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Cohort Study: Coffee Drinking and Mortality

6 Jul, 2018 | 03:22h | UTC

Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Expert reaction to research association between coffee and lower risk of death – Science Media Centre (free) AND Fresh grounds for coffee: Study shows it may boost longevity – Associated Press (free) AND Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too – NPR (free)

Related Studies: Meta-Analysis: Coffee consumption and health (free research and commentaries) AND Coffee Drinking and Mortality Studies (link to abstract and commentaries)

Another observational study showing possible benefits from drinking coffee.

Cohort Study: Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood

6 Jul, 2018 | 03:21h | UTC

Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study – JAMA Network Open (free)

Invited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)

Review: Cardiovascular Toxicity in Cancer Survivors

6 Jul, 2018 | 03:20h | UTC

Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future Directions – American College of Cardiology (free)

Opinion: Why Do-It-Yourself Blood Tests are a Bad Idea

6 Jul, 2018 | 03:16h | UTC

Why do-it-yourself blood tests are a bad idea – Common Sense Family Doctor (free)

“Routine blood testing in healthy people has numerous downsides that Holmes never mentioned, including poor predictive value, false positives, and overdiagnosis” (from Common Sense Family Doctor)

“When you go about testing everyone for everything, you don’t create a world of healthy people….you create a nightmare where everyone is sick” (from The BMJ Opinion)

Perspective: Four Principles to Make Evidence Synthesis More Useful for Policy

6 Jul, 2018 | 03:14h | UTC

Four principles to make evidence synthesis more useful for policy – Nature (free)

“Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues”.

Systematic Review: Continuity of Care and Mortality

6 Jul, 2018 | 03:17h | UTC

Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality – BMJ Open (free)

Commentaries: Seeing same doctor every time ‘reduces risk of death’ – NHS Choices (free) AND Sticking with 1 doctor could have health benefits: Study – UPI (free)

Review: Management of Irritable Bowel Syndrome

6 Jul, 2018 | 03:13h | UTC

American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome – American Journal of Gastroenterology (free for a limited period)

Clinical Practice Guidelines for Irritable Bowel Syndrome in Korea, 2017 Revised Edition – Journal of Neurogastroenterology and Motility (free) AND Evidence-based clinical practice guidelines for irritable bowel syndrome – Journal of Gastroenterology (free)

Source: NewsWise

CDC Guideline: Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent TB Infection

6 Jul, 2018 | 03:12h | UTC

Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidelines on Weekly Therapy for Latent TB Infection – Physician’s First Watch (free)

Related WHO Guideline: Latent TB Infection (free guideline and news release)

Perspective: Scientists on Twitter

6 Jul, 2018 | 03:15h | UTC

Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free)

“Great new study about science outreach via Twitter: Initially, scientists mostly tweet to each other. But after accumulating about 1000 followers, scientists reach an increasing number of journalists, policy makers, and other members of the public”. (via @JSheltzer see Tweet)

Study: The Plateau of Human Mortality

6 Jul, 2018 | 03:11h | UTC

The plateau of human mortality: Demography of longevity pioneers – Science (link to abstract – $ for full-text)

Commentaries: There’s no limit to longevity, says study that revives human lifespan debate – Nature News (free) AND Italian study suggests human lifespan could continue increasing – NHS Choices (free) AND Age 105? Then you’ve a better chance of living even longer – The Guardian (free) AND How Long Can We Live? The Limit Hasn’t Been Reached, Study Finds – The New York Times (free)

Study: Global Burden of Diabetes Attributable to Air Pollution

6 Jul, 2018 | 03:07h | UTC

The 2016 global and national burden of diabetes mellitus attributable to PM_2·5 air pollution – The Lancet Planetary Health (free)

Commentaries: Air pollution and diabetes: it’s time to get active! – The Lancet Planetary Health (free) AND Air pollution linked to 3.2 million new diabetes cases in one year – CNN (free) AND Air pollution contributes significantly to diabetes globally – Washington University School of Medicine (free)

Related: WHO Report: 9 out of 10 People Worldwide Breathe Polluted Air (free report and commentaries) AND Ambient Air Pollution in Relation to Diabetes (free research) AND The Lancet Commission on pollution and health (free resources) AND Air Pollution and Mortality (free research and commentaries) AND Global burden of disease attributable to ambient air pollution (free report and commentaries) AND 5.5 million lives were lost in 2013 to diseases associated with Air Pollution (free report and infographic)

Fri, July 6 – 10 Stories of The Day!

