Archives
#KidneyWk – Study: Baclofen Associated with Increased Risk of Encephalopathy in Patients with Chronic Kidney Disease
10 Nov, 2019 | 14:35h | UTCAssociation of Baclofen with Encephalopathy in Patients With Chronic Kidney Disease – JAMA (free for a limited period)
Commentary: Common muscle relaxant causes severe confusion in patients with kidney disease – University of Western Ontario (free)
#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
#KidneyWk – [Not Published Yet] Randomized Trial: Less Expensive Azathioprine as Good as Mycophenolate Mofetil in Kidney Transplant Recipients on Steroid-Free Low-Dose Cyclosporine Immunosuppression
10 Nov, 2019 | 14:33h | UTC#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019
Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology – 2019
10 Nov, 2019 | 13:59h | UTCRelated Guidelines: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and resources) AND Cardiovascular disease: risk assessment and reduction, including lipid modification – National Institute for Health and Care Excellence (free) AND Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal (free)
A New Twenty-first Century Science for Effective Epidemic Response
10 Nov, 2019 | 13:41h | UTCA new twenty-first century science for effective epidemic response – Nature (free for a limited period)
Podcast: Management of Multimorbidity
10 Nov, 2019 | 13:55h | UTC#181 The Multimorbidity Games with Josh Uy MD – The Curbsiders Internal Medicine Podcast (free text and audio)
See also: Episode List
Related: Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free) AND Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free)
FDA Safety Communication: Biotin Supplements May Result in Falsely Low Troponin Results
10 Nov, 2019 | 13:43h | UTCCommentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)
“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”
Practice-Changing? – Randomized Trial: Autofluorescence-Based Detection of the Parathyroid Glands During Total Thyroidectomy Reduces Postoperative Hypocalcemia Risk
10 Nov, 2019 | 13:45h | UTCAssociation of Autofluorescence-Based Detection of the Parathyroid Glands During Total Thyroidectomy With Postoperative Hypocalcemia Risk: Results of the PARAFLUO Multicenter Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Invited Commentary: New Technique to Reduce the Risk For Hypocalcemia in Thyroid Surgery (free for a limited period)
Meta-Analysis: Intravenous vs. Intravenous/Oral Antibiotics for Perforated Appendicitis in Pediatric Patients
10 Nov, 2019 | 13:34h | UTC
Meta-Analysis: Tool-Assisted Target Weight Adjustments in Chronic Dialysis Patients
10 Nov, 2019 | 13:38h | UTC
Study Commentary: Can C-reactive Protein Improve Treatment for COPD Exacerbations?
10 Nov, 2019 | 13:25h | UTCCan C-reactive protein improve treatment for COPD exacerbations? – PulmCCM (free)
Original Study: Randomized Trial: C-Reactive Protein Can Guide Antibiotics for COPD Exacerbations (link to abstract and commentaries)
Guideline Summary: Obesity Hypoventilation Syndrome
10 Nov, 2019 | 13:11h | UTCNew guidelines on obesity hypoventilation syndrome released – PulmCCM (free)
Original Article: ATS Guideline: Evaluation and Management of Obesity Hypoventilation Syndrome (free article and news release)
Recent Advances in Therapies for Eating Disorders
10 Nov, 2019 | 13:02h | UTCRecent advances in therapies for eating disorders – F1000Research (free)
Related Guidelines: Eating disorders: recognition and treatment – NICE Guideline (free) AND Gynecologic Care for Adolescents and Young Women With Eating Disorders – American College of Obstetricians and Gynecologists (free)
[Abstract Only] Randomized Trial: Treatments for Relapsed or Refractory FLT3-mutated Acute Myeloid Leukemia Compared
10 Nov, 2019 | 12:57h | UTCGilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: ADMIRAL: Gilteritinib vs Chemotherapy in Relapsed or Refractory FLT3-Mutated AML – The ASCO Post (free)
Review: Management of Cervical Spine Trauma in Children
10 Nov, 2019 | 13:05h | UTCManagement of cervical spine trauma in children – European Journal of Trauma and Emergency Surgery (free)
Viewpoint: Vaping—Seeking Clarity in a Time of Uncertainty
8 Nov, 2019 | 08:28h | UTCVaping—Seeking Clarity in a Time of Uncertainty – JAMA (free for a limited period)
Author Interview: Vaping—Seeking Clarity in a Time of Uncertainty (free audio)
Related: “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)
NCCN Guidelines: Gestational Trophoblastic Neoplasia
10 Nov, 2019 | 12:51h | UTC
NCCN Guidelines Insights: Kidney Cancer
10 Nov, 2019 | 12:49h | UTC
Fri November 8 – 10 Stories of The Day!
