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NICE Guideline | Heart valve disease presenting in adults: investigation and management.

18 Nov, 2021 | 08:44h | UTC

Heart valve disease presenting in adults: investigation and management – National Institute for Health and Care Excellence

Related Guidelines:

#ESCCongress – 2021 ESC/EACTS Guidelines for the management of valvular heart disease – in the new guidelines, more patients are eligible for surgical and transcatheter interventions, based not only on symptoms but also on imaging criteria.

2020 ACC/AHA Guideline for the management of patients with valvular heart disease

 

RCT: An exercise program reduced upper limb disability one year after non-reconstructive breast cancer surgery.

18 Nov, 2021 | 08:39h | UTC

Exercise versus usual care after non-reconstructive breast cancer surgery (UK PROSPER): multicentre randomised controlled trial and economic evaluation – The BMJ

Commentaries:

Exercise reduces upper limb disability after breast cancer surgery – BMJ / News Medical

Exercise Helps Ease Arm, Shoulder Pain After Breast Cancer Surgery- HealthDay

Structured Exercise Improves Upper Limb Function After Breast Ca Surgery – Physician’s Weekly

 

Commentary on Twitter

 

M-A: In patients with anterior circulation acute stroke and evidence of reversible cerebral ischemia across the 6–24 h time window, thrombectomy was associated with higher rates of independence in activities of daily living at 90 days than best medical therapy alone.

18 Nov, 2021 | 08:43h | UTC

Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis – The Lancet (link to abstract – $ for full-text)

 

Editorial: Twenty recommendations to individualize interventions in the early resuscitation of patients with sepsis.

18 Nov, 2021 | 08:38h | UTC

Twenty recommendations to individualize interventions in the early resuscitation of patients with sepsis – Critical Care

Related: Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

 

Review: A fresh look at coronary microembolization.

18 Nov, 2021 | 08:35h | UTC

A fresh look at coronary microembolization – Nature Reviews Cardiology (if this link is paywalled, try this one)

 

Commentary on Twitter

 

Demystifying the EEG report for intensivists.

18 Nov, 2021 | 08:36h | UTC

Demystifying the EEG Report – NeuroEMCrit

 

What Is the best maintenance therapy for ANCA vasculitis?

18 Nov, 2021 | 08:34h | UTC

What Is the Best Maintenance Therapy for ANCA Vasculitis? – Clinical Journal of the American Society of Nephrology

 

RCT: In Infants with infantile hemangioma, nadolol is noninferior to propranolol and may be an efficacious and safe alternative in cases of propranolol unresponsiveness or adverse events.

18 Nov, 2021 | 08:29h | UTC

Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma: A Randomized Clinical Trial – JAMA Pediatrics

Commentary: Oral Nadolol Feasible for the Treatment of Infantile Hemangiomas – HealthDay

 

Commentary on Twitter

 

New ACR radiation diagnostic reference levels for top 10 pediatric CT exams.

18 Nov, 2021 | 08:31h | UTC

News Release: New Radiation Diagnostic Reference Levels for Top 10 Pediatric CT Exams – American College of Radiology

Original Guideline: U.S. Diagnostic Reference Levels and Achievable Doses for 10 Pediatric CT Examinations – Radiology

Commentary: ACR releases new benchmarks to help radiology departments optimize radiation dose levels – Health Imaging

 

Case-control study: sleep disorders linked to more severe outcomes from COVID-19, study suggests.

17 Nov, 2021 | 08:50h | UTC

News Release: Sleep disorders linked with more severe outcomes from COVID-19, study suggests – Cleveland Clinic

Original Study: Association of Sleep-Related Hypoxia With Risk of COVID-19 Hospitalizations and Mortality in a Large Integrated Health System – JAMA Network Open

Commentary: Some sleep disorders may lead to worse COVID-19 outcomes – CIDRAP

 

Commentary on Twitter

 

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic.

17 Nov, 2021 | 08:56h | UTC

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic – European Heart Journal

Part 1—epidemiology, pathophysiology, and diagnosis

Part 2—care pathways, treatment, and follow-up

News release: European Society of Cardiology COVID-19 guidance launched – European Society of Cardiology

 

Commentaries on Twitter

 

Systematic Review: Multidisciplinary rehabilitation for older people with hip fractures.

18 Nov, 2021 | 08:28h | UTC

Summary: Are mixed-speciality (multidisciplinary) teams the best way to help older people recover from hip fracture? – Cochrane Library

Original Study: Multidisciplinary rehabilitation for older people with hip fractures – Cochrane Library

 

Commentary on Twitter

 

Observational study found monitoring outpatients with Covid-19 using text messages that allowed the report of worsening symptoms was associated with improved outcomes.

