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Opinion: With 128 Covid vaccines in clinical development, we don’t know if the approved/authorized ones are the best ones.

19 Nov, 2021 | 10:45h | UTC

With 128 Covid vaccines in clinical development, we don’t know if the approved/authorized ones are the best ones – STAT

 

Review: Counting the neurological cost of COVID-19.

19 Nov, 2021 | 10:52h | UTC

Counting the neurological cost of COVID-19 – Nature Reviews Neurology

 

Commentary on Twitter

 

Global, regional, and national causes of under-5 mortality in 2000–19: an updated systematic analysis with implications for the Sustainable Development Goals.

19 Nov, 2021 | 10:40h | UTC

Global, regional, and national causes of under-5 mortality in 2000–19: an updated systematic analysis with implications for the Sustainable Development Goals – The Lancet Child & Adolescent Health

 

Commentary on Twitter

 

Perspective | The Future of SARS-CoV-2 Vaccination — Lessons from Influenza.

19 Nov, 2021 | 10:49h | UTC

The Future of SARS-CoV-2 Vaccination — Lessons from Influenza – New England Journal of Medicine

 

Consensus and expert recommendations: basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population.

19 Nov, 2021 | 10:37h | UTC

Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine

 

Commentary on Twitter

 

WHO global report on trends in prevalence of tobacco use 2000-2025.

19 Nov, 2021 | 10:43h | UTC

WHO global report on trends in prevalence of tobacco use 2000-2025, fourth edition – World Health Organization

News Release: Tobacco use falling: WHO urges countries to invest in helping more people to quit tobacco – World Health Organization

 

Commentary on Twitter

 

Recommendations for women with gynecological cancer who received non-standard care during the COVID-19 pandemic.

19 Nov, 2021 | 10:33h | UTC

British Gynaecological Cancer Society recommendations for women with gynecological cancer who received non-standard care during the COVID-19 pandemic – International Journal of Gynecological Cancer

 

AAP Clinical Report: Biologics for Asthma and Allergic Skin Diseases in Children.

19 Nov, 2021 | 10:34h | UTC

Biologics for Asthma and Allergic Skin Diseases in Children – Pediatrics

 

AAP Clinical Report: Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant.

19 Nov, 2021 | 10:35h | UTC

Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant – Pediatrics

 

What is the functional/organic distinction actually doing in psychiatry and neurology?

19 Nov, 2021 | 10:29h | UTC

What is the functional/organic distinction actually doing in psychiatry and neurology? – Wellcome Open Research

 

Commentary on Twitter

 

M-A: Intravenous iron is associated with increased risk of infection when compared with oral iron or no iron, which must be balanced with the potential benefits of reducing blood transfusion requirements.

19 Nov, 2021 | 10:31h | UTC

Risk of Infection Associated With Administration of Intravenous Iron: A Systematic Review and Meta-analysis – JAMA Network Open

Invited Commentary: Intravenous Iron and Infection Risk—Still an Unanswered Question – JAMA Network Open

 

Commentary on Twitter

 

RCT: In patients with heart failure and preserved ejection fraction, Sacubitril/Valsartan reduced NT-proBNP, but did not improve exercise capacity and was associated with increased risk of hypotension (14.1% vs 5.5%).

19 Nov, 2021 | 10:27h | UTC

Effect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Quality of Life and Exercise Ability in Heart Failure With Preserved Ejection Fraction: No Time for Therapeutic Complacency – JAMA (free for a limited period)

 

Commentary on Twitter

 

Pro-Con Debate: Should all babies have their genome sequenced at birth?

19 Nov, 2021 | 10:19h | UTC

Should all babies have their genome sequenced at birth? – The BMJ

Related:

RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.

Whole genome sequencing may improve the diagnosis of rare diseases and shorten diagnostic journeys for patients.

Review: Genome sequencing as a diagnostic test.

 

RCT: In patients with multivessel coronary artery disease, a Fractional Flow Reserve (FFR) guided revascularization strategy did not reduce the risk of ischemic cardiovascular events or death at 1-year follow-up compared to a traditional strategy without FFR.

19 Nov, 2021 | 10:26h | UTC

Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Related:

RCT: In patients with three-vessel coronary artery disease, an FFR–guided PCI strategy was NOT noninferior to coronary bypass surgery – The 1-year incidence of the composite primary end point (death, myocardial infarction, or stroke) was 7.3% in the FFR-guided PCI group and 5.2% in the CABG group.

