Archives
Why the World Should Worry About India – “The world’s largest vaccine producer is struggling to overcome its latest COVID-19 surge—and that’s everyone’s problem.”
27 Apr, 2021 | 08:33h | UTCWhy the World Should Worry About India – The Atlantic
See also: Covid-19: Countries rally to support India through “storm that has shaken the nation” – The BMJ AND As India breaks another global Covid-19 record and hospitals run out of oxygen, countries pledge assistance and aid – CNN AND India’s COVID-19 crisis prompts global response – CIDRAP
Study in nursing homes shows rapid antigen testing could be a useful tool to identify contagious people at risk for transmitting SARS-CoV-2
27 Apr, 2021 | 08:35h | UTCEditorial: Utility of Rapid Antigen Tests in Nursing Homes
Commentary on Twitter
💥🆕 Despite lower positive agreement compared with RT-PCR, antigen test positivity had higher agreement with shedding of replication-competent virus. These results suggest that antigen testing could be a useful tool to rapidly identify contagious people. https://t.co/Dlw7ttLlSL pic.twitter.com/sGmfVIy02H
— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 26, 2021
M-A: Prophylaxis against Covid-19: 1 – no benefit from Hydroxychloroquine; 2 – as studies on ivermectin so far have been small, it remains very uncertain whether ivermectin reduces SARS-CoV-2 infection
27 Apr, 2021 | 08:44h | UTCProphylaxis against covid-19: living systematic review and network meta-analysis – The BMJ
The Utility of Chest CT imaging in suspected or diagnosed COVID-19 Patients – a review of literature
27 Apr, 2021 | 08:30h | UTC
Opinion | Real-world data, not predictions, should drive decisions on Covid-19 and school opening
27 Apr, 2021 | 08:26h | UTCReal-world data, not predictions, should drive decisions on Covid-19 and school opening – STAT
Commentary from the author on Twitter
Real-world data, not predictions, should drive decisions on Covid-19 and school opening with @elbeezuchdt @citizen_oregon: Concept is simple. Schools are half/closed due to alarmist inaccurate models. Use real-world data to drive our decisions on kids.https://t.co/HfZl8IAVXq
— Monica Gandhi MD, MPH (@MonicaGandhi9) April 23, 2021
Clinical Manifestation, Evaluation, and Rehabilitative Strategy of Dysphagia Associated With COVID-19
27 Apr, 2021 | 08:29h | UTC
Covid-19: Infections fell by 65% after first dose of AstraZeneca or Pfizer vaccine, data show
25 Apr, 2021 | 22:06h | UTC
Commentary on Twitter (thread – click for more)
Over one year into the #COVID19 pandemic, about 9⃣0⃣% of countries surveyed still report one or more disruptions to essential health services. Major efforts are required to restore and strengthen services in all countries.
👉 https://t.co/P34xPKY1Io pic.twitter.com/UYDQPX67Vw
— World Health Organization (WHO) (@WHO) April 23, 2021
Clinical review of 43 patients with COVID-19-associated Acute Transverse Myelitis and 3 patients with Acute Transverse Myelitis reported post-vaccination
27 Apr, 2021 | 08:32h | UTCCommentary: Rare neurological condition linked to COVID-19 cases in 21 countries – Houston Methodist
SARS-CoV-2 and Stroke Characteristics – higher rate of large vessel occlusions and stroke in young patients
25 Apr, 2021 | 22:01h | UTC
Commentary on Twitter
SARS-CoV-2 and #Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group #COVID19 #AHACOVID19 #AHAJournals @cgriessenauer @ArKatsanos https://t.co/Errp6MjQMV pic.twitter.com/QX5tAGQOXU
— Stroke AHA/ASA (@StrokeAHA_ASA) April 21, 2021
Opinion | The International Community Has One Job: Getting COVID-19 Under Control
25 Apr, 2021 | 22:09h | UTC
Commentary on Twitter
India is in a crisis of unimaginable scale & predictable severity–and our international leadership is MIA and ready to move on. Pull it together & do your ONE JOB: getting the entire world out of the COVID mass casualty catastrophe.
w/@glassmanamanda https://t.co/0Xj3KZgUTh
— Rachel Bonnifield (@rachelbnfield) April 23, 2021
Multicenter cohort study shows survival among ECMO-assisted patients is strongly associated with center experience
25 Apr, 2021 | 22:05h | UTCInvited commentary: COVID-19 and ECMO: a call for close cooperation and more investigation – The Lancet Respiratory Medicine
Commentary on Twitter
#ECMO network & outcomes during #COVID19 #pandemic in Paris:
➡️17 #ICUs
➡️6 mobile teams
➡️302 pts
➡️46% 90d survival, strongly associated with center experience.
Early #ECLS in high VV volume center advocated: centralize & regulate indications!@TheLancet https://t.co/PqAYWY82Hs pic.twitter.com/ironyGdyFa— M Velia Antonini (@FOAMecmo) April 21, 2021
WHO chief – The world can bring the global COVID-19 pandemic under control in the coming months provided it distributes the necessary resources fairly
25 Apr, 2021 | 22:08h | UTCSee also: Opinion | I Run the W.H.O., and I Know That Rich Countries Must Make a Choice – The New York Times
Commentary on Twitter
We have all the tools to tame the #COVID19 pandemic everywhere in a matter of months. It comes down to a simple choice: to share or not to share. My piece on #VaccinEquity in the @nytimes. https://t.co/OIRAogZPwl
— Tedros Adhanom Ghebreyesus (@DrTedros) April 23, 2021
Recommendations to address patients fear of adverse effects and COVID-19 vaccine hesitancy
25 Apr, 2021 | 21:58h | UTC
WHO: COVID-19 continues to disrupt essential health services in 90% of countries
25 Apr, 2021 | 22:12h | UTC
Commentary on Twitter (thread – click for more)
Over one year into the #COVID19 pandemic, about 9⃣0⃣% of countries surveyed still report one or more disruptions to essential health services. Major efforts are required to restore and strengthen services in all countries.
