M-A | Nonoperative vs. operative management of uncomplicated acute appendicitis.

Nonoperative vs Operative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis – JAMA Surgery (free for a limited period)

Related:

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

Commentary on Twitter

Nonoperative management with #antibiotics may be an alternative option to appendectomy in adult patients with uncomplicated acute #appendicitis, noting the possibility of longer hospital stays and potentially higher rates of recurrent appendicitis. https://t.co/4RbzU8SC8i

— JAMA Surgery (@JAMASurgery) July 27, 2022