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Consensus Statement: The Implications of Three Major New Trials for the Effect of Water, Sanitation and Hygiene on Childhood Diarrhea and Stunting

3 Sep, 2019 | 01:08h | UTC

The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement – BMC Medicine (free)

 

Mon September 2 – 10 Stories of The Day!

2 Sep, 2019 | 01:22h | UTC

 

1 – 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC)

News Release: Pollution and noise reduction advised in ESC guidelines on chronic coronary syndromes (free)

 

2 – 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC) (free)

 

3 – The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC): Developed in collaboration with the Association for European Paediatric and Congenital Cardiology (AEPC) (free)

 

4 – 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) (free)

 

5 – 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD) (free)

 

6 – Maximum-fixed energy shocks for cardioverting atrial fibrillation – European Heart Journal (free)

Commentary: Comparison of High vs. Escalating Shocks – CHESS – American College of Cardiology (free)

 

7 – Complete Revascularization with Multivessel PCI for Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Complete Versus Culprit-Only Revascularization Strategies to Treat Multivessel Disease After Early PCI for STEMI – COMPLETE – American College of Cardiology (free) AND Complete revascularisation is superior to culprit-lesion only intervention – European Society of Cardiology (free)

Related Cochrane Review: Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (free)

Related Meta-analysis: Complete Revascularization During Primary Percutaneous Coronary Intervention Reduces Death and Myocardial Infarction in Patients With Multivessel Disease: Meta-Analysis and Meta-Regression of Randomized Trials – JACC: Cardiovascular Interventions (free)

 

8 – Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction – DAPA-HF – American College of Cardiology (free) Dapagliflozin reduces death and hospitalisation in patients with heart failure – European Society of Cardiology (free)

 

9 – HiSTORIC Trial Supports Single-Test Rule-Out of MI Using High-Sensitivity Troponin – TCTMD (free) AND Risk-Based Thresholds for hs-Troponin I Safely Speed MI Rule-Out – MedPage Today (free registration required) AND HISTORIC: Early Rule-Out Strategy Using High-Sensitivity Cardiac Troponin I Reduced Length of Stay, Hospital Readmissions in Suspected ACS Patients – American College of Cardiology (free)

Related Studies: Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival (free study and commentaries)

 

10 – High-Sensitivity Troponin and The Application of Risk Stratification Thresholds in Patients with Suspected Acute Coronary Syndrome – Circulation (free PDF)

 

#ESCCongress – 2019 ESC Guidelines for the Diagnosis and Management of Chronic Coronary Syndromes

2 Sep, 2019 | 01:20h | UTC

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC)

News Release: Pollution and noise reduction advised in ESC guidelines on chronic coronary syndromes (free)

 

Related Commentary on Twitter

 

#ESCCongress – 2019 ESC Guidelines for the Diagnosis and Management of Acute Pulmonary Embolism

2 Sep, 2019 | 01:19h | UTC

2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC) (free)

 

Related Commentary on Twitter

 

#ESCCongress – 2019 ESC Guidelines for the Management of Patients with Supraventricular Tachycardia

2 Sep, 2019 | 01:17h | UTC

The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC): Developed in collaboration with the Association for European Paediatric and Congenital Cardiology (AEPC) (free)

 

Related Commentary on Twitter

 

#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias

2 Sep, 2019 | 01:15h | UTC

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) (free)

 

Related Commentary on Twitter

 

#ESCCongress – [Abstract Only] Randomized Trial: Complete Revascularization Superior to Culprit-lesion-only PCI in Patients with ST-segment Elevation Myocardial Infarction (STEMI) and Multivessel Coronary Artery Disease

2 Sep, 2019 | 01:11h | UTC

Complete Revascularization with Multivessel PCI for Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Complete Versus Culprit-Only Revascularization Strategies to Treat Multivessel Disease After Early PCI for STEMI – COMPLETE – American College of Cardiology (free) AND Complete revascularisation is superior to culprit-lesion only intervention – European Society of Cardiology (free)

Related Cochrane Review: Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (free)

