Patent Foramen Ovale (PFO) After Stroke: Meta-analysis suggests the application of a multivariable causal classification system may better distinguish patient subgroups who may benefit from PFO closure from those unlikely to receive benefit.

Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke – JAMA (link to abstract – $ for full-text)

Commentary: Classification System May Identify Patients Likely to Benefit from PFO Closure – Physician’s Weekly

Related:

Management of the Patient With Patent Foramen Ovale in 2021: A Spectrum of Cases

Practice advisory update summary: Patent foramen ovale and secondary stroke prevention: Report of the Guideline Subcommittee of the American Academy of Neurology – Neurology

Commentary on Twitter

Analysis of individual patient data from RCTs found application of a multivariable causal classification system to randomized trial results that distinguished subgroups who may benefit from patent foramen ovale (PFO) closure vs those unlikely to benefit https://t.co/L9Ic9EsNPG

— JAMA (@JAMA_current) December 15, 2021