Archives
Randomized Trial: Decontamination Strategies and Bloodstream Infections with Antibiotic-Resistant Microorganisms in Ventilated Patients
26 Oct, 2018 | 01:57h | UTCDecontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit (free for a limited period)
“Among patients receiving mechanical ventilation in ICUs with moderate to high ABX resistance prevalence, use of chlorhexidine mouthwash, selective oropharyngeal decontamination, or selective digestive tract decontamination was not associated with reductions in ICU-acquired bloodstream infections caused by MDRGNB vs standard care” (via @JAMA_current see Tweet with visual abstract)
Study: The AI Clinician Learns Optimal Treatment Strategies for Sepsis in Intensive Care
26 Oct, 2018 | 01:56h | UTCThe Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care – Nature Medicine (free link via Critical Care Reviews)
Commentaries: AI doctor could boost chance of survival for sepsis patients – Imperial College London (free) AND Artificial intelligence system could improve survival for sepsis patients – NHS National Institute for Health Research (free)
Randomized Trial: Protocolized Weaning with Early Extubation to Noninvasive Ventilation vs Invasive Weaning Among Patients Receiving Mechanical Ventilation
26 Oct, 2018 | 01:56h | UTCEffect of Protocolized Weaning with Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Weaning From Mechanical Ventilation: What Should Be Done When a Patient’s Spontaneous Breathing Trial Fails? (free for a limited period)
“Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation.”
Order Wisely Video Lectures: Appropriate Use of Tests & Treatments
26 Oct, 2018 | 01:55h | UTCOrder Wisely®: Appropriate use of tests & treatments – High Value Practice Academic Alliance (free) (via @KariTikkinen)
Comprehensive educational program that reviews appropriate use of imaging exams, lab tests, medications, transfusions and procedures to promote high-value practice.
Podcast: HIV Care for the Internist
26 Oct, 2018 | 01:48h | UTC#121 HIV Care for the Internist – Curbsiders Internal Medicine Podcast (free audio and summary)
Alex Nowbar’s Research Reviews, 22 October 2018
26 Oct, 2018 | 01:47h | UTCAlex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Want to Keep Your Brain Sharp? Take Care of Your Eyes And Ears
26 Oct, 2018 | 01:46h | UTCWant To Keep Your Brain Sharp? Take Care Of Your Eyes And Ears – NPR (free)
Related Articles: Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans – Journal of the American Geriatrics Society (free) AND Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing – NPR (free)
Randomized Trial: Theophylline Not Effective at Reducing COPD Exacerbations
26 Oct, 2018 | 01:44h | UTCEffect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: TWICS results suggest no role for low-dose theophylline as add-on therapy in COPD – Medwire News (free) AND Low-Dose Theophylline Not Effective at Reducing COPD Exacerbations, Study Finds – AJMC (free)
Randomized Trial: Radiotherapy to the Primary Tumour for Newly Diagnosed, Metastatic Prostate Cancer
26 Oct, 2018 | 01:45h | UTCCommentaries: Radiotherapy for newly diagnosed oligometastatic prostate cancer – The Lancet (free) AND ESMO 2018: Local radiotherapy improves survival in metastatic prostate cancer with low disease burden – eCancer News (free) AND Radiotherapy offers hopes in advanced prostate cancer – OnMedica (free) AND Cancer trial shows treating the prostate with radiotherapy improves survival – University of Birmingham (free)
Meta-Analysis: Enteral Nutrition Provided Within 48 hours After Admission in Severe Acute Pancreatitis
26 Oct, 2018 | 01:43h | UTC
Hospital Accreditation not Associated with Better Outcomes in Observational Study
26 Oct, 2018 | 01:42h | UTCCommentaries: Joint Commission accreditation doesn’t lead to better outcomes, study shows – Modern Healthcare (free) AND Doubt cast on value of hospital accreditation in Harvard study – Healthcare Dive (free)
Randomized Trial: Corticosteroid Injection vs. Night Splints for Carpal Tunnel Syndrome
26 Oct, 2018 | 01:40h | UTCInvited Commentary: Steroid injection or wrist splint for first-time carpal tunnel syndrome? (free)
“A single corticosteroid injection shows superior clinical effectiveness at 6 weeks compared with night-resting splints, making it the treatment of choice for rapid symptom response in mild or moderate carpal tunnel syndrome presenting in primary care.”
