Archives
[Abstract Only] Randomized trial: Intravenous haloperidol more effective than ondansetron for cannabis hyperemesis syndrome
11 Nov, 2020 | 09:08h | UTC
Commentary on Twitter
Excited to have been involved in this practice-changing RCT comparing Haloperidol (superior) to Ondansetron for Cannabis Hyperemesis Syndrome from @Qemerg @therealdraa_ron @savforrester Marco Sivilotti and others! Check it out!https://t.co/ylms5JIO9v
— Andrew K Hall (@AKHallMD) November 5, 2020
KDIGO Guideline Synopsis: Diabetes management in chronic kidney disease. Use of ACE inhibitors or ARBs, glycemic monitoring and targets, and choice of antihyperglycemic drugs are covered
11 Nov, 2020 | 09:09h | UTCOriginal guideline: Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease
Podcast on chronic cough. Don’t be afraid to try empiric therapies! PPIs for GERD, antihistamines and intranasal steroids for post-nasal drip, and inhaled corticosteroids for post-viral cough are generally low-risk and will treat many cases.
11 Nov, 2020 | 09:04h | UTC#241 Chronic Cough – The Curbsiders Internal Medicine Podcast
News Release [Not Published Yet]: Vaccine candidate 90% effective against Covid-19 according to manufacturer
10 Nov, 2020 | 09:41h | UTCNews Release: Pfizer and Biontech announce vaccine candidate against Covid-19 achieved success in first interim analysis from phase 3 study
Commentaries: What Pfizer’s landmark COVID vaccine results mean for the pandemic – Nature AND Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate – The BMJ AND Covid vaccine: First ‘milestone’ vaccine offers 90% protection – BBC AND Hopes rise for end of pandemic as Pfizer says vaccine is 90% effective – The Guardian AND Four reasons for encouragement based on Pfizer’s Covid-19 vaccine results – STAT AND Expert reaction to Pfizer and BioNTech reporting interim results from phase 3 COVID-19 vaccine trial – Science Media Centre
Meta-analysis: Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging can reduce cases of severe disability but increases symptomatic intracranial hemorrhage and deaths
11 Nov, 2020 | 09:06h | UTCIntravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data – The Lancet (free registration required)
Commentary on Twitter
Latebreaking at #ESOWSO2020—Intravenous alteplase for #stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data https://t.co/KDX2lHisbj pic.twitter.com/cnoiRhIReF
— The Lancet (@TheLancet) November 8, 2020
Another study shows hydroxychloroquine does not benefit adults hospitalized with COVID-19
10 Nov, 2020 | 09:39h | UTCEditorial: Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science
Commentary: Hydroxychloroquine does not benefit adults hospitalized with COVID-19 – NIH News Releases
Patients with Covid-19 and myocardial injury have increased in-hospital mortality, particularly if echocardiographic abnormalities are present
10 Nov, 2020 | 09:37h | UTC
Report: Large cluster of cases during a long flight shows seating proximity was strongly associated with infection risk
10 Nov, 2020 | 09:38h | UTCTransmission of SARS-CoV 2 During Long-Haul Flight – Emerging Infectious Diseases
Related studies: In-Flight Transmission of SARS-CoV-2 – Emerging Infectious Diseases AND A large national outbreak of COVID-19 linked to air travel, Ireland, summer 2020 – Eurosurveillance
Commentaries: Coronavirus can spread on airline flights, two studies show – CNN AND Do Masks On Plane Flights Really Cut Your Risk Of Catching COVID-19? – NPR AND Is it worth the risk? A guide to navigating holiday travel during the pandemic University of Texas Health Science Center at Houston
Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients
10 Nov, 2020 | 09:33h | UTCCommentaries: Candida auris Infection in COVID-19 Patients – NEJM Journal Watch AND Drug-resistant superbug thriving in hospitals hit hard by COVID-19 – National Geographic
In patients hospitalized with COVID-19, right ventricular dilation or dysfunction was independently associated with a >2-fold increase in risk for mortality
10 Nov, 2020 | 09:36h | UTCCommentaries: Utility of RV Remodeling Over Risk Stratification in COVID-19 – American College of Cardiology AND Damage to heart’s right ventricle predicts a greater chance of death from COVID-19 – Weill Cornell Medical College
Aspirin to be investigated as a possible treatment for COVID-19 in the RECOVERY trial
10 Nov, 2020 | 09:35h | UTCCommentary: Aspirin to be tested as potential COVID-19 drug in UK study – Reuters
[Abstract Only] Randomized trial: In patients with persistent atrial fibrillation, treatment with catheter ablation + vein of Marshall ethanol infusion increased the likelihood of remaining free of AF, compared with catheter ablation alone
10 Nov, 2020 | 09:32h | UTCEffect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary on Twitter
VENUS: randomized trial of vein of Marshall ethanol added to catheter ablation of persistent AF. 13 years in the making… I hope to be faster next time! https://t.co/EfW8d4FOtu
— Miguel Valderrábano (@MiguelVldrbno) October 27, 2020
Systematic review: Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. “At present, there are no convincing data supporting any specific inotropic or vasodilating therapy to reduce mortality in hemodynamically unstable patients with CS or LCOS.”
