All Posts
RCT | Talazoparib plus enzalutamide prolongs radiographic PFS vs. enzalutamide alone in metastatic castration-resistant prostate cancer
14 Jun, 2023 | 14:29h | UTCTalazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT | Second-line treatment with Axi-cel results in increased overall survival in large B-cell lymphoma
14 Jun, 2023 | 14:25h | UTCSurvival with Axicabtagene Ciloleucel in Large B-Cell Lymphoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Late breaking at #ASCO23: In the phase 3 ZUMA-7 trial, patients with relapsed or refractory large B-cell lymphoma who received axi-cel (CD19-specific CAR T cells) had a 27.4% lower risk of death than patients who received standard therapy. Full trial results:
— NEJM (@NEJM) June 5, 2023
Crossover RCT | THC and Cannabidiol demonstrate potential in Tourette syndrome tic management, despite cognitive impacts
14 Jun, 2023 | 14:27h | UTCTetrahydrocannabinol and Cannabidiol in Tourette Syndrome – NEJM Evidence
RCT | Cilta-cel shows superior progression-free survival over standard care in lenalidomide-refractory multiple myeloma
14 Jun, 2023 | 14:22h | UTCCilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Original Article: Cilta-cel or Standard Care in Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4) https://t.co/Wag2UTKOfH#ASCO23
— NEJM (@NEJM) June 6, 2023
Review | Acute graft-versus-host disease
14 Jun, 2023 | 14:20h | UTCAcute graft-versus-host disease – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Commentary on Twitter
Tissue damage resulting from allogenic hematopoietic cell transplantation conditioning regimens triggers cellular interactions and #inflammatory cascades that lead to acute #GraftVersusHost disease symptoms https://t.co/iHyUVoV75J pic.twitter.com/ob9X7zQWB8
— Nature Reviews Disease Primers (@DiseasePrimers) June 11, 2023
RCT | Valbenazine outperforms placebo in alleviating chorea in Huntington’s disease
14 Jun, 2023 | 14:18h | UTCSafety and efficacy of valbenazine for the treatment of chorea associated with Huntington’s disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
ASCO Guideline Update | Human epidermal growth factor receptor 2 testing in breast cancer
14 Jun, 2023 | 14:15h | UTC
Cluster RCT | Effects of implementation of a supervised walking program in veterans affairs hospitals
14 Jun, 2023 | 14:17h | UTCEffects of Implementation of a Supervised Walking Program in Veterans Affairs Hospitals: A Stepped-Wedge, Cluster Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Supervised Walking Program Benefits Veterans Admitted to Hospital – Physician’s Weekly
Commentary on Twitter
A supervised #WalkingProgram known as #STRIDE reduced skilled nursing facility admissions among older adults. https://t.co/nvkzcx5eVE pic.twitter.com/UJnJMtaxXG
— Annals of Int Med (@AnnalsofIM) June 8, 2023
Review | Basic, translational and clinical aspects of bronchiectasis in adults
14 Jun, 2023 | 14:13h | UTCBasic, translational and clinical aspects of bronchiectasis in adults – European Respiratory Review
Commentary on Twitter
ERR: Bronchiectasis is an underdiagnosed and heterogeneous disorder. Inflammation is a key driver of bronchiectasis and represents a therapeutic target for current and new treatments. https://t.co/mEDcNYvKJq pic.twitter.com/fWay0KgJ67
— ERS publications (@ERSpublications) June 9, 2023
Guidance to best tools and practices for systematic reviews
14 Jun, 2023 | 14:12h | UTCGuidance to best tools and practices for systematic reviews – Systematic Reviews
M-A | Oseltamivir fails to lower hospitalization risk in adult and adolescent influenza patients
13 Jun, 2023 | 14:12h | UTC
Commentary on Twitter
In this systematic review and meta-analysis of 15 RCTs, oseltamivir was not associated with reduced risk of first hospitalization compared with placebo or standard of care among influenza-infected adult and adolescent outpatients. https://t.co/UEqsbA2JQZ
— JAMA Internal Medicine (@JAMAInternalMed) June 12, 2023
Viewpoint | Detecting selection bias in observational studies—when interventions work too fast
13 Jun, 2023 | 14:09h | UTCDetecting Selection Bias in Observational Studies—When Interventions Work Too Fast – JAMA Internal Medicine (free for a limited period)
Commentary from the author on Twitter
Our paper in @JAMAInternalMed helps recognize confounding/biases in obs studies.https://t.co/qhptGVAIev
Look at image on left-a randomized study in which K better than V (slow separation of curves, plausible).
On right-retrospective obs study of VRD vs KRd.Early separation!! pic.twitter.com/mma9vGpueQ
— Manni Mohyuddin (@ManniMD1) June 12, 2023
Review | Wastewater monitoring can anchor global disease surveillance systems
13 Jun, 2023 | 14:07h | UTCWastewater monitoring can anchor global disease surveillance systems – The Lancet Global Health
Related:
Use of Wastewater for Mpox Outbreak Surveillance in California – New England Journal of Medicine
Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.
