All Posts

Pooled Analysis | Post-CABG graft failure found in 33.7% of patients, strongly linked to cardiac events

20 Jul, 2023 | 11:03h | UTC

Graft Failure After Coronary Artery Bypass Grafting and Its Association With Patient Characteristics and Clinical Events: A Pooled Individual Patient Data Analysis of Clinical Trials With Imaging Follow-Up – Circulation (free for a limited period)

 

Commentary on Twitter

#OriginalResearch: In this analysis pooling individual level data from randomized trails, graft failure occured in 34% of patients undergoing CABG and was associated w/ increased risk of adverse clinical events #AHAJournals @WCM_CTSurgery https://t.co/Vg7t56pg0x pic.twitter.com/gmseiefME0

— Circulation (@CircAHA) July 18, 2023

 

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Phase 2 Trial | Nivolumab shows promise as adjuvant therapy in completely resected Merkel cell carcinoma

20 Jul, 2023 | 11:02h | UTC

Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Adjuvant Nivolumab vs Observation for Patients With Completely Resected Merkel Cell Carcinoma – The ASCO Post

 

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RCT | Preterm infants show same feeding tolerance with NCPAP or HHHFNC

20 Jul, 2023 | 11:01h | UTC

Effect of Nasal Continuous Positive Airway Pressure vs Heated Humidified High-Flow Nasal Cannula on Feeding Intolerance in Preterm Infants With Respiratory Distress Syndrome: The ENTARES Randomized Clinical Trial – JAMA Network Open

Commentary: Changing oxygenation strategies not associated with differences in feeding intolerance in preterm infants – Physician’s Weekly

 

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M-A | Hepatic, extra-hepatic outcomes and causes of mortality in NAFLD

20 Jul, 2023 | 10:59h | UTC

Hepatic, Extra-hepatic Outcomes and Causes of Mortality in NAFLD – An Umbrella Overview of Systematic Review of Meta-Analysis – Journal of Clinical and Experimental Hepatology

 

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Phase 1–2 study | Liso-cel shows effectiveness against resistant CLL/SLL post BTK inhibitor, venetoclax treatment

20 Jul, 2023 | 10:58h | UTC

Lisocabtagene maraleucel in chronic lymphocytic leukaemia and small lymphocytic lymphoma (TRANSCEND CLL 004): a multicentre, open-label, single-arm, phase 1–2 study – The Lancet (link to abstract – $ for full-text)

News Release: Immunotherapy Improves Remission for Relapsed, Refractory Leukemia – Northwestern Medicine

 

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RCT | Ischemic stroke patients benefit from Panax notoginseng saponins therapy

20 Jul, 2023 | 10:57h | UTC

Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

Commentary: Do Panax notoginseng saponins (Xuesaitong soft capsules) improve function in patients with ischemic stroke? – News Medical

 

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Systematic Review | Platinum doublet therapy outperforms non-platinum for advanced NSCLC, performance status 2 patients

20 Jul, 2023 | 10:56h | UTC

Best first‐line therapy for people with advanced non‐small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status – Cochrane Library

Summary: Best therapy for people with advanced non-small cell lung cancer who have not been treated without a targetable mutation and moderately impaired performance status – Cochrane Library

 

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Systematic Review | Outcomes in deprescribing implementation trials and compliance with expert recommendations

20 Jul, 2023 | 10:55h | UTC

Outcomes in deprescribing implementation trials and compliance with expert recommendations: a systematic review – BMC Geriatrics

Related:

Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations – Medical Journal of Australia

RCT | Opioids not more effective than placebo for acute low back and neck pain

Deprescribing considerations for older people in general practice – Australian Journal of General Practice

Deprescribing Strategies for Opioids and Benzodiazepines with Emphasis on Concurrent Use: A Scoping Review – Journal of Clinical Medicine

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 

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Review | Painful diabetic peripheral neuropathy

20 Jul, 2023 | 10:53h | UTC

Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management – Diabetes, Metabolic Syndrome and Obesity

 

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Self-measured blood pressure telemonitoring programs: a pragmatic how-to guide

19 Jul, 2023 | 14:33h | UTC

Self-Measured Blood Pressure Telemonitoring Programs: A Pragmatic How-to Guide – American Journal of Hypertension

 

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Systematic Review | Vedolizumab for induction and maintenance of remission in Crohn’s disease

20 Jul, 2023 | 10:51h | UTC

Vedolizumab for induction and maintenance of remission in Crohn’s disease – Cochrane Library

 

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ASCO Guideline | Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy

19 Jul, 2023 | 14:31h | UTC

Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Systemic Cancer Therapy: ASCO Guideline Update – Journal of Clinical Oncology

