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Management of Hypertrophic Cardiomyopathy: JACC State-of-the-Art Review.
25 Jan, 2022 | 09:24h | UTC
RCT: Single-dose 1000 mg ertapenem is non-inferior to single-dose 500 mg ceftriaxone for the treatment of gonorrhea.
25 Jan, 2022 | 09:20h | UTCEfficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
New from @TheLancetInfDis Efficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial by @henryjdevries and colleagues https://t.co/K2fw5ORNlm pic.twitter.com/d8wz1Vc41Q
— The Lancet HIV (@TheLancetHIV) January 24, 2022
Podcast: Erectile dysfunction pearls.
25 Jan, 2022 | 09:16h | UTC#317 Erectile Dysfunction – The Curbsiders
Podcast: Inflammatory bowel disease in children.
25 Jan, 2022 | 09:18h | UTC#42: Inflammatory Bowel Disease – Go With Your Gut – The Cribsiders
RCT: Safety and efficacy of Daridorexant in patients with insomnia disorder.
25 Jan, 2022 | 09:15h | UTCSafety and efficacy of daridorexant in patients with insomnia disorder: results from two multicentre, randomised, double-blind, placebo-controlled, phase 3 trials – The Lancet Neurology (link to abstract – $ for full-text)
RCT: Fentanyl vs. placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department.
25 Jan, 2022 | 09:14h | UTCFentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: the FAKT study – a randomized clinical trial – Academic Emergency Medicine (link to abstract – $ for full-text)
Global, regional, and national time trends in mortality for congenital heart disease, 1990–2019: An age-period-cohort analysis for the Global Burden of Disease 2019 study.
25 Jan, 2022 | 09:13h | UTC
Commentary on Twitter
A new study using data from the #GBD 2019 study estimated trends in congenital #heartdisease (CHD) mortality in 204 countries and territories over the past 30 years.
Read more here: https://t.co/6NtW0TYMAG pic.twitter.com/VLCU9OuOwx
— eClinicalMedicine – The Lancet Discovery Science (@eClinicalMed) January 14, 2022
After a flurry of firsts, xenotransplantation is suddenly back in the spotlight.
25 Jan, 2022 | 09:09h | UTCAfter a flurry of firsts, xenotransplantation is suddenly back in the spotlight – STAT
Related: In 1st, US surgeons transplant pig heart into human patient.
Cohort study: In patients with a prosthetic joint, prophylactic antibiotics are probably not needed for invasive dental procedures.
25 Jan, 2022 | 09:11h | UTCCommentary: Prophylactic Antibiotics Not Needed Before Invasive Dental Procedures – HealthDay
Commentary on Twitter
Case-crossover study analyzing the incidence of invasive dental procedures (IDP) over the 15-months before 9,427 late prosthetic joint infection hospital admissions (LPJI) and found no evidence of a temporal association b/w IDP and LPJI. https://t.co/hcpwpN0B4H
— JAMA Network Open (@JAMANetworkOpen) January 19, 2022
Long-term results of RCT: GH replacement with once-weekly somapacitan is comparable to daily GH in children with growth hormone deficiency.
25 Jan, 2022 | 09:07h | UTC
RCT: A low FODMAP diet reduces symptoms in treated celiac patients with ongoing symptoms.
25 Jan, 2022 | 09:03h | UTC
Commentary on Twitter
A low FODMAP diet reduces symptoms in ‘𝘁𝗿𝗲𝗮𝘁𝗲𝗱’ #celiac patients with ongoing symptoms – a randomized controlled trial.
Brilliant RCT! Important word in the title is… ‘Treated’ (ie in histopathological remission).😉
🔓 https://t.co/R7oSnNhsWI pic.twitter.com/d0wbAa2nFg
— Nick Trott (@trott_nick) January 22, 2022
Massive open index of scholarly papers launches – “OpenAlex catalogues hundreds of millions of scientific documents and charts connections between them”.
