Archives
Randomized Trial: Low-Dose Imipramine for Refractory Functional Dyspepsia
26 Oct, 2018 | 02:47h | UTCLow-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Refractory functional dyspepsia: low-dose imipramine safe, effective – Univadis (free registration required)
Randomized Trial: Proton-Pump Inhibitors Prophylaxis of Little Benefit in the ICU
26 Oct, 2018 | 02:41h | UTCPantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU – New England Journal of Medicine (free for a limited period)
Editorial: Proton-Pump Inhibitor Prophylaxis in the ICU — Benefits Worth the Risks? (free for a limited period)
“Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)
Cohort Study: Angiotensin Converting Enzyme Inhibitors and Risk of Lung Cancer
26 Oct, 2018 | 02:43h | UTCEditorial: Angiotensin converting enzyme inhibitors and lung cancer (free)
Commentaries: Blood pressure drug linked to possible small increased risk of lung cancer – NHS Choices (free) AND Expert reaction to study looking at blood pressure drugs and lung cancer risk – Science Media Centre (free)
Meta-Analysis: Efficacy, Effectiveness, and Safety of Herpes Zoster Vaccines
26 Oct, 2018 | 02:42h | UTC“Using the adjuvant recombinant subunit vaccine might prevent more cases of herpes zoster than using the live attenuated vaccine, but the adjuvant recombinant subunit vaccine also carries a greater risk of adverse events at injection sites.”
Randomized Trial: Low vs Intermediate Tidal Volume Strategy in ICU Patients Without ARDS
26 Oct, 2018 | 02:39h | UTCEffect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past (free)
“Among patients in the ICU receiving invasive ventilation, a strategy with low tidal volume was not more effective than a strategy using intermediate tidal volume.”
Prophylactic Hypothermia Questioned After Severe Traumatic Brain Injury
26 Oct, 2018 | 02:40h | UTCEffect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients with Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hypothermia After Traumatic Brain Injury (free)
Commentary: Hypothermia for Severe TBI Called into Question – NEJM Journal Watch (free)
Study: Association of Weather with Incidence of Myocardial Infarction
26 Oct, 2018 | 02:38h | UTCCommentaries: Your risk of a heart attack could increase as it gets colder, study says – CNN (free) AND Cold, cloudy weather ‘could increase your risk of having heart attack’ – The Guardian (free)
Observational Study: Blood Pressure Levels and Outcomes in Patients With Diabetes Mellitus and Coronary Artery Disease
26 Oct, 2018 | 02:36h | UTCEditorial: The Ongoing Saga of Optimal Blood Pressure Level in Patients With Diabetes Mellitus and Coronary Artery Disease (free)
“A U‐shaped relationship between cardiovascular outcomes and BPs was observed.”
Observational Study: Blood Pressure Levels and Outcomes in Patients With Peripheral Artery Disease
26 Oct, 2018 | 02:33h | UTCEditorial: New Curveball for Hypertension Guidelines? Blood Pressure Targets in Peripheral Artery Disease (free)
“we found a higher rate of lower extremity PAD events with higher and lower SBP and pulse pressure and with lower DBP.”
