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ERS Guidelines: High-flow nasal cannula in acute respiratory failure.

12 Nov, 2021 | 10:29h | UTC

ERS Clinical Practice Guidelines: High-flow nasal cannula in acute respiratory failure – European Respiratory Journal

 

Map: The world according to covid vaccine coverage.

12 Nov, 2021 | 10:34h | UTC

The world according to covid vaccine coverage – The BMJ

 

Commentary on Twitter

 

2022 ASA Guidelines for Management of the Difficult Airway.

12 Nov, 2021 | 10:31h | UTC

2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway – Anesthesiology

Related:

Consensus-based recommendations for management of the difficult airway: part 1. Difficult airway management encountered in an unconscious patient.

Difficult airway management in neonates and infants: knowledge of devices and a device-oriented strategy.

Consensus Guideline: Pediatric Airway Management in COVID-19 Patients

Guidelines for Awake Tracheal Intubation in Adults

Position Paper: Management of Unanticipated Difficult Airways in Children in Anesthetic Practice

Review: Difficult Airway Management Algorithms (several resources on the subject)

The Difficult Airway Trolley: A Narrative Review and Practical Guide

 

WHO, CDC | Global progress against measles threatened amidst COVID-19 pandemic.

12 Nov, 2021 | 10:27h | UTC

News Release: Global progress against measles threatened amidst COVID-19 pandemic – World Health Organization

Report: Progress Toward Regional Measles Elimination — Worldwide, 2000–2020 – CDC Morbidity and Mortality Weekly Report

Commentary: Measles is a renewed global threat after 22 million babies missed their vaccines during the pandemic, CDC warns – CNN

 

Commentary on Twitter (thread – click for more)

 

Series: Diversity, equity, and inclusion in medical research.

12 Nov, 2021 | 10:23h | UTC

Homepage: DEI in medical research – Nature Medicine

Editorial: Diversity, equity and inclusion: we are in it for the long run

Opinion articles:

Role of funders in addressing the continued lack of diversity in science and medicine

The US National Institutes of Health approach to inclusive excellence

Promoting diversity and inclusion in STEMM starts at the top

A commitment to scientific equity from a philanthropic funder

 

Commentary on Twitter (thread – click for more)

 

EMA Recommendation: Dapagliflozin 5mg should no longer be used for the treatment of Type 1 Diabetes Mellitus due to increased risk of diabetic ketoacidosis.

12 Nov, 2021 | 10:28h | UTC

Forxiga (dapagliflozin) 5mg should no longer be used for the treatment of Type 1 Diabetes Mellitus – European Medicines Agency

 

Cohort study: In patients with nonalcoholic steatohepatitis and obesity, bariatric surgery was associated with lower risk of incident major adverse liver outcomes and major adverse cardiovascular events.

12 Nov, 2021 | 10:24h | UTC

Association of Bariatric Surgery With Major Adverse Liver and Cardiovascular Outcomes in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis – JAMA (free for a limited period)

Editorial: Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis – JAMA (free for a limited period)

 

Commentary on Twitter

 

Among patients with cancer who received decompressive G-tubes for nutrition or malignant bowel obstruction, nearly half presented with stage IV disease and died within one month of placement.

12 Nov, 2021 | 09:55h | UTC

Gastrostomy Tube for Nutrition and Malignant Bowel Obstruction in Patients with Cancer – Journal of the National Comprehensive Cancer Network

Commentary: Risks and Benefits Associated With Gastrostomy Tubes for Patients With Cancer – The ASCO Post

 

M-A: Efficacy of amisulpride for depressive symptoms in individuals with mental disorders.

12 Nov, 2021 | 10:21h | UTC

Efficacy of amisulpride for depressive symptoms in individuals with mental disorders: A systematic review and meta-analysis – Human Psychopharmacology: Clinical & Experimental

 

Commentary on Twitter

 

Some immune checkpoint inhibitors can cause serious arrhythmias and myocarditis.

12 Nov, 2021 | 09:57h | UTC

News release: Some immune checkpoint inhibitors can cause serious arrhythmias and myocarditis – University of California San Francisco Medical Center

Original study: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis – Circulation (link to abstract – $ for full-text)

Related:

Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study.

AHA Scientific Statement: Recognition, prevention, and management of arrhythmias and autonomic disorders in cardio-oncology.

 

Cohort study: Among older adults with diabetes who were hospitalized for common medical conditions, intensification of diabetes medications at hospital discharge was associated with an increased short-term risk of severe hypoglycemia events but was not associated with improved glycemic control.