Report: Talking About Dying
26 Oct, 2018 | 01:39h | UTCNews Release: New report asks why doctors find it so hard to talk to patients about dying (free)
Commentaries: Doctors must talk ‘honestly’ to patients about dying – OnMedica (free) AND Doctors ‘need to start early conversation with patients about dying’ – BBC (free)
Eosinophilic Esophagitis: Review and Update
26 Oct, 2018 | 01:38h | UTCEosinophilic Esophagitis: Review and Update – Frontiers in Medicine (free)
Systematic Review: Prokinetics for Functional Dyspepsia
26 Oct, 2018 | 01:36h | UTCProkinetics for functional dyspepsia – Cochrane Library (free)
Summary: Medications which promote stomach movement to relieve upper abdominal discomfort that does not have a specific cause – Cochrane Library (free)
“we are unable to say whether prokinetics are effective for the treatment of functional dyspepsia.”
Review: How Early Media Exposure May Affect Cognitive Function
26 Oct, 2018 | 01:38h | UTCRelated Article: Screen media use and ADHD-related behaviors: Four decades of research – Proceedings of the National Academy of Sciences (free)
Canadian Guideline for Physical Activity Throughout Pregnancy
26 Oct, 2018 | 01:37h | UTC
Cohort Study: Association of Cardiorespiratory Fitness With Long-term Mortality
26 Oct, 2018 | 01:35h | UTCCommentaries: Expansive New Study Says Not Exercising Is Worse for Your Health Than Smoking – TIME (free) AND Researchers show better cardiorespiratory fitness leads to longer life – MedicalXpress (free)
Mon, October 22 – 10 Stories of The Day!
22 Oct, 2018 | 00:46h | UTC
1 – Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: TWICS results suggest no role for low-dose theophylline as add-on therapy in COPD – Medwire News (free) AND Low-Dose Theophylline Not Effective at Reducing COPD Exacerbations, Study Finds – AJMC (free)
Commentaries: Joint Commission accreditation doesn’t lead to better outcomes, study shows – Modern Healthcare (free) AND Doubt cast on value of hospital accreditation in Harvard study – Healthcare Dive (free)
Invited Commentary: Steroid injection or wrist splint for first-time carpal tunnel syndrome? (free)
“A single corticosteroid injection shows superior clinical effectiveness at 6 weeks compared with night-resting splints.”
News Release: New report asks why doctors find it so hard to talk to patients about dying (free)
Commentaries: Doctors must talk ‘honestly’ to patients about dying – OnMedica (free) AND Doctors ‘need to start early conversation with patients about dying’ – BBC (free)
Related Article: Screen media use and ADHD-related behaviors: Four decades of research – Proceedings of the National Academy of Sciences (free)
7 – Review: Eosinophilic Esophagitis: Review and Update – Frontiers in Medicine (free)
9 – Prokinetics for functional dyspepsia – Cochrane Library (free)
Summary: Medications which promote stomach movement to relieve upper abdominal discomfort that does not have a specific cause – Cochrane Library (free)
“We are unable to say whether prokinetics are effective for the treatment of functional dyspepsia.”
Commentaries: Expansive New Study Says Not Exercising Is Worse for Your Health Than Smoking – TIME (free) AND Researchers show better cardiorespiratory fitness leads to longer life – MedicalXpress (free)
Fri, October 26 – 10 Stories of The Day!
26 Oct, 2018 | 00:04h | UTC
1 – Oxygen therapy for acutely ill medical patients: a clinical practice guideline – The BMJ (free)
News Release: New guidance recommends minimal oxygen use for most people in hospital – The BMJ (free)
Related: Multimorbidity: A Priority for Global Health Research (free report and commentaries) AND Meta-Analysis: Effectiveness of Interventions for Managing Multiple High-Burden Chronic Diseases in Older Adults (free study and commentaries) Designing a High-Performing Health Care System for Patients with Complex Needs (several perspectives on the subject)
4 – Perspective: The troubling epidemic of unnecessary C-sections around the world, explained – VOX (free)
Related WHO Recommendations: Non-Clinical Interventions to Reduce Unnecessary Cesarean Sections (free guideline and commentaries)
Related The Lancet Series: Optimising Cesarean Section Use (free articles)
Related Cochrane Review: Non‐Clinical Interventions for Reducing Unnecessary Caesarean Section (free review and summary)
“The C-section rate has doubled in less than a generation, from 12 percent of all births in 2000 to 21 percent in 2015.”