Related Meta-analysis: Complete Revascularization During Primary Percutaneous Coronary Intervention Reduces Death and Myocardial Infarction in Patients With Multivessel Disease: Meta-Analysis and Meta-Regression of Randomized Trials – JACC: Cardiovascular Interventions (free)

 

Related Commentary on Twitter

https://twitter.com/tomjcahill/status/1168149684575227905

 

#ESCCongress – 2019 ESC Guidelines on Diabetes, Pre-diabetes, and Cardiovascular Diseases

2 Sep, 2019 | 01:14h | UTC

2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD) (free)

 

Related Commentary on Twitter

 

#ESCCongress – Randomized Trial Suggests Maximum-fixed Energy Shocks (360-360-360 J) are More Effective for Cardioverting Atrial Fibrillation

2 Sep, 2019 | 01:12h | UTC

Maximum-fixed energy shocks for cardioverting atrial fibrillation – European Heart Journal (free)

Commentary: Comparison of High vs. Escalating Shocks – CHESS – American College of Cardiology (free)

 

Related Commentary on Twitter

 

#ESCCongress – [Not Published Yet] Randomized Trial Supports Single High-sensitive Troponin Measurement to Rule out Myocardial Infarction

2 Sep, 2019 | 01:06h | UTC

Commentaries: HiSTORIC Trial Supports Single-Test Rule-Out of MI Using High-Sensitivity Troponin – TCTMD (free) AND Risk-Based Thresholds for hs-Troponin I Safely Speed MI Rule-Out – MedPage Today (free registration required) AND HISTORIC: Early Rule-Out Strategy Using High-Sensitivity Cardiac Troponin I Reduced Length of Stay, Hospital Readmissions in Suspected ACS Patients – American College of Cardiology (free)

Related Studies: Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival (free study and commentaries)

 

Related Commentary on Twitter

 

#ESCCongress – [Not Published Yet] Randomized Trial: SGLT2 inhibitors Seems Beneficial for Heart Failure Even in Nondiabetics

2 Sep, 2019 | 01:09h | UTC

Commentaries: Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction – DAPA-HF – American College of Cardiology (free) Dapagliflozin reduces death and hospitalisation in patients with heart failure – European Society of Cardiology (free)

 

Related Commentary on Twitter

 

#ESCCongress – [Abstract Only] Randomized Trial: Angiotensin–Neprilysin Inhibition Not Beneficial for Heart Failure with Preserved Ejection Fraction

2 Sep, 2019 | 01:03h | UTC

Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: PARAGON-HF: Sacubitril-Valsartan in HFpEF Patients Did Not Result in Significantly Lower Rates of Hospitalizations, Death – American College of Cardiology (free)

 

Related Commentary on Twitter

 

#ESCCongress – Observational Study: A Low High-sensitive Troponin has a Negative Predictive Value of 99.8% for Myocardial Infarction or Cardiac Death Within 30 days in Patients with Suspected Acute Coronary Syndrome and at Least 2 Hours of Symptoms

2 Sep, 2019 | 01:04h | UTC

High-Sensitivity Troponin and The Application of Risk Stratification Thresholds in Patients with Suspected Acute Coronary Syndrome – Circulation (free PDF)

 

#ESCCongress – Cohort Study: Cardiovascular Disease Patients May Benefit More from Exercise than Healthy People

2 Sep, 2019 | 00:58h | UTC

Mortality reduction with physical activity in patients with and without cardiovascular disease – European Heart Journal (free)

News Release: Cardiovascular disease patients benefit more from exercise than healthy people – European Society of Cardiology (free)

 

#ESCCongress – [Abstract Only] Randomized Trial: Prasugrel Better than Ticagrelor for Patients with Acute Coronary Syndrome with Planned Invasive Evaluation

2 Sep, 2019 | 00:59h | UTC

Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Prasugrel cuts ischaemic events in acute coronary syndrome patients – European Society of Cardiology (free) AND Prasugrel Bests Ticagrelor in ACS Patients Heading to PCI: ISAR-REACT 5 – TCTMD (free) AND Intracoronary Stenting and Antithrombotic Regimen 5 – ISAR-REACT 5 – American College of Cardiology (free)

 

