All Posts | Links Medicus - Free Medical News & Perspective

Nonoperative management with #antibiotics may be an alternative option to appendectomy in adult patients with uncomplicated acute #appendicitis, noting the possibility of longer hospital stays and potentially higher rates of recurrent appendicitis. https://t.co/4RbzU8SC8i

— JAMA Surgery (@JAMASurgery) July 27, 2022

RCT | Effects of walking exercise at a pace with vs. without ischemic leg symptoms on functional performance measures in people with lower extremity peripheral artery disease.

28 Jul, 2022 | 13:27h | UTC

Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomized Clinical Trial – Journal of the American Heart Association

News Release: ‘No pain, no gain’ approach improves walking ability with peripheral artery disease – American Heart Association

Perspective | Climbing melatonin use for insomnia raises safety concerns.

28 Jul, 2022 | 13:24h | UTC

Climbing Melatonin Use for Insomnia Raises Safety Concerns – JAMA (free for a limited period)

Guideline | Eyelid surgery for upper visual field improvement.

28 Jul, 2022 | 13:19h | UTC

American Society of Plastic Surgeons Evidence-Based Clinical Practice Guideline: Eyelid Surgery for Upper Visual Field Improvement – Plastic and Reconstructive Surgery (free for a limited period)

Cohort Study | Physical and mental activity, disease susceptibility, and risk of dementia.

28 Jul, 2022 | 13:22h | UTC

Physical and Mental Activity, Disease Susceptibility, and Risk of Dementia: A Prospective Cohort Study Based on UK Biobank – Neurology

News Release: Study: Chores, exercise, and social visits linked to lower risk of dementia – American Academy of Neurology

NICE Guideline Update | Melanoma: assessment and management.

28 Jul, 2022 | 13:21h | UTC

Melanoma: assessment and management – National Institute for Health and Care Excellence

Guideline | Management of diabetic macular edema.

28 Jul, 2022 | 13:18h | UTC

Management of Diabetic Macular Edema: Guidelines from the Emirates Society of Ophthalmology – Ophthalmology and Therapy

Consensus statement on the management of familial hypercholesterolemia.

28 Jul, 2022 | 13:16h | UTC

2022 Consensus statement on the management of familial hypercholesterolemia in Korea – The Korean Journal of Internal Medicine

Cohort Study | Androgen-deprivation therapy and risk of death from cardio-vascular disease in prostate cancer patients.

28 Jul, 2022 | 13:13h | UTC

Androgen-deprivation therapy and risk of death from cardio-vascular disease in prostate cancer patients: a nationwide lithuanian population-based cohort study – The Aging Male

News Release: Hormone therapy for prostate cancer increases the risk of dying from cardiovascular disease – Taylor & Francis

Cohort Study | Predictive utility of a validated polygenic risk score for long-term risk of coronary heart disease in young and middle-aged adults.

28 Jul, 2022 | 13:15h | UTC

Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults – Circulation (free for a limited period)

News Release: Old-School Health Assessment Beats Genetic Test for Predicting Heart Disease – Nuke University

Cohort Study | Association of ultraprocessed food consumption with risk of dementia.

28 Jul, 2022 | 13:10h | UTC

Association of Ultraprocessed Food Consumption With Risk of Dementia: A Prospective Cohort – Neurology (link to abstract – $ for full-text)

Commentary: Dementia Risk Climbs With Intake of Ultra-Processed Foods — Swapping out ultra-processed for unprocessed or minimally processed foods can lower risk sharply – MedPage Today (link to abstract – $ for full-text)

RCT | Efficacy and safety of topical hypericin photodynamic therapy for early-stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides).

28 Jul, 2022 | 13:09h | UTC

Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial – JAMA Dermatology (free for a limited period)

Commentary on Twitter

The findings of this randomized clinical trial indicate that synthetic hypericin photodynamic therapy is effective in early-stage patch and plaque mycosis fungoides−cutaneous T-cell lymphoma and has a favorable safety profile. https://t.co/hHfDESptQF

— JAMA Dermatology (@JAMADerm) July 21, 2022

Comparison of 6 mortality risk scores for prediction of 1-year mortality risk in older adults with multimorbidity.

