Archives
Case report: Persistence and evolution of SARS-CoV-2 in an immunocompromised host
13 Nov, 2020 | 09:24h | UTC
Commentary on Twitter (thread – click for more)
This summer, we partnered with the clinical team of an immunosuppressed patient with recurrent COVID and multiple hospitalizations. His NP swab VL reached 1 billion copies 5 months after initial dx. The team's Q: is this pt being re-infected w/ COVID? 1/ https://t.co/vkVerBUUPg
— Jonathan Li (@DrJLi) November 12, 2020
How risky is air travel in the pandemic? Here’s what the science says
13 Nov, 2020 | 09:22h | UTCHow risky is air travel in the pandemic? Here’s what the science says – Vox
Tranexamic acid after traumatic brain injury: Exploratory analysis combining data from CRASH-2 and CRASH-3 trials suggests reduced mortality
13 Nov, 2020 | 09:21h | UTC
Commentary on Twitter
📊🔍 IPD meta-analysis of #CRASH2 and #CRASH3 trials show rapid #TXA (<3 hrs) reduces early deaths by >20% in both studies
Highly consistent results that #TXA reduces trauma deaths regardless of the location of the #bleeding 🩸
READ @Crit_Care 👉https://t.co/s3vkm6c6Tf pic.twitter.com/og9jYi5tqo
— Clinical Trials Unit – Global Health Trials Group (@CTU_LSHTM) November 11, 2020
Perspective: Many younger adults need to take Covid-19 more seriously as demographics shift
13 Nov, 2020 | 09:25h | UTCYounger Adults Caught in COVID-19 Crosshairs as Demographics Shift – JAMA
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/jenabbasi/status/1326909913805828100
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus
13 Nov, 2020 | 09:19h | UTC
Older age and frailty are frequently associated with atypical and unspecific COVID-19 presentations, including functional decline, acute mental change, and hypotension
12 Nov, 2020 | 09:22h | UTC
Commentary on Twitter
DIVERGENT: age, #frailty, and presentations of #COVID19
Typical symptoms were uncommon in frail and older
patients; they were more likely to experience functional decline and key features of delirium. #geriatrics @geronsociety @OxfordJournals #gerontolhttps://t.co/jRhwvacsVm pic.twitter.com/9zhHZjsSoy— Marlon Aliberti (@marlon_aliberti) November 5, 2020
Case-control study: COVID-19-associated stroke is associated with worse outcomes and increased mortality
12 Nov, 2020 | 09:24h | UTCCommentary: Risk of death, disability after stroke much higher for COVID-19 patients – Cardiovascular Business
[Abstract Only] Study: An automated predictive model can identify hospitalized adults outside the ICU at risk for clinical deterioration for whom interventions by rapid-response teams could be implemented
13 Nov, 2020 | 09:16h | UTCAutomated Identification of Adults at Risk for In-Hospital Clinical Deterioration – New England Journal of Medicine (link to abstract – $ for full-text)
Review for the public on the different kinds of COVID-19 tests. It covers the differences and similarities between molecular, antigen, and serologic tests.
12 Nov, 2020 | 09:19h | UTC
Wearing cloth or disposable surgical face masks has no effect on vigorous exercise performance in healthy individuals
12 Nov, 2020 | 09:21h | UTCCommentary: Face masks don’t hinder breathing during exercise, study finds – University of Saskatchewan
Why do COVID death rates seem to be falling? Correct use of corticosteroids, hard-won experience, younger patients, and reduced strain on hospitals are all possibilities
12 Nov, 2020 | 09:16h | UTCWhy do COVID death rates seem to be falling? – Nature
New Guideline on neonatal opioid withdrawal syndrome provides advice on monitoring the newborn for withdrawal symptoms, supportive care, and breastfeeding
12 Nov, 2020 | 09:14h | UTCNeonatal Opioid Withdrawal Syndrome – Pediatrics
Commentaries: Pediatrics Group Issues Recommendations on Neonatal Opioid Withdrawal Syndrome – NEJM Journal Watch AND New guidelines address rise in opioid use during pregnancy – Associated Press
[Preprint] Validation of home oxygen saturation as a marker of clinical deterioration in patients with suspected COVID-19: Even small deflections in oxygen saturations of 1-2% below 96% confer an increased mortality risk.
