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A Delphi study of rescue and clinical subject matter experts on the extrication of patients following a motor vehicle collision.

23 Jun, 2022 | 10:19h | UTC

A Delphi study of rescue and clinical subject matter experts on the extrication of patients following a motor vehicle collision – Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

 

RCT: Weaning of maintenance immunosuppressive therapy in lupus nephritis.

23 Jun, 2022 | 10:18h | UTC

Weaning of maintenance immunosuppressive therapy in lupus nephritis (WIN-Lupus): results of a multicentre randomised controlled trial – Annals of Rheumatic Diseases

 

Many researchers say they’ll share data — but don’t.

23 Jun, 2022 | 10:13h | UTC

Many researchers say they’ll share data — but don’t – Nature

 

M-A: Intravenous iron vs. oral iron vs. no iron with or without erythropoiesis‐ stimulating agents for cancer patients with anemia.

23 Jun, 2022 | 10:10h | UTC

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer patients with anaemia: a systematic review and network meta‐analysis – Cochrane Library

Summary: Which combinations of medicines are best for the prevention and treatment of anaemia in people with cancer? – Cochrane Library

 

RCT: Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y Gastric bypass on weight loss, comorbidities, and reflux at 10 years in adult patients with obesity.

23 Jun, 2022 | 10:17h | UTC

Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA Surgery (free for a limited period)

 

Commentary on Twitter

 

Systematic Review: Interventions to improve water, sanitation, and hygiene for preventing soil‐transmitted helminth infection.

23 Jun, 2022 | 10:09h | UTC

Interventions to improve water, sanitation, and hygiene for preventing soil‐transmitted helminth infection – Cochrane Library

Summary: Interventions to improve water, sanitation, and hygiene for preventing soil-transmitted helminth infection – Cochrane Library

 

Commentary from the author on Twitter

 

M-A: Early versus delayed complete revascularization in patients presenting with ST-segment elevation myocardial infarction and multivessel disease.

23 Jun, 2022 | 10:11h | UTC

Early versus delayed complete revascularisation in patients presenting with ST-segment elevation myocardial infarction and multivessel disease: a systematic review and meta-analysis of randomised controlled trials – openheart

 

M-A: Effectiveness of pharmacological-based interventions, including education and prescribing strategies, to reduce subacute pain after total hip or knee arthroplasty.

23 Jun, 2022 | 10:04h | UTC

Effectiveness of Pharmacological-Based Interventions, Including Education and Prescribing Strategies, to Reduce Subacute Pain After Total Hip or Knee Arthroplasty: A Systematic Review of Randomized Controlled Trials – Pain Medicine

Commentary: Multimodal Analgesia and Education Reduces Postoperative Arthroplasty Pain, Opioid Consumption – Rheumatology Advisor

 

Commentary on Twitter

 

RCTs: Risankizumab as induction therapy for Crohn’s disease.

23 Jun, 2022 | 10:02h | UTC

Risankizumab as induction therapy for Crohn’s disease: results from the phase 3 ADVANCE and MOTIVATE induction trials – The Lancet (link to abstract – $ for full-text)

Related: Risankizumab as maintenance therapy for moderately to severely active Crohn’s disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Systematic Review: Pyronaridine‐artesunate for treating uncomplicated Plasmodium falciparum malaria.

23 Jun, 2022 | 10:07h | UTC

Pyronaridine‐artesunate for treating uncomplicated Plasmodium falciparum malaria – Cochrane Library

Summary: Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria – Cochrane Library

 

Cohort Study: Optimizing both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease.

23 Jun, 2022 | 10:01h | UTC

Optimising both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease – Annals of Rheumatic Diseases (link to abstract – $ for full-text)

Commentary: Low-dose glucocorticoids show no negative impact on BMD – medwire News

 

Commentary on Twitter

 

Study Commentary: Simple tool identifies the people with diabetes most likely to develop foot ulcers.

23 Jun, 2022 | 10:00h | UTC

Commentary: Simple tool identifies the people with diabetes most likely to develop foot ulcers – National Institute for Health and Care Research

Original Study: Development and validation of a clinical prediction rule for development of diabetic foot ulceration: an analysis of data from five cohort studies – BMJ Open Diabetes Research & Care

 

Phase II RCT: FLOT vs. FLOT/Trastuzumab/Pertuzumab perioperative therapy of human epidermal growth factor receptor 2–positive resectable esophagogastric adenocarcinoma.

23 Jun, 2022 | 09:58h | UTC

FLOT Versus FLOT/Trastuzumab/Pertuzumab Perioperative Therapy of Human Epidermal Growth Factor Receptor 2–Positive Resectable Esophagogastric Adenocarcinoma: A Randomized Phase II Trial of the AIO EGA Study Group – Journal of Clinical Oncology (link to abstract – $ for full-text)

 

Prognosis of patients with primary melanoma stage I and II according to American Joint Committee on Cancer version 8 validated in two independent cohorts.

