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Systematic Review: Probiotics for treatment of chronic constipation in children.

30 Mar, 2022 | 10:12h | UTC

Probiotics for treatment of chronic constipation in children – Cochrane Library

Summary: Probiotics for treatment of chronic constipation in children – Cochrane Library

Systematic Review: Pregabalin add‐on for drug‐resistant focal epilepsy.

30 Mar, 2022 | 10:10h | UTC

Pregabalin add‐on for drug‐resistant focal epilepsy – Cochrane Library

Summary: Pregabalin add-on for drug-resistant focal epilepsy – Cochrane Library

End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry.

30 Mar, 2022 | 10:08h | UTC

End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry – European Heart Journal. Acute Cardiovascular Care

Commentary on Twitter

#EHJACVC Editors Choice:
End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry

Big thank you to the @TIMIStudyGroup #CCCTN group for this important analysis! https://t.co/QJaPoTurLc pic.twitter.com/leOZRBNGTB

— EHJACVC Editor-in-Chief (@EHJACVCEiC) March 29, 2022

Cohort Study: Risk factors for complications after surgery for pancreatic neuroendocrine tumors.

30 Mar, 2022 | 10:03h | UTC

Risk factors for complications after surgery for pancreatic neuroendocrine tumors – Surgery

Commentary on Twitter

Risk factors for complications after surgery for pancreatic neuroendocrine tumors@hpb_so @NANETS1 @AHPBA @EAHPBA @Cancer_UMCU @UMCU_Intl @me4_so
🆓#openaccess #VisualAbstract
https://t.co/uVNFRqpKKP pic.twitter.com/iIVbQSBawD

— SURGERY Journal (@SurgJournal) March 25, 2022

Safety and economic analysis of selective histopathology following cholecystectomy: multicenter, prospective, cross-sectional study.

30 Mar, 2022 | 09:59h | UTC

Safety and economic analysis of selective histopathology following cholecystectomy: multicentre, prospective, cross-sectional FANCY study – British Journal of Surgery

Commentary on Twitter

Open Access in the April BJS: Safety and economic analysis of selective histopathology following cholecystectomy: FANCY study https://t.co/3qUVzf6Xwu @AmyLightnerMD @bplwijn @des_winter @ksoreide @MalinASund @evanscolorectal @nfmkok @robhinchliffe1 @young_bjs pic.twitter.com/dtFJpVJkke

— BJS (@BJSurgery) March 28, 2022

What to expect when women with axial spondyloarthritis are expecting: Prevalence of complications of pregnancies in women with axial spondyloarthritis.

30 Mar, 2022 | 10:01h | UTC

What to expect when women with axial spondyloarthritis are expecting: Prevalence of complications of pregnancies in women with axial spondyloarthritis – Seminars in Arthritis and Rheumatism

Commentary on Twitter

ICYMI: Among 98 women with axSpA, there were 335 pregnancies & 279 live births – 52% uncomplicated and 48% complicated (13%) multiple complications. axSpA had more Preterm birth (13 vs 5%), pre-eclampsia (7 vs 3%), Low birth Wt (8 vs 3%) https://t.co/1oFBKSUzzy pic.twitter.com/oLbYis81Y9

— Dr. John Cush (@RheumNow) March 28, 2022

Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019.

30 Mar, 2022 | 09:55h | UTC

Burden of non-communicable diseases among adolescents aged 10–24 years in the EU, 1990–2019: a systematic analysis of the Global Burden of Diseases Study 2019 – The Lancet Child & Adolescent Health

Invited Commentary: 30-year NCD burden data for EU adolescents merit close attention – The Lancet Child & Adolescent Health (free registration required)

Commentary on Twitter (thread – click for more)

New #GBD study: #NCD mortality substantially declined among #adolescents (10-24 years) in the #EU between 1990 and 2019. But disability has remained mostly unchanged, with a concerning rise in disability burden attributed to mental disorders https://t.co/V94kubDqOR #IAHW2022

— The Lancet Child & Adolescent Health (@LancetChildAdol) March 25, 2022

Systematic Review: The global gap in treatment coverage for major depressive disorder in 84 countries from 2000–2019.

30 Mar, 2022 | 09:49h | UTC

The global gap in treatment coverage for major depressive disorder in 84 countries from 2000–2019: A systematic review and Bayesian meta-regression analysis – PLOS Medicine

Commentary: PLOS Medicine: Study highlights worldwide disparities in treatment rates for major depressive disorder – Institute for Health Metrics and Evaluation

M-A: Effectiveness of cognitive–behavioral therapies of varying complexity in reducing depression in adults.

30 Mar, 2022 | 09:46h | UTC

Effectiveness of cognitive–behavioural therapies of varying complexity in reducing depression in adults: systematic review and network meta-analysis – British Journal of Psychiatry (link to abstract – $ for full-text)

News Release: Enhanced CBT can radically reduce long-term depression, finds study – University of Manchester

AI estimation of gestational age from blind ultrasound sweeps in low-resource settings.

30 Mar, 2022 | 09:53h | UTC

AI Estimation of Gestational Age from Blind Ultrasound Sweeps in Low-Resource Settings – NEJM Evidence

Commentary on Twitter

Pregnancies were dated in a low-resource setting using a mobile phone and a low-cost ultrasound probe to acquire sweeps of the gravid abdomen by untrained personnel. An AI program yielded dates that were similar to those obtained in higher resource sites. https://t.co/Cc3NTTDzfg pic.twitter.com/cEug9kMXQF

— NEJM Evidence (@NEJMEvidence) March 28, 2022

M-A: Artificial intelligence in fracture detection.

