Archives
NICE Guideline: Cannabis-Based Medicinal Products
12 Nov, 2019 | 11:27h | UTCCannabis-based medicinal products – National Institute for Health and Care Excellence (free)
Commentaries: Drug experts on the new guidance for medicinal cannabis – The Conversation (free) AND Ian Hamilton: New guidelines for prescribing medicinal cannabis—another dashed hope for patients – The BMJ Opinion (free)
Related: Guideline for Prescribing Medical Cannabinoids in Primary Care – Canadian Family Physician (free) AND Cannabinoids for Chronic Pain – Therapeutics Initiative AND (free) Meta-Analysis: Insufficient Evidence for The Use of Cannabinoids for Treating Mental Disorders – The Lancet Psychiatry (link to abstract and commentaries) AND The Effects of Cannabis Among Adults With Chronic Pain – Annals of Internal Medicine (link to abstract and commentaries)
“In short, NICE has concluded that more research is needed before it can recommend the use of cannabis-based products for medicinal use.” (from The Conversation)
Choosing Wisely in Otology/Neurotology: Five Things Physicians and Patients Should Question
13 Nov, 2019 | 10:35h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
ACR Consensus Guideline: O-RADS Risk Stratification and Management System for Ovarian-Adnexal Reporting
12 Nov, 2019 | 11:25h | UTC
#ACR19 – Randomized Trial: Low-Dose Corticosteroids for Short Periods Effective and Safe for Hand Osteoarthritis
12 Nov, 2019 | 11:23h | UTCResults of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial – The Lancet (free registration required)
Commentaries: Low-Dose Oral Prednisolone Substantially Improves Pain and Function in Hand Osteoarthritis – American College of Rheumatology (free) AND Short-term prednisolone offers HOPE for painful hand osteoarthritis – Medicine Matters (free) AND Short Course of Low-Dose Prednisolone for Painful Hand Osteoarthritis – MedicalResearch.com (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
Study: Testosterone Therapy Linked to Increased Risk of Venous Thromboembolism Among Men with and Without Hypogonadism
12 Nov, 2019 | 11:22h | UTCAssociation of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Using testosterone therapy in 6-month case period associated with doubling of VTE risk for men both with and without clinical hypogonadism. https://t.co/rosKWgWgBS
— JAMA Internal Medicine (@JAMAInternalMed) November 11, 2019
Meta-Analysis: Aspirin for Primary Prevention of Cardiovascular Disease with a Particular Focus on Subgroups
12 Nov, 2019 | 11:19h | UTCRelated: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)
Meta-Analysis: Nutrient Supplements Reduce Child Mortality in Low- and Middle-income Countries
12 Nov, 2019 | 11:17h | UTCCommentaries: Nutrient supplements significantly reduce child deaths – University of California (free) AND Children receiving small-quantity lipid-based nutrient supplementary foods have lower mortality rates – American Society for Nutrition (free)
Onco-Nephrology: Cancer, Chemotherapy and Kidney
12 Nov, 2019 | 11:15h | UTCOnco-Nephrology: Cancer, chemotherapy and kidney – Nephrología (free)
Related: Onco-Nephrology: Core Curriculum – American Journal of Kidney Diseases (free) AND Onco-nephrology: an appraisal of the cancer and chronic kidney disease links – Nephrology Dialysis Transplantation (free) AND Opening an onconephrology clinic: recommendations and basic requirements – Nephrology Dialysis Transplantation (free) AND Onco-nephrology: current concepts and future perspectives – Japanese Journal of Clinical Oncology (free)
Randomized Trial: 0/1-hour High-sensitivity Cardiac Troponin T Protocol Enables Faster Discharge of Patients with Suspected Acute Coronary Syndrome
12 Nov, 2019 | 11:20h | UTCA Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes – Circulation (free for a limited period)