17 Nov, 2021 | 08:53h | UTC

Comparative Effectiveness of an Automated Text Messaging Service for Monitoring COVID-19 at Home – Annals of Internal Medicine

News Release: Automated Texting System Saved Lives Weekly During First COVID Surge – Penn Medicine

Commentaries:

Monitoring outpatients by text appeared to reduce mortality from COVID-19 – ACP Internist

Texting saved lives during Covid. What does that mean for health care’s future? – STAT

 

Commentary from the author on Twitter (thread – click for more)

 

The big questions about Covid-19 booster shots – “From the why to the who, we still need a lot of answers about booster shots”.

17 Nov, 2021 | 08:48h | UTC

The big questions about Covid-19 booster shots – Vox

 

Commentary on Twitter

 

Pfizer COVID Pill to Be Made, Sold Cheaply in 95 Poor Countries.

17 Nov, 2021 | 08:40h | UTC

Pfizer COVID Pill to Be Made, Sold Cheaply in 95 Poor Countries – HealthDay

See also:

Pfizer agrees to license generic versions of its COVID-19 pill — in some countries – NPR

Pfizer and Medicines Patent Pool Reach ‘Ground-breaking’ Voluntary Licensing Deal for New COVID-19 Treatment Pill – Health Policy Watch

Pfizer Will Allow Its Covid Pill to Be Made and Sold Cheaply in Poor Countries – The New York Times (a few articles per month are free)

 

AAN Guideline: Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease.

17 Nov, 2021 | 08:32h | UTC

Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary – Neurology

News Release: AAN Issues Guideline for Treatment of Early Parkinson’s Disease – American Academy of Neurology

 

MSF responds to Pfizer and Medicines Patent Pool license for new Covid-19 treatment – “The deal, however, only covers 53 percent of the world’s population and excludes people in several upper-middle-income countries, leaving this promising medicine out of reach for millions”.

17 Nov, 2021 | 08:38h | UTC

MSF responds to Pfizer and Medicines Patent Pool license for new Covid-19 treatment – Médecins Sans Frontières

 

Commentary on Twitter

 

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

17 Nov, 2021 | 08:42h | UTC

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians – The Journal of the American Board of Family Medicine

Related:

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Individual participant data meta-analysis of major randomized trials showed that treatment of hypertension with ACEIs or ARBs reduced the risk of new-onset type 2 diabetes compared to other drugs.

17 Nov, 2021 | 08:29h | UTC

Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis – The Lancet

Commentaries:

Expert reaction to an individual participant data meta-analysis on blood pressure lowering and risk of onset of type-2 diabetes – Science Media Centre

Blood pressure drugs could prevent type 2 diabetes, study finds – The Guardian

 

Position Statement: Preoperative Care for Cataract Surgery – “In spite of evidence debunking the utility of testing before cataract surgery, studies suggest that medical testing and the use of medical consultations before cataract surgery continue to increase”.

17 Nov, 2021 | 08:33h | UTC

Preoperative Care for Cataract Surgery: The Society for Ambulatory Anesthesia Position Statement – Anesthesia & Analgesia

 

Commentary on Twitter

 

Randomized, crossover clinical trial: In patients with heart failure with preserved ejection fraction and chronotropic incompetence, betablocker withdrawal improved maximal functional capacity.

17 Nov, 2021 | 08:27h | UTC

Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction – Journal of the American College of Cardiology

Commentary: Peak VO2 Improved After Beta-Blocker Withdrawal in Some HFpEF Patients: Beta-blockers may not benefit HFpEF patients with chronotropic incompetence – MedPage Today (free registration required)

 

Nursing care for oncologic patients undergoing surgery using an enhanced recovery approach.

17 Nov, 2021 | 08:22h | UTC

Oncologic Surgical Care Using an Enhanced Recovery Approach – AACN Advanced Critical Care

News release: Enhanced Recovery Approach Changes Care for Surgical Oncology Patients – American Association of Critical-Care Nurses

Related: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

 

Phase 2 RCT: Once-weekly cagrilintide is effective for weight management in people with overweight and obesity.

17 Nov, 2021 | 08:23h | UTC

Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial – The Lancet (link to abstract – $ for full-text)

 

RCT: Adjustable intragastric balloon resulted in significant weight loss at 32 weeks, but intolerance caused early removal of the device in 17% of patients, and device-related serious adverse events were observed in 4% of patients.

17 Nov, 2021 | 08:26h | UTC

Adjustable intragastric balloon for treatment of obesity: a multicentre, open-label, randomised clinical trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.

17 Nov, 2021 | 08:19h | UTC

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps – Nature Medicine

 

Commentary on Twitter

 

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