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Cohort Study: In Patients with Rectal Cancer, Restriction of Neoadjuvant Chemoradiotherapy to High‐Risk Patients Achieved Good Results

29 Jun, 2018 | 03:10h | UTC

Oncological outcome after MRI‐based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial – British Journal of Surgery (link to abstract – $ for full-text)

Commentaries: Many patients with rectal cancer may not need chemoradiotherapy – eCancer News (free) AND Limiting Chemo to High-Risk Rectal Cancer Called Feasible – MedPage Today (free registration required) AND OCUM Trial: Some Rectal Cancers Need Only Surgery – Medscape (free registration required)

 


Cohort Study: Midlife Contributors to Socioeconomic Differences in Frailty During Later Life

29 Jun, 2018 | 03:12h | UTC

Midlife contributors to socioeconomic differences in frailty during later life: a prospective cohort study – The Lancet Public Health (free)

Commentaries: Frailty: from clinical syndrome to epidemiological construct? – The Lancet Public Health (free) AND Old before your time? Scientists have put together five warning signs middle-aged people will suffer from frailness in retirement – Daily Mail (free) AND Five modifiable risk factors found to help reach healthy old age – OnMedica (free)

Related Study: Impact of Healthy Lifestyle Factors on Life Expectancies (link to abstract and commentaries)

 


Randomized Trial: Heat-Stable Carbetocin vs Oxytocin to Prevent Hemorrhage after Vaginal Birth

29 Jun, 2018 | 03:08h | UTC

Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth – New England Journal of Medicine (free)

Commentaries: Heat-stable drug could save thousands from post-childbirth bleeding: WHO – Reuters (free) AND Saving Moms’ Lives During Childbirth Just Got Easier – NPR (free)

 


Study Guide: Rip Current Heroes Study Guide

29 Jun, 2018 | 03:09h | UTC

Rip Current Heroes Study Guide – National Geographic (free PDF)

News Release: Rip Current Heroes Study Guide (Free)

Videos: Rip Current Heroes (free)

Related Reports: Preventing drowning: an implementation guide – World Health Organization (free) AND Global report on drowning: preventing a leading killer – World Health Organization (free) AND Hidden Hazards: An Exploration of Open Water Drowning and Risks for Children – Safe Kids Worldwide (free PDF)

Source: Global Health NOW Newsletter

“Each year they kill, on average, more lives in Australia than bushfires, floods, cyclones and sharks combined.
The global drowning prevention community is out to spread the word on identifying and escaping deadly #ripcurrents with a public awareness campaign today. Check out a documentary and study guide focused on rip current science and survival strategies from National Geographic and Australia’s Rob Brander, a global expert in the field from UNSW Sydney”. (from Global Health NOW Newsletter)

 


Meta-Analysis: Associations Between Alcohol Consumption and Incidence of Hypertension

29 Jun, 2018 | 03:05h | UTC

Sex‐Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta‐Analysis of Cohort Studies – Journal of the American Heart Association (free for a limited period)

Related Study: Effects of Repeated Binge Drinking on Blood Pressure Levels and Other Cardiovascular Health Metrics in Young Adults: National Health and Nutrition Examination Survey, 2011‐2014 – Journal of the American Heart Association (free for a limited period)

Editorial: Alcohol Consumption, Hypertension, and Cardiovascular Health Across the Life Course: There Is No Such Thing as a One‐Size‐Fits‐All Approach (free)

Commentaries: Young binge drinkers may have higher heart risks – AHA Newsroom (free) AND Alcohol Intake Tied to Elevated Blood Pressure – NEJM Physician’s First Watch (free) AND Binge drinking may increase heart risks for younger people – UPI (free)

 


Guideline Synopsis: Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Associated With Cardiac Channelopathies

29 Jun, 2018 | 03:06h | UTC

Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Associated With Cardiac Channelopathies – JAMA Cardiology (free for a limited period)

Original Guideline: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death – Circulation (free PDF)

 


AAP Clinical Report: The Prenatal Visit

29 Jun, 2018 | 03:07h | UTC

The Prenatal Visit – The American Academy of Pediatrics (free)