5 – The skeptic: What precision medicine revolution? – MIT Technology Review (free)
Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free)
6 – Review: Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances – Liver Research (free)
7 – Review: Pacemaker‐mediated arrhythmias – Journal of Arrythmia (free)
8 – Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Refractory functional dyspepsia: low-dose imipramine safe, effective – Univadis (free registration required)
Editorial: Angiotensin converting enzyme inhibitors and lung cancer (free)
Commentaries: Blood pressure drug linked to possible small increased risk of lung cancer – NHS Choices (free) AND Expert reaction to study looking at blood pressure drugs and lung cancer risk – Science Media Centre (free)
“Using the adjuvant recombinant subunit vaccine might prevent more cases of herpes zoster than using the live attenuated vaccine, but the adjuvant recombinant subunit vaccine also carries a greater risk of adverse events at injection sites.”
Thu, October 25 – 10 Stories of The Day!
25 Oct, 2018 | 00:01h | UTC
1 – Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU – New England Journal of Medicine (free for a limited period)
Editorial: Proton-Pump Inhibitor Prophylaxis in the ICU — Benefits Worth the Risks? (free for a limited period)
“Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)
2 – Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients with Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hypothermia After Traumatic Brain Injury (free)
Commentary: Hypothermia for Severe TBI Called into Question – NEJM Journal Watch (free)
3 – Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past (free)
“Among patients in the ICU receiving invasive ventilation, a strategy with low tidal volume was not more effective than a strategy using intermediate tidal volume.”
Commentaries: Your risk of a heart attack could increase as it gets colder, study says – CNN (free) AND Cold, cloudy weather ‘could increase your risk of having heart attack’ – The Guardian (free)
Editorial: The Ongoing Saga of Optimal Blood Pressure Level in Patients With Diabetes Mellitus and Coronary Artery Disease (free)
“A U‐shaped relationship between cardiovascular outcomes and BPs was observed.”
Editorial: New Curveball for Hypertension Guidelines? Blood Pressure Targets in Peripheral Artery Disease (free)
“we found a higher rate of lower extremity PAD events with higher and lower SBP and pulse pressure and with lower DBP.”
Commentaries: Score predicts 90-day readmission risk after myocardial infarction – ACP Hospitalist (free) AND Novel risk predictor identifies likelihood of readmission after AMI – Cardiovascular Business (free)
8 – Review: Pulmonary Embolism: Contemporary Medical Management and Future Perspectives – Annals of Vascular Disease (free PDF)
Related Guideline: Surgical Management of Lower Urinary Tract Symptoms attributed to BPH (free guideline and commentary)
Original Article: Self-monitoring blood glucose improves glycemic control in type 2 diabetes without intensive treatment: A systematic review and meta-analysis – Diabetes Research and Clinical Practice (link to abstract – $ for full-text)
Wed, October 24 – 10 Stories of The Day!
24 Oct, 2018 | 00:01h | UTC
1 – ACTIVE: A technical package for increasing physical activity – World Health Organization (free PDF)
News Release: WHO launches ACTIVE: a toolkit for countries to increase physical activity and reduce noncommunicable diseases (free)
Editorials: Challenges and Opportunities for Studying Routine Screening for Abuse (free) AND Addressing Intimate Partner Violence and Abuse of Older or Vulnerable Adults in the Health Care Setting—Beyond Screening (free)
4 – Perspective: Superfoods Are a Marketing Ploy – The Atlantic (free) (via @edyong209 and @onisillos)
5 – Perspective: The Problem With Probiotics – The New York Times (free)
Related: Probiotic Safety—No Guarantees (free perspective)
“There are potential harms as well as benefits, and a lot of wishful thinking and imprecision in the marketing of products containing them.”