👉 https://t.co/P34xPKY1Io pic.twitter.com/UYDQPX67Vw
— World Health Organization (WHO) (@WHO) April 23, 2021
U.S. lifts pause on use of J&J’s Covid-19 vaccine
25 Apr, 2021 | 21:57h | UTCU.S. lifts pause on use of J&J’s Covid-19 vaccine – STAT
See also: CDC, FDA lift pause on using J&J’s coronavirus vaccine, add safety warning – CNN AND ACIP opts to lift pause on Johnson & Johnson vaccine – CIDRAP
One million coronavirus sequences: popular genome site hits mega milestone
25 Apr, 2021 | 21:59h | UTCOne million coronavirus sequences: popular genome site hits mega milestone – Nature
Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
25 Apr, 2021 | 21:17h | UTCNews release: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal – University of Oxford
Original study (preprint): High Efficacy of a Low Dose Candidate Malaria Vaccine, R21 in 1 Adjuvant Matrix-M™, with Seasonal Administration to Children in Burkina Faso – The Lancet
Commentaries: Malaria vaccine hailed as potential breakthrough – BBC AND Oxford Malaria vaccine proves highly effective in Burkina Faso trial – The Guardian
Commentary on Twitter (thread – click for more)
💡AMAZING—First high >75% efficacy vaccine for a disease with 229 million cases & 409,000 deaths worldwide in 2019 —#Malaria!
Created by Oxford, produced by Serum Institute of India, & supporting adjuvant by Novavax, SII expects to make 200 mil doses a year!
Science! #vaccine pic.twitter.com/gnPMvXxww6
— Eric Feigl-Ding (@DrEricDing) April 23, 2021
Resurgence of SARS-CoV-2: detection by community viral surveillance
25 Apr, 2021 | 21:55h | UTCResurgence of SARS-CoV-2: detection by community viral surveillance – Science
Commentary on Twitter
A #SARSCoV2 surveillance program tested in England in 2020 successfully detected a resurgence of virus infection at low prevalence, @imperialcollege researchers say. Such programs can augment routine surveillance to inform public health interventions. https://t.co/veilAJ8YX4 pic.twitter.com/9YFQbvtqbw
— Science Magazine (@ScienceMagazine) April 23, 2021
RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies
25 Apr, 2021 | 21:14h | UTCIntracytoplasmic sperm injection versus conventional in-vitro fertilisation in couples with infertility in whom the male partner has normal total sperm count and motility: an open-label, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
🔴New RCT in @TheLancet
⭐In couples with infertility + normal total sperm count and motility ➡️ ICSI did not improve the livebirth rate compared with conventional IVF.
No excuses left to do ICSI for all.
Full text ⬇️https://t.co/6FYX7TeDRN— Rita Vassena (@RitaVassena) April 23, 2021
RCT: Promising results with vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischemic stroke
25 Apr, 2021 | 21:10h | UTCCommentary: Vagus nerve stimulation: a potential new treatment for ischaemic stroke – The Lancet
Commentary on Twitter
Very important @TheLancet study showing #vagus nerve stimulation improves rehabilitation ischemic #stroke.
Kudos Prof Jesse Dawson @UofGlasgow at colleagues!https://t.co/DsIH3wMuAp pic.twitter.com/QtzBBDVnso
— Prof. Kevin J. Tracey, MD (@KevinJTraceyMD) April 23, 2021
Opinion | What it Means to be a Medical Conservative
25 Apr, 2021 | 21:06h | UTCWhat it Means to be a Medical Conservative – Stop and Think
New studies in patients with moderate-to-severe psoriasis show greater skin clearance with Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F
25 Apr, 2021 | 21:08h | UTCStudy 1: Bimekizumab versus Secukinumab in Plaque Psoriasis – New England Journal of Medicine
Study 2: Bimekizumab versus Adalimumab in Plaque Psoriasis – New England Journal of Medicine
Related studies: Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase trial – The Lancet AND Bimekizumab versus ustekinumab for the treatment of moderate to severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week, multicentre, double-blind, active comparator and placebo controlled phase 3 trial – The Lancet
Analysis of 1060 Cases of Drug-Induced Acute Pancreatitis – a large proportion of cases were caused by antineoplastic (16.89%), antibiotic (12.08%), and anticonvulsant (9.72%) drugs
25 Apr, 2021 | 20:55h | UTCAnalysis of 1060 Cases of Drug-Induced Acute Pancreatitis – Gastroenterology
RCT: Metformin vs. insulin in gestational diabetes – metformin was associated better glycemic control, lower risk of hypoglycemia, and less maternal weight gain
25 Apr, 2021 | 21:03h | UTCMeDiGes Study. Metformin versus insulin in gestational diabetes: Glycemic control, and obstetrical and perinatal outcomes. Randomized prospective trial. – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Related: Randomized trial tests metformin in women with type 2 diabetes in pregnancy AND Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis – PLOS Medicine AND Case-Control Study: Metformin Exposure in First Trimester of Pregnancy is Not Associated with Congenital Anomalies
RCT: Induction of Labor at Term with Vaginal Misoprostol or a PGE2 Pessary – little difference in outcomes, the clinical risk-benefit ratio justifies the use of both drugs
25 Apr, 2021 | 20:59h | UTCInduction of Labor at Term With Vaginal Misoprostol or a PGE2 Pessary: a Noninferiority RCT – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)