Study: Score Predicts 90-Day Risk of Readmission After Acute Myocardial Infarction
26 Oct, 2018 | 02:32h | UTCCommentaries: Score predicts 90-day readmission risk after myocardial infarction – ACP Hospitalist (free) AND Novel risk predictor identifies likelihood of readmission after AMI – Cardiovascular Business (free)
Pulmonary Embolism: Contemporary Medical Management and Future Perspectives
26 Oct, 2018 | 02:32h | UTCReview: Pulmonary Embolism: Contemporary Medical Management and Future Perspectives – Annals of Vascular Disease (free PDF)
Meta-Analysis: Self-Monitoring of Blood Glucose Provides no Important Benefit for Most People with Type 2 Diabetes
26 Oct, 2018 | 02:30h | UTCOriginal Article: Self-monitoring blood glucose improves glycemic control in type 2 diabetes without intensive treatment: A systematic review and meta-analysis – Diabetes Research and Clinical Practice (link to abstract – $ for full-text)
Guideline: Male Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia
26 Oct, 2018 | 02:31h | UTCRelated Guideline: Surgical Management of Lower Urinary Tract Symptoms attributed to BPH (free guideline and commentary)
ACTIVE: A Technical Package for Increasing Physical Activity
26 Oct, 2018 | 02:29h | UTCACTIVE: A technical package for increasing physical activity – World Health Organization (free PDF)
News Release: WHO launches ACTIVE: a toolkit for countries to increase physical activity and reduce noncommunicable diseases (free)
Meta-Analysis: Cefazolin vs. Antistaphylococcal Penicillins for MSSA Bacteremia
26 Oct, 2018 | 02:27h | UTC
Perspective: Superfoods Are a Marketing Ploy
26 Oct, 2018 | 02:26h | UTCSuperfoods Are a Marketing Ploy – The Atlantic (free) (via @edyong209 and @onisillos)
USPSTF Statement: Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults
26 Oct, 2018 | 02:28h | UTCEditorials: Challenges and Opportunities for Studying Routine Screening for Abuse (free) AND Addressing Intimate Partner Violence and Abuse of Older or Vulnerable Adults in the Health Care Setting—Beyond Screening (free)
Perspective: The Problem with Probiotics
26 Oct, 2018 | 02:08h | UTCThe Problem With Probiotics – The New York Times (free)
Related: Probiotic Safety—No Guarantees (free perspective)
“There are potential harms as well as benefits, and a lot of wishful thinking and imprecision in the marketing of products containing them.”
The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine
26 Oct, 2018 | 02:06h | UTCPerspective: The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine – TCTMD (free)
Organic Foods for Cancer Prevention??
26 Oct, 2018 | 02:04h | UTCAssociation of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study – JAMA Internal Medicine (free for a limited period)
Commentaries: Organic Foods for Cancer Prevention—Worth the Investment? – JAMA Internal Medicine (free for a limited period) AND Organic food and cancer – Science Media Centre (free) AND Organic foods tied to slightly lower cancer risk – Reuters (free)
Study: Deep Neural Network Improves Fracture Detection by Clinicians
26 Oct, 2018 | 02:05h | UTC“How to reduce emergency doctor misinterpretation of wrist X-rays for fracture by nearly 50%? Deep learning AI, of course” (via @EricTopol see Tweet)
Randomized Trial: Treatments of Advanced Triple-Negative Breast Cancer Compaired
26 Oct, 2018 | 02:03h | UTCAtezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (free for a limited period)
Commentaries: Not So Fast With Immune Therapy For Breast Cancer – Forbes (free) AND Immunotherapy drugs show some promise against breast cancer – STAT (free)
“…the benefit for most women was small, raising questions about whether the treatment is worth its high cost and side effects.” (from STAT)
Study: Diagnosis of Pulmonary Embolism During Pregnancy
26 Oct, 2018 | 02:02h | UTCDiagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Algorithm Rules Out Pulmonary Embolism in Pregnancy – NEJM Journal Watch (free) AND Algorithm Validated for Pulmonary Embolism Diagnosis in Pregnancy – MedPage Today (free registration required)
Randomized Trial: Energy-Dense versus Routine Enteral Nutrition in the Critically Ill
26 Oct, 2018 | 01:59h | UTCEnergy-Dense versus Routine Enteral Nutrition in the Critically Ill – New England Journal of Medicine (free for a limited period)
Energy-dense formulation for enteral delivery of nutrition was not associated with better outcomes.
Randomized Trial: Antipsychotics Ineffective for Delirium in Intensive Care Patients
26 Oct, 2018 | 02:01h | UTCHaloperidol and Ziprasidone for Treatment of Delirium in Critical Illness – New England Journal of Medicine (free for a limited period)
Editorial: Dopamine Antagonists in ICU Delirium (free for a limited period)
Commentaries: Common use of antipsychotics shown ineffective for delirium in intensive care patients – NIH News Releases (free) AND Antipsychotic Drugs Don’t Ease ICU Delirium Or Dementia – NPR (free) AND Antipsychotics ineffective for treating ICU delirium – Vanderbilt University Medical Center (free)
Related Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium (free)