8 Nov, 2019 | 08:42h | UTC
Commentary: The Management of Subclinical Atrial Fibrillation: The Pathway to True Medical Expertise – American Heart Association (free)
Top Things to Know: Subclinical and Device-Detected Atrial Fibrillation (free)
Related: Apple Watch Can Spot Atrial Fibrillation, But More Research is Needed (several commentaries on the subject)
2 – Vaping—Seeking Clarity in a Time of Uncertainty – JAMA (free for a limited period)
Author Interview: Vaping—Seeking Clarity in a Time of Uncertainty (free audio)
Related: “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)
Commentaries: Vaping not worth potential heart risk, researchers say – Ohio State University (free) AND Vaping risks significant, says new review – News Medical (free) AND E-cigs may damage the heart, study says – MedicalXpress (free)
Related: Alveolar recruitment in acute respiratory distress syndrome: should we open the lung (no matter what) or may accept (part of) the lung closed? – Intensive Care Medicine (free) AND Recruitment maneuver does not provide any mortality benefit over lung protective strategy ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis and systematic review of the randomized controlled trials – Journal of Intensive Care (free) AND Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free study and editorial)
6 – Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)
Source: EvidenceAlerts
“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”
7 – Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)
Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)
Commentary: Choosing Wisely Examines Pediatric Surgical Practices to Avoid – NEJM Journal Watch (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
9 – Ann Robinson’s journal review, 7 November 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
Commentaries: Difficulty sleeping linked with raised risk of heart attack and stroke – NHS Choices (free) AND Insomnia in adults linked to heart attack and stroke – CNN (free) AND Insomnia maybe a significant risk factor for heart attacks and strokes – News Medical (free)
Cardiovascular Risk of Electronic Cigarettes: A Review of Preclinical and Clinical Studies
8 Nov, 2019 | 08:22h | UTCCommentaries: Vaping not worth potential heart risk, researchers say – Ohio State University (free) AND Vaping risks significant, says new review – News Medical (free) AND E-cigs may damage the heart, study says – MedicalXpress (free)
AHA Scientific Statement: Subclinical and Device-Detected Atrial Fibrillation: Pondering the Knowledge Gap
8 Nov, 2019 | 08:38h | UTCCommentary: The Management of Subclinical Atrial Fibrillation: The Pathway to True Medical Expertise – American Heart Association (free)
Top Things to Know: Subclinical and Device-Detected Atrial Fibrillation (free)
Related: Apple Watch Can Spot Atrial Fibrillation, But More Research is Needed (several commentaries on the subject)
Meta-Analysis: Effect of Lung Recruitment Maneuver on Oxygenation, Physiological Parameters and Mortality in ARDS Patients
8 Nov, 2019 | 08:00h | UTCRelated: Alveolar recruitment in acute respiratory distress syndrome: should we open the lung (no matter what) or may accept (part of) the lung closed? – Intensive Care Medicine (free) AND Recruitment maneuver does not provide any mortality benefit over lung protective strategy ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis and systematic review of the randomized controlled trials – Journal of Intensive Care (free) AND Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free study and editorial)
[Abstract Only] Randomized Trial Suggests Possible Harm from Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation
8 Nov, 2019 | 07:49h | UTCRandomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)
Source: EvidenceAlerts
“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”
Systematic Review: Strategies to Reduce Non-ventilator-associated Hospital-acquired Pneumonia
8 Nov, 2019 | 08:14h | UTC
Ann Robinson’s journal review—7 November 2019
8 Nov, 2019 | 07:15h | UTCAnn Robinson’s journal review, 7 November 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
[Abstract Only] Study: Evidence of Bacterial Transmission from Probiotic Capsule to Blood in ICU Patients
8 Nov, 2019 | 07:36h | UTCGenomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)
Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)
Related Commentary on Twitter
The use of #probiotics in hospitals is increasing. Now the first proof via genomic sequencing that these pills can induce sepsis https://t.co/mY0gxPXFQ1 @NatureMedicine by @TechnionLive's @idanyelin @harvardmed and collaborators pic.twitter.com/GZ6HgwxWyR
— Eric Topol (@EricTopol) November 7, 2019