Archives
RCT | Stereotactic radiosurgery vs. conventional radiotherapy for localized vertebral metastases of the spine
24 Apr, 2023 | 13:37h | UTCStereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology/RTOG 0631 Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Audio interview: Radiosurgery of Spine Metastasis—NRG/RTOG 0631 RCT Final Results – JAMA
Commentary on Twitter
Phase 3 rand trial of spinal radiosurgery vs. conventional external beam radiation therapy for pts w/spinal metastases showed radiosurgery did not significantly improve pain response at 3mo but showed feasibility that makes it widely used today. https://t.co/LvZY1nbUpS #RadOnc
— JAMA Oncology (@JAMAOnc) April 20, 2023
Cold static preservation at 10°C shows promising results for safely extending lung transplantation timeframes
24 Apr, 2023 | 13:38h | UTCExtension of Cold Static Donor Lung Preservation at 10°C – NEJM Evidence
Commentary on Twitter
Donor lungs for transplantation are stored on ice and transplanted as rapidly as possible. In an advance that may ease transplant logistics, Ali et al. now report that prolonged storage of donor lungs at 10°C may lead to equivalent outcomes.
Read the Original Article:
— NEJM Evidence (@NEJMEvidence) April 22, 2023
Cohort Study | Prehospital end-tidal CO2 levels and mortality in suspected severe traumatic brain injury patients
24 Apr, 2023 | 13:35h | UTCEditorial: Prehospital ventilation targets in severe traumatic brain injury – Intensive Care Medicine
Commentary on Twitter
Prehospital etCO2 in severe #TBI, BRAIN-PROTECT study
🚁 L-shaped association with mortality
🧠 35-45 mmHg seems reasonable target: lower ETCO2? sharp mortality ⬆️
🖇️ https://t.co/DC0DoHa00NWith editorial on MV targets & reliability of available data
🖇️ https://t.co/jVZ4zZVHxv pic.twitter.com/74vKxjyGpA— Intensive Care Medicine (@yourICM) April 20, 2023
Guideline | Management of pheochromocytoma and paraganglioma in patients harboring germline SDHD pathogenic variants
24 Apr, 2023 | 13:32h | UTCClinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants – The Lancet Diabetes & Endocrinology (free registration required)
Commentary on Twitter
https://twitter.com/TheLancetEndo/status/1647547884361981953
M-A | 5-alpha-reductase inhibitors are not associated with increased risk of mortality from prostate cancer
24 Apr, 2023 | 13:30h | UTCAssociation Between 5α-Reductase Inhibitors and Prostate Cancer Mortality: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)
Commentary on Twitter
Systematic review & meta-analysis drawing on 2 decades of epidemiologic literature and including data from over 3 million patients shows no significant association between use of 5-alpha reductase inhibitor use and mortality from prostate cancer. https://t.co/3l9jT1l2P9 #PCSM
— JAMA Oncology (@JAMAOnc) April 21, 2023
Perioperative opioids: a narrative review contextualizing new avenues to improve prescribing
24 Apr, 2023 | 13:26h | UTC
Preliminary study show wireless pacemakers may be safe and effective for children with bradycardia
24 Apr, 2023 | 13:27h | UTCNews Release: Wireless pacemakers may be safe, effective for children with irregular heart rhythms – American Heart Association
Commentary: Leadless Pacemakers Could Prove Useful for Pediatric Patients with Arrhythmias – HCP Live
SR | Etiology, diagnosis, and modern management of chronic pancreatitis
24 Apr, 2023 | 13:29h | UTCEtiology, Diagnosis, and Modern Management of Chronic Pancreatitis: A Systematic Review – JAMA Surgery (free for a limited period)
Brief Review | Acute kidney injury
24 Apr, 2023 | 13:24h | UTCAcute kidney injury – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Acute kidney injury common in #ICU, influencing outcomes: not only focus on prevention, optimize treatment! In this review:
🫘 prevention
🫘 conservative management
🫘 optimal timing of initiation of RR