 

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Changes to breast structure and function across a woman’s lifespan: implications for managing and modeling female breast injuries

19 Jul, 2023 | 14:29h | UTC

Changes to breast structure and function across a woman’s lifespan: Implications for managing and modeling female breast injuries – Clinical Biomechanics

Commentary: Breast injuries are common for female athletes. Here’s why better awareness and reporting are needed – The Conversation

 

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Survey Study | ChatGPT’s performance in simulated patient-provider interactions

19 Jul, 2023 | 14:28h | UTC

Putting ChatGPT’s Medical Advice to the (Turing) Test: Survey Study – JMIR Medical Education

News Release: ChatGPT’s responses to healthcare-related queries ‘nearly indistinguishable’ from those provided by humans – NYU Tandon School of Engineering

Related: ChatGPT’s responses to patient questions rated higher for quality and empathy than physicians

 

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RCT | Solanezumab fails to slow cognitive decline in preclinical Alzheimer’s disease

19 Jul, 2023 | 14:26h | UTC

Trial of Solanezumab in Preclinical Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Related:

RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns

 

Commentary on Twitter

Original Article: Trial of Solanezumab in Preclinical Alzheimer’s Disease (A4 trial) https://t.co/lCXsVoiP8i #AAIC23 pic.twitter.com/e8DplR27yd

— NEJM (@NEJM) July 18, 2023

 

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FDA approves first nonprescription daily oral contraceptive

19 Jul, 2023 | 14:25h | UTC

FDA Approves First Nonprescription Daily Oral Contraceptive – U.S. Food & Drug Administration

Commentary: FDA approves first daily over-the-counter birth control pill, Opill – a pharmacist and public health expert explain this new era in contraception – The Conversation

 

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Systematic Review | An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice

19 Jul, 2023 | 14:23h | UTC

An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice: A systematic review – Palliative Medicine

 

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Podcast | Hematuria pearls

19 Jul, 2023 | 14:19h | UTC

#404 Hematuria with Dr. Derek Fine – The Curbsiders

 

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Large bowel obstruction | ED presentation, evaluation, and management

19 Jul, 2023 | 14:17h | UTC

Large bowel obstruction: ED presentation, evaluation, and management – emDocs

 

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M-A | Population-level smoke-free legislation tied to better cardiovascular, respiratory, birth outcomes

19 Jul, 2023 | 14:13h | UTC

Evaluation of Population-Level Tobacco Control Interventions and Health Outcomes: A Systematic Review and Meta-Analysis – JAMA Network Open

Commentary: Smoke-Free Legislation Linked to Drop in Adverse Health Outcomes – HealthDay

 

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IARC, WHO agency, identifies aspartame as potentially carcinogenic but probably safe within established acceptable daily intake

18 Jul, 2023 | 13:58h | UTC

News Release: Aspartame hazard and risk assessment results released – World Health Organization

Commentaries:

Expert reaction to IARC and JEFCA summary on aspartame – Science Media Centre

Does artificial sweetener aspartame really cause cancer? What the WHO listing means for your diet soft drink habit – The Conversation

Aspartame Hazard and Risk Assessment Results Released by IARC and JECFA – The ASCO Post

 

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AHA Scientific Statement | Cardiopulmonary impact of electronic cigarettes and vaping products

18 Jul, 2023 | 13:56h | UTC

Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products: A Scientific Statement From the American Heart Association – Circulation

News Releases:

Current evidence identifies health risks of e-cigarette use; long-term research needed – American Heart Association

As e-cigarette use grows, more research needed on long-term effects of vaping – American Heart Association

Top Things to Know: Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products – American Heart Association

Commentary: Vaping’s Risks to CV Health Not Yet Fully Known: AHA – CIDRAP

 

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RCT | Direct oral challenge noninferior to skin testing followed by direct oral challenge in low-risk penicillin allergy patients

18 Jul, 2023 | 13:54h | UTC

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

See also: Visual Abstract

News Release: World-first clinical trial to help millions with penicillin allergies – Vanderbilt University Medical Center

Commentary: Trial supports use of direct oral challenge for penicillin allergy – CIDRAP

 

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RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

18 Jul, 2023 | 13:51h | UTC

Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorials:

Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)

Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)

Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre

Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.

 

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Nationwide Cohort Study | Adolescent hypertension linked with increased stroke risk in young adulthood

18 Jul, 2023 | 13:49h | UTC

Adolescent Hypertension Is Associated With Stroke in Young Adulthood: A Nationwide Cohort of 1.9 Million Adolescents – Stroke

Commentary: The Relationship Between Adolescent Hypertension and Stroke Risk After Age 40 Years – Neurology Advisor

 

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