Archives

“longer follow-up regarding valve degeneration will be needed to confirm TAVR as the preferred treatment for low-risk patients with severe AS.” (from American College of Cardiology)

9 – Cochrane Special Collection: Diagnosing Dementia – Cochrane Library (free articles)

Commentary: Dementia diagnosis: a decade of evidence – Evidently Cochrane (free)

10 – News Release: AAN Recommends People 65+ be Screened Yearly for Memory Problems – American Academy of Neurology (free)

Original Recommendations: Quality improvement in neurology: Mild cognitive impairment quality measurement set – American Academy of Neurology (free PDF)

USPSTF Disagrees: USPSTF Draft Statement: Insufficient Evidence to Recommend Screening for Cognitive Impairment in Older Adults (free)

Guideline: Diagnosis and Treatment of Low Back Pain

20 Sep, 2019 | 08:25h | UTC

VA/DoD Clinical Practice Guideline: Diagnosis and Treatment of Low Back Pain – Journal of General Internal Medicine (free)

Source: Low back pain: joint guidelines from US Departments of Veterans Affairs, Defense – Univadis (free registration required)

Cohort Study: Lateral Nodal Features on Restaging MRI Associated with Lateral Local Recurrence in Low Rectal Cancer

22 Sep, 2019 | 22:46h | UTC

Lateral Nodal Features on Restaging Magnetic Resonance Imaging Associated With Lateral Local Recurrence in Low Rectal Cancer After Neoadjuvant Chemoradiotherapy or Radiotherapy – JAMA Surgery (free for a limited period)

Commentaries: Lateral Lymph Nodes as the Achilles Heel of Low Rectal Cancer Surgery After Neoadjuvant Chemoradiation Therapy: Are We Close to Solving the Riddle? – JAMA Surgery (free) AND Features on Restaging MRI Associated With Local Recurrence After Neoadjuvant Treatment in Low Rectal Cancer – The ASCO Post (free) AND MRI Helps Decisions on Lateral Nodal Disease in Rectal Cancer – Medscape (free registration required)

[Abstract Only] Randomized Trial: SGLT2 Inhibitor Improves Outcomes in Patients with Heart Failure Even in the Absence of Diabetes

20 Sep, 2019 | 08:27h | UTC

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction – New England Journal of Medicine (link to abstract – $ for full-text)

Related 2019 ESC Congress News Release, Before Publication: Randomized Trial: SGLT2 inhibitors Seems Beneficial for Heart Failure Even in Nondiabetics (free commentaries)

Commentaries: SGLT2 Inhibitor Dapagliflozin Lowers Risk for Worsening Heart Failure – NEJM Journal Watch (free) AND New research shows dapagliflozin used to treat diabetes can also treat heart failure, in patients with and without diabetes (the DAPA-HF Study) – Diabetologia (free)

Randomized Trial: No Difference in Major Cardiovascular Outcomes in Patients with Type 2 Diabetes Treated with DPP-4 Inhibitor vs. Sulfonylurea

20 Sep, 2019 | 08:15h | UTC

Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Sulfonylureas and Cardiovascular Safety: The Final Verdict? – JAMA (free for a limited period)

Commentary: CAROLINA: No Added Heart Risk With Sulfonylureas – MedPage Today (free registration required)

Cohort Study: Early Palliative Care Linked to Increased Survival and Reduced Risk of Death in an Acute Care Setting Among Patients with Advanced Lung Cancer

20 Sep, 2019 | 08:21h | UTC

Association of Early Palliative Care Use With Survival and Place of Death Among Patients With Advanced Lung Cancer Receiving Care in the Veterans Health Administration – JAMA Oncology (free for a limited period)

Editorial: Prolonged Survival With Palliative Care—It Is Possible, but Is It Necessary? (free)

Commentaries: Early Palliative Care Associated with Increased Survival in Lung Cancer Patients – MedicalResearch.com (free) AND Early palliative care for advanced lung cancer increases survival – Veterans Affairs Research Communications (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free summary and original article)

Metabolic Support in the Critically Ill: A Consensus of 19

20 Sep, 2019 | 08:12h | UTC

Metabolic support in the critically ill: a consensus of 19 – Critical Care (free) (via Park M, MD)

Meta-analysis: Preoxygenation Before Intubation in Adult Patients with Acute Hypoxemic Respiratory Failure

20 Sep, 2019 | 08:14h | UTC

Preoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials – Critical Care (free) (via Park M, MD)

Cohort Study: Metformin Linked to Reduced Risk of Cardiovascular Events Compared to Sulfonylurea Among Patients with Diabetes and Reduced Kidney Function

20 Sep, 2019 | 08:19h | UTC

Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function – JAMA (free for a limited period)

Commentaries: Metformin Superior for Lowering CV Risk in Diabetics Who Progress to CKD – Renal & Urology News (free) AND Metformin Monotherapy Benefits Heart Even in Early CKD – MedPage Today (free registration required)