🫘 longer-term post #AKI follow-up@ForniLuiG
🖇️ https://t.co/SPz70YfJIK pic.twitter.com/qGqo08CP6E— Intensive Care Medicine (@yourICM) April 18, 2023
Brief Review | The use of high-flow nasal oxygen
24 Apr, 2023 | 13:23h | UTCThe use of high-flow nasal oxygen – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
The use of high‑flow nasal oxygen:
💨 acute hypoxemic respiratory failure
💨 acute hypercapnic respiratory failure
💨 weaning from mechanical ventilation
💨 special populations: immunocompromised patients & tracheostomised patients
🖇️ https://t.co/3ZzGabkh0M pic.twitter.com/ieVCWjPDwE— Intensive Care Medicine (@yourICM) April 20, 2023
Brief Review | Aerosolized antibiotics in critical care
24 Apr, 2023 | 13:21h | UTCAerosolised antibiotics in critical care – Intensive Care Medicine
Related: How to Use Nebulized Antibiotics in Severe Respiratory Infections – Antibiotics
Commentary on Twitter
Aerosolised antibiotics in #ICU
💨 delivery to tracheobronchial tree? easy
💨 delivery to infected lung parenchyma? difficult
💨 clinical delivery of aerosolized ABTS
💨 how to address unmet clinical needs from a research standpoint
Free to read #FOAMcc
🖇️ https://t.co/tLjcvyUpY7 pic.twitter.com/brhTAGczRr— Intensive Care Medicine (@yourICM) April 22, 2023
Cohort Study | Circulating tumor DNA methylation may enable early detection of recurrence in colorectal cancer
24 Apr, 2023 | 13:12h | UTCEarly Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation – JAMA Oncology (free for a limited period)
Editorial: Liquid Biopsy Assessment of Molecular Residual Disease in Localized Colorectal Cancer: Is It Ready for Prime Time? – JAMA Oncology (free for a limited period)
Commentary on Twitter
Cohort study of 299 pts w/stage I-III colorectal cancer, evaluating ctDNA evaluation w/methylation markers, showed ctDNA before & after surgery, after adjuvant chemo, & during longitudinal monitoring is highly associated w/recurrence. https://t.co/csHNz5kWz3 #CRCSM #GICSM
— JAMA Oncology (@JAMAOnc) April 21, 2023
Cohort Study | Prenatal exposure to antiseizure medication and incidence of childhood-onset psychiatric disorders
24 Apr, 2023 | 13:10h | UTCPrenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders – JAMA Neurology (link to abstract – $ for full-text)
Author Interview: Prenatal Exposure to Antiseizure Medication and Psychiatric Disorders – JAMA
Commentary on Twitter
Study strengthens the evidence for the warning against the use of valproate in pregnancy, supports concerns about the use of topiramate, and provides a preliminary indication for caution with the use of levetiracetam in pregnancy. https://t.co/BZzZP0tSZs
— JAMA Neurology (@JAMANeuro) April 17, 2023
RCT | Intermittent fasting plus early time-restricted eating vs. calorie restriction and standard care in adults at risk of type 2 DM
24 Apr, 2023 | 13:07h | UTCIntermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial – Nature Medicine (if the link is paywalled, try this one)
News Release: Fasting diet reduces risk markers of type 2 diabetes – University of Adelaide
Related:
Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition
Commentary on Twitter
A study in @NatureMedicine comparing intermittent fasting plus early time-restricted eating (iTRE) to calorie restriction in adults at risk of type 2 diabetes shows that iTRE was associated with greater improvements in postprandial glucose metabolism. 🔒 https://t.co/NsMn5xLvmE pic.twitter.com/gNbfGORhby
— Nature Portfolio (@NaturePortfolio) April 19, 2023
RCT | Peri-intubation hypoxia after delayed vs. rapid sequence intubation in critically injured patients on arrival to trauma triage
24 Apr, 2023 | 13:04h | UTCPeri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)
Review | The management of pregnant trauma patients
24 Apr, 2023 | 13:01h | UTCThe Management of Pregnant Trauma Patients: A Narrative Review – Anesthesia & Analgesia (free for a limited period)