12 Nov, 2021 | 09:51h | UTC

Intensification of Diabetes Medications at Hospital Discharge and Clinical Outcomes in Older Adults in the Veterans Administration Health System – JAMA Network Open

 

Cohort study: After an episode of severe hypoglycemia in older adults with diabetes, sulfonylurea or insulin treatment deintensification occurred in fewer than 50% of episodes.

12 Nov, 2021 | 09:53h | UTC

Deintensification of Treatment With Sulfonylurea and Insulin After Severe Hypoglycemia Among Older Adults With Diabetes – JAMA Network Open

 

Commentary on Twitter

 

Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis – “Each day of antibiotic therapy was associated with 4% increased odds of experiencing an adverse event”.

12 Nov, 2021 | 09:47h | UTC

Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis – Clinical Microbiology and Infection

 

Commentary on Twitter

 

IDSA Guidelines on Infection Prevention for Healthcare Personnel Caring for Patients with Suspected or Known COVID-19.

11 Nov, 2021 | 09:01h | UTC

Infectious Diseases Society of America Guidelines on Infection Prevention for Healthcare Personnel Caring for Patients with Suspected or Known COVID-19

 

Commentary on Twitter

 

White-Coat Hypertension: Pathophysiological and Clinical Aspects.

12 Nov, 2021 | 09:48h | UTC

White-Coat Hypertension: Pathophysiological and Clinical Aspects: Excellence Award for Hypertension Research 2020 – Hypertension (free for a limited period)

 

Podcast | COVID Updates: The Outpatient Edition.

11 Nov, 2021 | 08:57h | UTC

COVID Updates: The Outpatient Edition – The Curbsiders

 

Commentary on Twitter

 

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

11 Nov, 2021 | 08:59h | UTC

COVID antiviral pills: what scientists still want to know – Nature

Related:

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

M-A: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19.

11 Nov, 2021 | 08:53h | UTC

Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs – Nutritional Journal

 

Perspective | COVID’s endgame: Scientists have a clue about where SARS-CoV-2 is headed.

11 Nov, 2021 | 08:55h | UTC

COVID’s endgame: Scientists have a clue about where SARS-CoV-2 is headed – NPR

 

An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2.

11 Nov, 2021 | 08:52h | UTC

An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2 – The Pediatric Infectious Diseases Journal

Related:

Ten Things to Know About Multisystem Inflammatory Syndrome in Children (MIS-C).

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

 

Consensus Statement: Advancing the global public health agenda for non-alcoholic fatty liver disease.

11 Nov, 2021 | 08:48h | UTC

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Related:

Clinical Care Pathway for the Risk Stratification and Management of Patients with Nonalcoholic Fatty Liver Disease.

Non-alcoholic fatty liver disease: A patient guideline.

State of the art review: Management of non-alcoholic fatty liver disease

M-A: Non-alcoholic fatty liver disease linked to increased risk of fatal and non-fatal cardiovascular events.

M-A: non-invasive tests for advanced fibrosis can reduce the need for biopsy in patients with non-alcoholic fatty liver disease.

Review: Dietary carbohydrates and fats in nonalcoholic fatty liver disease.

 

Commentary on Twitter

 

RCT: In patients with acute stroke eligible for intravenous alteplase and endovascular treatment, intravenous alteplase before endovascular treatment did not improve outcomes compared to endovascular treatment alone.

11 Nov, 2021 | 08:43h | UTC

A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

 

RCT: In patients with acute myocardial infarction complicated by a reduced left ventricular ejection fraction, pulmonary congestion, or both, Sacubitril–valsartan was not associated with improved outcomes compared to Ramipril.

11 Nov, 2021 | 08:44h | UTC

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

 

Whole genome sequencing may improve the diagnosis of rare diseases and shorten diagnostic journeys for patients.

11 Nov, 2021 | 08:46h | UTC

News Release: Whole genome sequencing improves diagnosis of rare diseases and shortens diagnostic journeys for patients – Queen Mary University of London

Original Study: 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report – New England Journal of Medicine

Related:

RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.

Review: Genome sequencing as a diagnostic test.

 

RCT: Universal screening in high schools can help identify and initiate treatment for depression in adolescents.

11 Nov, 2021 | 08:35h | UTC

Screening in High Schools to Identify, Evaluate, and Lower Depression Among Adolescents: A Randomized Clinical Trial – JAMA Network Open

News release: School-based screening increases identification of, treatment for depression – Penn State

Commentaries:

Universal Depression Screening in Schools—Promises and Challenges in Addressing Adolescent Mental Health Need – JAMA Network Open

Universal School-Based Depression Screening May Connect More Students to Care – Psychiatric News Alert

 

Commentaries on Twitter

 

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