News Release: What to cover during prenatal visit: AAP clinical report offers guidance – AAP News (free)

Commentaries: Urge expectant parents to have prenatal pediatrician visit – Pediatric News (free) AND AAP updates recommendations for prenatal visits – Healio (free registration required)

 


Opinion: FDA Repays Industry by Rushing Risky Drugs to Market

29 Jun, 2018 | 02:59h | UTC

FDA Repays Industry by Rushing Risky Drugs to Market – ProPublica (free)

 


Guideline: Intraoperative Management of Adult Patients With Obstructive Sleep Apnea

29 Jun, 2018 | 02:58h | UTC

Society of Anesthesia and Sleep Medicine Guideline on Intraoperative Management of Adult Patients With Obstructive Sleep Apnea – Anesthesia & Analgesia (free PDF)

 


Systematic Review: Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis

29 Jun, 2018 | 03:00h | UTC

Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review – JAMA Dermatology (free for a limited period)

Commentaries: What is the Role of Diet in Psoriasis and Psoriatic Arthritis? – MedicalResearch.com (free) AND Dietary Changes Can Lessen Severity of Psoriatic Disease – Medscape (free registration required) AND Can Diet Help in Psoriasis? – MedPage Today (free) AND NPF Dietary Recommendations for Psoriatic Disease – RheumNow (free)

 


Guideline: Nutritional Considerations in Pediatric Pancreatitis

29 Jun, 2018 | 02:57h | UTC

Nutritional Considerations in Pediatric Pancreatitis: A Position Paper from the NASPHAN Pancreas Committee and ESPHAN Cystic Fibrosis/Pancreas Working Group – Journal of Pediatric Gastroenterology and Nutrition (free)

Commentary: Pediatric pancreatitis: nutritional care recommendations from ESPGHAN-NASPGHAN – Univadis (free registration required)

 


ASCO Guideline: Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases

29 Jun, 2018 | 02:55h | UTC

Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

 


Guideline: Follow-up After Vascular Surgery Arterial Procedures

29 Jun, 2018 | 02:51h | UTC

The Society for Vascular Surgery practice guidelines on follow-up after vascular surgery arterial procedures – Journal of Vascular Surgery (free)

 


ASCO Guideline: Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

29 Jun, 2018 | 02:56h | UTC

Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

 


Cohort Study: Retinal Nerve Fiber Layer Thinning and Future Cognitive Decline

29 Jun, 2018 | 02:53h | UTC

Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography – JAMA Neurology (free for a limited period)

Commentaries: Eye Sign of Dementia Risk? Thinning of Retinal Nerve Fiber Layer – MedicalResearch.com (free) AND Are the Eyes Windows to Early Dementia? – MedPage Today (free registration required)

“A thinner Retinal Nerve Fiber Layer is associated with worse cognitive function in individuals without a neurodegenerative disease as well as greater likelihood of future cognitive decline”.

 


USPSTF Statement: Screening for Osteoporosis to Prevent Fractures

29 Jun, 2018 | 02:52h | UTC

Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Osteoporosis (free) AND Osteoporosis Screening—2 Steps May Be Too Much for Women Younger Than 65 Years (free)

Author Interview: USPSTF Recommendation Statement: Screening for Osteoporosis to Prevent Fractures (free)

See also: USPSTF Final Recommendation Statement (free)

 


Case Series: Recurrent Glioblastoma Treated with Recombinant Poliovirus

29 Jun, 2018 | 02:50h | UTC

Recurrent Glioblastoma Treated with Recombinant Poliovirus – New England Journal of Medicine (free for a limited period)

Editorial: Exploiting Viruses to Treat Diseases (free for a limited period)

Commentaries: Doctors Try Genetically Modified Poliovirus As Experimental Brain Cancer Treatment – NPR (free) AND Poliovirus therapy shows early promise in patients with aggressive brain cancer but questions linger – STAT (free)

 


Randomized Trial: Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care

29 Jun, 2018 | 02:49h | UTC

Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care – New England Journal of Medicine (free for a limited period)