See also: Infographic (free for a limited period)
2023 ACC expert consensus on management of heart failure with preserved ejection fraction
21 Apr, 2023 | 13:10h | UTCCommentaries:
New Expert Consensus Papers Aim to Boost Management, Outcomes in HFpEF – TCTMD
RCT | Piperacillin-tazobactam better than cefoxitin in antimicrobial prophylaxis for open pancreatoduodenectomy
21 Apr, 2023 | 13:08h | UTCPiperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Informing a Rational Approach to Antimicrobial Prophylaxis in Open Pancreatoduodenectomy – JAMA (free for a limited period)
Commentary on Twitter
Study findings support the use of piperacillin-tazobactam as perioperative antimicrobial prophylaxis for open pancreatoduodenectomy. https://t.co/M9qAVrePRH pic.twitter.com/xq01qPTHQO
— JAMA (@JAMA_current) April 20, 2023
Study estimates poor diet causes 70% of diabetes cases globally
21 Apr, 2023 | 13:06h | UTCIncident type 2 diabetes attributable to suboptimal diet in 184 countries – Nature Medicine
News Release: Study links poor diet to 14 million cases of type 2 diabetes globally – Tufts University
Commentary on Twitter
An analysis in @NatureMedicine estimates that 70% of new global cases of type 2 diabetes are attributable to suboptimal intake of 11 dietary factors, with substantial differences in dietary risks across world regions and nations. https://t.co/MYoLRt3rhO pic.twitter.com/Pv7I6Mhvxu
— Nature Portfolio (@NaturePortfolio) April 19, 2023
RCT | Pregnant individuals benefit from brief interpersonal psychotherapy for depression
21 Apr, 2023 | 13:05h | UTCCommentary: Interpersonal Psychotherapy Reduces Depression Symptoms of Pregnant Women – HCP Live
Commentary on Twitter
A randomized clinical trial of prenatal interpersonal psychotherapy showed rapid decreases in depression. Depression in the intervention group dropped from 37% before intervention to 6% after (vs. 26% in control group). https://t.co/rJADZZkfER
— JAMA Psychiatry (@JAMAPsych) April 19, 2023
M-A | Electroconvulsive therapy may be superior to ketamine for patients with major depressive episode
21 Apr, 2023 | 13:03h | UTCKetamine vs Electroconvulsive Therapy for Major Depressive Episode: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries:
Electroconvulsive Therapy Bests Ketamine in Treating Major Depressive Episodes – HCP Live
Review | The importance of using placebo controls in nonpharmacological randomized trials
21 Apr, 2023 | 13:02h | UTCThe importance of using placebo controls in nonpharmacological randomised trials – Pain
RCT | Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata
21 Apr, 2023 | 13:00h | UTCEfficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial – The Lancet (link to abstract – $ for full-text)
News Release: Progress in search for alopecia areata treatment for adolescents – Yale News
Commentary on Twitter
Ritlecitinib might be a treatment option for alopecia areata in patients aged 12 years and older, suggests a new study: https://t.co/jKUxEbo4AZ
Below, a graphical abstract 👇 pic.twitter.com/JIJtTGHeE4
— The Lancet (@TheLancet) April 17, 2023
M-A | Adverse events related to tirzepatide (a dual GIP/GLP-1 receptor agonist)
21 Apr, 2023 | 12:59h | UTCAdverse Events Related to Tirzepatide – Journal of the Endocrine Society
Related:
Tirzepatide Once Weekly for the Treatment of Obesity – New England Journal of Medicine
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis – Nature Medicine
Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
ACSM expert consensus statement on exertional heat illness: recognition, management, and return to activity
19 Apr, 2023 | 13:27h | UTCRelated:
Exertional heat stroke: pathophysiology and risk factors – BMJ Medicine
Classic and exertional heatstroke – Nature Reviews Disease Primers
Treatment and Prevention of Heat-Related Illness – New England Journal of Medicine