Archives
M-A: The viral shedding time (VST) determines disease transmission and the duration of infectiousness in SARS-CoV-2 infections – this study found that symptomatic infections, infected adults, persons with chronic diseases, and persons receiving corticosteroid treatment have longer VST
3 May, 2021 | 05:37h | UTC
Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination
3 May, 2021 | 05:43h | UTCSee also: Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine — United States, March–April 2021 – Centers for Disease Control and Prevention AND Updated Recommendations from the Advisory Committee on Immunization Practices for Use of the Janssen (Johnson & Johnson) COVID-19 Vaccine After Reports of Thrombosis with Thrombocytopenia Syndrome Among Vaccine Recipients — United States, April 2021 – Centers for Disease Control and Prevention
M-A: Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease – “a 5 mm Hg reduction of systolic BP reduced the risk of major CV events by about 10%, irrespective of previous diagnoses of CV disease, and even at normal or high–normal BP values”
3 May, 2021 | 05:29h | UTCCommentaries: Many more people could benefit from blood pressure-lowering medication – The Lancet AND Decisions about antihypertensive treatment should focus on reducing cardiovascular risk – The Lancet
Highly Recommended (video): The Culture Of Medicine Kills Doctors And Patients (w/Dr. Robert Pearl)
3 May, 2021 | 05:32h | UTCThe Culture Of Medicine Kills Doctors And Patients (w/Dr. Robert Pearl) – ZDoggMD
Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.
3 May, 2021 | 05:18h | UTCCommentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – RBC transfusion at a threshold of 7 g/dL; Erythromycin infusion is suggested before endoscopy; and endoscopy is suggested within 24 hours after presentation.
3 May, 2021 | 05:27h | UTC
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – antimicrobials, herbal and dietary supplements, and anticancer therapeutics are the most common classes of agents
3 May, 2021 | 05:22h | UTC
Randomized trial: Admission Avoidance Hospital at Home + Geriatric Assessment led to similar outcomes compared to hospital admission for older persons
3 May, 2021 | 05:13h | UTCIs Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Related: Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
Study: Despite clinical practice guidelines recommending cervical cancer screening every 3 years or cotesting with HPV and cytologic testing every 5 years, many women get tested much more often
3 May, 2021 | 05:19h | UTC
RCT: Discontinuing nasal continuous positive airway pressure either at 5 cm H2O vs. 3 cm H2O in infants ≤32 weeks of gestational age
3 May, 2021 | 05:15h | UTCDiscontinuing Nasal Continuous Positive Airway Pressure in Infants ≤32 Weeks of Gestational Age: A Randomized Control Trial – The Journal of Pediatrics (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/DrAbdulRazak_MD/status/1321226454471004160
The Lancet Series | Miscarriage matters
3 May, 2021 | 05:11h | UTCEditorial: Miscarriage: worldwide reform of care is needed
- Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss
- Sporadic miscarriage: evidence to provide effective care
- Recurrent miscarriage: evidence to accelerate action
Study on five million Swedes finds links between blood groups and disease risks
3 May, 2021 | 05:09h | UTCNews Release: Study on five million Swedes finds links between blood groups and disease risks – Karolinska Institutet
Original Study: An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk – eLife
M-A: Delayed antibiotic prescribing for respiratory tract infections is a safe and effective strategy for most patients
30 Apr, 2021 | 08:33h | UTCCommentaries: Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection – HealthDay
RCT: Tranexamic acid for the prevention of blood loss after cesarean delivery – even though TA resulted in a significantly lower incidence of estimated blood loss, the clinical relevance of the findings was small
30 Apr, 2021 | 08:38h | UTC
Commentaries on Twitter
Another typically "positive" trial for TXA.
"the mean between-group difference was approximately 100 ml …. the clinical relevance of this narrow difference is questionable"
– No difference in RBC transfusions.
– 0.4% vs 0.1% VTE at 3 mos.— Ryan Radecki, MD MS (@emlitofnote) April 28, 2021
NEJM-Prevention of Blood Loss after Cesarean Delivery | tranexamic acid ➡️ significantly lower incidence of EBL greater than 1000 ml or RBC transfusion by day 2 than placebo, but did not result in a ⬇️ incidence of hemorrhage-related secondary outcomes https://t.co/ydF5HgHM0N
— Skeptical Scalpel (@Skepticscalpel) April 28, 2021
AHA Statement: Management of Stage 1 Hypertension in Adults With a Low 10-Year Risk for Cardiovascular Disease – “There is a lack of randomized clinical trials that have evaluated CVD outcomes among individuals with stage 1 hypertension and a low 10-year ASCVD risk”
30 Apr, 2021 | 08:37h | UTCNews Release: If slightly high blood pressure doesn’t respond to lifestyle change, medication can help – American Heart Association
Top Things to Know: Management of Stage 1 Hypertension in Adults With a Low 10-Year Risk for Cardiovascular Disease – American Heart Association
Commentary: The Hypertension Pandemic: Need for a Strategic Evidence-based Response – American Heart Association
Review: Evolution and Current Status of the Multidisciplinary Management of Locally Advanced Rectal Cancer
30 Apr, 2021 | 08:31h | UTC
Cohort Study: The risk of overdose with concomitant use of Z-Drugs (zolpidem, zopiclone, zaleplon) and prescription opioids is significantly increased
30 Apr, 2021 | 08:32h | UTCThe Risk of Overdose With Concomitant Use of Z-Drugs and Prescription Opioids: A Population-Based Cohort Study – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary: Co-prescribing Opioids, Z-Drugs May Increase Risk of Overdose – Psychiatric News Alert
FDA says it will ban all menthol cigarettes and flavored cigars
30 Apr, 2021 | 08:29h | UTCFDA says it will ban all menthol cigarettes and flavored cigars – STAT
See also: FDA Moves To Ban Cigarettes And Flavored Cigars – NPR
AHA Statement: Prevention of Viridans Group Streptococcal Infective Endocarditis – Antibiotic prophylaxis for invasive dental procedures is suggested only for high-risk patients with the following conditions: 1) cardiac prosthetic valve; 2) previous infective endocarditis; 3) congenital heart disease; or 4) previous heart transplant
30 Apr, 2021 | 08:35h | UTCNews release: Good dental health may help prevent heart infection from mouth bacteria – American Heart Association
Top Things to Know: Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association
Slide set: Prevention of Viridans Group Streptococcal Infective Endocarditis
Commentaries: Commentary for Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association
Commentary on Twitter (thread – click for more)
In 2007, antibiotic prophylaxis to prevent VGS IE was scaled back.