6 – Perspective: The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine – TCTMD (free)
“How to reduce emergency doctor misinterpretation of wrist X-rays for fracture by nearly 50%? Deep learning AI, of course” (via @EricTopol see Tweet)
8 – Association of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study – JAMA Internal Medicine (free for a limited period)
Commentaries: Organic Foods for Cancer Prevention—Worth the Investment? – JAMA Internal Medicine (free for a limited period) AND Organic food and cancer – Science Media Centre (free) AND Organic foods tied to slightly lower cancer risk – Reuters (free)
9 – Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (free for a limited period)
Commentaries: Not So Fast With Immune Therapy For Breast Cancer – Forbes (free) AND Immunotherapy drugs show some promise against breast cancer – STAT (free)
“…the benefit for most women was small, raising questions about whether the treatment is worth its high cost and side effects.” (from STAT)
10 – Diagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Algorithm Rules Out Pulmonary Embolism in Pregnancy – NEJM Journal Watch (free) AND Algorithm Validated for Pulmonary Embolism Diagnosis in Pregnancy – MedPage Today (free registration required)
Cohort Study: Pre-Eclampsia and Risk of Dementia Later in Life
19 Oct, 2018 | 00:15h | UTCPre-eclampsia and risk of dementia later in life: nationwide cohort study – The BMJ (free)
Editorial: Pre-eclampsia and the brain (free)
Commentaries: Pre-eclampsia linked to raised risk of vascular dementia – OnMedica (free) AND Pre-eclampsia linked to an increased risk of dementia later in life – The BMJ (free)
Perspective: To Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications
19 Oct, 2018 | 00:14h | UTCTo Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications – JAMA (free for a limited period)
Related: Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease (link to abstract and commentaries)
Tue, October 23 – 10 Stories of The Day!
23 Oct, 2018 | 00:01h | UTC
#LIVE2018 – Highlights from the European Society of Intensive Care Medicine Congress (via Critical Care Reviews)
1 – #LIVE2018 – Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness – New England Journal of Medicine (free for a limited period)
Editorial: Dopamine Antagonists in ICU Delirium (free for a limited period)
Commentaries: Common use of antipsychotics shown ineffective for delirium in intensive care patients – NIH News Releases (free) AND Antipsychotic Drugs Don’t Ease ICU Delirium Or Dementia – NPR (free) AND Antipsychotics ineffective for treating ICU delirium – Vanderbilt University Medical Center (free)
Related Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium (free)
2 – #LIVE2018 – Energy-Dense versus Routine Enteral Nutrition in the Critically Ill – New England Journal of Medicine (free for a limited period)
Energy-dense formulation for enteral delivery of nutrition was not associated with better outcomes.
3 – #LIVE2018 – Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit (free for a limited period)
“Among patients receiving mechanical ventilation in ICUs with moderate to high ABX resistance prevalence, use of chlorhexidine mouthwash, selective oropharyngeal decontamination, or selective digestive tract decontamination was not associated with reductions in ICU-acquired bloodstream infections caused by MDRGNB vs standard care” (via @JAMA_current see Tweet with visual abstract)
4 – #LIVE2018 – Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Weaning From Mechanical VentilationWhat Should Be Done When a Patient’s Spontaneous Breathing Trial Fails? (free for a limited period)
“Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation.”
5 – The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care – Nature Medicine (free link via Critical Care Reviews)
Commentaries: AI doctor could boost chance of survival for sepsis patients – Imperial College London (free) AND Artificial intelligence system could improve survival for sepsis patients – NHS National Institute for Health Research (free)
6 – Videos: Order Wisely®: Appropriate use of tests & treatments – High Value Practice Academic Alliance (free) (via @KariTikkinen)
Comprehensive educational program that reviews appropriate use of imaging exams, lab tests, medications, transfusions and procedures to promote high-value practice.
7 – Podcast: #121 HIV Care for the Internist – Curbsiders Internal Medicine Podcast (free audio and summary)
8 – Alex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
9 – Want To Keep Your Brain Sharp? Take Care Of Your Eyes And Ears – NPR (free)
Related Articles: Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans – Journal of the American Geriatrics Society (free) AND Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing – NPR (free)
Commentaries: Radiotherapy for newly diagnosed oligometastatic prostate cancer – The Lancet (free) AND ESMO 2018: Local radiotherapy improves survival in metastatic prostate cancer with low disease burden – eCancer News (free) AND Radiotherapy offers hopes in advanced prostate cancer – OnMedica (free) AND Cancer trial shows treating the prostate with radiotherapy improves survival – University of Birmingham (free)