#ESCCongress – Systematic FFR has no additional benefit at diagnostic angiography in patients with chest pain.

#ACC21 – RCT: In patients with STEMI undergoing complete revascularization, an FFR-guided strategy did not improve outcomes compared to an angiography-guided strategy.

Randomized Trial: Five-Year Outcomes with PCI Guided by FFR

 

Novel gene therapy for hemophilia A leads to sustained expression of clotting factor and reduced bleeding events.

19 Nov, 2021 | 10:25h | UTC

News release: Novel gene therapy for hemophilia a leads to sustained expression of clotting factor and reduced bleeding events – Children’s Hospital of Philadelphia

Original Study: Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A – New England Journal of Medicine

 

Commentary on Twitter

 

M-A: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality.

18 Nov, 2021 | 08:59h | UTC

Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis – The BMJ

 

Commentary on Twitter

 

Long-term results of RCT: Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for patients with locally advanced rectal cancer.

19 Nov, 2021 | 10:15h | UTC

Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Author Interview: Chemoradiotherapy Plus Induction or Consolidation Chemotherapy for Locally Advanced Rectal Cancer – JAMA Oncology

 

Commentary on Twitter

 

Review: Should children under 12 years of age be vaccinated against COVID-19?

18 Nov, 2021 | 08:56h | UTC

Should children be vaccinated against COVID-19? – Archives of Disease in Childhood

 

Commentary from the author on Twitter (thread – click for more)

 

Review: Treatment selection in first-line metastatic renal cell carcinoma—the contemporary treatment paradigm in the age of combination therapy.

19 Nov, 2021 | 10:14h | UTC

Treatment Selection in First-line Metastatic Renal Cell Carcinoma—The Contemporary Treatment Paradigm in the Age of Combination Therapy: A Review – JAMA Oncology (free for a limited period)

 

Covid: Children in UK told to delay jab for 12 weeks after infection.

18 Nov, 2021 | 08:54h | UTC

Covid: Children told to delay jab for 12 weeks after infection – BBC

Original Report: Joint Committee on Vaccination and Immunisation (JCVI) advice on COVID-19 vaccination in people aged 16 to 17 years: 15 November 2021

 

Observational study finds mRNA vaccination is associated with an effectiveness of 85% against Covid-19 hospitalization.

18 Nov, 2021 | 08:49h | UTC

Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity – JAMA

Editorial: Understanding Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination – JAMA

Commentary: COVID-19 vaccines 85% effective against hospital cases but weaken over time – TCTMD

Related Study: Study compares the decline in effectiveness for Moderna, Pfizer, and Janssen vaccines and consequences for mortality.

 

[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.

18 Nov, 2021 | 08:48h | UTC

Inhaled Corticosteroids for Outpatients with Covid-19: A Meta-Analysis – medRxiv

Commentary: Favourable meta-analysis of inhaled corticosteroids in COVID-19 outpatients – News Medical

Related:

PRINCIPLE RCT: Inhaled budesonide improves time to recovery from COVID-19 in people at high risk of complications in the community.

Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.

RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19

Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19

 

Commentary on Twitter

 

Observational study finds the effectiveness of mRNA vaccination against Covid-19 hospitalization was lower (77%) among immunocompromised adults than among immunocompetent adults (90%).

18 Nov, 2021 | 08:52h | UTC

Effectiveness of 2-Dose Vaccination with mRNA COVID-19 Vaccines Against COVID-19–Associated Hospitalizations Among Immunocompromised Adults — Nine States, January–September 2021 – CDC Morbidity and Mortality Weekly Report

Related:

CDC Guidance: Immunocompromised may need a fourth Covid-19 shot.

 

Commentary on Twitter (thread – click for more)

 

8 lingering questions about the new Covid pills from Merck and Pfizer.

18 Nov, 2021 | 08:46h | UTC

8 lingering questions about the new Covid pills from Merck and Pfizer – STAT

Related:

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

Observational study in patients with stroke with large-vessel occlusion presenting in the extended window suggests non-contrast CT is as good as CT perfusion or MRI to select patients for thrombectomy.

18 Nov, 2021 | 08:41h | UTC

Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion – JAMA Neurology

Commentary: Noncontrast CT a cost-friendly alternative to select late-stroke patients for thrombectomy – Health Imaging

 

Commentary on Twitter

 

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