Related Commentary on Twitter

 

#ESCCongress – [Not Published Yet] Randomized Trial: Clopidogrel a Better Option than Ticagrelor or Prasugrel for Elderly Patients with Non-ST-segment Elevation Acute Coronary Syndrome

2 Sep, 2019 | 00:57h | UTC

Commentaries: Randomized Comparison of Clopidogrel Versus Ticagrelor or Prasugrel in Patients of 70 years or Older With Non-ST-Elevation Acute Coronary Syndrome – POPular AGE – American College of Cardiology (free) AND POPULAR AGE Supports Clopidogrel Over Ticagrelor in Elderly ACS Patients – TCTMD (free)

 

Meta-Analysis: Menopausal Hormone Therapy Increases Breast Cancer Risk

30 Aug, 2019 | 08:55h | UTC

Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence – The Lancet (free)

Commentaries: Menopausal hormones: definitive evidence for breast cancer – The Lancet (free) AND Menopausal hormone therapy and 20-year breast cancer mortality – The Lancet (free) AND Hormone therapy during menopause raises breast cancer risk for years, study finds – STAT (free) AND Expert reaction to study looking at HRT use and risk of breast cancer – Science Media Centre (free)

 

#ESCCongress – [Abstract Only] Randomized Trial: No Overall Benefit from Ticagrelor added to Aspirin in Patients with Stable Coronary Disease and Diabetes

2 Sep, 2019 | 00:56h | UTC

Ticagrelor in Patients with Stable Coronary Disease and Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Related Study: Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial – The Lancet (free registration required)

Commentaries: THEMIS: No overall benefit of ticagrelor in people with diabetes, coronary artery disease – Medicine Matters (free) AND THEMIS, THEMIS-PCI Assess Benefits of Ticagrelor Plus Aspirin in Patients With Stable CAD and Diabetes, History of PCI – American College of Cardiology (free)

 

Related Commentary on Twitter

https://twitter.com/megnahprakash/status/1168196208847798273

 

Fri August 30 – 10 Stories of The Day!

30 Aug, 2019 | 08:59h | UTC

 

1 – Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence – The Lancet (free)

Commentaries: Menopausal hormones: definitive evidence for breast cancer – The Lancet (free) AND Menopausal hormone therapy and 20-year breast cancer mortality – The Lancet (free) AND Hormone therapy during menopause raises breast cancer risk for years, study finds – STAT (free) AND Expert reaction to study looking at HRT use and risk of breast cancer – Science Media Centre (free)

 

2 – WHO joins coalition for free digital access to health research – World Health Organization (free)

See also: World Health Organization and TDR Join cOAlition S to Support Free and Immediate Access to Health Research – Plan S (free)

Related: Plan S: Making Full and Immediate Open Access a Reality (free) AND Open Access 2018: A Year of Funders and Universities Drawing Lines in the Sand (free)

 

3 – Is IJ or Subclavian Safer Under Ultrasound Guidance? – Journal Feed (free)

Original Article: Complications in internal jugular vs subclavian ultrasound-guided central venous catheterization: a comparative randomized trial – Intensive Care Medicine (free)

 

4 – News Release: FDA recommends health care facilities and manufacturers begin transitioning to duodenoscopes with disposable components to reduce risk of patient infection – U.S. Food & Drug Administration (free)

Commentaries: FDA: Hospitals Should Start Switching to Duodenoscopes with Disposable Endcaps – NEJM Journal Watch (free) AND Hospitals Should Replace Infection-Prone Scopes With Safer Models, F.D.A. Says – The New York Times (10 articles per month are free) AND FDA Urges Transition to Disposable Duodenoscopes – Medscape (free registration required)

Related: Duodenoscopes: These Medical Devices Are Inserted Into 500,000 Patients Each Year — but Are Tough to Sterilize (free commentary, reviews and guidelines)

 

5 – Medical education needs to stop burning out students — now – STAT (free)

Related: Meta-analysis: The Global Prevalence of Anxiety Among Medical Students (free studies)

 

6 – RoB 2: a revised tool for assessing risk of bias in randomised trials – The BMJ (free)

 

