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Small Observational Study Suggests Active Surveillance is Feasible for Small Renal Masses

20 Jun, 2019 | 05:56h | UTC

Extended Duration of Active Surveillance of Small Renal Masses: A Prospective Cohort Study – Journal of Urology (free)

Commentary: Active Surveillance Safe for Small Renal Tumors – MedPage Today (free registration required)

 


Meta-Analysis: Antithrombotic Strategies in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

20 Jun, 2019 | 06:04h | UTC

Safety and Efficacy of Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-analysis of Randomized Controlled Trials – JAMA Cardiology (free for a limited period)

Commentary: In High-Risk AF Patients, NOAC Plus P2Y12Inhibitor Tied to Less Bleeding – NEJM Journal Watch (free)

 


[Abstract Only] Randomized Trial: Septoplasty May Improve Quality of Life for Patients with Nasal Obstruction and a Deviated Septum

20 Jun, 2019 | 06:03h | UTC

Septoplasty with or without concurrent turbinate surgery versus non-surgical management for nasal obstruction in adults with a deviated septum: a pragmatic, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Surgery for Deviated Septum Linked to Better Quality of Life – NEJM Journal Watch (free)

 


Systematic Review: Effects of Rapid Initiation of Antiretroviral Therapy for People Living with HIV

20 Jun, 2019 | 05:43h | UTC

Rapid initiation of antiretroviral therapy for people living with HIV – Cochrane Library (free)

Summary: Effects of starting antiretroviral therapy within one week of diagnosis on people living with HIV – Cochrane Library (free)

 


Perspective: Collateral Benefits of Preventive Chemotherapy — Expanding the War on Neglected Tropical Diseases

20 Jun, 2019 | 05:49h | UTC

Collateral Benefits of Preventive Chemotherapy — Expanding the War on Neglected Tropical Diseases – New England Journal of Medicine (free)

 


Wed June 19 – 10 Stories of The Day!

19 Jun, 2019 | 08:35h | UTC

 

1 – Screening for Abdominal Aortic Aneurism – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Reaffirms Recommendations on AAA Screening in Draft Statement – NEJM Journal Watch (free)

 

2 – Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations – British Journal of Anaesthesia (free)

Related Report: Anesthesia, Surgery and Life-Threatening Allergic Reactions (free)

Source: Critical Care Reviews Newsletter

 

3 – Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

 

4 – Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

 

5 – Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Systolic Blood Pressure and Systolic Heart Failure Outcomes – American College of Cardiology (free) AND Lower Systolic BP in HFrEF Patients Linked to Mortality – NEJM Journal Watch (free)

“There is an urgent need for randomized controlled trials to evaluate optimal SBP reduction goals in patients with HFrEF.”

 

6 – Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation – BJOG (free)

News Release: RCOG provides new guidance for doctors and women on when to give birth if waters break early (free)

 

7 – When more is not better: 10 ‘don’ts’ in endometriosis man`Sagement. An ETIC* position statement – Human Reproduction Open (free)

 

8 – Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Peptide Innovation for Early Diabetes Treatment 6 – PIONEER 6 – American College of Cardiology (free) AND Oral semaglutide falls just short of cardioprotection in event-driven PIONEER 6 – Medicine Matters (free) AND Oral Semaglutide Meets CV Safety Mark, Reduces Events in High-Risk T2D Patients – AJMC (free)

 

9 – Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: MONALEESA-7 Shows Overall Survival Benefit for Ribociclib/Endocrine Therapy – The ASCO Post (free)

 

10 – Homepage: Future of Critical Care Medicine (FCCM) 2018 – Critical Care (free articles)

– Thinking forward: promising but unproven ideas for future intensive care

– Science and fiction in critical care: established concepts with or without evidence?

– Evolving concepts for safer ventilation

– NIV through the helmet can be used as first-line intervention for early mild and moderate ARDS: an unproven idea thinking out of the box

– Extracorporeal gas exchange: when to start and how to end?

– Minimizing catecholamines and optimizing perfusion

– Physiology and technology for the ICU in vivo

– Sepsis: personalization v protocolization?