30 Mar, 2022 | 08:51h | UTC

Artificial Intelligence in Fracture Detection: A Systematic Review and Meta-Analysis – Radiology

News Release: AI helps radiologists detect bone fractures – Radiological Society of North America

Cohort Study: Socio-economic variations determine the clinical presentation, etiology and outcome of infective endocarditis.

30 Mar, 2022 | 09:50h | UTC

Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry – European Heart Journal – Quality of Care and Clinical Outcomes

Commentary on Twitter

Infective #endocarditis – do socio-economic factors impact presentation and prognosis? Unfortunately yes, according to data from EURO-ENDO Registry: https://t.co/JdKM5igihR #CVD #EHJQCCO @cpgale3 @diogoasantosfer pic.twitter.com/pkclJdRsdU

— European Society of Cardiology Journals (@ESC_Journals) March 28, 2022

Artificial intelligence evaluation of 122 969 mammography examinations from a population-based screening program.

30 Mar, 2022 | 08:49h | UTC

Artificial Intelligence Evaluation of 122 969 Mammography Examinations from a Population-based Screening Program – Radiology

News Release: AI shows potential in breast cancer screening programs – Radiological Society of North America

Cohort Study: Characteristics and prognosis of acquired resistance to immune checkpoint inhibitors in gastrointestinal cancer.

30 Mar, 2022 | 08:47h | UTC

Characteristics and Prognosis of Acquired Resistance to Immune Checkpoint Inhibitors in Gastrointestinal Cancer – JAMA Network Open

Invited Commentary: Acquired Immunotherapy Resistance in Gastrointestinal Cancers – JAMA Network Open

Cohort Study: Prenatal occupational disinfectant exposure linked to increased risk of childhood allergies.

30 Mar, 2022 | 08:48h | UTC

Prenatal occupational disinfectant exposure and childhood allergies: the Japan Environment and Children’s study – Occupational & Environmental Medicine

Commentary: Disinfectant use by pregnant women may increase risk for asthma and eczema in children – BMJ/News Medical

Commentary on Twitter

Disinfectant use during pregnancy linked to childhood asthma and eczema, suggests @OEM_BMJ research https://t.co/90JYoTFHpo pic.twitter.com/zlqouZWQSM

— BMJ Group (@bmj_company) March 29, 2022

Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.

29 Mar, 2022 | 10:16h | UTC

Cost-effectiveness of a Household Salt Substitution Intervention: Findings From 20,995 Participants of the Salt Substitute and Stroke Study (SSaSS) – Circulation

Commentary: ACC: Use of Salt Substitute to Prevent Stroke Is Cost-Saving – HealthDay

Original Study: #ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

Former CDC director: Low sodium salt could save millions of lives – CNN

Is salt good for you after all? The evidence says no.

Systematic Review: Altered dietary salt intake for people with chronic kidney disease.

New WHO benchmarks help countries reduce salt intake and save lives.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

Cohort Study: Coronary artery and cardiac disease are common in patients with type 2 myocardial infarction.

29 Mar, 2022 | 10:14h | UTC

Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study – Circulation

Commentary: AHA News: Undiagnosed Heart Disease May Be Common in People With Heart Attacks Not Caused by Clots – HealthDay

Commentary on Twitter

#OriginalResearch: #DEMAND_MI 1st prospective study to undertake systematic cardiac imaging in patients with type 2 MI. Results show high prevalence of LV dysfunction & CAD @damini_dey @imagingmedsci @marcdweck @jdinaus @andabularga @RyanWereski @chapdoc1 https://t.co/dygODQ92vs pic.twitter.com/ny3Fsyx7wH

— Circulation (@CircAHA) March 28, 2022

Opinion: Global vaccination must be swifter.

29 Mar, 2022 | 10:12h | UTC

Global vaccination must be swifter – Nature

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals.

29 Mar, 2022 | 10:09h | UTC

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals – UK Health Security Agency

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

Meta-analysis of randomized trials: GLP1 receptor agonists increase the risk of gallbladder and biliary diseases (RR, 1.37; 95% CI, 1.23-1.52).

29 Mar, 2022 | 10:02h | UTC

Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (free for a limited period)

Commentary: GLP-1 Receptor Agonists: How Safe Are They for the Gallbladder?— Link with gallbladder, biliary diseases could be due to weight loss associated with class of drug – MedPage Today (free registration required)

Cohort Study: Preconception paternal use of metformin linked to increased risk of congenital problems in offspring.

29 Mar, 2022 | 10:04h | UTC

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Paternal metformin use associated with major birth defects if used during period of sperm development – American College of Physicians

Expert reaction to study of birth defects and diabetic men using metformin during sperm development – Science Media Centre

Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19.

29 Mar, 2022 | 10:05h | UTC

Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19. A joint guideline of the Brazilian Association of Emergency Medicine (ABRAMEDE), Brazilian Medical Association (AMB), Brazilian Society of Angiology and Vascular Surgery (SBACV), Brazilian Society of Geriatrics and Gerontology (SBGG), Brazilian Society of Infectious Diseases (SBI), Brazilian Society of Family and Community Medicine (SBFMC), and Brazilian Thoracic Society (SBPT) – The Brazilian Journal of Infectious Diseases

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers.

29 Mar, 2022 | 09:58h | UTC

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers – Nature Medicine

See also: Suicide risk and mortality among patients with cancer – Nature Medicine (if the link is paywalled, try this one)

Invited Commentary: Shining a light on the psychological burden of cancer – Nature Medicine

Commentary on Twitter

Patients with cancer who are diagnosed with a psychiatric disorder had a higher incidence of mortality and are at greater risk of self-harm compared with other patients with cancer, according to a paper published in @NatureMedicine. https://t.co/U5b7ODKSNd pic.twitter.com/816N6ZCfms

— Nature Portfolio (@NaturePortfolio) March 28, 2022