Archives
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
29 Oct, 2021 | 10:20h | UTCRelated:
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
Review: How I manage a patient with MRSA bacteremia.
31 Oct, 2021 | 19:54h | UTCHow I manage a patient with MRSA bacteraemia – Clinical Microbiology and Infection
The effectiveness of the AstraZeneca vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo was 77.9% against symptomatic Covid-19, 87.6% against hospitalization, and 93.6% against death.
29 Oct, 2021 | 10:25h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/MHitchingsEpi/status/1453779176826105857
Under-reporting of deaths limits our understanding of true burden of covid-19.
29 Oct, 2021 | 10:18h | UTCUnder-reporting of deaths limits our understanding of true burden of covid-19 – The BMJ
Related:
Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.
Just how do deaths due to COVID-19 stack up?
Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter
Mortality data have been essential in understanding the spread of covid-19 and navigating the trade-offs that underlie political decision making, yet under-reporting in official death records has greatly obscured this understanding.
What should be done?https://t.co/pI8aVpa3NR
— The BMJ (@bmj_latest) October 14, 2021
Complications of critical COVID-19: Diagnostic and therapeutic considerations for the mechanically ventilated patient.
29 Oct, 2021 | 10:14h | UTC
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
29 Oct, 2021 | 10:16h | UTCmRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern – Science
Commentary from the author on Twitter (thread – click for more)
Antibodies come and go, but memory cells are forever (maybe not forever, but at least 6 months). Our latest in @ScienceMagazine: https://t.co/YHHBMrMsTA
How long does immune memory last after #mRNA vax? Is it effective vs. variants? What about “boosted” responses?
Full 🧵⬇️… pic.twitter.com/oZ5BxLuVdw
— Rishi Goel (@rishirajgoel) October 14, 2021
2021 AHA/ACC Guideline for the Evaluation and Diagnosis of Chest Pain.
29 Oct, 2021 | 09:57h | UTCExecutive Summary: 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain – Journal of the American College of Cardiology
News Release: First-Ever Guideline Focused Solely on Chest Pain Evaluation, Diagnosis Released
Guideline Hub: Guideline for the Evaluation and Diagnosis of Chest Pain
Key Points: 2021 AHA/ACC Chest Pain Guideline – American College of Cardiology
Commentary: New Chest Pain Guidelines Out at Last: Most Tests Have a Role – TCTMD
Commentary on Twitter (thread – click for more)
The Chest Pain Guidelines are now released!https://t.co/xQxCWzReEN
Top 10: CHEST PAINS
Thanks to the entire writing group and my co-cahirs: Deb Murkerjee & Phil Levy
💥First Chest Pain Guidelines @AHAScience @ACCinTouch pic.twitter.com/s17piamrKR— Dr. Martha Gulati ♥️🫀❤️🩹🇨🇦 (@DrMarthaGulati) October 28, 2021
Nine Pandemic Words That Almost No One Gets Right.
29 Oct, 2021 | 10:12h | UTCNine Pandemic Words That Almost No One Gets Right – The Atlantic
Systematic Review: Not enough evidence to inform the decision to either interrupt or continue anticoagulation before catheter ablation in patients with arrhythmia.
29 Oct, 2021 | 09:50h | UTC
Systematic Review: GLP-1 receptor agonists and SGLT-2 inhibitors are likely to reduce the risk of death from cardiovascular disease and death from any cause in people with both diabetes and established cardiovascular disease.
29 Oct, 2021 | 09:52h | UTC
Commentary on Twitter
The effects of DPP‐4 inhibitors, GLP‐1 receptor agonists and SGLT‐2 inhibitors for people with #CardiovascularDisease https://t.co/0FwffSCqbC New @CochraneHeart network meta-analysis looks at evidence from 31 studies. #CardiovascularResearch
— The Cochrane Library (@CochraneLibrary) October 27, 2021
WHO Guideline for clinical management of exposure to lead.
29 Oct, 2021 | 09:56h | UTCGuideline for clinical management of exposure to lead – World Health Organization
Executive Summary: Guideline for clinical management of exposure to lead
See also: International Lead Poisoning Prevention Week 2021
Commentary on Twitter (thread – click for more)
It's International Lead Poisoning Prevention Week
Exposure to lead affects human health, especially children's health. There is no safe level of exposure to lead. Even low levels of lead exposure may cause lifelong health problems.
Let's #BanLeadPaint
👉https://t.co/O7NeRcMrW7 pic.twitter.com/mBV13Urf9r
— World Health Organization (WHO) (@WHO) October 24, 2021
Systematic Review: Management of cutaneous immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors.
29 Oct, 2021 | 09:46h | UTCManagement of Cutaneous Immune-Related Adverse Events in Patients With Cancer Treated With Immune Checkpoint Inhibitors: A Systematic Review – JAMA Oncology (free for a limited period)
Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis.
