Archives
Bioethics | Should clinical guidelines incorporate cost pathways for persons with financial hardship?
28 Feb, 2021 | 20:54h | UTC
Joint Statement: Hydroxychloroquine use with respect to retinal toxicity
28 Feb, 2021 | 20:41h | UTCCommentary: Societies Agree on Eye Safety for HCQ – MedPage Today (free registration required) AND ACR, medical societies reach consensus on hydroxychloroquine retinopathy – Healio (free registration required)
Commentary on Twitter
🆕 Joint statement on #Hydroxychloroquine use with respect to retinal toxicity 👀 by several #rheumatology and #opthtalmology societies. #ocular #toxicity relates to #HCQ dosage and duration of use and is seen in 4.3% to 13.8% of patients 🔎#Lupus #SLEhttps://t.co/ocFSCmgVsN
— Laurent ARNAUD (@Lupusreference) February 18, 2021
Systematic Review: Cardiovascular Effects of Medical Marijuana
28 Feb, 2021 | 20:48h | UTCCardiovascular Effects of Medical Marijuana: A Systematic Review – The American Journal of Medicine
M-A: Adjuvant corticosteroids are effective in lowering the risk of kidney scarring in children with acute pyelonephritis
28 Feb, 2021 | 20:38h | UTCAdjuvant corticosteroids for prevention of kidney scarring in children with acute pyelonephritis: a systematic review and meta-analysis – Archives of Disease in Childhood (link to abstract – $ for full-text)
U.S. Guidelines panel recommendation for long-acting injectable antiretroviral regimen in adults and adolescents with HIV
28 Feb, 2021 | 20:34h | UTCWhat’s New in the Guidelines? Panel’s Recommendation for Long-Acting Injectable Cabotegravir and Rilpivirine in Persons with HIV
Indian Guidelines for pediatric skin care in neonates, infants, and children
28 Feb, 2021 | 20:37h | UTCIndian Academy of Pediatrics Guidelines for Pediatric Skin Care
CDC studies on superspreading events at fitness facilities
26 Feb, 2021 | 08:44h | UTCCommentaries: Going maskless is a key factor in Covid-19 outbreaks at gyms, studies say – CNN AND A Chicago gym saw dozens of COVID-19 cases after infected people attended HIIT classes without masks – Insider
Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19
26 Feb, 2021 | 08:48h | UTC
Commentary on Twitter
Why do 2 randomized trials of tocilizumab, an interleukin-6 blocker, for severe covid-19, have opposite results?
Today @NEJMhttps://t.co/g8LCrhhpLyhttps://t.co/BcN3wOwsl0 pic.twitter.com/sLrQUYI1pf— Eric Topol (@EricTopol) February 25, 2021
PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?
28 Feb, 2021 | 20:43h | UTCEditorial: Navigating treatment approaches for presumed ESBL-producing infections
Commentary on Twitter (thread – click for more)
🔥NEW🔥 PRO-CON Debate on the role of carbapenems in infections caused by Enterobacterales resistant to ceftriaxone. #AMR @BSACandJAC @IDdocAdi @ABsteward
— JAC-AMR (@jac_amr) February 24, 2021
WHO Report: Preparing for Long COVID 2021
26 Feb, 2021 | 08:46h | UTCIn the wake of the pandemic: preparing for Long COVID (2021) – World Health Organization
Commentaries: Long COVID sufferer still has disease’s debilitating symptoms nearly a year after first falling ill – EuroNews AND Debilitating ‘long-COVID’ may have severe health, social impacts: WHO – Reuters
Related: Dr. Fauci says new data suggests ‘long’ Covid symptoms can last up to 9 months – CNBC
New protocol tested SARS-CoV-2 positivity on day 9 among quarantined student contacts of confirmed cases, resulting in safe reduction in loss of instructional time
26 Feb, 2021 | 08:42h | UTCCommentary: Is the CDC 10-day COVID-19 quarantine guideline enough? – News Medical
Commentary on Twitter
In this study of a 9-day testing protocol for student contacts of confirmed #COVID19 cases in 1 Florida county, a reduction in loss of instructional time was found that was less than what would have occurred with 14-day quarantine https://t.co/YPft2oAvYk
— JAMA (@JAMA_current) February 19, 2021
Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19
26 Feb, 2021 | 08:43h | UTCCommentary: Studies help discern severe COVID from related kids’ syndrome – CIDRAP
Commentary on Twitter
In this case series using national MIS-C registry data, kids w MIS-C were younger (6-12 y), more likely to be non-Hispanic Black, & have severe CV or mucocutaneous involvement and more extreme inflammation vs kids w severe #COVID19 https://t.co/jmCCDPXLmf @BostonChildrens
— JAMA (@JAMA_current) February 25, 2021
Real-world data confirms Pfizer-BioNTech vaccine effectiveness
25 Feb, 2021 | 09:09h | UTCAudio Interview: The Real-World Effectiveness of Covid-19 Vaccination – New England Journal of Medicine
Commentaries: Real-world trial of Pfizer COVID vaccine finds high 2-dose, good 1-dose protection – CIDRAP AND Pfizer-BioNTech vaccine performs as well in the real world as in clinical trials, new study concludes – STAT AND In boost for COVID-19 battle, Pfizer vaccine found 94% effective in real world – Reuters AND Expert reaction to NEJM paper on Pfizer-BioNTech vaccine roll-out in Israel and COVID-19 outcomes – Science Media Centre
Commentary on Twitter (thread – click for more)
1/
We've just confirmed the effectiveness of the Pfizer-BioNTech vaccine outside of randomized trials.Details @NEJM: https://t.co/POgXK8owvM
Yes, great news, but let's talk about methodological issues that arise when using #observational data to estimate vaccine effectiveness.
