All Posts
Post-trial follow-up | Metastasis-directed therapy vs. observation in oligometastatic prostate cancer.
18 Oct, 2022 | 12:47h | UTCCommentary: Metastasis-Directed Therapy for Prostate Cancer Found Beneficial Long-Term – Cancer Therapy Advisor
Commentary on Twitter
🚀 #JCO #RapidCommunication: STOMP & ORIOLE show improved progression-free survival w metastsis driven therapy over observation in oligometastatic #ProstateCancer
🎯 Largest benefit for patients harboring a high-risk mutation #PCSM @matthewdeek @piet_ost https://t.co/OO8kcTVvFT pic.twitter.com/FqxGisz34F— Journal of Clinical Oncology (@JCO_ASCO) September 19, 2022
Review | Artificial intelligence in perioperative medicine.
18 Oct, 2022 | 12:43h | UTC
M-A | Proactive therapeutic drug monitoring vs. conventional management for inflammatory bowel diseases.
18 Oct, 2022 | 12:42h | UTC
Commentary on Twitter
October's Editor's Essential Reading examines proactive therapeutic drug monitoring versus conventional management for inflammatory bowel diseases @vipuljairath @ChrisMa_YYC https://t.co/kNAia4yowO pic.twitter.com/wfgQSQtM1O
— Gastroenterology (@AGA_Gastro) September 28, 2022
Perspective | Reducing bureaucracy in clinical trials.
18 Oct, 2022 | 12:41h | UTCReducing bureaucracy in clinical trials – UEG Journal
Review | New endoscopic tools in inflammatory bowel disease.
18 Oct, 2022 | 12:40h | UTCNew endoscopic tools in inflammatory bowel disease – UEG Journal
Interpreting and assessing confidence in network meta-analysis results: an introduction for clinicians.
18 Oct, 2022 | 12:39h | UTC
Cohort Study | Association of daily step count and intensity with incident dementia.
18 Oct, 2022 | 12:38h | UTCCommentaries:
Higher Step Counts Equal Better CV Health: UK Biobank – TCTMD
Related:
Cohort Study | Association of step counts over time with the risk of chronic diseases.
Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.
M-A | Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome.
18 Oct, 2022 | 12:37h | UTC
Review | Inhaled sedation in the intensive care unit.
18 Oct, 2022 | 12:35h | UTCInhaled sedation in the intensive care unit – Anaesthesia Critical Care & Pain Medicine
Post-trial follow-up | Longer-term all-cause and cardiovascular mortality with intensive blood pressure control.
17 Oct, 2022 | 12:41h | UTCLonger-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control: A Secondary Analysis of a Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
Author Interview: Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control – JAMA
Commentaries:
Benefits of Intensive Blood Pressure Control May Not Persist After Trial Intervention – HCP Live
Related:
Study: Real-world blood pressure measurements vs. measurements taken in the SPRINT trial
Studies: Intensive versus Standard Blood-Pressure Control
Commentary on Twitter
In a secondary analysis of SPRINT, the mortality benefits of intensive BP control attenuated after the trial, while outpatient systolic BP increased by an average of 7 mm Hg for participants in the intensive treatment group. https://t.co/INSo2zYzhp #Research
— JAMA Cardiology (@JAMACardio) October 12, 2022
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study.
17 Oct, 2022 | 12:39h | UTCSee also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
Using the Burden of Proof analytical tool, a meta-analysis found weak or no evidence of associations between unprocessed #redmeat consumption and increased risk of six #cardiometabolic disease and #cancer outcomes. @IHME_UW https://t.co/3b7Sa9zCA1
— Nature Medicine (@NatureMedicine) October 10, 2022
Health effects associated with vegetable consumption: a Burden of Proof study.
17 Oct, 2022 | 12:40h | UTCHealth effects associated with vegetable consumption: a Burden of Proof study – Nature Medicine
See also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
A meta-analysis using the Burden of Proof function identified modest evidence supporting a protective role of #vegetable consumption and #ischemicheartdisease, #stroke and esophageal cancer, but not type 2 #diabetes. @IHME_UW https://t.co/1w8OAELSvU
— Nature Medicine (@NatureMedicine) October 10, 2022
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study.
17 Oct, 2022 | 12:37h | UTCSee also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
A systematic review using the Burden of Proof meta-analytic method found a significant harmful effect between high systolic #bloodpressure and #ischemicheartdisease. @IHME_UW https://t.co/hewQ9nsCTh
— Nature Medicine (@NatureMedicine) October 10, 2022
Health effects associated with smoking: a Burden of Proof study.