28 Jul, 2022 | 13:07h | UTC

Comparison of 6 Mortality Risk Scores for Prediction of 1-Year Mortality Risk in Older Adults With Multimorbidity – JAMA Network Open

M-A | Breast cancer recurrence after immediate and delayed postmastectomy breast reconstruction.

28 Jul, 2022 | 13:05h | UTC

Breast cancer recurrence after immediate and delayed postmastectomy breast reconstruction—A systematic review and meta-analysis – Cancer

RCT | Trial of Anti-BDCA2 antibody Litifilimab for cutaneous Lupus Erythematosus.

28 Jul, 2022 | 13:06h | UTC

Trial of Anti-BDCA2 Antibody Litifilimab for Cutaneous Lupus Erythematosus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: BDCA2-Targeting Antibody May Be Effective for Cutaneous Lupus — In small randomized trial, litifilimab shows superiority over placebo for skin disease activity – MedPage Today (free registration required)

Commentary on Twitter

Litifilimab, a blood dendritic cell antigen 2 antibody, was superior to placebo with regard to a measure of disease activity in cutaneous lupus erythematosus at 16 weeks. https://t.co/1hQVnzMOYV pic.twitter.com/mPkFp23TnA

— NEJM (@NEJM) July 27, 2022

M-A | Negative-pressure wound therapy for prevention of sternal wound infection after adult cardiac surgery.

28 Jul, 2022 | 13:03h | UTC

Negative-Pressure Wound Therapy for Prevention of Sternal Wound Infection after Adult Cardiac Surgery: Systematic Review and Meta-Analysis – Journal of Clinical Medicine

M-A | The efficacy of topical sucralfate in improving pain and wound healing after hemorrhoidectomy procedure.

28 Jul, 2022 | 13:02h | UTC

The efficacy of topical sucralfate in improving pain and wound healing after haemorrhoidectomy procedure: A systematic review, meta-analysis, and meta-regression of randomised clinical trials – International Wound Journal

USPSTF Recommendations | Behavioral counseling interventions to promote a healthy diet and physical activity in adults without cardiovascular disease risk factors.

27 Jul, 2022 | 12:26h | UTC

Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Disease Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Implications of the New Recommendation on Behavioral Counseling Interventions to Promote Healthy Eating and Physical Activity – JAMA

Updated USPSTF Recommendations for Behavioral Counseling Interventions: Gaps, Challenges, and Opportunities – JAMA Internal Medicine

Improving Behavioral Counseling for Primary Cardiovascular Disease Prevention – JAMA Cardiology

Evidence Report: Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Cardiovascular Disease Risk Factors: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Author Interview: USPSTF Recommendation: Behavioral Counseling Interventions to Promote Healthy Behaviors for CVD Prevention – JAMA

Patient Page: Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity to Prevent CVD in Adults Without Risk Factors – JAMA

RCT | Effect of high- vs. low-dose tranexamic acid infusion on need for red blood cell transfusion and adverse events in patients undergoing cardiac surgery.

27 Jul, 2022 | 12:21h | UTC

Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial – JAMA (free for a limited period)

Commentary on Twitter

https://twitter.com/JAMA_current/status/1551960541488451586

RCT | Vitamin B6 supplements could reduce anxiety and depression.

27 Jul, 2022 | 12:19h | UTC

News Release: Vitamin B6 supplements could reduce anxiety and depression – University of Reading

Original Study: High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression – Human Psychopharmacology: Clinical and Experimental

Commentary: B6 a New Approach for Depression, Anxiety? – Medscape (free registration required)

RCT | Short vs. extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia.

27 Jul, 2022 | 12:17h | UTC

Short versus extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia: a non-inferiority, open-label, multicentre, randomised trial – The Lancet Haematology (link to abstract – $ for full-text)

Commentary: Short-Course or Extended Antibiotics in Febrile Neutropenia? – Medscape (free registration required)

Commentary on Twitter

NEW online—Short-term is not inferior to extended carbapenem in patients with haematological malignancy and neutropenic fever of unknown origin, however, higher serious adverse events and mortality were noted in the short treatment group: the SHORT trial https://t.co/FOp1M3D6cL pic.twitter.com/6z5e8MSEgQ

— The Lancet Haematology (@TheLancetHaem) June 10, 2022