Archives
Review: Clinical Management of Hyperkalemia. Classification and monitoring, when to reinitiate RAASi therapy, use oral K+-binding agents, and more
5 Nov, 2020 | 08:58h | UTCClinical Management of Hyperkalemia – Mayo Clinic Proceedings
Review: Diagnosis and treatment of lower extremity venous thromboembolism. Role of pretest probability and D-Dimer on diagnosis + treatment issues such as postthrombotic syndrome and the role of new anticoagulants
5 Nov, 2020 | 09:00h | UTCDiagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review – JAMA (free for a limited period)
Summary: Diagnosis and Treatment of Lower Extremity Venous Thromboembolism – American College of Cardiology
Screening: earlier detection of disease is not necessarily better
5 Nov, 2020 | 08:53h | UTCScreening: earlier detection of disease is not necessarily better – Evidently Cochrane
Systematic Review: Little benefit from phlebotonics in patients with venous insufficiency
5 Nov, 2020 | 08:54h | UTCPhlebotonics for venous insufficiency – Cochrane Library
The neurological sequelae of pandemics and epidemics. A review of large and important epidemics of human history in which neurological manifestations are evident
5 Nov, 2020 | 08:51h | UTCThe neurological sequelae of pandemics and epidemics – Journal of Neurology
Review of clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort
5 Nov, 2020 | 08:46h | UTC
Commentary on Twitter
Protecting lung (vs excessive stress/strain) & diaphragm (vs atrophy/injury due to low/excessive efforts) bedside:
➡️ inspiratory/expiratory MV settings
➡️ monitoring & managing effort or drive
➡️ managing dyssynchrony
➡️ sedation
➡️ adjuvant strategieshttps://t.co/pdvKndwHYY pic.twitter.com/irvrX9WxTj— Intensive Care Medicine (@yourICM) November 2, 2020
[Abstract Only] Randomized, open-label trial: Olanzapine seems effective for the prevention of vomiting in children and adolescents receiving highly emetogenic chemotherapy
5 Nov, 2020 | 08:48h | UTCOlanzapine for Prevention of Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy: Investigator-Initiated, Randomized, Open-Label Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary on Twitter
RCT of adding Olanzapine to Nausea regimen (aprepitant, ondan, dex)
231 children, cycle 1 of highly emetogenic chemo
Primary endpoint: complete response= no vomiting + no rescue med use
78% v 59% day 1
74% v 47% days 1-5
64% v 38% overall#supponc https://t.co/cZFM8bLXKg— Arjun Gupta (@guptaarjun90) September 16, 2020
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS. Dosage, timing of initiation, mode of administration, duration of therapy, infection surveillance, tapering, and more
5 Nov, 2020 | 08:45h | UTC
Commentary on Twitter
Glucocorticoids in #ARDS… focus not only on molecule! Key elements to achieve optimal response to therapy:
➡️ dosage (initial, overtime, adjustments)
➡️ timing of initiation
➡️ mode of administration
➡️ duration of therapy
➡️ tapering
➡️ co-interventionshttps://t.co/4b9vtNXsb7 pic.twitter.com/X6UZyMSI1r— Intensive Care Medicine (@yourICM) November 4, 2020
SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts
4 Nov, 2020 | 09:51h | UTC
Commentary on Twitter
Important new study on #SARSCoV2 transmission of >1,100 cases with 7,700 close contacts
— 36% asymptomatic; require testing
— Household contact risk: sharing bedroom >5X; speaking w/ 1° case for ≥ 30 min: 7.9Xhttps://t.co/lSKebOzoNf @TheLancetInfDis pic.twitter.com/UTtkCUqlRn— Eric Topol (@EricTopol) November 3, 2020
Study: Strategies to prevent super-spreading events could have a significant impact on the overall transmission of Covid-19
4 Nov, 2020 | 09:56h | UTCOriginal study: Evidence that coronavirus superspreading is fat-tailed – Proceedings of the National Academy of Sciences
New CDC Report found that pregnant women with Covid-19 are more likely to have severe illness
4 Nov, 2020 | 09:47h | UTCCommentary: Pregnant women with Covid-19 face higher risk of severe illness and death, study says – CNN
Key populations for early COVID-19 immunization: Preliminary guidance for policy
4 Nov, 2020 | 09:46h | UTC
Commentary on Twitter
Preliminary guidance on key populations for early #COVID19 immunization: groups include those at high risk for severe illness and death, essential workers, #Indigenous communities. Read the evidence-based guideline https://t.co/Tc3vBdJxSV @CPHO_Canada @GovCanHealth @CaroQuach pic.twitter.com/3vyGkL87AD
— CMAJ (@CMAJ) November 3, 2020
The double threat of COVID-19 in Africa
4 Nov, 2020 | 09:43h | UTCThe Double Threat of COVID-19 in Africa – Think Global Health
Association between industry payments to physicians and device selection in ICD implantation
4 Nov, 2020 | 09:40h | UTCAssociation Between Industry Payments to Physicians and Device Selection in ICD Implantation – JAMA (free for a limited period)