6 Jul, 2018 | 00:36h | UTC

1 – Report: Delivering quality health services: A global imperative for universal health coverage – World Health Organization (free)

News Release: Low quality healthcare is increasing the burden of illness and health costs globally (free)

Commentary: Universal quality healthcare coverage—a commitment to building a healthier and more productive society – The BMJ Opinion (free)

2 – Hypothalamic–Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free PDF)

Commentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)

3 – Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model – JAMA Oncology (free)

Editorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)

Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)

Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)

4 – Review: Heart failure with preserved ejection fraction: from mechanisms to therapies – European Heart Journal (free)

5 – Review: Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies – Circulation (free)

6 – Hidden conflicts? – Science Magazine (free)

““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)

7 – Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview – European Spine Journal (free)

8 – Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care – The BMJ (free)

Commentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)

9 – Species-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)

Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)

10 – Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial – The Lancet Infectious Diseases (free)

Invited Commentary: Preventing urinary tract infections in patients with neurogenic bladder (free)

Systematic Review: Treatments for Heart Failure with Preserved Ejection Fraction

6 Jul, 2018 | 03:08h | UTC

Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Summary: Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

This Cochrane review suggests mineralocorticoid receptor antagonists may be of benefit to reduce hospitalizations, while the meta-analysis in Heart suggests beta-blockers may improve all-cause and cardiovascular mortality…

HPV Vaccination: Balancing Facts

6 Jul, 2018 | 03:10h | UTC

Editorial: HPV vaccination: balancing facts – Cochrane Library (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)

Thu, July 5 – 10 Stories of The Day!

5 Jul, 2018 | 01:37h | UTC

1 – Guideline for Antibiotic Use in Adults with Community-acquired Pneumonia – The Korean Society of Infectious Disease (free)

2 – An evidence-based approach to evaluation and management of the febrile child in Indian emergency department – International Journal of Critical Illness & Injury Science (free)

3 – Pathophysiology, diagnosis and management of MINOCA: an update – European Heart Journal: Acute Cardiovascular Care (free)

4 – Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study – Journal of the American Heart Association (free)

Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): It’s Time to Face Reality! (free)

5 – Treatment of Angina: Where Are We? – Cardiology (free)

Source: Critical Care Reviews Newsletter

6 – Adverse effect of long work hours on incident diabetes in 7065 Ontario workers followed for 12 years – BMJ Open Diabetes Research & Care (free)

Commentaries: Clocking up 45+ working hours/week linked to heightened risk of diabetes in women – BMJ, via ScienceDaily (free) AND Greater Risk of Diabetes in Women With Longer Work Week – MedicalResearch.com (free)

Related Study: Effect of Work Stressors on the Risk of Type 2 Diabetes (link to abstract and commentary)

7 – Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates – Nature Medicine (link to abstract – $ for full-text)

Commentaries: Pregnancy loss occurs in 26 percent of Zika-infected monkeys – NIH News Releases (free) AND Monkey studies suggest Zika role in miscarriage may be higher than thought – CIDRAP (free)

8 – Alarming polio outbreak spreads in Congo, threatening global eradication efforts – Science (free)

9 – Carbohydrate Replacement of Rice or Potato with Lentils Reduces the Postprandial Glycemic Response in Healthy Adults in an Acute, Randomized, Crossover Trial – The Journal of Nutrition (link to abstract – $ for full-text)

Commentaries: Lentils significantly reduce blood glucose levels – University of Guelph, via ScienceDaily (free) AND Replace Carbs With Lentils to Blunt Glucose Spike After Meals – Medscape (free registration required)

10 – Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease Risk Factor Development: An Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hypertensive disorders during pregnancy associated with increased rates of later CVD – ACP Internist (free) AND High blood pressure in pregnancy tied to heart disease risk afterward – Reuters (free) AND Women who experience hypertensive disorders during pregnancy are at high risk for developing high blood pressure, diabetes, and high cholesterol later in life – 2 Minute Medicine (free)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries) AND Gestational Hypertension and Future Risk of Cardiovascular Disease (free research and editorial)

Tue, July 3 – 10 Stories of The Day!

3 Jul, 2018 | 00:06h | UTC

1 – A Multicenter Study of Patient-Reported Infectious and Noninfectious Complications Associated With Indwelling Urethral Catheters – JAMA Internal Medicine (free)

Commentary: Foleys Aren’t Fun: Patient Study Shows Catheter Risks – University of Michigan, via NewsWise (free)

“More than half of patients surveyed while they had a urinary catheter, and again weeks later, reported a complication – and infections were only part of the problem” (from NewsWise)

2 – Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

“Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. Whether these increases in mortality and readmission result from patient differences, differences in care, or a combination remains unclear”.

3 – Review: Chronic hyperkalemia in non-dialysis CKD: controversial issues in nephrology practice – Journal of Nephrology (free)

4 – Opinion: Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free)

“The World Health Organization has made “internet gaming” a diagnosable disorder. But many experts aren’t even sure it exists”.

