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Risk of BA.5 infection among persons exposed to previous SARS-CoV-2 variants.

1 Sep, 2022 | 11:56h | UTC

Risk of BA.5 Infection among Persons Exposed to Previous SARS-CoV-2 Variants – New England Journal of Medicine

 

Commentary on Twitter

 

Cohort Study | Dolutegravir in pregnancy as compared with current HIV regimens.

1 Sep, 2022 | 11:55h | UTC

Dolutegravir in Pregnancy as Compared with Current HIV Regimens in the United States – New England Journal of Medicine (link to abstract – $ for full-text)

Related:

RCT | 72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy.

WHO Recommends Dolutegravir as Preferred HIV Treatment Option in All Populations

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

RCT: Dolutegravir or Darunavir in combination with Zidovudine or Tenofovir to treat HIV.

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1

 

Commentary on Twitter

 

Reports of asymptomatic monkeypox suggest that, at the very least, some infections go unnoticed.

1 Sep, 2022 | 11:54h | UTC

Reports of Asymptomatic Monkeypox Suggest That, at the Very Least, Some Infections Go Unnoticed – JAMA

 

Guideline | Patient preparation and radiation protection guidance for adult patients undergoing radioiodine treatment for thyroid cancer.

1 Sep, 2022 | 11:53h | UTC

Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK – Clinical Oncology

 

RCT | Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery.

1 Sep, 2022 | 11:52h | UTC

Driving pressure-guided ventilation and postoperative pulmonary complications in thoracic surgery: a multicentre randomised clinical trial – British Journal of Anaesthesia

 

RCT | Placement of an intrauterine device within 48 hours after early medical abortion.

1 Sep, 2022 | 11:51h | UTC

Placement of an intrauterine device within 48 hours after early medical abortion – a randomized controlled trial – American Journal of Obstetrics & Gynecology

 

Cohort Study | Women have a lower incidence of ventricular fibrillation compared to men after an acute myocardial infarction.

1 Sep, 2022 | 11:49h | UTC

Incidence, Characteristics, and Outcomes of Ventricular Fibrillation Complicating Acute Myocardial Infarction in Women Admitted Alive in the Hospital – Journal of the American Heart Association

 

RCT | In patients with rheumatoid arthritis, Tofacitinib is associated with increased risk of infections compared to TNF inhibitors.

1 Sep, 2022 | 11:50h | UTC

Infections in patients with rheumatoid arthritis receiving tofacitinib versus tumour necrosis factor inhibitors: results from the open-label, randomised controlled ORAL Surveillance trial – Annals of Rheumatic Diseases

 

Commentary on Twitter

 

Multicenter, international retrospective audit of lower extremity open fractures.

1 Sep, 2022 | 11:48h | UTC

International Lower Limb Collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures – British Journal of Surgery

 

Severity of Esophageal Anastomotic Leak in patients after esophagectomy: the SEAL score.

1 Sep, 2022 | 11:47h | UTC

Severity of oEsophageal Anastomotic Leak in patients after oesophagectomy: the SEAL score – British Journal of Surgery

 

Commentary on Twitter (thread – click for more)

 

Single-arm phase 2 study | Neoadjuvant Nivolumab plus Ipilimumab and Adjuvant Nivolumab in localized deficient mismatch repair/microsatellite instability-high gastric or esophagogastric junction adenocarcinoma.

1 Sep, 2022 | 11:47h | UTC

Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability-High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study – Journal of Clinical Oncology

 

Study Commentary | Zinc for the prevention or treatment of respiratory tract infections: a new systematic review.

1 Sep, 2022 | 11:46h | UTC

Zinc for the prevention or treatment of respiratory tract infections: A new systematic review – Science-Based Medicine

Original Study: M-A: Zinc might help to stave off respiratory infection symptoms and cut illness duration – “But quality of evidence variable, and no clarity on optimal formulation or dose”.

 

Meta-analysis of observational studies | Leisure activities and the risk of dementia.

1 Sep, 2022 | 11:44h | UTC

Leisure Activities and the Risk of Dementia: A Systematic Review and Meta-Analysis – Neurology

News Release: Which Leisure Activities Are Linked to Lower Risk of Dementia? – American Academy of Neurology

 

Incorporating productivity loss in health economic evaluations: a review of guidelines and practices worldwide.

