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WHO Global Patient Safety Action Plan 2021-2030.

5 Aug, 2021 | 08:51h | UTC

Global Patient Safety Action Plan 2021-2030 – World Health Organization

Commentary on Twitter

Delighted to launch the @WHO Global #PatientSafety Action Plan 2021 – 2030, focusing on:
-understanding the extent of the problem
-closing policy gaps
-addressing inadequate application of safety science in policies
-putting policies into practicehttps://t.co/63Fj1xgVEX

— Tedros Adhanom Ghebreyesus (@DrTedros) August 4, 2021

Coronavirus infections three times lower in double vaccinated people – REACT.

5 Aug, 2021 | 08:53h | UTC

Coronavirus infections three times lower in double vaccinated people – REACT – Imperial College London

AAOS Guideline: Pharmacologic, physical, and cognitive pain alleviation for musculoskeletal extremity/pelvis surgery.

5 Aug, 2021 | 08:49h | UTC

Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery – American Academy of Orthopaedic Surgeons

Evidence summary: Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery

News release: Clinical Practice Guideline and Appropriate Use Criteria for the Evaluation of Pharmacologic, Physical, and Cognitive Pain Alleviation for Musculoskeletal Extremity/Pelvis Surgery

Guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy.

5 Aug, 2021 | 08:47h | UTC

European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force—Second revision – European Journal of Neurology

UEG and ESNM consensus on gastroparesis.

5 Aug, 2021 | 08:46h | UTC

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis – UEG Journal

RCT: Similar outcomes with Milrinone vs. Dobutamine in the treatment of cardiogenic shock.

5 Aug, 2021 | 08:44h | UTC

Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Visual abstract: Milrinone vs. Dobutamine in Cardiogenic Shock

Commentary: Inotrope Showdown Leaves No Winner in Cardiogenic Shock – MedPage Today (link to abstract – $ for full-text)

RCT: Therapeutic hypothermia may cause harm in moderate or severe neonatal encephalopathy in low-income and middle-income countries.

5 Aug, 2021 | 08:43h | UTC

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh – The Lancet Global Health

News release: Brain injury treatment may cause harm in low and middle income nations – Imperial College London

Commentary: Hypoxic ischaemic encephalopathy in low resource settings—time to stop cooling? – The Lancet Global Health

Methodology over metrics: current scientific standards are a disservice to patients and society.

5 Aug, 2021 | 08:42h | UTC

Methodology over metrics: current scientific standards are a disservice to patients and society – Journal of Clinical Epidemiology

The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018.

5 Aug, 2021 | 08:37h | UTC

The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018 – BMC Oncology

Meta-Research: A Comprehensive Review of Randomized Trials Leading to “Medical Reversals” in Three Medical Journals

Frequency of Medical Reversal Among Published Randomized Controlled Trials Assessing Cardiopulmonary Resuscitation

Review: Medical Reversals in Family Practice

Sham Surgeries: A Tale of Medical Reversals & the Role of the Media

International consensus recommendations on key outcome measures for organ preservation after (chemo) radiotherapy in patients with rectal cancer.

5 Aug, 2021 | 08:38h | UTC

International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer – Nature Reviews Clinical Oncology

Cancer care in the wake of a cyberattack: how to prepare and what to expect.

5 Aug, 2021 | 08:41h | UTC

Cancer Care in the Wake of a Cyberattack: How to Prepare and What to Expect – JCO Oncology Practice

Commentary on Twitter

https://twitter.com/tbplante/status/1422729615488032768

Commentary on the Latest AAP Guidelines for the Febrile Neonate.

5 Aug, 2021 | 08:36h | UTC

Small Talk – Hot Off The Presses: The Latest AAP Guidelines for the Febrile Neonate – emDocs

Original guideline:

AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.

M-A: Low prevalence of bacterial meningitis among well-appearing febrile infants aged 29-60 days with positive urinalysis results – “These results suggest that for these infants, the decision to use lumbar puncture should not be guided by urinalysis results alone”.

Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis

[Abstract Only] Observational Study Suggests Testing for Meningitis May Not be Necessary for Febrile Well-Appearing Young Infants with Positive Urinalysis

Study: Clinical Prediction Rule to Identify Febrile Infants at Low Risk for Serious Bacterial Infections

Cohort Study: Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections

Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls.

5 Aug, 2021 | 08:33h | UTC

Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls – New England Journal of Medicine

Visual abstract: Risdiplam-Treated Infants with Type 1 SMA vs. Historical Controls

Pulmonary aspiration of gastric contents: a closed claims analysis.

5 Aug, 2021 | 08:34h | UTC

Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis – Anesthesiology

Review: Lung transplantation for interstitial lung disease.