25 Jan, 2022 | 09:04h | UTCMassive open index of scholarly papers launches – Nature
M-A: BRCA1 and BRCA2 pathogenic variants and prostate cancer risk.
25 Jan, 2022 | 09:01h | UTC
European CDC on Omicron: “among Omicron cases reported to TESSy, 1.14% were hospitalised, 0.16% required ICU admission/respiratory support, and 0.06% died”.
24 Jan, 2022 | 08:54h | UTC
Case-control study: 3 doses of mRNA vaccines were associated with reduced infections with SARS-CoV-2 Omicron and Delta variants compared to no vaccination or 2 doses.
24 Jan, 2022 | 08:56h | UTCCommentaries: New data show booster doses protect against Omicron – CIDRAP
Related CDC Studies:
Commentary on Twitter
Study suggests receipt of 3 doses of mRNA #COVID19 vaccine, vs 2 doses or being unvaccinated, was associated with protection against both the Omicron and Delta variants; higher odds ratios for Omicron suggest less protection for Omicron than for Delta. https://t.co/kOZh0fq5TL
— JAMA (@JAMA_current) January 21, 2022
Review: Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups.
25 Jan, 2022 | 08:59h | UTC
WHO updated roadmap for prioritizing uses of COVID-19 vaccines.
24 Jan, 2022 | 08:49h | UTCWHO SAGE Roadmap for prioritizing uses of COVID-19 vaccines – World Health Organization
Commentary: WHO: COVID boosters should start with most vulnerable – Associated Press
Commentary on Twitter (thread – click for more)
UPDATED: The Strategic Advisory Group of Experts (SAGE) have revised the Roadmap for Prioritising Uses of #COVID19 vaccines.
👉 https://t.co/FJFlMpBSSK pic.twitter.com/4SNH7ZpSwz
— World Health Organization (WHO) (@WHO) January 21, 2022
WHO advisers weigh in on COVID-19 boosters, Pfizer vaccine in younger kids.
24 Jan, 2022 | 08:35h | UTCWHO advisers weigh in on COVID-19 boosters, Pfizer vaccine in younger kids – CIDRAP
Updated Guideline: Recommended drugs and biologics in adult patients with COVID-19.
24 Jan, 2022 | 08:52h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/ASPphysician/status/1484874519252721664
WHO Technical Brief: Enhancing response to Omicron SARS-CoV-2 variant.
24 Jan, 2022 | 08:36h | UTCEnhancing response to Omicron SARS-CoV-2 variant – World Health Organization
A guide to immunotherapy for COVID-19.
24 Jan, 2022 | 08:29h | UTCA guide to immunotherapy for COVID-19 – Nature Medicine
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
24 Jan, 2022 | 08:28h | UTCA blood atlas of COVID-19 defines hallmarks of disease severity and specificity – Cell
Commentary on Twitter:
A simple😉one-page summary of everything you need to know about Covid hallmarks of severity in the blood, how it differs from flu, sepsis, and much morehttps://t.co/s81Qb2SXmu @CellCellPress @KnightGenetics
(actually quite a rich resource @UniofOxford) pic.twitter.com/bk0AxwLItn— Eric Topol (@EricTopol) January 22, 2022
No amount of alcohol is good for the heart, says World Heart Federation.
24 Jan, 2022 | 08:23h | UTCNews Release: No amount of alcohol is good for the heart, says World Heart Federation
Commentary: No amount of alcohol is good for the heart, new report says, but critics disagree on science – CNN
Flying in the COVID-19 era: Science-based risk assessments and mitigation strategies on the ground and in the air.
24 Jan, 2022 | 08:32h | UTCFlying in the COVID-19 Era: Science-based Risk Assessments and Mitigation Strategies on the Ground and in the Air – National Academies of Sciences, Engineering, and Medicine (free registration required)
SARS-CoV-2 breakthrough infections elicit potent, broad and durable neutralizing antibody responses.
24 Jan, 2022 | 08:26h | UTCNews Release: Breakthrough infections spur strong antibody responses – University of Washington School of Medicine