Commentaries: Improved Glycemic Control With Closed-Loop Insulin Delivery System – Endocrinology Advisor (free) AND Closed-Loop Diabetes Systems (Artificial Pancreas) Can Be Used For Inpatient Care – MedicalResearch.com (free)

 


Cohort Study: Defibrillation Strategies and Outcomes After Out-of-Hospital Cardiac Arrest

29 Jun, 2018 | 02:43h | UTC

Different defibrillation strategies in survivors after out-of-hospital cardiac arrest – Heart (link to abstract – $ for full-text)

Commentary: Onsite defibrillators helping to increase cardiac arrest survival – Reuters (free)

Related Studies: Impact of Bystander Automated External Defibrillator Use on Outcomes (free study and commentaries) AND Use of public defibrillators linked to out-of-hospital cardiac arrest survival (link to abstract and commentaries) AND Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest (link to abstract and commentaries)

 


Review: Deprescribing Proton Pump Inhibitors

29 Jun, 2018 | 02:41h | UTC

Deprescribing Proton Pump Inhibitors – Therapeutics Initiative (free)

Related guidelines: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)

 


Randomized Trial: More Weight Loss Associated with Better Outcomes in Knee Osteoarthritis

29 Jun, 2018 | 02:39h | UTC

Intentional Weight Loss for Overweight and Obese Knee Osteoarthritis Patients: Is More Better? – Arthritis Care & Research (free PDF)

Commentaries: Long-term weight loss of at least 20% helps improve outcomes in overweight, obese patients with knee osteoarthritis – ACP Internist (free) AND When it comes to weight loss in overweight and obese adults with knee osteoarthritis, more is better – Wiley, via ScienceDaily (free) AND More weight loss tied to less knee pain for obese people – Reuters (free) AND More Weight Loss Linked To Greater Decrease in Knee Arthritis Pain – MedicalResearch.com (free)

 


Study: The Economic Cost of Inadequate Sleep

29 Jun, 2018 | 02:37h | UTC

The economic cost of inadequate sleep – Sleep (free)

Commentaries: Inadequate sleep could cost countries billions – Oxford University Press USA, via EurekAlert (free) AND Wake-up call: Sleepiness ‘epidemic’ costing global economies billions – The Sidney Morning Herald (free)

 


Systematic Review: Donepezil for Dementia Due to Alzheimer’s Disease

29 Jun, 2018 | 02:36h | UTC

Donepezil for dementia due to Alzheimer’s disease – Cochrane Library (free)

Summary: Donepezil for people with dementia due to Alzheimer’s disease – Cochrane Library (free)

 


Cohort Study: Percutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer

29 Jun, 2018 | 02:34h | UTC

Percutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer: A Population-Based Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Percutaneous ablation may be preferred to nephrectomy for selected patients with early-stage renal cancer – ACP Internist (free) AND New Findings Support Ablation for Small Renal Tumors – Renal & Urology News (free)

Related Meta-Analysis: Radiofrequency ablation versus partial nephrectomy for treatment of renal masses: A systematic review and meta-analysis – The Kaohsiung Journal of Medical Sciences (free) AND Radiofrequency Ablation Versus Partial Nephrectomy in Treating Small Renal Tumors: A Systematic Review and Meta-Analysis – Medicine (free)

“Percutaneous ablation for T1a renal cancer has similar 5-year survival rates to radical nephrectomy but with far fewer 30-day complications and less kidney failure (via @AnnalsofIM see Tweet)

 


Case-Control Study: Hospital-at-Home Care Program Associated with Improved Outcomes and Patient Experiences

29 Jun, 2018 | 02:32h | UTC

Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine (free for a limited period)

Editorial: Hospital-at-Home Care Programs—Is the Hospital of the Future at Home? (free for a limited period)

Author Interview: Association of a Bundled Hospital-at-Home Program With Clinical Outcomes and Patient Experiences (free)

Commentaries: Hospital-at-Home Bundled Program Associated With Better Clinical Outcomes, Patient Experiences – AJMC (free) AND Clinical outcomes and patient experiences vastly improved with hospital at home – The Mont Sinai Hospital (free) AND Hospital-at-Home Care a Potential Alternative to Inpatient Care – Physician’s First Watch (free)

 


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