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A practical approach to the guideline-directed pharmacological treatment of heart failure with reduced ejection fraction.

17 Oct, 2022 | 12:15h | UTC

A practical approach to the guideline-directed pharmacological treatment of heart failure with reduced ejection fraction – ESC Heart Failure

RCT | Adjuvant capecitabine following concurrent CTX-RT in locoregionally advanced nasopharyngeal carcinoma.

17 Oct, 2022 | 12:15h | UTC

Adjuvant Capecitabine Following Concurrent Chemoradiotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma: A Randomized Clinical Trial – JAMA Oncology

Cohort Study | Diagnostic yield of ECG-gated cardiac CT in the acute phase of ischemic stroke vs. transthoracic echocardiography.

17 Oct, 2022 | 12:23h | UTC

Diagnostic Yield of ECG-Gated Cardiac CT in theAcute Phase of Ischemic Stroke vsTransthoracic Echocardiography – Neurology (link to abstract – $ for full-text)

Author Interview: ECG-Gated Cardiac CT in Acute Ischemic Stroke vs Transthoracic Echocardiography

Commentary: Add Cardiac CT to Acute Stroke Imaging to Detect Cardioembolism -Medscape (free registration required)

Participation of older adults in clinical trials for new drug applications and biologics license applications from 2010-2019.

17 Oct, 2022 | 12:12h | UTC

Participation of Older Adults in Clinical Trials for New Drug Applications and Biologics License Applications From 2010 Through 2019 – JAMA Network Open

Commentary on Twitter

Underrepresentation of adults above age 75-80 years found in evaluation of new medications. 60-75 year-olds were reasonably well represented in clinical trials in proportion to the prevalence data in the US. #OAResearch https://t.co/2RL5fTo3LA

— JAMA Network Open (@JAMANetworkOpen) October 14, 2022

Cohort Study | Incidence and survival in synchronous and metachronous liver metastases from colorectal cancer.

17 Oct, 2022 | 12:14h | UTC

Incidence and Survival in Synchronous and Metachronous Liver Metastases From Colorectal Cancer – JAMA Network Open

RCT | Effect of front-of-package information, fruit imagery, and sugar warning labels on parent beverage choices for children.

17 Oct, 2022 | 12:11h | UTC

Effect of Front-of-Package Information, Fruit Imagery, and High–Added Sugar Warning Labels on Parent Beverage Choices for Children: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

Front-of-pack "HIGH ADDED SUGARS" warnings that show added sugar content in teaspoons can lead parents to choose healthier drinks for their young children, even in the presence of fruit imagery and nutrient claims. #OAReaserch https://t.co/qNzt5lFIjO

— JAMA Network Open (@JAMANetworkOpen) October 13, 2022

RCTs | Thrombectomy improved recovery in basilar artery stroke but increased procedural complications and hemorrhages.

14 Oct, 2022 | 14:20h | UTC

Study 1: Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)

Study 2: Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)

Registry-based cohort study: Endovascular treatment vs. best medical management in acute basilar artery occlusion strokes.

RCT: Endovascular therapy for stroke due to basilar-artery occlusion – “endovascular therapy and medical therapy did not differ significantly with respect to a favorable functional outcome”.

Commentary on Twitter

In 340 Chinese patients with basilar-artery occlusion, endovascular treatment resulted in better neurologic outcomes than medical care. Approximately one third of patients underwent intravenous thrombolysis. https://t.co/ZqHirYnjoH pic.twitter.com/fuRV3rFWX7

— NEJM (@NEJM) October 13, 2022

Review | Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease.

14 Oct, 2022 | 14:19h | UTC

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

Special Statement | Postpartum visit checklists for normal pregnancy and complicated pregnancy.

14 Oct, 2022 | 14:18h | UTC

Society for Maternal-Fetal Medicine Special Statement: Postpartum visit checklists for normal pregnancy and complicated pregnancy – American Journal of Obstetrics & Gynecology

Original Guideline: ACOG Postpartum Toolkit (PDF)

Position Statement | Chronic kidney disease as cardiovascular risk factor in routine clinical practice.

14 Oct, 2022 | 14:17h | UTC

Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association – Nephrology Dialysis Transplantation

Position Statement | Home blood pressure monitoring.

14 Oct, 2022 | 14:16h | UTC

Home blood pressure monitoring: a position statement from the Korean Society of Hypertension Home Blood Pressure Forum – Clinical Hypertension

2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement – Journal of Hypertension

Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice – Internal and Emergency Medicine

Randomized Diagnostic Study: home blood pressure measurements correlate better with 24-h ambulatory monitoring measurements compared to clinic, and kiosk measurements.

Study suggests a 30-second interval between automated office blood pressure measurements is as accurate and reliable as a 60-second interval.

USPSTF Statement recommends screening for hypertension in adults 18 years or older with office blood pressure measurement – diagnostic confirmation with blood pressure measurements outside of the clinical setting is advised before starting treatment

Study suggests that 7 days of home blood pressure monitoring is likely better than 24h ambulatory monitoring or 3 office measurements

Recommendations for the diagnosis and treatment of patients with locally advanced and metastatic breast cancer.

14 Oct, 2022 | 14:12h | UTC

AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2022 – Breast Care

Expert Consensus | Cardiac computed tomographic imaging in cardio-oncology.