Editorial: Reconsidering Health Care Fraud and Abuse Laws (free for a limited period)
Commentary on Twitter
More evidence that payments from industry to physicians influence clinical decisions. Great paper led by @AmarMD99 in @YaleCardiology shows that patients most likely to receive ICD/CRD made by manufacturer that provided largest payments to their physician https://t.co/P1Hh2VAxur
— Joseph Ross (@jsross119) November 3, 2020
Randomized trial: Vitamin C does not improve iron absorption in adult patients with iron deficiency anemia
4 Nov, 2020 | 09:42h | UTCCommentary: Study: Vitamin C Supplements Have No Effect on Iron-Deficiency Anemia – NEJM Journal Watch
Commentary on Twitter
RCT finds oral iron alone is equivalent to oral iron + #vitaminC in improving hemoglobin and iron absorption in patients with iron deficiency #anemia https://t.co/atSVVnGkEV #VisualAbstract
— JAMA Network Open (@JAMANetworkOpen) November 2, 2020
Analysis: Adversity in childhood is linked to mental and physical health throughout life
4 Nov, 2020 | 09:28h | UTCAdversity in childhood is linked to mental and physical health throughout life – The BMJ
Commentary on Twitter
Adversity in the first years of life may deleteriously affect the course of human development. This #BMJInfographic presents some of these challenges and the mechanisms by which they can affect health throughout childhood and into adulthoodhttps://t.co/9cJAgmhrcr @will_s_t pic.twitter.com/Qsfp0YR9fZ
— The BMJ (@bmj_latest) November 3, 2020
Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes
4 Nov, 2020 | 09:38h | UTC
Commentary on Twitter
PUBLISHED! We wanted to showcase what a low-carb approach could achieve for people with #T2D in UK NHS general practice Our @BMJNutrition paper published today. Open access PLEASE read it https://t.co/zxj2XESBaO HUGE thanks to patients and staff @nnedpro Hurrah! pic.twitter.com/BLML1vSA6i
— Dr David Unwin (@lowcarbGP) November 3, 2020
Review: Contraceptive challenges in women with common medical conditions
4 Nov, 2020 | 09:22h | UTCContraceptive Challenges in Women With Common Medical Conditions – Mayo Clinic Proceedings
Review: Management of common postoperative complications
4 Nov, 2020 | 09:26h | UTCManagement of Common Postoperative Complications – Mayo Clinic Proceedings
[Abstract Only] Randomized trial: Corticosteroids do not alter respiratory outcomes in preschool children presenting with acute wheeze
4 Nov, 2020 | 09:17h | UTC
Commentary on Twitter
It’s October, a 2yo has a runny nose, cough & wheeze. 10 puffs of salbutamol via a spacer & they look better.
To pred, or not to pred?
This randomised double blinded placebo controlled trial says: no difference.
Might this change your practice? ^NShttps://t.co/qGannfkmu0
— ADC (@ADC_BMJ) October 17, 2020
Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort
4 Nov, 2020 | 09:19h | UTC
Commentary on Twitter
Protecting lung (vs excessive stress/strain) & diaphragm (vs atrophy/injury due to low/excessive efforts) bedside:
➡️ inspiratory/expiratory MV settings
➡️ monitoring & managing effort or drive
➡️ managing dyssynchrony
➡️ sedation
➡️ adjuvant strategieshttps://t.co/pdvKndwHYY pic.twitter.com/irvrX9WxTj— Intensive Care Medicine (@yourICM) November 2, 2020
Perspective: Under ISCHEMIA’s long shadow, cardiologists ponder shifting guidelines, care
4 Nov, 2020 | 09:20h | UTCUnder ISCHEMIA’s Long Shadow, Cardiologists Ponder Shifting Guidelines, Care – TCTMD
Original study and commentaries: ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease AND ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease
Updated clinical guide for the critical care management of adults with COVID-19
3 Nov, 2020 | 03:18h | UTC
Science’s English dominance hinders diversity—but the community can work toward change
4 Nov, 2020 | 09:18h | UTCScience’s English dominance hinders diversity—but the community can work toward change – Science
Age-specific mortality and immunity patterns of SARS-CoV-2
3 Nov, 2020 | 03:16h | UTCAge-specific mortality and immunity patterns of SARS-CoV-2 – Nature
Commentaries on Twitter
Our analysis on age-specific mortality and immunity patterns of SARS-CoV-2 has now been published @nature. We look at COVID-19 death data in 45 countries and 22 serostudies to investigate the consistency of infection & fatality patterns across countries https://t.co/KLYR7XrFo8
— Megan O'Driscoll (@meganodris) November 2, 2020
The effect of age on the #COVID19 infection fatality rate. Just published @nature, data from 45 countries, 22 seroprevalence studies https://t.co/TWSogoHMMh
by @meganodris @hsalje @SCauchemez @fdlwang @datcummings @andrewazman and colleagues pic.twitter.com/pXtvZky4xA— Eric Topol (@EricTopol) November 2, 2020