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How Denmark Decided COVID Isn’t a Critical Threat to Society – “The country became the first in the EU to lift all COVID restrictions despite leading the world in per capita infections”.

7 Feb, 2022 | 08:48h | UTC

How Denmark Decided COVID Isn’t a Critical Threat to Society – The Atlantic

Related:

Covid: Europe set for ‘long period of tranquillity’ in pandemic, says WHO.

As Denmark scraps COVID restrictions, WHO urges caution.

Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

 


Scientists admit their Covid mistakes – “Being proved wrong lies at the heart of scientific progress. Here, experts reveal what they got wrong during the pandemic”.

7 Feb, 2022 | 08:46h | UTC

‘The case for masks became hugely stronger’: scientists admit their Covid mistakes – The Guardian

 


The costs and benefits of primary prevention of zoonotic pandemics.

7 Feb, 2022 | 08:45h | UTC

The costs and benefits of primary prevention of zoonotic pandemics – Science Advances

Commentary: Preventing pandemics costs far less than controlling them – Duke University

 


ERC-ESICM guidelines on temperature control after cardiac arrest in adults.

7 Feb, 2022 | 08:44h | UTC

ERC-ESICM guidelines on temperature control after cardiac arrest in adults – Intensive Care Medicine (if the link is paywalled, try this one)

Related:

M-A: In comatose survivors of cardiac arrest, targeted hypothermia is not associated with improved survival or better neurological outcomes vs. targeted normothermia.

RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

 

Commentary on Twitter

 


A highly virulent variant of HIV-1 circulating in the Netherlands.

7 Feb, 2022 | 08:42h | UTC

A highly virulent variant of HIV-1 circulating in the Netherlands – Science

Commentaries:

New highly virulent and damaging HIV variant discovered in the Netherlands – University of Oxford

Highly virulent HIV variant found circulating in Europe – Nature

 


Guideline: Management and follow-up of gallbladder polyps – “If the patient has no risk factors for malignancy, and a gallbladder polypoid lesion of 5 mm or less, follow-up is not required”.

7 Feb, 2022 | 08:39h | UTC

Management and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE – European Radiology

 


Wilderness Medical Society Clinical Practice Guidelines on Anaphylaxis.

7 Feb, 2022 | 08:41h | UTC

Wilderness Medical Society Clinical Practice Guidelines on Anaphylaxis – Wilderness and Environmental Medicine

Related Guidelines:

Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update

Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update

Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Heat Illness: 2019 Update

Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update

Wilderness Medical Society Clinical Practice Guidelines for the Treatment and Prevention of Drowning: 2019 Update

Wilderness Medical Society Clinical Practice Guidelines for Spinal Cord Protection

Wilderness Medical Society Clinical Practice Guidelines for Water Disinfection for Wilderness, International Travel, and Austere Situations

Wilderness Medical Society Clinical Practice Guidelines for Diabetes Management

 


Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

7 Feb, 2022 | 08:36h | UTC

Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

 


AUA/SMSNA Guideline: Disorders of Ejaculation.

7 Feb, 2022 | 08:37h | UTC

Disorders of Ejaculation: An AUA/SMSNA Guideline – American Urological Association

 


Patent Foramen Ovale (PFO) After Stroke: Meta-analysis suggests the application of a multivariable causal classification system may better distinguish patient subgroups who may benefit from PFO closure from those unlikely to receive benefit.

7 Feb, 2022 | 08:31h | UTC

Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke – JAMA (link to abstract – $ for full-text)

Commentary: Classification System May Identify Patients Likely to Benefit from PFO Closure – Physician’s Weekly

Related:

Management of the Patient With Patent Foramen Ovale in 2021: A Spectrum of Cases

Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology – Neurology

 

Commentary on Twitter

 


NCCN Guidelines Insights: Squamous Cell Skin Cancer, Version 1.2022.

7 Feb, 2022 | 08:34h | UTC

NCCN Guidelines Insights: Squamous Cell Skin Cancer, Version 1.2022 – Journal of the National Comprehensive Cancer Network

 


Summary: 2021 CDC guidelines on sexually transmitted infections.

7 Feb, 2022 | 08:33h | UTC

2021 CDC guidelines on sexually transmitted infections – Family Medicine

Original Guideline: CDC releases new guidelines for the treatment of sexually transmitted infections.

Related: WHO Guidelines for the management of symptomatic sexually transmitted infections.

 


Cluster Randomized Trial: Personalizing psychotherapy treatment intensity (stratified care) has the potential to improve depression treatment outcomes compared to a stepped care model, in which most patients initially access only low-intensity treatments, progressing to more intensive psychotherapies as needed.