“There was no convincing evidence that VGS IE frequency, morbidity, or mortality has increased since 2007.”
Thanks Drs. @LBaddour1, Daniel DeSimone and Walter Wilsonhttps://t.co/r9It8c3IwA pic.twitter.com/EO3gcKZAzG
— Mayo Clinic Infectious Diseases (@MayoClinicINFD) April 18, 2021
AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”
30 Apr, 2021 | 08:25h | UTCNews release: Guidance on treatment for rare blood clots and low platelets related to COVID-19 vaccine – American Heart Association
Study with 6.9 million people in England shows severe Covid-19 in young people can mostly be explained by obesity – At a BMI of more than 23 kg/m2, there was a linear increase in risk of severe COVID-19
30 Apr, 2021 | 08:22h | UTCCommentaries: Severe COVID in young people can mostly be explained by obesity – new study – The Conversation AND Obesity studies highlight severe COVID outcomes, even in young adults – CIDRAP AND Expert reaction to study looking at a potential link between body weight and risk of severe COVID-19, especially for younger adults – Science Media Centre
Commentary on Twitter (thread – click for more)
NEW—Study of health records of nearly 7 million people in England found that the risk of worse outcomes from #COVID19 starts rising in people with a BMI above 23kg/m2—considered to be in the healthy range.
Read in @TheLancetEndo: https://t.co/5ibn3yb1xO 1/2 pic.twitter.com/4MwnGq95Sz
— The Lancet (@TheLancet) April 29, 2021
Debate: Should masks be worn outdoors?
30 Apr, 2021 | 08:21h | UTCShould masks be worn outdoors? – The BMJ
Commentaries: Experts debate on wearing masks outdoors – News Medical AND Do masks need to be worn outdoors? – Advanced Science News
Commentary on Twitter (thread – click for more)
Who do so many of us go off about outdoor masking?
Because if governments can show its people that it's taking #COVID19 seriously by focusing on outdoor masking while ignoring the living and working conditions driving so many infections, we'll get nowhere.#endpandemictheatre
— Stefan Baral (@sdbaral) April 29, 2021
Cohort study: Association of maternal SARS-CoV-2 infection in pregnancy with neonatal outcomes – “although babies born of test-positive mothers are more likely to be born early, extremely few were infected with COVID-19”
30 Apr, 2021 | 08:17h | UTCAssociation of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes – JAMA
News release: Low risk of infection in babies born to mothers with COVID-19 – Karolinska Institutet
Editorial: Understanding Risk for Newborns Born to SARS-CoV-2–Positive Mothers – JAMA
Commentary on Twitter
Maternal #SARSCoV2 infection in pregnancy was significantly associated with small increases in the absolute risk of respiratory disorders and some other neonatal morbidities https://t.co/ANkXkaxnwp
— JAMA (@JAMA_current) April 29, 2021
Household COVID-19 risk and in-person schooling – “While in-person schooling is associated with household COVID-19 risk, this risk can likely be controlled with properly implemented school-based mitigation measures”
30 Apr, 2021 | 08:19h | UTCHousehold COVID-19 risk and in-person schooling – Science
Commentary on Twitter
After analyzing responses from the #COVID19 Symptom Survey, @JustinLessler et al. find support for the idea that in-person schooling increases COVID-19 risk to household members; but also evidence that common mitigation measures can reduce this risk. https://t.co/DFtCoN0FEE pic.twitter.com/gxt7nkhdMb
— Science Magazine (@ScienceMagazine) April 29, 2021
Opinion | The world could be doing much more to help India: Countries can’t go it alone in tackling Covid-19
30 Apr, 2021 | 08:16h | UTCThe world could be doing much more to help India – Vox
See also: WHO provides update on India’s surging epidemic second wave and variant B.1.617 – Science Speaks: Global ID News AND People Are Talking About A ‘Double Mutant’ Variant In India. What Does That Mean? – NPR AND WHO says India COVID crisis could ‘happen anywhere’ – MedicalXpress AND India’s COVID-19 Crisis Is Spiraling Out of Control. It Didn’t Have to Be This Way – TIME