5 – Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

6 – Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April–May, 2018: an epidemiological study – The Lancet (free)

Invited Commentary: Ebola virus disease: 11 323 deaths later, how far have we come? (free)

Related: Ebola Outbreak in Congo ‘Largely Contained’, says WHO (free statement and commentary)

7 – Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach – The Lancet (free)

Commentaries: Patient-centred care for multimorbidity: an end in itself? – The Lancet (free) AND Results of the largest ever multimorbidity trial in primary care challenge current thinking -NIHR News (free)

Related: Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers (series of free articles on the topic) AND Multimorbidity: A Priority for Global Health Research (free report and commentaries)

“In the largest ever trial of an intervention to treat people with multiple long-term conditions (multimorbidity) in primary care, NIHR-researchers found that the patient-centred approach taken improved patients’ experience of their care but did not improve their health-related quality of life. This is a challenge to current thinking on which UK and international guidelines are based”. (from NIHR News)

8 – Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Expert reaction to research association between coffee and lower risk of death – Science Media Centre (free) AND Fresh grounds for coffee: Study shows it may boost longevity – Associated Press (free) AND Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too – NPR (free)

Related Studies: Meta-Analysis: Coffee consumption and health (free research and commentaries) AND Coffee Drinking and Mortality Studies (link to abstract and commentaries)

Another observational study showing possible benefits from drinking coffee.

9 – Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study – JAMA Network Open (free)

Invited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)

10 – Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future Directions – American College of Cardiology (free)

Wed, July 4 – 10 Stories of The Day!

4 Jul, 2018 | 00:20h | UTC

1 – Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)

Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)

2 – The Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories Out” – JAMA Internal Medicine (free for a limited period)

3 – Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Epinephrine vs. Norepinephrine for Cardiogenic Shock – American College of Cardiology (free) AND Norepinephrine Bests Epinephrine in Battle of the Vasopressors in Cardiogenic Shock – TCTMD (free)

4 – Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)

5 – Editorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)

6 – Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM – Recommendations and Statements for Girls and Women – Geburtshilfe Frauenheilkd (free)

7 – Influenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

8 – Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)

Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)

9 – Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study – The BMJ (free)

In this large international, population-based database, no evidence was found of an overall increased risk of congenital anomalies after first trimester metformin exposure.

10 – Australia wins landmark WTO ruling on plain tobacco packaging – Reuters (free)

Other commentaries: WTO Tobacco Ruling Opens Door to New Plain-Packaging Laws – Bloomberg (free) AND ‘Resounding victory’: Australia wins tobacco plain packaging dispute – The Guardian (free) AND Australian Tobacco Plain Packaging Upheld In Decision At WTO – Intellectual Property Watch (free)

Source: International Health Policies Newsletter

Mon, July 2 – 10 Stories of The Day!

2 Jul, 2018 | 00:27h | UTC

1 – Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality – BMJ Open (free)

Commentaries: Seeing same doctor every time ‘reduces risk of death’ – NHS Choices (free) AND Sticking with 1 doctor could have health benefits: Study – UPI (free)

2 – Opinion: Why do-it-yourself blood tests are a bad idea – Common Sense Family Doctor (free)

“Routine blood testing in healthy people has numerous downsides that Holmes never mentioned, including poor predictive value, false positives, and overdiagnosis” (from Common Sense Family Doctor)

“When you go about testing everyone for everything, you don’t create a world of healthy people….you create a nightmare where everyone is sick” (from The BMJ Opinion)

3 – Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free)

4 – Four principles to make evidence synthesis more useful for policy – Nature (free)

Related: A fresh approach to evidence synthesis – Nature (free)

“Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues”.

5 – American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome – American Journal of Gastroenterology (free for a limited period)

Source: NewsWise

6 – Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidelines on Weekly Therapy for Latent TB Infection – Physician’s First Watch (free)

Related WHO Guideline: Latent TB Infection (free guideline and news release)

7 – The plateau of human mortality: Demography of longevity pioneers – Science (link to abstract – $ for full-text)

Commentaries: There’s no limit to longevity, says study that revives human lifespan debate – Nature News (free) AND Italian study suggests human lifespan could continue increasing – NHS Choices (free) AND Age 105? Then you’ve a better chance of living even longer – The Guardian (free) AND How Long Can We Live? The Limit Hasn’t Been Reached, Study Finds – The New York Times (free)

8 – Editorial: HPV vaccination: balancing facts – Cochrane Library (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)

9 – Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Summary: Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

This Cochrane review suggests mineralocorticoid receptor antagonists may be of benefit to reduce hospitalizations, while the meta-analysis in Heart suggests beta-blockers may improve all-cause and cardiovascular mortality…

10 – The 2016 global and national burden of diabetes mellitus attributable to PM_2·5 air pollution – The Lancet Planetary Health (free)

Commentaries: Air pollution and diabetes: it’s time to get active! – The Lancet Planetary Health (free) AND Air pollution linked to 3.2 million new diabetes cases in one year – CNN (free) AND Air pollution contributes significantly to diabetes globally – Washington University School of Medicine (free)

Related: WHO Report: 9 out of 10 People Worldwide Breathe Polluted Air (free report and commentaries) AND Ambient Air Pollution in Relation to Diabetes (free research) AND The Lancet Commission on pollution and health (free resources) AND Air Pollution and Mortality (free research and commentaries) AND Global burden of disease attributable to ambient air pollution (free report and commentaries) AND 5.5 million lives were lost in 2013 to diseases associated with Air Pollution (free report and infographic)