Commentaries: World-First Trial Cuts ED Wait Times and Admissions – Flinders University (free) AND Ruling Out MI Safe With 0/1-Hour High-Sensitivity Troponin: RAPID-TNT – TCTMD (free)
Related Studies/Commentaries Highlighting Problems with High-sensitivity Cardiac Troponin: Myths in Emergency Medicine: Is hs-cTnT Worth the Downstream Testing? – Emergency Medicine News (free) AND Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome – The Lancet (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival – Journal of the American College of Cardiology (free) AND Cohort Study: High Sensitivity Cardiac Troponin May Result in Misdiagnosis of Acute Myocardial Infarction – The BMJ (free)
Guideline: Diagnosis, Therapy and Follow-up of Vaginal Cancer
12 Nov, 2019 | 10:53h | UTC
Review: Sleep-Related Disorders in Neurology and Psychiatry
12 Nov, 2019 | 11:16h | UTCSleep-Related Disorders in Neurology and Psychiatry – Deutsches Ärzteblatt international (free)
Perspective: Hospital Administration Response to Physician Stress and Burnout
12 Nov, 2019 | 10:52h | UTCHospital administration response to physician stress and burnout – Journal of Hospital Practice (free)
Source: Hospital Medicine Virtual Journal Club
Meta-Analysis: Different Transmission Routes and the Risk of Advanced HIV Disease
12 Nov, 2019 | 10:51h | UTC
Review: Transcatheter Mitral Valve Replacement in the Transcatheter Aortic Valve Replacement Era
12 Nov, 2019 | 10:50h | UTC
#ACR19 – [Not Published Yet] Randomized Trial: Methotrexate May Reduce Joint Damage Progression in Erosive Hand Osteoarthritis
12 Nov, 2019 | 10:49h | UTCAbstract: Methotrexate in Patients with Hand Erosive Osteoarthritis Refractory to Usual Treatments: A Randomized, Double-blind, Placebo-controlled Trial (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
#ACR19 – [Not Published Yet] Randomized Trial: Ultrasound to Guide Treatment Strategy Not Beneficial in Early Rheumatoid Arthritis
12 Nov, 2019 | 10:46h | UTCUltrasound to Guide Treatment Strategy Not Beneficial in Early RA – American College of Rheumatology (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
#ACR19 – [Not Published Yet] Study: Hydroxychloroquine May Reduce the Risk of Recurrent Congenital Heart Block in Subsequent Pregnancies of Women with Anti-SSA/Ro Antibodies
12 Nov, 2019 | 10:48h | UTC#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
#ACR19 – [Not Published Yet] Study: Gadolinium-Enhanced MRI of Shoulders May Improve Diagnostic Accuracy and Predict Polymyalgia Rheumatica Recurrence
12 Nov, 2019 | 10:45h | UTC#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
#ACR19 – [Not Published Yet] Meta-Analysis: For People with Osteoarthritis, Opioids Offer Minor Pain Relief and Function Benefits, but No Quality of Life Benefit
12 Nov, 2019 | 10:48h | UTCAbstract: Is There Any Role for Opioids in the Management of OA? (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
#KidneyWk – Randomized Trial: Vitamin D and Omega-3 Fatty Acids Do Not Preserve Kidney Function in Patients with Type 2 Diabetes
10 Nov, 2019 | 14:36h | UTCEffect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)
Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
Related Commentary on Twitter
Study findings do not support the use of #vitaminD or #omega3 fatty acid supplementation for preserving kidney function in adults with #type2diabetes https://t.co/ppUnvwMXRR #KidneyWk
— JAMA (@JAMA_current) November 9, 2019
#ACR19 – [Not Published Yet] Cohort Study: Half of People with Rheumatoid Arthritis Treated with Immune Checkpoint Inhibitors for Cancer Experience Flare, but Most Able to Continue Treatment
12 Nov, 2019 | 10:45h | UTCAbstract: Risk of Immunotherapy Related Toxicity in Patients with Rheumatoid Arthritis (free)
#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting
Mon November 11 – 10 Stories of The Day!