29 Oct, 2021 | 09:49h | UTC
Commentary on Twitter
Post-cardiac arrest brain injury, narrative review:
🧠pathophysiology: primary (ischemic) & secondary (reperfusion)
🧠treatment options
🧠outcomes
🧠neuroprognostication
🧠@ERC_resus @ESICM 2021 algorithm for prognostication
Open #FOAMcc #FOAMres @yourICM https://t.co/b8GRhE3MuF pic.twitter.com/q10DJVRJOp— Intensive Care Medicine (@yourICM) October 27, 2021
Stimulant prescription linked to increased short-term risks of cardiovascular events in older adults.
29 Oct, 2021 | 09:47h | UTCAssessment of Stimulant Use and Cardiovascular Event Risks Among Older Adults – JAMA Network Open
Commentaries:
Stimulants Linked to Early Risk of CV Events in Elderly – TCTMD
Stimulants May Pose Short-Term Cardiovascular Risks in Older Adults – Psychiatric News Alert
Predatory publishers’ latest scam: bootlegged and rebranded papers.
29 Oct, 2021 | 09:45h | UTCPredatory publishers’ latest scam: bootlegged and rebranded papers – Nature
Related: Predatory Journals: No Definition, No Defense
RCT: Early treatment of Covid-19 with SARS-CoV-2 neutralizing antibody Sotrovimab is associated with reduced risk of hospitalization.
28 Oct, 2021 | 10:20h | UTC
Commentary on Twitter
In this phase 3 trial, sotrovimab or placebo was administered to outpatients within 5 days after the onset of #COVID19 symptoms. Patients receiving sotrovimab had a lower incidence of hospitalization for any reason. #IDTwitter https://t.co/4VcgoK3xac pic.twitter.com/W82v3jNRmB
— NEJM (@NEJM) October 27, 2021
Merck to allow other nations to produce new COVID-19 antiviral.
28 Oct, 2021 | 10:18h | UTCMerck to allow other nations to produce new COVID-19 antiviral – CIDRAP
See also:
Merck will allow drugmakers in other countries to make its COVID-19 pill – NPR
Related:
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.
28 Oct, 2021 | 10:22h | UTCCommentaries:
The TOGETHER Trial: COVID-19 and Fluvoxamine Take Two – REBEL EM
The antidepressant fluvoxamine can keep COVID-19 patients out of the hospital – ScienceNews
Related:
Commentary on Twitter
NEW in @LancetGH: Using SSRI #fluvoxamine to treat high-risk outpatients with early-diagnosed #COVID19 reduced the need for prolonged observation in an emergency setting or hospitalisation: largest trial to date. https://t.co/BVtMju74lp @TogetherTrial pic.twitter.com/F1FnZuyqdY
— The Lancet (@TheLancet) October 27, 2021
Two observational studies cast doubt on the effects of school closures to reduce the spread of Covid-19.
28 Oct, 2021 | 10:17h | UTCStudy 2: The impact of school opening model on SARS-CoV-2 community incidence and mortality – Nature Medicine
Commentaries on Twitter
Results from a study in the US published in @NatureMedicine indicate that schools can reopen for in-person learning without substantially increasing community case rates of SARS-CoV-2. However, the impacts are variable and more study is needed. https://t.co/NFt1vNNb76 pic.twitter.com/fNgsJn6WLg
— Nature Portfolio (@NaturePortfolio) October 27, 2021
(thread – click for more)
2 new @NatureMedicine papers
First from half of US public school data
"Schools can open for in-person learning during the pandemic with minimal contribution to sustained community incidence of infections, provided other public safety measures are adopted."https://t.co/gn8MzrYVxE pic.twitter.com/qGfQLMzDEW— Eric Topol (@EricTopol) October 27, 2021
Brain fog can persist for months after COVID diagnosis.
28 Oct, 2021 | 10:13h | UTCAssessment of Cognitive Function in Patients After COVID-19 Infection – JAMA Network Open
Commentaries:
Brain fog can persist 8 months after COVID diagnosis – CIDRAP
What COVID vaccines for young kids could mean for the pandemic.
28 Oct, 2021 | 10:15h | UTCWhat COVID vaccines for young kids could mean for the pandemic – Nature
Related: FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts.
28 Oct, 2021 | 10:11h | UTCCommentaries:
Respiratory Subphenotypes of COVID-19-Related ARDS – ICU Management & Practice
Commentary on Twitter
NEW—At baseline, #COVID19-related #ARDS has no consistent resp subphenotype. Pts diverged from fairly homogenous to a more heterogeneous popn, w/ trajectories of ventilatory ratio and mechanical power being the most discriminatory.
PRoVENT–COVID study: https://t.co/v8GTVcYLxq pic.twitter.com/Tv72jOzuAC
— The Lancet Respiratory Medicine (@LancetRespirMed) October 13, 2021
Systematic Review: Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer.
28 Oct, 2021 | 09:58h | UTC
ESC Consensus Document | Frailty in cardiology: definition, assessment and clinical implications for general cardiology.
28 Oct, 2021 | 09:59h | UTC
Systematic Review: Avoidance of bottles during the establishment of breastfeeds in preterm infants – “Avoiding the use of bottles when preterm infants need supplementary feeds probably increases the extent of any breastfeeding at discharge”.
28 Oct, 2021 | 09:56h | UTCAvoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library
Summary: Avoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library