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Systematic Review | Antihistamines to prevent and treat motion sickness.
19 Oct, 2022 | 14:21h | UTCAntihistamines for motion sickness – Cochrane Library
Summary: Antihistamines to prevent and treat motion sickness – Cochrane Library
Commentary on Twitter
New from Cochrane Evidence: Antihistamines are likely to reduce the risk of developing motion sickness in susceptible adults under normal conditions, e.g. traveling by car or boat, but they may be more likely to cause drowsiness than placebo https://t.co/l3gtX9ad7T… pic.twitter.com/EcQZYmwMrU
— Cochrane ENT (@CochraneENT) October 17, 2022
Pneumonia update for emergency clinicians.
19 Oct, 2022 | 14:19h | UTCPneumonia Update for Emergency Clinicians – Current Emergency and Hospital Medicine Reports
Cohort Study | ARBs linked to decreased incidence of epilepsy compared with other antihypertensives.
19 Oct, 2022 | 14:18h | UTCAssociation Between Angiotensin Receptor Blocker Therapy and Incidence of Epilepsy in Patients With Hypertension – JAMA Neurology (free for a limited period)
Related:
Loneliness and health – Nature Reviews Disease Primers (if the link is paywalled, try this one)
The prevalence of loneliness across 113 countries: systematic review and meta-analysis – The BMJ
Social Isolation and Loneliness – World Health Organization
Psychological Distress and Loneliness Reported by US Adults in 2018 and April 2020 – JAMA
Phase 2 RCT | Efficacy of adjunctive D-Cycloserine to intermittent theta-burst stimulation for major depressive disorder.
19 Oct, 2022 | 14:16h | UTCEfficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries:
Commentary on Twitter
In this RCT w 50 participants, those receiving intermittent theta-burst stimulation w adjunctive D-Cycloserine had significantly greater improvements in depressive symptoms compared to stimulation w placebo. https://t.co/AnP93WnkdG #Research
— JAMA Psychiatry (@JAMAPsych) October 12, 2022
Post-trial follow-up | Nivolumab plus ipilimumab vs. chemotherapy as first-line treatment for metastatic non-small cell lung cancer.
19 Oct, 2022 | 14:17h | UTCFive-Year Survival Outcomes With Nivolumab Plus Ipilimumab Versus Chemotherapy as First-Line Treatment for Metastatic Non-Small Cell Lung Cancer in CheckMate 227 – Journal of Clinical Oncology (link to abstract – $ for full-text)
Original Study: #ESMO19 –Randomized Trial: Improved Overall Survival with Combined Immunotherapy for Advanced Non–Small-Cell Lung Cancer
RCT | Combination of pitavastatin and ezetimibe vs. monotherapy of pitavastatin in patients with primary hypercholesterolemia.
19 Oct, 2022 | 14:15h | UTC
Safety of Upadacitinib in moderate-to-severe atopic dermatitis: an integrated analysis of phase 3 studies.
19 Oct, 2022 | 14:14h | UTC
M-A | Endothelin receptor antagonists do not improve outcomes in idiopathic pulmonary fibrosis.
19 Oct, 2022 | 14:14h | UTC
M-A | Nasal protection strategy reduces the incidence of nasal pressure injuries during nasotracheal intubation.
19 Oct, 2022 | 14:13h | UTC
M-A | Safety of sotagliflozin in diabetes mellitus type 1 and type 2.
19 Oct, 2022 | 14:12h | UTC
M-A | Cardiovascular and renal efficacy and safety of sodium-glucose cotransporter-2 inhibitors in patients without diabetes.
19 Oct, 2022 | 14:11h | UTC
Review | Optimizing PO2 during peripheral veno-arterial ECMO.
19 Oct, 2022 | 14:10h | UTCOptimizing PO2 during peripheral veno-arterial ECMO: a narrative review – Critical Care
Systematic Review | Conservative vs. surgical management for femoro-acetabular impingement.
19 Oct, 2022 | 14:09h | UTCRelated:
RCT | Vonoprazan noninferior to Lansoprazole for healing and maintenance of healing of erosive esophagitis.
19 Oct, 2022 | 14:08h | UTC
Retrospective Cohort Study | Trends in the association between diabetes and cardiovascular events, 1994-2019.
18 Oct, 2022 | 12:58h | UTCTrends in the Association Between Diabetes and Cardiovascular Events, 1994-2019 – JAMA (free for a limited period)
Related Study: Study shows that the leading causes of hospitalization of adults with diabetes are changing.
Cluster RCT | Primary prophylaxis with CSFs fails to improve outcomes in patients at intermediate risk for febrile neutropenia.
18 Oct, 2022 | 12:58h | UTC
RCT | Moderate vs. intensive pushing during the active phase of the 2nd stage of labor among nulliparous women with an epidural.
18 Oct, 2022 | 12:56h | UTCAlternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (Phase Active du Second STade trial) among nulliparous women with an epidural – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter
Alternative to intensive management of the active phase of the second stage of labor: a multicenter randomized trial (PASST trial) among nulliparous women with an epidural – A, Intervention (moderate pushing) group. B, Control (intensive pushing) group. https://t.co/IfdNfWHo57 pic.twitter.com/KmZTYV8eIP
— AJOG (@AJOG_thegray) October 14, 2022
RCT | Two-year effects of Semaglutide in adults with overweight or obesity.
18 Oct, 2022 | 12:53h | UTCCommentary: STEP 5: Sustained semaglutide treatment maintains weight loss – medwire News
Related:
RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity
Commentary on Twitter
Results from the STEP 5, testing #semaglutide as an adjuct to behavioral interventions in adults with #overweight or #obesity, demonstrate sustained #weightloss over a period of 104 weeks. @ProfBatterhamMD @seanwharton @DrGeorgiaRigas https://t.co/0mBtzhCYID
— Nature Medicine (@NatureMedicine) October 11, 2022
Perspective | The polypill: from concept and evidence to implementation.
18 Oct, 2022 | 12:55h | UTCThe polypill: from concept and evidence to implementation – The Lancet (free registration required)
Related:
Opinion: A new important study supports wider use of the polypill
Perspective: Are Polypills and Population-based Treatment the Next Big Things?
The Polypill Revisited: Why We Still Need Population-Based Approaches in the Precision Medicine Era
Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population
Perspective: The Polypill and the Long Journey to Major Impact
Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care
Guideline | Diagnosis and management of febrile neutropenia in patients with cancer.
18 Oct, 2022 | 12:52h | UTCRelated:
Guideline | Sarcopenia: screening, diagnosis, management and prevention.
18 Oct, 2022 | 12:51h | UTCRelated:
Position Statement | Changing the name of diabetes insipidus.
18 Oct, 2022 | 12:50h | UTC
Cohort Study | Association between osseointegration of lower extremity amputation and mortality among adults.
18 Oct, 2022 | 12:49h | UTC
Cohort Study | Association of attention-deficit/hyperactivity disorder diagnosis with adolescent quality of life.
18 Oct, 2022 | 12:48h | UTC
Commentary on Twitter
Adolescents with an ADHD diagnosis reported similar quality of life overall and on 3 subdomains but worse outcomes for 5 other aspects of quality of life compared adolescents with similar levels of hyperactive/inattentive behaviors but no ADHD diagnosis. https://t.co/5o0MNfEzjD
— JAMA Network Open (@JAMANetworkOpen) October 13, 2022
Systematic Review | Reconstructive surgery for treating pressure ulcers – little evidence to guide recommendations.
18 Oct, 2022 | 12:46h | UTCReconstructive surgery for treating pressure ulcers – Cochrane Library