– Host-pathogen interaction during mechanical ventilation: systemic or compartmentalized response?

– Preserving the quality of life: nutrition in the ICU

– The continuum of critical care

 


USPSTF Draft Statement: Screening for Abdominal Aortic Aneurism

19 Jun, 2019 | 08:26h | UTC

Screening for Abdominal Aortic Aneurism – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Reaffirms Recommendations on AAA Screening in Draft Statement – NEJM Journal Watch (free)

 


Consensus Recommendations: Management of Suspected Immediate Perioperative Allergic Reactions

19 Jun, 2019 | 08:20h | UTC

Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations – British Journal of Anaesthesia (free)

Related Report: Anesthesia, Surgery and Life-Threatening Allergic Reactions (free)

Source: Critical Care Reviews Newsletter

 


Consensus Clinical Scoring for Suspected Perioperative Immediate Hypersensitivity Reactions

19 Jun, 2019 | 08:18h | UTC

Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

 


Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy

19 Jun, 2019 | 08:19h | UTC

Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

 


[Abstract Only] Cohort Study: Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction

19 Jun, 2019 | 07:55h | UTC

Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Systolic Blood Pressure and Systolic Heart Failure Outcomes – American College of Cardiology (free) AND Lower Systolic BP in HFrEF Patients Linked to Mortality – NEJM Journal Watch (free)

“There is an urgent need for randomized controlled trials to evaluate optimal SBP reduction goals in patients with HFrEF.”

 


Guideline: Management of Preterm Prelabor Rupture of Membranes

19 Jun, 2019 | 07:52h | UTC

Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation – BJOG (free)

News Release: RCOG provides new guidance for doctors and women on when to give birth if waters break early (free)

 


[Abstract Only] Randomized Trial: Overall Survival with a (CDK) 4/6 inhibitor plus Endocrine Therapy in Breast Cancer

19 Jun, 2019 | 07:48h | UTC

Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: MONALEESA-7 Shows Overall Survival Benefit for Ribociclib/Endocrine Therapy – The ASCO Post (free)

 


Position Statement: 10 ‘Don’ts’ in Endometriosis Management

19 Jun, 2019 | 07:51h | UTC

When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement – Human Reproduction Open (free)

 


[Abstract Only] Randomized Trial: Oral GLP-1 Receptor Agonist and Cardiovascular Outcomes in Patients with Type 2 Diabetes

19 Jun, 2019 | 07:49h | UTC

Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Peptide Innovation for Early Diabetes Treatment 6 – PIONEER 6 – American College of Cardiology (free) AND Oral semaglutide falls just short of cardioprotection in event-driven PIONEER 6 – Medicine Matters (free) AND Oral Semaglutide Meets CV Safety Mark, Reduces Events in High-Risk T2D Patients – AJMC (free)

 


Guideline: Management of the Child’s Airway Under Anesthesia

18 Jun, 2019 | 07:04h | UTC

Management of the child’s airway under anaesthesia: The French guidelines – Anaesthesia Critical Care & Pain Medicine (free)

Related: Current Concepts in the Management of the Difficult Pediatric Airway – Current Anesthesiology Reports (free) AND Unanticipated difficult airway management in children – the consensus statement of the Paediatric Anaesthesiology and Intensive Care Section and the Airway Management Section of the Polish Society of Anaesthesiology and Intensive Therapy and the Polish Society of Neonatology. Anaesthesiology Intensive Therapy (free PDF)

 


Supplement: Future of Critical Care Medicine

19 Jun, 2019 | 06:49h | UTC

Homepage: Future of Critical Care Medicine (FCCM) 2018 – Critical Care (free articles)

– Thinking forward: promising but unproven ideas for future intensive care

– Science and fiction in critical care: established concepts with or without evidence?

– Evolving concepts for safer ventilation

– NIV through the helmet can be used as first-line intervention for early mild and moderate ARDS: an unproven idea thinking out of the box

– Extracorporeal gas exchange: when to start and how to end?