23 Jun, 2022 | 09:57h | UTC

Prognosis of Patients With Primary Melanoma Stage I and II According to American Joint Committee on Cancer Version 8 Validated in Two Independent Cohorts: Implications for Adjuvant Treatment – Journal of Clinical Oncology

 

5-year follow up of a RCT: Ruxolitinib versus best available therapy in inadequately controlled polycythemia vera without splenomegaly.

23 Jun, 2022 | 09:55h | UTC

Ruxolitinib versus best available therapy in inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): 5-year follow up of a randomised, phase 3b study – The Lancet Haematology (link to abstract – $ for full-text)

Original Study: Ruxolitinib for the treatment of inadequately controlled polycythaemia vera without splenomegaly (RESPONSE-2): a randomised, open-label, phase 3b study – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Induction chemotherapy in nasopharyngeal carcinoma- A systematic review of phase III clinical trials.

23 Jun, 2022 | 09:54h | UTC

Induction chemotherapy in nasopharyngeal carcinoma- A systematic review of phase III clinical trials – Cancer Treatment and Research Communications

 

USPSTF Statement: The current evidence is insufficient to recommend vitamins for the prevention of cardiovascular disease or cancer.

22 Jun, 2022 | 12:21h | UTC

Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report and Systematic Review: Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and Cancer – JAMA

Patient Page: Vitamins and Minerals to Prevent Cardiovascular Disease and Cancer – JAMA

Editorial: Why Too Many Vitamins Feels Just About Right – JAMA Internal Medicine

Author Interview: Why Too Many Vitamins Feels Just About Right – JAMA

Commentary: Vitamins, Supplements Useless for Most People: Expert Panel – HealthDay

 

ASA and APSF statement on perioperative testing for the COVID-19 virus.

22 Jun, 2022 | 12:19h | UTC

ASA and APSF Statement on Perioperative Testing for the COVID-19 Virus – American Society of Anesthesiologists

Commentary: ASA, APST Update Perioperative SARS-CoV-2 Testing Recommendations – HealthDay

Related:

Surgical Triage and Timing for Patients with COVID: A Guidance Statement from the Society of Thoracic Surgeons – Annals of Thoracic Surgery

When to operate after SARS-CoV-2 infection? A review on the recent consensus recommendation of the DGC/BDC and the DGAI/BDA – Langenbeck’s Archives of Surgery

Guideline Update: Timing of elective surgery and risk assessment after SARS-CoV-2 infection – “The guidance remains that patients should avoid elective surgery within 7 weeks of infection, unless the benefits of doing so exceed the risk of waiting”.

Perioperative cardiovascular considerations prior to elective noncardiac surgery in patients with a history of Covid-19.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

BJS commission on surgery and perioperative care post-COVID-19.

The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

 

Computing for Audiology: Smartphone tympanometer for diagnosing middle ear disorders.

22 Jun, 2022 | 12:16h | UTC

Performing tympanometry using smartphones – Communications Medicine

News Release: Computing for Audiology: Smartphone tympanometer for diagnosing middle ear disorders – Bioengineering

 

Commentary on Twitter

 

RCT: Spinal anesthesia is associated with more pain and prescription analgesic use after hip surgery compared to general anesthesia.

22 Jun, 2022 | 12:11h | UTC

News Release: Spinal Anesthesia Associated with More Pain, Prescription Analgesic Use After Hip Surgery Compared with General Anesthesia – American College of Physicians

Study: Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery: A Randomized Clinical Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Original Publication: Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults – New England Journal of Medicine

Commentary: Spinal Anesthesia Tied to More Severe Pain After Hip Fracture Surgery – HealthDay

Related:

Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial – Anesthesiology

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial – Anesthesiology

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial – JAMA

 

Cohort Study: Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals.

22 Jun, 2022 | 12:18h | UTC

Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals – British Journal of Sports Medicine

News Release: Inability to stand on one leg in mid to later life linked to higher risk of death – University fo Bristol

 

Commentary on Twitter

 

Self-care management of bothersome symptoms as recommended by clinicians for patients with a chronic condition: A Delphi study.

22 Jun, 2022 | 12:13h | UTC

Self-care management of bothersome symptoms as recommended by clinicians for patients with a chronic condition: A Delphi study – Heart & Lung

 

Cohort Study: Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA.

22 Jun, 2022 | 12:07h | UTC

Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases – The Lancet

Commentaries:

COVID-19 mRNA vaccination and myocarditis or pericarditis – The Lancet

Myocarditis and Pericarditis After the COVID-19 mRNA Vaccination – American College of Cardiology

Related:

SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents – JAMA Cardiology

Myocarditis and pericarditis after COVID-19 vaccination: clinical management guidance for healthcare professionals – UK Health Security Agency

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Review: SARS-CoV-2 infection and COVID-19 vaccination in pregnancy.

22 Jun, 2022 | 12:09h | UTC

SARS-CoV-2 infection and COVID-19 vaccination in pregnancy – Nature Reviews Immunology

 

Review: Sex differences in sequelae from COVID-19 infection and in long COVID syndrome.

22 Jun, 2022 | 12:06h | UTC

Sex differences in sequelae from COVID-19 infection and in long COVID syndrome: a review – Current Medical Research and Opinion

Commentary: Women more likely to have long COVID, different symptom profile – CIDRAP

 

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