7 Feb, 2022 | 08:28h | UTC

Stratified Care vs Stepped Care for Depression: A Cluster Randomized Clinical Trial – JAMA Psychiatry

Author Interview: Stratified Care vs Stepped Care for Depression

Commentary: Tailoring Psychotherapy Intensity to Patients More Effective Than Stepped Care Approach, Study Finds – Psychiatric News Alert

 


Therapies for Olfactory Dysfunction — an Update.

7 Feb, 2022 | 08:29h | UTC

Therapies for Olfactory Dysfunction — an Update – Current Allergy and Asthma Reports (if the link is paywalled, try this one)

 


M-A: Tranexamic acid in aneurysmal subarachnoid hemorrhage does not improve clinical outcomes or mortality.

7 Feb, 2022 | 08:26h | UTC

Efficacy and safety of tranexamic acid in aneurysmal subarachnoid hemorrhage: A meta-analysis of randomized controlled trials – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

 


Review: Classification of uremic toxins and their role in kidney failure.

7 Feb, 2022 | 08:23h | UTC

Classification of Uremic Toxins and Their Role in Kidney Failure – Clinical Journal of the American Society of Nephrology

 


In a series of simultaneous pancreas and kidney transplantation cases, long-term data demonstrated that patient and graft survival were equivalent for conventional donation after circulatory death (DCD) vs. donation after brainstem death. The utilization of DCD pancreases may expand the donor pool with comparable results to DBD transplantation.

7 Feb, 2022 | 08:24h | UTC

Outcomes for circulatory death and brainstem death pancreas transplantation with or without use of normothermic regional perfusion – British Journal of Surgery

 


Perspective: Understand the real reasons reproducibility reform fails.

7 Feb, 2022 | 08:26h | UTC

Understand the real reasons reproducibility reform fails – Nature

 


Review: Post-transplant cardiovascular disease.

7 Feb, 2022 | 08:20h | UTC

Post-Transplant Cardiovascular Disease – Clinical Journal of the American Society of Nephrology

 


Review: video-based telemedicine for kidney disease care.

7 Feb, 2022 | 08:22h | UTC

Video-Based Telemedicine for Kidney Disease Care: A Scoping Review – Clinical Journal of the American Society of Nephrology

Editorial: Telehealth and Kidney Disease Care: Role after the Public Health Emergency? – Clinical Journal of the American Society of Nephrology

Patient Voice: Patient Views on Telehealth for Kidney Disease Care – Clinical Journal of the American Society of Nephrology

 


The kidney in normal aging: a comparison with chronic kidney disease.

7 Feb, 2022 | 08:18h | UTC

The Kidney in Normal Aging: A Comparison with Chronic Kidney Disease – Clinical Journal of the American Society of Nephrology

 


Thinking outside the box: novel kidney protective strategies in kidney transplantation.

7 Feb, 2022 | 08:16h | UTC

Thinking Outside the Box: Novel Kidney Protective Strategies in Kidney Transplantation – Clinical Journal of the American Society of Nephrology

 


M-A: The effect of Dexmedetomidine as a sedative agent for mechanically ventilated patients with sepsis.

7 Feb, 2022 | 08:15h | UTC

The Effect of Dexmedetomidine as a Sedative Agent for Mechanically Ventilated Patients With Sepsis: A Systematic Review and Meta-Analysis – Frontiers in Medicine

 


A cohort study including 11 US hospitals and 232 patients with Vancomycin-resistant enterococci (VRE) showed an 18% mortality rate; failure of early eradication of VRE from the bloodstream was the strongest predictor of in-hospital mortality.

7 Feb, 2022 | 08:12h | UTC

Contemporary Clinical and Molecular Epidemiology of Vancomycin-Resistant Enterococcal Bacteremia: A Prospective Multicenter Cohort Study (VENOUS I) – Open Forum Infectious Diseases

 

Commentary on Twitter

 


RCT: Ketamine is a short-term effective treatment for some suicidal patients in hospital.

4 Feb, 2022 | 10:05h | UTC

News Release: Ketamine is a short-term effective treatment for some suicidal patients in hospital – BMJ

Original Article: Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial – The BMJ

Editorial: Ketamine for suicidal ideation – The BMJ

Related:

RCT: Ketamine induced remission in 46% of patients but was NOT non-inferior to electroconvulsive therapy for the treatment of hospitalized patients with unipolar depression.

Systematic Review: Ketamine for the treatment of mental health and substance use disorders.

Phase 2 RCT: Adjunctive ketamine with relapse prevention–based psychological therapy shows promise for the treatment of alcohol use disorder.

RCT: Effects of ketamine vs. midazolam on neurocognition at 24 hours in depressed patients with suicidal ideation.

Randomized trial: Repeated Ketamine administration for chronic posttraumatic stress disorder

Ketamine and Depression: A Narrative Review

 


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