– Minimizing catecholamines and optimizing perfusion

– Physiology and technology for the ICU in vivo

– Sepsis: personalization v protocolization?

– Host-pathogen interaction during mechanical ventilation: systemic or compartmentalized response?

– Preserving the quality of life: nutrition in the ICU

– The continuum of critical care

 


Perspective: “Miracle Medical Machine ECMO Makes Heroic Rescues, but Leaves Patients in Limbo”

18 Jun, 2019 | 06:58h | UTC

Miracle medical machine ECMO makes heroic rescues, but leaves patients in limbo – Kaiser Health News / USA Today (free)

“ECMO is not designed to be a destination, but a bridge to somewhere – recovery, transplantation or an implanted heart device. But when patients are too sick to reach those goals, ECMO can become a “bridge to nowhere,” leaving the patient in limbo…”

 


State of The Art Review: Advances in Rehabilitation for Chronic Diseases

18 Jun, 2019 | 06:59h | UTC

Advances in rehabilitation for chronic diseases: improving health outcomes and function – The BMJ (free)

 


Randomized Trial: No Difference in HIV Incidence with Different Forms of Contraception

18 Jun, 2019 | 06:56h | UTC

HIV incidence among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: a randomised, multicentre, open-label trial – The Lancet (free)

Commentaries: First randomised trial finds no substantial difference in risk of acquiring HIV for three different forms of contraception – The Lancet (free) AND How should we listen to ECHO? – The Lancet (free) AND Depo-Provera, an Injectable Contraceptive, Does Not Raise H.I.V. Risk – The New York Times (10 articles per month are free) AND ‘Reassuring’ contraceptives and HIV trial also a wake-up call, experts say – Devex (free)

 

Related Commentary on Twitter

 


Cohort Study: Cardiovascular Disease After Hypertensive Disorders of Pregnancy Largely Explained by Conventional Cardiovascular Risk Factors

18 Jun, 2019 | 06:42h | UTC

Association of Conventional Cardiovascular Risk Factors With Cardiovascular Disease After Hypertensive Disorders of Pregnancy: Analysis of the Nord-Trøndelag Health Study – JAMA Cardiology (free)

Commentary: Hypertension During Pregnancy Increases Later CVD Risk by More Than 50% – TCTMD (free)

Related: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (free) AND Gestational Hypertension and Future Risk of Cardiovascular Disease (free) Research: Conjoint Associations of Gestational Diabetes and Hypertension With Diabetes, Hypertension, and Cardiovascular Disease in Parents (free) AND Cohort Study: Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease (link to abstract and commentaries)

 


[Abstract Only] Randomized Trial: Chemotherapy Alone vs. Chemotherapy Plus Radiation Therapy for Locally Advanced Endometrial Cancer

18 Jun, 2019 | 06:54h | UTC

Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Carboplatin & paclitaxel chemotherapy alone should remain standard treatment for endometrial cancer – NRG Oncology (free) AND Radiation’s Role Questioned in Stage III Uterine Cancer – MedPage Today (free registration required) AND Chemo Alone in Advanced Endometrial Cancer? – Medscape (free registration required)

 


Meta-Analysis: Risk Factors for Patellofemoral Pain

18 Jun, 2019 | 06:52h | UTC

Risk factors for patellofemoral pain: a systematic review and meta-analysis – British Journal of Sports Medicine (free)

 


Academic Medical Centers: Too Large for Their Own Health?

18 Jun, 2019 | 06:40h | UTC

Academic Medical Centers: Too Large for Their Own Health? – JAMA (free for a limited period)

Related: Advancing the Academic Medical Center Value Debate: Are Teaching Hospitals Worth It? – JAMA (free for a limited period)

Author Interview: Academic Medical Centers—Too Large for Their Own Good? (free audio)

 


[Abstract Only] New Index for Preoperative Cardiovascular Evaluation

18 Jun, 2019 | 06:38h | UTC

New Index for Preoperative Cardiovascular Evaluation – American College of Cardiology (free)

Original Article: A New Index for Pre-Operative Cardiovascular Evaluation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

 


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