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RCT of patients with acute hypoxemic respiratory failure due to #COVID19 found an initial strategy of CPAP, compared with conventional oxygen therapy, significantly reduced the composite outcome of tracheal intubation or mortality within 30 days. https://t.co/fznFigiFmu pic.twitter.com/b7mHssbfkp

— JAMA (@JAMA_current) January 24, 2022

Review: Treatment for peritoneal metastasis of patients with colorectal cancer.

26 Jan, 2022 | 01:17h | UTC

Treatment for Peritoneal Metastasis of Patients With Colorectal Cancer – Annals of Coloproctology

ACP living, rapid review: risk for reinfection after SARS-CoV-2.

25 Jan, 2022 | 09:47h | UTC

Risk for Reinfection After SARS-CoV-2: A Living, Rapid Review for American College of Physicians Practice Points on the Role of the Antibody Response in Conferring Immunity Following SARS-CoV-2 Infection – Annals of Internal Medicine

Commentary on Twitter

Risk for Reinfection After #SARSCoV2: previous infection reduced risk for reinfection by 87% (95% CI, 84% to 90%). Protection remained above 80% for at least 7 months, but no study followed patients after the emergence of the Delta or #Omicron variant. https://t.co/eruEf1w8Vo

— Prof. Nick Talley (@Prof_NickTalley) January 25, 2022

New CPR guidance addresses more contagious COVID-19 variants amidst evolving pandemic.

25 Jan, 2022 | 09:48h | UTC

News release: New CPR guidance addresses more contagious COVID-19 variants amidst evolving pandemic – American Heart Association

See Guidance: 2022 Interim Guidance to Healthcare Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates with Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with the American Academy of Pediatrics, American Association for Respiratory Care, The Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists

WHO drops opposition to boosters – recommends third Pfizer jab for adults & two vaccines for children ages 5 & up.

25 Jan, 2022 | 09:45h | UTC

WHO Drops Opposition to Boosters – Recommends Third Pfizer Jab for Adults & Two Vaccines for Children Ages 5 & Up – Health Policy Watch

WHO updated roadmap for prioritizing uses of COVID-19 vaccines.

WHO advisers weigh in on COVID-19 boosters, Pfizer vaccine in younger kids.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

25 Jan, 2022 | 09:43h | UTC

Carditis After COVID-19 Vaccination With a Messenger RNA Vaccine and an Inactivated Virus Vaccine: A Case–Control Study – Annals of Internal Medicine

News release: BNT162b2 COVID-19 vaccine associated with increased risk of carditis – American College of Physicians

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa.

25 Jan, 2022 | 09:41h | UTC

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study – The Lancet

Commentary: Omicron severity: milder but not mild – The Lancet

Commentary on Twitter

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in S. Africa, Lancet. Individuals with Omicron vs previous infections 80% lower odds of being admitted to hospital, 70% lower odds of severe disease than Deltahttps://t.co/528NWfKrDN

— Monica Gandhi MD, MPH (@MonicaGandhi9) January 23, 2022

COVID-19: endemic doesn’t mean harmless.

25 Jan, 2022 | 09:36h | UTC

COVID-19: endemic doesn’t mean harmless – Nature

[Preprint] Cohort study: Reduced risk of hospitalization associated with infection with SARS-CoV-2 Omicron relative to Delta.

25 Jan, 2022 | 09:40h | UTC

Reduced Risk of Hospitalisation Associated With Infection With SARS-CoV-2 Omicron Relative to Delta: A Danish Cohort Study – SSRN / Preprints with The Lancet

Commentaries:

Danish report: lower risk of hospitalisation with Omicron – Copenhagen Post

Omicron has a 36% lower risk for hospitalization compared to Delta: Denmark study – Outbreak News Today

Commentary on Twitter

New Danish population-based cohort study confirms lower (36%, 95%CI 44%-25%) risk of hospitalization with Omicron compared with Delta.
The risk also seems to be reduced irrespective of vaccination status.

Pre-print can be found here: https://t.co/LfRrw1H3CY pic.twitter.com/Ql3zPyZyRE

— Anders Husby (@a_husby) January 20, 2022

ASH-ASPHO Choosing Wisely Campaign: 5 hematologic tests and treatments to question in children.

25 Jan, 2022 | 09:33h | UTC

The ASH-ASPHO Choosing Wisely Campaign: 5 hematologic tests and treatments to question – Blood Advances

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

We will be living with COVID for foreseeable future; but we can end acute phase of pandemic this year — WHO Director General.

25 Jan, 2022 | 09:34h | UTC

We Will be Living with COVID for Foreseeable Future; but We Can End Acute Phase of Pandemic this Year — WHO Director General – Health Policy Watch

Guidelines on Screen Time and Digital Wellness in Infants, Children and Adolescents – “children below 2 years age should not be exposed to any type of screen, whereas exposure should be limited to a maximum of one hour of supervised screen time per day for children 24-59 months age, and less than two hours per day for children 5-10 years age”.

25 Jan, 2022 | 09:30h | UTC

Indian Academy of Pediatrics Guidelines on Screen Time and Digital Wellness in Infants, Children and Adolescents

Developing a how-to-guide for Health Technology Reassessment: “The HTR Playbook”.

25 Jan, 2022 | 09:26h | UTC

Developing a How-to-Guide for Health Technology Reassessment: “The HTR Playbook” – International Journal of Health Policy and Management

[Preprint] Omicron SARS-CoV-2 variant is associated with reduced risk of hospitalization and length of stay compared with Delta.

25 Jan, 2022 | 09:37h | UTC

Omicron (BA.1) SARS-CoV-2 variant is associated with reduced risk of hospitalization and length of stay compared with Delta (B.1.617.2) – medRxiv

Commentary on Twitter

In Portugal, Omicron hospitalizations were 75% reduced compared with Delta, risk adjusted. Vaccination reduced hospitalizations 84%, w/a booster 93%https://t.co/MvkfuF3mzx pic.twitter.com/zyk2INWNis

— Eric Topol (@EricTopol) January 23, 2022