CDC unveils its latest weapon in Covid-19 detection: wastewater.
[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.
Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT
The myriad ways sewage surveillance is helping fight COVID around the world – Nature
It’s time to begin a national wastewater testing program for Covid-19 – STAT
Coronavirus: Testing sewage an ‘easy win’ – BBC
Saving time and money in biomedical publishing: the case for free-format submissions with minimal requirements
13 Jun, 2023 | 14:08h | UTCCommentary: Revealed: the millions of dollars in time wasted making papers fit journal guidelines – Nature
Review | Diagnosis and management of depression in adolescents
13 Jun, 2023 | 14:05h | UTCDiagnosis and management of depression in adolescents – Canadian Medical Association Journal
News Release: How to diagnose and manage depression in adolescents: A new review for clinicians – Canadian Medical Association Journal
AHA Scientific Statement | Contaminant metals as cardiovascular risk factors
13 Jun, 2023 | 14:04h | UTCNews Release: Chronic exposure to lead, cadmium and arsenic increases risk of cardiovascular disease – American Heart Association
Top Things to Know: Contaminant Metals as CV Risk Factors – American Heart Association
Commentary: Toxic Metals: The Poisons that are “Killing Us Softly” – American Heart Association
Commentary on Twitter
⚠️ Chronic exposure to lead, cadmium & arsenic ⬆️ risk of CVD
Monitoring exposure in ?, ?& ?is important for reducing inequity in CVD risk, according to a new AHA scientific statement published in @JAHA_AHA
✍️ @GLamasMD @anavasachttps://t.co/v5TOvvettD pic.twitter.com/36iCmfDmDP
— AHA Science (@AHAScience) June 12, 2023
Consensus Statement | Three-dimensional transesophageal echocardiography
13 Jun, 2023 | 14:02h | UTC
RCT | No change in delayed graft function with normothermic perfusion vs. cold storage in kidney transplants
13 Jun, 2023 | 14:00h | UTC
Commentary on Twitter
In an open-label, randomized controlled trial, normothermic machine perfusion of kidneys from donation after circulatory death was found to be feasible and safe but did not reduce the rate of delayed graft function compared to static cold storage. https://t.co/faaAzK3bpc pic.twitter.com/iL7Je7Z7jO
— Nature Medicine (@NatureMedicine) June 2, 2023
Review | The cervical spine in tension type headache
13 Jun, 2023 | 13:58h | UTCThe cervical spine in tension type headache – Musculoskeletal Science and Practice
Commentary on Twitter
The cervical spine in tension type headache
???https://t.co/EFcxBlDO34 pic.twitter.com/y7SyA3T7qt
— Physio Meets Science (@PhysioMeScience) June 1, 2023
Machine learning proves effective in predicting left ventricular hypertrophy through ECG analysis, study shows
13 Jun, 2023 | 13:57h | UTC
Commentary on Twitter
Predicting left ventricular hypertrophy from the 12-lead electrocardiogram in the UK Biobank imaging study using #MachineLearning https://t.co/3pnVQtkPH5 #EHJDigital #WhyCMR @BruiningNico @rafavidalperez @GerdHindricks @rbcasado pic.twitter.com/jbjuBJVIHW
— European Society of Cardiology Journals (@ESC_Journals) June 2, 2023
Review | Challenges and opportunities in antimicrobial stewardship among hematopoietic stem cell transplant and oncology patients
13 Jun, 2023 | 13:55h | UTC
Review | Screening for prostate cancer: evidence, ongoing trials, policies and knowledge gaps
13 Jun, 2023 | 13:52h | UTCScreening for prostate cancer: evidence, ongoing trials, policies and knowledge gaps – BMJ Oncology
RCT | Capivasertib–fulvestrant improves PFS vs. fulvestrant alone in HR+ advanced breast cancer
13 Jun, 2023 | 13:54h | UTCCapivasertib in Hormone Receptor–Positive Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Video: Capivasertib in Advanced Breast Cancer | NEJM
Commentary: Capivasertib-fulvestrant therapy increases PFS in HR-positive breast cancer – MedicalXpress
Commentary on Twitter
Among persons with breast cancer previously treated with hormonal therapy, the AKT pathway inhibitor capivasertib when added to fulvestrant significantly prolonged progression-free survival as compared with fulvestrant alone. Full results of CAPItello-291: https://t.co/ZCBHkG305b
— NEJM (@NEJM) May 31, 2023
Review | How to use cardiac troponin in non-cardiac surgery
13 Jun, 2023 | 13:50h | UTC
Consensus Statement | Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging
13 Jun, 2023 | 13:49h | UTCClinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group – Nature Reviews Cardiology (if the link is paywalled, try this one)
Commentary on Twitter
Check out our new Consensus Statement by @ProfDewey and the Quantitative Cardiovascular Imaging Study Group on the optimal use of imaging modalities to detect and assess coronary artery stenosis and atherosclerosis | https://t.co/WcKzwvE3UU pic.twitter.com/bipgb1zYuE
— Nature Reviews Cardiology (@NatRevCardiol) June 8, 2023