10 Nov, 2020 | 09:30h | UTC
Cohort study: Nighttime high blood pressure phenotype linked to worse cardiovascular prognosis
10 Nov, 2020 | 09:29h | UTCCommentaries: People who experience high blood pressure while sleeping have increased risk of heart attacks, strokes – News Medical / American Heart Association AND Sleeptime BP Spikes Tied to Heart Troubles – Physician’s Weekly
[Abstract Only]: Randomized trial: Drug-coated balloons non-inferior to drug-eluting stents for small coronary artery disease
10 Nov, 2020 | 09:27h | UTCLong-term efficacy and safety of drug-coated balloons versus drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Long-term efficacy and safety of drug-coated balloons vs drug-eluting stents for small coronary artery disease (BASKET-SMALL 2): 3-year follow-up of a randomised, non-inferiority trial https://t.co/Fmi4sZTSdU pic.twitter.com/UfznQp6gkh
— The Lancet (@TheLancet) October 20, 2020
Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.
10 Nov, 2020 | 09:26h | UTCCurrent and evolving standards of care for patients with ARDS – Annals of Intensive Care
Commentary on Twitter
#ARDS current & evolving standards of care
➡️ definition 10y after Berlin
➡️ MV: P/volume limits; PEEP & recruitment; spontaneous breathing
➡️ adjuncts: proning; NMBAs; iNO; #ECMO
➡️ pharmacotherapy: steroids; fluids; specific agents
➡️ #COVID19#FOAMcc https://t.co/rXGsAs2M4D pic.twitter.com/6FRWXtBiME— Intensive Care Medicine (@yourICM) November 7, 2020
WHO: Preliminary findings indicate that a SARS-CoV-2 mink-associated variant strain has moderately decreased sensitivity to neutralizing antibodies. The implications are not yet well understood.
9 Nov, 2020 | 01:34h | UTCSARS-CoV-2 mink-associated variant strain – Denmark – World Health Organization
Commentaries: Spread of mutated coronavirus in Danish mink ‘hits all the scary buttons,’ but fears may be overblown – STAT AND Six countries reported coronavirus on mink farms, WHO says – MedicalXpress AND What’s the science behind mink and coronavirus? – BBC
Review: Use of multiple period, cluster randomized, crossover trial designs for comparative effectiveness research
10 Nov, 2020 | 09:22h | UTC
This article outlines the key methodological and ethical requirements needed for the robust design of multiple period, cluster randomised, crossover trialshttps://t.co/CMky7icWhY
— The BMJ (@bmj_latest) November 6, 2020
Video: Herd immunity as a coronavirus pandemic strategy
9 Nov, 2020 | 01:32h | UTCHerd Immunity as a Coronavirus Pandemic Strategy – JAMA
Perioperative evaluation and management of patients with diabetes, thyroid disease, and adrenal insufficiency. Use of insulin and noninsulin diabetic medications, management of hyper and hypothyroidism, and use of stress-dose corticosteroids are some of the subjects reviewed
10 Nov, 2020 | 09:24h | UTCPerioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings
What can we expect from new SARS-CoV-2 rapid tests? They promise to aid public health responses to COVID-19, since they can deliver results in a matter of minutes in the field, rather than taking days in clinical diagnostic labs
9 Nov, 2020 | 01:30h | UTCCoronavirus testing finally gathers speed – Nature
Biden’s ready to start his pandemic response immediately. “He will reach out to Tony Fauci. He will declare his intent to be an active participant in the WHO and in the world”
9 Nov, 2020 | 01:29h | UTCBiden’s ready to start his pandemic response immediately – STAT
[Preprint] Covid-19 vs. Influenza in Kids: Despite negligible fatality, complications including pneumonia, acute respiratory distress syndrome and multi-system inflammatory syndrome were more frequent in children/adolescents with Covid-19 than with influenza
9 Nov, 2020 | 01:27h | UTC
Study shows preexisting cross-reactive antibodies against common cold coronaviruses may protect against SARS-CoV-2 and are more common in children
9 Nov, 2020 | 01:28h | UTCPreexisting and de novo humoral immunity to SARS-CoV-2 in humans – Science
Commentaries: Pre-existing coronavirus antibodies could help protect children against new pandemic strain – Francis Crick Institute AND Expert reaction to study looking at pre-existing coronavirus antibodies – Science Media Centre
Commentary on Twitter
Do some people have cross-reactive antibodies to #SARSCoV2? If so, who are they? And are these cross-reactive Abs protective against #COVID19? A fascinating study by @KevinWNg et al provides answers. Thread. (1/n)
https://t.co/U9UVrwztX5— Prof. Akiko Iwasaki (@VirusesImmunity) November 7, 2020
Global study shows poor nutrition in school years may have created a 20cm height gap across nations
9 Nov, 2020 | 01:24h | UTCCommentaries: Poor diet: Children 20cm shorter as a result, analysis says – BBC AND Poor nutrition in school years may have created 20cm height gap across nations – Imperial College London
Commentary on Twitter
NEW—Most comprehensive global study to date suggests concerning height and BMI trends among school-aged children and adolescents: a pooled analysis of 2181 population-based studies with 65 million participantshttps://t.co/CXlqcAvYHA pic.twitter.com/Nzj1krjuhH
— The Lancet (@TheLancet) November 5, 2020