, 2021 | 10:35h | UTC

The COVID pandemic has harmed researcher productivity – and mental health – Nature

 

Boosting immunity to COVID-19 vaccines – “New studies highlight the immunological benefits of COVID-19 vaccine boosters, but questions remain over how to best make use of a limited global supply”.

12 Nov, 2021 | 10:37h | UTC

Boosting immunity to COVID-19 vaccines – Nature Medicine

 

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