14 Oct, 2022 | 14:14h | UTC

Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS) – Journal of Cardiovascular Computed Tomography

Commentary on Twitter

New SCCT Expert Consensus co-endorsed by @ICOSociety: #YesCCT in Cardio-Oncology

This document fills existing gaps about CCT in Cardio-Oncology w experts in cardio-oncology, CCT imaging and cancer medicine @journalCCT 👉https://t.co/lNaQ37sKoQ @onco_cardiology @CardiacCTGuy pic.twitter.com/hILbBimfmZ

— Heart_SCCT (@Heart_SCCT) September 19, 2022

4-year follow-up of a RCT | Pembrolizumab with vs. without chemotherapy in recurrent or metastatic head and neck SCC.

14 Oct, 2022 | 14:11h | UTC

Pembrolizumab With or Without Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Updated Results of the Phase III KEYNOTE-048 Study – Journal of Clinical Oncology

Original Study: Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study – The Lancet (link to abstract – $ for full-text)

M-A | The prognostic value of CAC zero among individuals presenting with chest pain.

14 Oct, 2022 | 14:10h | UTC

The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain: A Meta-Analysis – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

RCT | A low-intensity psychosocial intervention improved recovery from depression in older adults in Brazil.

14 Oct, 2022 | 14:09h | UTC

A task-shared, collaborative care psychosocial intervention for improving depressive symptomatology among older adults in a socioeconomically deprived area of Brazil (PROACTIVE): a pragmatic, two-arm, parallel-group, cluster-randomised controlled trial – The Lancet Health Longevity

Invited Commentary: Empowering older adults and their communities to cope with depression in resource-limited settings – The Lancet Health Longevity

Commentary on Twitter

Empowering older adults and their communities to cope with #depression in resource-limited settings https://t.co/8GShpxpcOX @clausuemoto #Geriatrics

Our commentary @LancetLongevity about the incredible PRO-ACTIVE intervention by @scazufca & cols https://t.co/x2UerUFAYY pic.twitter.com/IP0DqTmGdP

— Marlon Aliberti (@marlon_aliberti) October 3, 2022

Under a Creative Commons Attribution (CC BY 4.0) License

Cohort Study | Carotid plaque characteristics predict recurrent ischemic stroke and transient ischemic attack.

14 Oct, 2022 | 14:08h | UTC

Carotid Plaque Characteristics Predict Recurrent Ischemic Stroke and TIA: The PARISK (Plaque At RISK) Study – JACC: Cardiovascular Imaging

Cohort Study | Purpose in life (Ikigai) and employment status in relation to cardiovascular mortality.

14 Oct, 2022 | 14:06h | UTC

Purpose in life (Ikigai) and employment status in relation to cardiovascular mortality: the Japan Collaborative Cohort Study – BMJ Open

Perspective | The case for mild stimulation for in vitro fertilization.

14 Oct, 2022 | 14:07h | UTC

The case for mild stimulation for IVF: recommendations from The International Society for Mild Approaches in Assisted Reproduction – Reproductive Biomedicine Online

Commentary on Twitter

New Review paper from @GeetaNargund & the #ISMAAR committee recommends mild ovarian stimulation for IVF should be considered in all clinical scenarios, for effective pregnancy outcomes

Safer, better tolerated and less expensive than conventional IVF.https://t.co/Jv2H2ucQUc pic.twitter.com/LtOSfE98PG

— Reproductive BioMedicine Online (@RBMOnline) September 9, 2022

Cohort Study | Elevated C-reactive protein and subsequent patient-reported cognitive problems in older breast cancer survivors.

14 Oct, 2022 | 14:03h | UTC

Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study – Journal of Clinical Oncology

News Release: Long-term study supports link between inflammation and cognitive problems in older breast cancer survivors – University of California

Review | Heart failure after right ventricular myocardial infarction.

14 Oct, 2022 | 14:05h | UTC

Heart Failure After Right Ventricular Myocardial Infarction – Current Heart Failure Reports

Cluster RCT | Culturally sensitive vs. standard behavioral approach for promoting weight-loss maintenance in black women.

14 Oct, 2022 | 14:04h | UTC

Promoting weight-loss maintenance among Black women primary care patients: A cluster RCT of a culturally sensitive versus standard behavioural approach – Clinical Obesity

Review | Point-of-care ultrasound in pediatric nephrology.

14 Oct, 2022 | 14:03h | UTC

Point-of-care ultrasound in pediatric nephrology – Pediatric Nephrology (if the link is paywalled, try this one)

M-A | Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections.

14 Oct, 2022 | 14:02h | UTC

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis – The Lancet Microbe

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

Commentary on Twitter

To reduce risk of surgical site infections.
👉 chlorhexidine in alcohol better than iodine (esp non-clean surgery)
👉 but only at 2-2.5%. Higher concentration not better!
👉 olanexidine possible alternative but only 1x RCT@LancetMicrobe https://t.co/C8FHtEdYlf pic.twitter.com/FXwEOIg4Pf

— Gabriele Pollara (@gpollara) August 22, 2022

Illustrations under a Creative Commons Attribution (CC BY 4.0) license

M-A | Incidence of cutaneous adverse events with Phosphoinositide 3-Kinase inhibitors as adjuvant therapy in patients with cancer.

14 Oct, 2022 | 14:01h | UTC

Incidence of Cutaneous Adverse Events With Phosphoinositide 3-Kinase Inhibitors as Adjuvant Therapy in Patients With Cancer: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)

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