Cohort Study | Circulating tumor DNA methylation may enable early detection of recurrence in colorectal cancer

Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation – JAMA Oncology (free for a limited period)

Editorial: Liquid Biopsy Assessment of Molecular Residual Disease in Localized Colorectal Cancer: Is It Ready for Prime Time? – JAMA Oncology (free for a limited period)

Related: Study shows patients with circulating tumor DNA are at increased risk of relapse after surgery for resectable colorectal cancer

Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices – Journal of Clinical Oncology

Commentary on Twitter

Cohort study of 299 pts w/stage I-III colorectal cancer, evaluating ctDNA evaluation w/methylation markers, showed ctDNA before & after surgery, after adjuvant chemo, & during longitudinal monitoring is highly associated w/recurrence. https://t.co/csHNz5kWz3 #CRCSM #GICSM

— JAMA Oncology (@JAMAOnc) April 21, 2023