7 – Screening for Social Determinants of Health: The Known and Unknown – JAMA (free)

Commentary: JAMA paper: Doctors encouraged to consider social determinants screening, referrals – Northwell Health (free)

 

8 – Initiation of sodium polystyrene sulphonate and the risk of gastrointestinal adverse events in advanced chronic kidney disease: a nationwide study – Nephrology Dialysis Transplantation (free)

Commentary: Hyperkalemia Drug Again Linked to Adverse GI Events – Renal & Urology News (free)

Related Study: Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated with Sodium Polystyrene Sulfonate (link to abstract and commentary)

 

9 – Use of sodium glucose cotransporter 2 inhibitors and risk of major cardiovascular events and heart failure: Scandinavian register based cohort study – The BMJ (free)

Commentaries: SGLT2 inhibitors cut heart failure risk for T2D patients – Cardiovascular Business (free) AND Newer diabetes drug drops heart failure risk by 34 percent, study says – UPI (free)

Related observational studies: SGLT2 agents may reduce cardiovascular risk in diabetics (link to abstract and commentaries)

 

10 – Intake of Dietary Fiber, Fruits, and Vegetables and Risk of Diverticulitis – American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: More fruit and cereal fiber tied to less risk of common bowel disease – Reuters (free)

 

Randomized Trial: Is Internal Jugular or Subclavian Safer Under Ultrasound Guidance?

30 Aug, 2019 | 08:52h | UTC

Is IJ or Subclavian Safer Under Ultrasound Guidance? – Journal Feed (free)

Original Article: Complications in internal jugular vs subclavian ultrasound-guided central venous catheterization: a comparative randomized trial – Intensive Care Medicine (free)

 

WHO Joins Coalition for Free Digital Access to Health Research

30 Aug, 2019 | 08:53h | UTC

WHO joins coalition for free digital access to health research – World Health Organization (free)

See also: World Health Organization and TDR Join cOAlition S to Support Free and Immediate Access to Health Research – Plan S (free)

Related: Plan S: Making Full and Immediate Open Access a Reality (free) AND Open Access 2018: A Year of Funders and Universities Drawing Lines in the Sand (free)

 

FDA Recommends Transition to Duodenoscopes with Disposable Components to Reduce Risk of Patient Infection

30 Aug, 2019 | 08:50h | UTC

News Release: FDA recommends health care facilities and manufacturers begin transitioning to duodenoscopes with disposable components to reduce risk of patient infection – U.S. Food & Drug Administration (free)

Commentaries: FDA: Hospitals Should Start Switching to Duodenoscopes with Disposable Endcaps – NEJM Journal Watch (free) AND Hospitals Should Replace Infection-Prone Scopes With Safer Models, F.D.A. Says – The New York Times (10 articles per month are free) AND FDA Urges Transition to Disposable Duodenoscopes – Medscape (free registration required)

Related: Duodenoscopes: These Medical Devices Are Inserted Into 500,000 Patients Each Year — but Are Tough to Sterilize (free commentary, reviews and guidelines)

 

Perspective: Medical Education Needs to Stop Burning out Students — Now

30 Aug, 2019 | 08:46h | UTC

Medical education needs to stop burning out students — now – STAT (free)

Related: Meta-analysis: The Global Prevalence of Anxiety Among Medical Students (free studies)

 

RoB 2: A Revised Tool for Assessing Risk of Bias in Randomized Trials

30 Aug, 2019 | 08:36h | UTC

RoB 2: a revised tool for assessing risk of bias in randomised trials – The BMJ (free)

 

Study: Sodium Polystyrene Sulphonate is Associated with Increased Risk of GI Adverse Events in Patients with CKD

30 Aug, 2019 | 08:28h | UTC

Initiation of sodium polystyrene sulphonate and the risk of gastrointestinal adverse events in advanced chronic kidney disease: a nationwide study – Nephrology Dialysis Transplantation (free)

Commentary: Hyperkalemia Drug Again Linked to Adverse GI Events – Renal & Urology News (free)

Related Study: Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated with Sodium Polystyrene Sulfonate (link to abstract and commentary)

 

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