5 Aug, 2021 | 08:32h | UTC

Lung transplantation for interstitial lung disease – European Respiratory Review

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

4 Aug, 2021 | 10:06h | UTC

Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2 – The Lancet Child & Adolescent Health

Invited commentary: Citizen science and biomedical research (free registration required)

Commentaries:

Expert reaction to study looking at long-lasting symptoms from COVID-19 in children – Science Media Centre

Long Covid uncommon in children, analysis finds – King’s College London

Study finds long-term Covid symptoms rare in school-age children – The Guardian

Most children with Covid-19 recover within a week, but a small percentage have long-term symptoms, a study says. – The New York Times

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Cohort study: Risk factors for long covid in previously hospitalized children.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Commentary on Twitter

New @LancetChildAdol is a very reassuring prospective study of >250,000 children, >1700 with + covid test, age 5-17, that shows the risk for chronic Covid symptoms is quite low; 4.4% beyond 4 weekshttps://t.co/XVFs0UtHWC pic.twitter.com/XBVH5wmFve

— Eric Topol (@EricTopol) August 3, 2021

AAP Interim guidance on supporting the emotional and behavioral health needs of children, adolescents, and families during the COVID-19 pandemic.

4 Aug, 2021 | 10:03h | UTC

Interim Guidance on Supporting the Emotional and Behavioral Health Needs of Children, Adolescents, and Families During the COVID-19 Pandemic – American Academy of Pediatrics

Review: Tuberous sclerosis complex for the pulmonologist.

5 Aug, 2021 | 08:30h | UTC

Tuberous sclerosis complex for the pulmonologist – European Respiratory Review

Opinion (video): “The Delta Surge May Collapse Faster Than You Think.”

4 Aug, 2021 | 09:53h | UTC

The Delta Surge May Collapse Faster Than You Think – ZDoggMD

The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.

How the coronavirus infects cells — and why Delta is so dangerous.

COVID vaccines slash viral spread, but Delta is an unknown – “Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty”.

CDC changes mask guidance in response to threat of Delta variant of Covid-19.

Position statement: Perioperative management of post-COVID-19 surgical patients.

4 Aug, 2021 | 10:00h | UTC

Perioperative management of post-COVID-19 surgical patients: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement – Indian Journal of Anaesthesia

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

WSES Position Paper: The management of surgical patients in the emergency setting during COVID-19 pandemic

Preparing previously COVID-19-positive patients for elective surgery: A framework for preoperative evaluation

Commentary on Twitter

Interesting position statement (from India) for perioperative management of post-COVID-19 surgical patients. Highlights important points to consider but appears overly cautious, recommending a lot of preop testing. #COVID19 https://t.co/oOR1ik21ha

— Steven Cohn, MD (@preopconsult) August 3, 2021

AAP Guidance: Post-COVID-19 conditions in children and adolescents.

4 Aug, 2021 | 10:01h | UTC

Post-COVID-19 Conditions in Children and Adolescents – American Academy of Pediatrics

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

4 Aug, 2021 | 09:55h | UTC

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset – eLlife

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

Commentary on Twitter (thread – click for more)

Excess mortality across the world with the World Mortality Dataset – officially published at @eLife!https://t.co/bCudrKhZ6d

A thread on data, findings, and more.

1

(Illustration by Gal Kabiri) pic.twitter.com/oqtXRqUQH9

— Ariel Karlinsky (@ArielKarlinsky) August 3, 2021

Antimicrobial stewardship in the ICU in COVID times: the known unknowns.

4 Aug, 2021 | 09:16h | UTC

Antimicrobial stewardship in the ICU in COVID times: the known unknowns – International Journal of Antimicrobial Agents

IDSA Updated Covid-19 Guidance: Co-Infection and Antimicrobial Stewardship – “bacterial coinfections with SARS-CoV-2 infection are relatively infrequent (likely occurring in less than 10% of hospitalized COVID-19 patients)”.

Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

Too many COVID-19 patients get unneeded ‘just in case’ antibiotics

RCT: Text-message reminders can increase COVID-19 vaccinations.

4 Aug, 2021 | 09:12h | UTC

Behavioral Nudges Increase COVID-19 Vaccinations – Nature

Commentaries:

Text-message ‘nudges’ can encourage holdouts to get COVID vaccination, study finds – UCLA

Text reminders boost vaccine appointments – Carnegie Mellon University

Commentary on Twitter

Sometimes the tools that actually work in public health are profoundly boring. Here, a text message reminder system is shown in a randomized trial to increase vaccine uptake. Years of HIV adherence research has shown the value of simple nudges like this.https://t.co/1ndpnQ6Ha6 https://t.co/Gltll8DTJ4

— Natalie E. Dean, PhD (@nataliexdean) August 3, 2021

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

4 Aug, 2021 | 09:07h | UTC

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia position statement – Pain

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