Meta-Research: A Comprehensive Review of Randomized Trials Leading to “Medical Reversals” in Three Medical Journals

Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals – eLife (free)

Commentaries: Almost 400 medical practices found ineffective in analysis of 3,000 studies – eLIFE (free) AND Hundreds of current medical practices may be ineffective – Medical News Today (free)

Related Commentary on Twitter

A review of more than 3,000 randomized clinical trials in NEJM, Lancet and JAMA reveals 396 medical reversals (results later shown to be wrong, usually in systematic reviews). 22 studies in pulmonary diseases and 45 in critical care medicine were affected. https://t.co/uAW9r3SMJs

— Claudia Dobler, MD, PhD (@ClaudiaCDobler) June 11, 2019