11 Nov, 2019 | 11:40h | UTC
1 – Development of Risk Prediction Equations for Incident Chronic Kidney Disease – JAMA (free for a limited period)
See Calculator: Risk of Developing Reduced Kidney Function (free tool)
Editorial: Predicting Risk of Kidney Disease: Is Risk-Based Kidney Care on the Horizon? – JAMA (free for a limited period)
Commentaries: New Tool Predicts Five-Year Risk of Chronic Kidney Disease With High Accuracy – Johns Hopkins Bloomberg School of Public Health (free) AND Researchers Develop Tool to Identify Those at Risk of Future CKD – AJMC (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
2 – Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)
Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
3 – Association of Baclofen with Encephalopathy in Patients With Chronic Kidney Disease – JAMA (free for a limited period)
Commentary: Common muscle relaxant causes severe confusion in patients with kidney disease – University of Western Ontario (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
4 – A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
6 – CDC Reports: Risk Factors for E-Cigarette, or Vaping, Product Use–Associated Lung Injury (EVALI) Among Adults Who Use E-Cigarette, or Vaping, Products — Illinois, July–October 2019 (free) AND Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injury — 10 States, August–October 2019 (free)
Commentaries: In a breakthrough, health officials identify possible culprit behind vaping illnesses: vitamin E acetate – STAT (free) AND Vaping Illnesses Are Linked to Vitamin E Acetate, C.D.C. Says – The New York Times (10 articles per month are free) AND CDC Finds Possible Culprit In Outbreak Of Vaping-Related Lung Injuries – NPR (free)
Related: Viewpoint: Vaping—Seeking Clarity in a Time of Uncertainty (free) AND “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)
Related Guidelines: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and resources) AND Cardiovascular disease: risk assessment and reduction, including lipid modification – National Institute for Health and Care Excellence (free) AND Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal (free)
8 – #181 The Multimorbidity Games with Josh Uy MD – The Curbsiders Internal Medicine Podcast (free audio)
See also: Episode List
Related: Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free) AND Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free)
9 – Association of Autofluorescence-Based Detection of the Parathyroid Glands During Total Thyroidectomy With Postoperative Hypocalcemia Risk: Results of the PARAFLUO Multicenter Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Invited Commentary: New Technique to Reduce the Risk For Hypocalcemia in Thyroid Surgery (free for a limited period)
Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)
“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”
#KidneyWk – [Abstract Only] Randomized Trial: New Drug May Reduce Itch Intensity in Hemodialysis Patients
10 Nov, 2019 | 14:34h | UTCA Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
#KidneyWk – Study: Development of a Risk Prediction Calculator for Incident Chronic Kidney Disease
10 Nov, 2019 | 14:39h | UTCDevelopment of Risk Prediction Equations for Incident Chronic Kidney Disease – JAMA (free for a limited period)
See Calculator: Risk of Developing Reduced Kidney Function (free tool)
Editorial: Predicting Risk of Kidney Disease: Is Risk-Based Kidney Care on the Horizon? – JAMA (free for a limited period)
Commentaries: New Tool Predicts Five-Year Risk of Chronic Kidney Disease With High Accuracy – Johns Hopkins Bloomberg School of Public Health (free) AND Researchers Develop Tool to Identify Those at Risk of Future CKD – AJMC (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
Related Commentary on Twitter
Equations for predicting risk of incident #CKD were developed from more than 5 million individuals from 34 multinational cohorts and demonstrated high discrimination and variable calibration in diverse populations https://t.co/7uNRpv4m3Y #KidneyWk
— JAMA (@JAMA_current) November 8, 2019
CDC: Vaping Lung Illness Probably Caused by Vitamin E Acetate
10 Nov, 2019 | 14:30h | UTCCDC Reports: Risk Factors for E-Cigarette, or Vaping, Product Use–Associated Lung Injury (EVALI) Among Adults Who Use E-Cigarette, or Vaping, Products — Illinois, July–October 2019 (free) AND Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injury — 10 States, August–October 2019 (free)
Commentaries: In a breakthrough, health officials identify possible culprit behind vaping illnesses: vitamin E acetate – STAT (free) AND Vaping Illnesses Are Linked to Vitamin E Acetate, C.D.C. Says – The New York Times (10 articles per month are free) AND CDC Finds Possible Culprit In Outbreak Of Vaping-Related Lung Injuries – NPR (free)
Related: Viewpoint: Vaping—Seeking Clarity in a Time of Uncertainty (free) AND “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)