Related Commentary on Twitter

Monotherapy treatment with #metformin, compared with a #sulfonylurea, was associated with a lower risk of MACE among patients with diabetes and reduced kidney function https://t.co/Z1EZAjOOET

— JAMA (@JAMA_current) September 19, 2019

Meta-Analysis: Transcatheter vs. Surgical Aortic Valve Replacement in Low-Risk Patients

20 Sep, 2019 | 08:07h | UTC

Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Meta-Analysis of TAVR vs. SAVR in Low-Risk Patients – American College of Cardiology (free) AND TAVR Survival Surpasses SAVR in Low-Risk Patients: Meta-analysis – Medscape (free registration required)

“The one clear unknown that everyone points to is valve durability” (form Medscape)

“longer follow-up regarding valve degeneration will be needed to confirm TAVR as the preferred treatment for low-risk patients with severe AS.” (from American College of Cardiology)

Cochrane Special Collection: Diagnosing Dementia

20 Sep, 2019 | 08:06h | UTC

Cochrane Special Collection: Diagnosing Dementia – Cochrane Library (free articles)

Commentary: Dementia diagnosis: a decade of evidence – Evidently Cochrane (free)

Study: Half of Trials Supporting New Cancer Drug Approvals in Europe Were Judged to be at High Risk of Bias

20 Sep, 2019 | 07:46h | UTC

Design characteristics, risk of bias, and reporting of randomised controlled trials supporting approvals of cancer drugs by European Medicines Agency, 2014-16: cross sectional analysis – The BMJ (free)

Editorial: Flawed evidence underpins approval of new cancer drugs (free)

Commentaries: Gauging the validity of cancer drug trials: a call for collaboration – The BMJ Opinion (free) AND Questions raised over quality of trials supporting new cancer drugs approvals – OnMedica (free) AND Evidence underpinning approval of new cancer drugs raises questions – The BMJ (free)

“Around half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, which indicates that treatment effects might have been exaggerated, concludes a new study.” (from The BMJ news release)

AAN Recommends People 65+ be Screened Yearly for Memory Problems

20 Sep, 2019 | 08:03h | UTC

News Release: AAN Recommends People 65+ be Screened Yearly for Memory Problems – American Academy of Neurology (free)

Original Recommendations: Quality improvement in neurology: Mild cognitive impairment quality measurement set – American Academy of Neurology (free PDF)

USPSTF Disagrees: USPSTF Draft Statement: Insufficient Evidence to Recommend Screening for Cognitive Impairment in Older Adults (free)

Guideline: Rotator Cuff Repair Surgery Procedure‐specific Postoperative Pain Management Recommendations

20 Sep, 2019 | 07:44h | UTC

PROSPECT guideline for rotator cuff repair surgery: systematic review and procedure‐specific postoperative pain management recommendations – Anaesthesia (free)

Systematic Review: The Association Between Headache and Low Back Pain

20 Sep, 2019 | 07:45h | UTC

The association between headache and low back pain: a systematic review – The Journal of Headache and Pain (free)

Commentary: Persistent headache or back pain ‘twice as likely’ in the presence of the other – University of Warwick (free)

News Releases: 4 groups issue consensus report on healthy beverages for 0- to 5-year-olds – American Academy of Pediatrics (free) AND Leading Health Organizations Support First-Ever Consensus Recommendations to Encourage Young Children’s Consumption of Healthy Drinks – American Heart Association (free)

Commentaries: What Should Young Children Drink? Mostly Milk and Water, Scientists Say – The New York Times (10 articles per month are free) AND Parents Should Limit Kids’ Juice Consumption, Guidelines Say – U.S. News (free)

See also: Health Kids, Health Drinks (free resources for the public)

2 – Global Preparedness Monitoring Board. A world at risk: annual report on global preparedness for health emergencies – World Health Organization (free PDF)

See also: Executive Summary (free PDF) AND Global Preparedness Monitoring Board Website (free resources)

Commentaries: Experts detail global pandemic readiness gaps, offer steps – CIDRAP (free) AND World at risk of pandemics that could kill millions, panel warns – Reuters (free) AND Experts warn world ‘grossly unprepared’ for future pandemics – The Guardian (free)

3 – Polypill for Cardiovascular Disease Prevention in an Underserved Population – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Polypill Drops BP, LDL Cholesterol in a Disadvantaged US Population – TCTMD (free) AND One daily combo pill helps lower heart disease risk in study of underserved patients – American Heart Association (free) AND Fixed Dose Combination Polypill Can Reduce Barriers to Cardiovascular Care – MedicalResearch.com (free) AND One pill with four drugs may lower heart risks in poor population – Reuters (free) AND All-in-One Pill Reduces Blood Pressure, Cholesterol Levels in U.S. Study – Vanderbilt University Medical Center (free)

Related Randomized Trial: Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases (link to abstract and commentaries)

4 – C-section babies are missing key microbes – Nature News (free)

Original Study: Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth – Nature (link to abstract – $ for full-text)

Other Commentaries: Babies’ gut bacteria affected by delivery method, Baby Biome project shows – Wellcome Sanger Institute (free) AND Babies born by C-section have more potentially infectious bacteria in their guts – ScienceNews (free)

“UK study provides the best evidence yet that the way infants are born can alter their microbiomes — but the health effects are unclear.”