— Miguel Hernán (@_MiguelHernan) February 24, 2021
Study finds increased COVID-19 mortality among adults with Down syndrome
26 Feb, 2021 | 08:39h | UTCCommentaries: Adults with Down syndrome 3 times more likely to die of COVID, study finds – CIDRAP AND International study finds increased COVID-19 mortality among adults with Down syndrome – Case Western Reserve University
Related: COVID-19 is 10 times deadlier for people with Down syndrome, raising calls for early vaccination – Science (a few articles per month are free)
COVID-19 hospitalizations attributable to cardiometabolic conditions
26 Feb, 2021 | 08:40h | UTCCommentary: Study estimates two-thirds of COVID-19 hospitalizations due to four conditions – Tufts University
Commentary on Twitter
https://twitter.com/Dmozaffarian/status/1364993823370338312
Opinion – Catching COVID from surfaces is very unlikely. So perhaps we can ease up on the disinfecting
26 Feb, 2021 | 08:38h | UTCRelated: Coronavirus is in the air — there’s too much focus on surfaces – Nature AND COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature
Ghana receives first historic shipment of COVID-19 vaccinations from international COVAX facility
25 Feb, 2021 | 09:12h | UTCSee also: Ghana becomes recipient of historic first shipment of COVAX vaccines – World Health Organization
Commentaries: Covax vaccine-sharing scheme delivers first doses to Ghana – BBC AND Covax delivers first Covid vaccines in ‘momentous occasion’ – The Guardian AND COVAX delivers its first vaccine shots with shipment to Ghana – Reuters
Cohort study: A single conventional Troponin combined with HEART score may be as good as serial measurements for safe discharge of patients with chest pain in the ED
26 Feb, 2021 | 08:32h | UTCEditorial: Troponin Testing in the Emergency Department—When 2 Become 1
Commentary: Single Troponin Test May Be Enough for Safe Discharge of Chest Pain Patients – TCTMD
RCT: Effect of screening by clinical breast examination on breast cancer incidence and mortality after 20 years
26 Feb, 2021 | 08:34h | UTCCommentaries: The story of the Mumbai breast screening study – The BMJ Opinion
This trial found that regular breast examination by trained female health workers in Mumbai led to earlier diagnosis and reduced deaths from breast cancer in women aged 50 and olderhttps://t.co/TQCHLbVO8L
— The BMJ (@bmj_latest) February 25, 2021
CAR T-cell therapy produces deep, sustained remissions in patients with relapsed myeloma
26 Feb, 2021 | 08:31h | UTCOriginal study: Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma – New England Journal of Medicine
Editorial: Five principles for the intelligent use of AI in medical imaging
26 Feb, 2021 | 08:29h | UTCFive principles for the intelligent use of AI in medical imaging – Intensive Care Medicine
Commentary on Twitter
5 key principles that should be remembered for smart use of #ArtificialIntelligence as adoption of #MachineLearning systems becomes more widespread in medical imaging:
➡️knowledge base
➡️metrics
➡️bias
➡️model fragility
➡️error-prone behavior#DataScience https://t.co/h1iFAyCq35 pic.twitter.com/OvNVtwfl94— Intensive Care Medicine (@yourICM) January 17, 2021
Integrated palliative and oncology care for patients receiving treatment for acute myeloid leukemia
26 Feb, 2021 | 08:25h | UTCOriginal article: Effectiveness of Integrated Palliative and Oncology Care for Patients With Acute Myeloid Leukemia: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Decreasing patient-reported burden of treatment: A systematic review of quantitative interventional studies
26 Feb, 2021 | 08:21h | UTC
Phase 2 trial: Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia
26 Feb, 2021 | 08:30h | UTCMuscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Phase II Results Promising for New Schizophrenia Drug Combo – MedPage Today
Systematic Review: Insufficient evidence to decide whether surgical intervention is beneficial or harmful for the early management of Bell’s palsy
26 Feb, 2021 | 08:20h | UTCSurgical interventions for the early management of Bell’s palsy – Cochrane Library
Summary: Surgical operation for Bell’s palsy (idiopathic facial paralysis) – Cochrane Library