1 Sep, 2022 | 11:41h | UTC

Incorporating productivity loss in health economic evaluations: a review of guidelines and practices worldwide for research agenda in China – BMJ Global Health

 

Study shows dentists should give antibiotics to high-risk patients to help prevent infectious endocarditis.

1 Sep, 2022 | 11:43h | UTC

News Release: Dentists should give antibiotics to high-risk patients to help prevent life-threatening heart infection – The University of Sheffield

Original Study: Antibiotic Prophylaxis Against Infective Endocarditis Before Invasive Dental Procedures – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: UK dentists should give antibiotics to patients at risk of heart infection – study – The Guardian

 

Characteristics and outcomes of anterior mediastinal cystic lesions diagnosed on chest MRI: implications for management of cystic lesions.

1 Sep, 2022 | 11:41h | UTC

Characteristics and outcomes of anterior mediastinal cystic lesions diagnosed on chest MRI: implications for management of cystic lesions – Insights into Imaging

 

Meta-analysis of randomized trials | Antibiotic therapy vs. appendicectomy for uncomplicated acute appendicitis.

1 Sep, 2022 | 11:40h | UTC

Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis – BJS Open

Related:

Nonoperative vs Operative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis – JAMA Surgery

Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses – World Journal of Surgery

Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.

Review: Diagnosis of uncomplicated and complicated appendicitis in adults.

Another RCT evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis.

A Randomized trial comparing antibiotics with appendectomy for appendicitis

Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin

Observational study: 67.1% success rate with nonoperative management of children with uncomplicated appendicitis

Randomized Trial: Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs. Appendectomy for Uncomplicated Acute Appendicitis

Meta-Analysis: Antibiotic Treatment vs. Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children

Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis – Pediatric Surgery International

 

Commentary on Twitter

 

Why it’s not safe to shower during a thunderstorm.

1 Sep, 2022 | 11:38h | UTC

Why it’s not safe to shower during a thunderstorm – The Conversation

 

Perspective | Ensuring an accurate scientific record in an era of pre-print servers.

1 Sep, 2022 | 11:38h | UTC

Ensuring an Accurate Scientific Record in an Era of Pre-print Servers – Deutsches Ärzteblatt International

 

RCT | The effect of a liberal approach to glucose control in critically ill patients with type 2 diabetes.

1 Sep, 2022 | 11:37h | UTC

The Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

 

Commentary from the author on Twitter

 

Systematic Review | The effect of heparin and its preparations on disseminated intravascular coagulation mortality and hospitalization.

1 Sep, 2022 | 11:34h | UTC

The Effect of Heparin and Its Preparations on Disseminated Intravascular Coagulation Mortality and Hospitalization: A Systematic Review – International Journal of Clinical Practice

 

Systematic Review | Duplex ultrasound for diagnosing symptomatic carotid stenosis in the extracranial segments.

1 Sep, 2022 | 11:36h | UTC

Duplex ultrasound for diagnosing symptomatic carotid stenosis in the extracranial segments – Cochrane Library

Summary: How accurate is duplex ultrasound (DUS) imaging for diagnosing carotid artery stenosis in symptomatic patients? – Cochrane Library

 

M-A | The impact of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury on mortality and clinical outcomes.

1 Sep, 2022 | 11:33h | UTC

The impact of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury on mortality and clinical outcomes: a meta-analysis – Clinical Kidney Journal

Related:

Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial – The Lancet (link to abstract – $ for full-text)

Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury – New England Journal of Medicine

Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials – The Lancet

Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis – Critical Care

Comparison between watchful waiting strategy and early initiation of renal replacement therapy in the critically ill acute kidney injury population: an updated systematic review and meta-analysis – Annals of Intensive Care

 

Guideline | Fecal immunochemical testing in patients with signs or symptoms of suspected colorectal cancer.

31 Aug, 2022 | 11:52h | UTC

Faecal immunochemical testing (FIT) in patients with signs or symptoms of suspected colorectal cancer (CRC): a joint guideline from the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG) – Gut

Commentary: Guidelines update: use of FIT in colorectal cancer referrals – PULSE

 

Review/Perspective | European hypertension guideline downgrading of beta-blockers is not justified.

31 Aug, 2022 | 11:51h | UTC

Diverse pharmacological properties, trial results, comorbidity prescribing and neural pathophysiology suggest European hypertension guideline downgrading of beta-blockers is not justified – Blood Pressure

 

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