5 – Less is more in critical care is supported by evidence-based medicine – Intensive Care Medicine (free for a limited period)

Related: Less is More: Ten Reasons for Considering to Discontinue Unproven Interventions (free commentaries)

6 – Less is more in nutrition: critically ill patients are starving but not hungry – Intensive Care Medicine (free)

7 – Alex Nowbar’s journal review, 18 September 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

8 – National Trends in Utilization and 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys – Journal of the American Society of Nephrology (link to abstract – $ for full-text)

Commentaries: HCV-Infected Donor Kidneys Offer Good Short-Term Graft Function – Renal & Urology News (free) AND Hepatitis C-infected kidneys function as well as others after transplant, study says – CNN (free) AND Hepatitis C-Infected Kidneys Function Similar to Uninfected Organs One Year After Transplant – Penn Medicine (free) AND Kidney Transplants from Donors with HCV Safe and Functional 1 Year Post-Transplantation – American Society of Nephrology (ASN) (free)

Related Studies: Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients (link to abstract and commentaries) AND Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients (link to abstract and commentaries) AND Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus–Infected Donors to Noninfected Recipients (link to abstract and commentaries)

9 – Testing for Meningitis in Febrile Well-Appearing Young Infants With a Positive Urinalysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Could meningitis testing be omitted in febrile infants with positive UTI? – Univadis (free registration required)

10 – Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis. An Official American Thoracic Society Research Statement – American Journal of Respiratory and Critical Care Medicine (free)

Related: Immune Checkpoint Inhibitor Toxicities (guidelines and reviews on the subject)

Consensus Statement: Healthy Beverage Consumption in Early Childhood: Recommendations from Key Health and Nutrition Organizations

19 Sep, 2019 | 10:28h | UTC

Consensus Statement: Healthy Beverage Consumption in Early Childhood: Recommendations from Key National Health and Nutrition Organizations – Health Eating Research (free PDF)

News Releases: 4 groups issue consensus report on healthy beverages for 0- to 5-year-olds – American Academy of Pediatrics (free) AND Leading Health Organizations Support First-Ever Consensus Recommendations to Encourage Young Children’s Consumption of Healthy Drinks – American Heart Association (free)

Commentaries: What Should Young Children Drink? Mostly Milk and Water, Scientists Say – The New York Times (10 articles per month are free) AND Parents Should Limit Kids’ Juice Consumption, Guidelines Say – U.S. News (free)

See also: Health Kids, Health Drinks (free resources for the public)

A World at Risk: Annual Report on Global Preparedness for Health Emergencies

19 Sep, 2019 | 10:27h | UTC

Global Preparedness Monitoring Board. A world at risk: annual report on global preparedness for health emergencies – World Health Organization (free PDF)

See also: Executive Summary (free PDF) AND Global Preparedness Monitoring Board Website (free resources)

Commentaries: Experts detail global pandemic readiness gaps, offer steps – CIDRAP (free) AND World at risk of pandemics that could kill millions, panel warns – Reuters (free) AND Experts warn world ‘grossly unprepared’ for future pandemics – The Guardian (free)

Less is More in Critical Care is Supported by Evidence-based Medicine

19 Sep, 2019 | 08:15h | UTC

Less is more in critical care is supported by evidence-based medicine – Intensive Care Medicine (free for a limited period)

[Abstract Only] Randomized Trial: Polypill for Cardiovascular Disease Prevention in an Underserved Population

19 Sep, 2019 | 08:19h | UTC

Polypill for Cardiovascular Disease Prevention in an Underserved Population – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Polypill Drops BP, LDL Cholesterol in a Disadvantaged US Population – TCTMD (free) AND One daily combo pill helps lower heart disease risk in study of underserved patients – American Heart Association (free) AND Fixed Dose Combination Polypill Can Reduce Barriers to Cardiovascular Care – MedicalResearch.com (free) AND One pill with four drugs may lower heart risks in poor population – Reuters (free) AND All-in-One Pill Reduces Blood Pressure, Cholesterol Levels in U.S. Study – Vanderbilt University Medical Center (free)

Related Randomized Trial: Effectiveness of Polypill for Primary and Secondary Prevention of Cardiovascular Diseases (link to abstract and commentaries)

Ritalin at 75: What Does the Future Hold?

Study: Hand Sanitizer Shown Less Effective than Hand Washing Against Flu

Study: Prediction System for Risk of Allograft Loss in Patients Receiving Kidney Transplants

Fri September 20 – 10 Stories of The Day!