17 Oct, 2022 | 12:36h | UTCHealth effects associated with smoking: a Burden of Proof study – Nature Medicine
See also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Commentary on Twitter
A meta-analysis using the Burden of Proof method reported consistent evidence supporting harmful associations between #smoking and 28 different #health outcomes. @IHME_UW https://t.co/0tEnMvTwG6
— Nature Medicine (@NatureMedicine) October 10, 2022
[Not published yet] Aspirin noninferior to LMW Heparin for prevention of death or pulmonary embolism after fracture surgery.
17 Oct, 2022 | 12:36h | UTC
Position Statement | Use of biomarkers for the management of heart failure and acute coronary syndrome.
17 Oct, 2022 | 12:34h | UTC
Consensus Paper | Follow-up strategies for patients with splenic trauma managed non-operatively.
17 Oct, 2022 | 12:35h | UTC
Guidelines for point-of-care ultrasound: part one (common heart and pulmonary applications).
17 Oct, 2022 | 12:32h | UTC
Isocitrate dehydrogenase mutant gliomas: consensus review on diagnosis, management, and future directions.
17 Oct, 2022 | 12:31h | UTC
Cohort Study | Visit-to-visit SBP variability linked to increased risk of atrial fibrillation in middle-aged and older populations.
17 Oct, 2022 | 12:30h | UTC
Special Issue | Antibiotic resistance in the ICU.
17 Oct, 2022 | 12:28h | UTCHomepage: Antibiotic Resistance
Editorial: Antibiotic Resistance
Antibiotic Stewardship in Critical and Emergency Care
Pharmacokinetic/Pharmacodynamic Principles to Combat Antimicrobial Resistance
Multidrug-Resistant Gram-Negative Bacteria in the ICU
Rapid Diagnostics and Antimicrobial Resistance in the ICU
Diagnostic Stewardship in Five Common Infectious Syndromes
Does Antimicrobial Resistance Affect Clinical Outcomes in the ICU?
Reducing Antibiotic Resistance in the ICU
Post-trial follow-up | Adjuvant Olaparib in patients with germline pathogenic variants in BRCA1/2 and high risk, early breast cancer.
17 Oct, 2022 | 12:27h | UTCOriginal Study: Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
OS from #OlympiA now out on Annals. After 3.5y of f-up, pts receiving adjuvant olaparib derived a significant OS benefit (4y Δ 3.4%, 89.8% vs 86.4%). No increased risk of MDS/AML with olaparib. Important to test for BRCA in potentially eligible patients.https://t.co/ygkr0cOwF0 pic.twitter.com/bg4Y2yyXwZ
— Paolo Tarantino (@PTarantinoMD) October 11, 2022
Images under a Creative Commons Attribution (CC BY 4.0) license
Fungal infections | Pathogenesis, antifungals and alternate treatment approaches.
17 Oct, 2022 | 12:24h | UTC
Commentary on Twitter
Fungal infections:
Pathogenesis, antifungals and alternate treatment approacheshttps://t.co/JMcmzsL3GA #OpenAccess pic.twitter.com/5xAi5IGRGf
— MicrobesInfect (@MicrobesInfect) April 27, 2022
Under a Creative Commons license
Single-arm phase 2 study | A less intensive treatment strategy may be effective for patients with stage IIA and stage IIB seminoma.
17 Oct, 2022 | 12:25h | UTCSingle-dose carboplatin followed by involved-node radiotherapy for stage IIA and stage IIB seminoma (SAKK 01/10): a single-arm, multicentre, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary: De-escalation Strategy in Seminoma: An Alternative Option? – Medscape (free registration required)
Commentary on Twitter
🚨🚨
SAKK 01/10 results are out!! 👇🏽Stage IIA/B testicular seminoma➡️
1️⃣cycle of carboplatin+involved node RT
116 pts, median FU 4.5yrs
3yr PFS 93.7%, 7 relapses, all successfully salvaged. Seminoma-specific surv 💯%
Generally well tolerated, gr3+tox chemo-related https://t.co/vI6ipafhZ8— Sophia Kamran, MD (@sophia_kamran) October 11, 2022
M-A | Association of atrial septal aneurysm and shunt size with stroke recurrence and benefit from patent foramen ovale closure.
17 Oct, 2022 | 12:24h | UTCAssociation of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure – JAMA Neurology (free for a limited period)
Commentary: Anatomic Features Key for Selecting Patients Best Suited to PFO Closure – TCTMD
Commentary on Twitter
Patients with both large shunt and atrial septal aneurysm (ASA) benefit substantially more from patent foramen ovale than patients with large shunt alone, small shunt and ASA, or neither large shunt or ASA. https://t.co/lYL5sOnTCW #Research
— JAMA Neurology (@JAMANeuro) October 11, 2022