12 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
*BREAKING* First paper examining home oxygen saturation in COVID confirmed cases as a trigger for initial hospital assessment. We need to rapidly implement a hybrid community-hospital COVID Oximetry@home #COVIDvirtualward @richardhorton1 @bmj_latest https://t.co/0SjrUT0Tjw pic.twitter.com/0TgPPRUBqv
— Matt Inada-Kim (@mattinadakim) November 8, 2020
Prone position in ARDS patients: why, when, how and for whom
12 Nov, 2020 | 09:11h | UTCProne position in ARDS patients: why, when, how and for whom – Intensive Care Medicine
Commentary on Twitter
Prone position in #ARDS
➡️ effects: chest wall/lung mechanics, ventilation, perfusion, gas exchange
➡️ hemodynamics
➡️ whom & when? indications/contraindications
➡️ ventilator settings
➡️ how to perform bedside
➡️ impact on outcomes
➡️ unanswered questionshttps://t.co/rCU7QOQSlw pic.twitter.com/rpBK8kRE9W— Intensive Care Medicine (@yourICM) November 10, 2020
Opinion: “Why the Pfizer and BioNTech vaccine is a cause for optimism — and skepticism. Vaccine science by press release has to stop”
11 Nov, 2020 | 09:25h | UTCWhy the Pfizer and BioNTech vaccine is a cause for optimism — and skepticism – Vox
Related commentaries: Champagne and questions greet first data showing that a COVID-19 vaccine works – Science AND 90% efficacy for Pfizer’s COVID-19 mRNA vaccine is striking. But we need to wait for the full data – The Conversation
See also: Science by press release: When the story gets ahead of the science – CNN
[Preprint] A machine learning study of 534,023 Medicare beneficiaries with COVID-19: Implications for personalized risk prediction to identify candidates for early vaccine and therapeutics allocation.
12 Nov, 2020 | 09:15h | UTCCommentary: Largest-to-Date COVID Mortality Study Released – MedPage Today (free registration required)
Pfizer vaccine: What an ‘efficacy rate above 90%’ really means
11 Nov, 2020 | 09:23h | UTCPfizer vaccine: what an ‘efficacy rate above 90%’ really means – The Conversation
Cluster randomized trial: Mass distribution of azithromycin to preschool children in sub-Saharan Africa increases azithromycin resistance by 7-fold, also causing resistance to nonmacrolide antibiotics
12 Nov, 2020 | 09:13h | UTC
Pfizer’s ultra-cold vaccine could be difficult to distribute
11 Nov, 2020 | 09:22h | UTCPfizer’s ultra-cold vaccine could be difficult to distribute – The Conversation
Covid-19: Reopening places such as restaurants, gyms, hotels, cafes, and religious organizations are predicted to cause the largest increase in infections
11 Nov, 2020 | 09:26h | UTCMobility network models of COVID-19 explain inequities and inform reopening – Nature
Commentaries: Restaurants and gyms were spring ‘superspreader’ sites. Occupancy limits could control Covid, new study predicts – STAT AND How to stop restaurants from driving COVID infections – Nature AND Covid Superspreader Risk Is Linked to Restaurants, Gyms, Hotels – Bloomberg AND Covid-19 modeling study suggests which places may have highest risk of spread — but occupancy limits can help – CNN
Commentary on Twitter
Reopening places such as restaurants, fitness centers, cafes, and hotels carries the highest risk for transmitting SARS-CoV-2, according to a study in Nature. Reducing occupancy in these venues may result in a large reduction in predicted infections. https://t.co/aSSrwnnep9 pic.twitter.com/GdTZdZy12Y
— Nature Portfolio (@NaturePortfolio) November 10, 2020
Randomized trial: vitamin D, omega-3 fatty acids, or a strength-training exercise program do not improve clinical outcomes in older adults
11 Nov, 2020 | 09:11h | UTCEffect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial – JAMA (free for a limited period)
Study: N95 masks with exhalation valves do not work
11 Nov, 2020 | 09:20h | UTCCommentary: N95 Masks With Exhalation Valves Don’t Slow The Spread Of Covid-19 – Forbes
Commentary on Twitter
N95 😷😷with valves don't workhttps://t.co/qGZIEzE1Sh @AIP_Publishing today pic.twitter.com/mI9pVmFtfa
— Eric Topol (@EricTopol) November 10, 2020
Derivation and validation of the HA2T2 (Hypoxia, Age, Troponin) COVID‐19 mortality risk score
11 Nov, 2020 | 09:18h | UTC
Commentary on Twitter
Predicting in-hospital mortality among patients with #COVID19 using the simple HA2T2 (hypoxia, age and troponin) score. https://t.co/FTDceIijZl @KevinManocha @bradpeltzer @MonikaSafford @ParagGoyalMD @JAHA_AHA @WeillCornell @nyphospital pic.twitter.com/vGTNSg8wyO
— Jim Cheung (@DrJCheungEP) November 10, 2020
[Not Published Yet] Randomized trial: Long-acting injectable drug every 8 weeks is highly effective in preventing HIV acquisition in women
11 Nov, 2020 | 09:17h | UTCCommentary: NIH study finds long-acting injectable drug prevents HIV acquisition in cisgender women – NIH News Releases
USPSTF Statement: Insufficient evidence to recommend screening for high blood pressure in children and adolescents
11 Nov, 2020 | 09:14h | UTCScreening for High Blood Pressure in Children and Adolescents – U.S. Preventive Services Task Force
Author interview: USPSTF Recommendation: Screening for Hypertension in Children and Adolescents
JAMA Patient Page: Screening for High Blood Pressure in Children and Adolescents