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Global Covid-19 deaths surpass five million.
2 Nov, 2021 | 02:59h | UTCGlobal Covid-19 deaths surpass five million – CNN
See also:
The COVID-19 pandemic has now killed 5 million people around the world – NPR
G20 leaders back COVID measures as deaths top 5 million – CIDRAP
Covid-19 deaths pass five million worldwide – BBC
Related:
Under-reporting of deaths limits our understanding of true burden of covid-19.
Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.
Just how do deaths due to COVID-19 stack up?
Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter
The number of people who have died from Covid-19 around the world surpassed five million early Monday, according to data held by the Johns Hopkins University Coronavirus Resource Center https://t.co/7XRJ8cWNTl
— CNN (@CNN) November 1, 2021
Review: Infectious disease in an era of global change.
3 Nov, 2021 | 09:50h | UTCInfectious disease in an era of global change – Nature Reviews Microbiology
Commentary on Twitter
This Review published in @NatureRevMicro examines how global changes — climate change, urbanization and global travel and trade — have increased the risk of infectious disease outbreaks like COVID-19 and Zika virus. https://t.co/09coqRyPLq pic.twitter.com/30EvYrHcN0
— Nature Portfolio (@NaturePortfolio) November 2, 2021
In Covid-19 vaccinated people, those with prior infection are likely to have more antibodies.
2 Nov, 2021 | 03:03h | UTCNews release: In Covid-19 Vaccinated People, Those with Prior Infection Likely to Have More Antibodies – Johns Hopkins Medicine
Original Article: Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection – JAMA
ASCO Guideline Update: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.
2 Nov, 2021 | 02:51h | UTC
A comprehensive review of vascular complications in COVID-19.
2 Nov, 2021 | 03:01h | UTC
J&J Covid-19 vaccination is associated with increased risk of cerebral venous sinus thrombosis.
2 Nov, 2021 | 03:02h | UTCCommentary: Cerebral Venous Sinus Thrombosis Rate Up After Ad26.COV2.S Shot – HealthDay
Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States.
2 Nov, 2021 | 02:58h | UTCRelated:
Deaths from COVID ‘incredibly rare’ among children.
Increased temperatures contributed to more than 200,000 cases of kidney disease in 15 years in Brazil alone.
2 Nov, 2021 | 02:46h | UTC
Study shows increased risk of Guillain-Barré syndrome following vaccination with recombinant zoster vaccine – “an attributable risk of 3 cases per million RZV (Shingrix) doses”.
2 Nov, 2021 | 02:45h | UTCRisk of Guillain-Barré Syndrome Following Recombinant Zoster Vaccine in Medicare Beneficiaries – JAMA Internal Medicine (free for a limited period)
Consensus Statement: Preoperative management of gastrointestinal and pulmonary medications.
2 Nov, 2021 | 02:53h | UTCRelated articles from Mayo Clinic Proceedings:
Consensus Statement: Preoperative management of endocrine, hormonal, and urologic medications
Consensus statement: Preoperative management of opioid and nonopioid analgesics
Review: Preoperative Cardiac Risk Assessment
Review | Perioperative cardiac risk reduction in noncardiac surgery.
Systematic Review of Perioperative Cardiac Risk Prediction Indices
Review: Perioperative venous thromboembolism prophylaxis
Short Review: Metronidazole-induced neurotoxicity.
2 Nov, 2021 | 02:41h | UTCMetronidazole-induced neurotoxicity – Canadian medical Association Journal
Commentary on Twitter
The ability of metronidazole to cause neurotoxicity is not widely appreciated. Here's our quick overview led by @DanicaQuickfall, just out in @CMAJ.
https://t.co/7sggYzCzGN pic.twitter.com/miW0trFuYv— David Juurlink (@DavidJuurlink) October 25, 2021
ASCO Guideline: Management of immune-related adverse events in patients treated with Chimeric Antigen Receptor T-Cell Therapy.
2 Nov, 2021 | 02:47h | UTC
Short Review: Ketamine for the treatment of acute pain.
2 Nov, 2021 | 02:43h | UTCKetamine for the treatment of acute pain – Canadian Medical Association Journal
Commentary on Twitter
If you manage pain in hospital, low-dose ketamine should be in your toolkit. And not just in the ED.
Quick overview with @WKSilverstein & @JonZipursky in @CMAJ: https://t.co/w5h3vIMiEK pic.twitter.com/gVO7W9dcYY
— David Juurlink (@DavidJuurlink) November 1, 2021
Observational study suggests a third dose of the Pfizer COVID-19 vaccine can prevent severe COVID-19-related outcomes, compared with only two doses received at least 5 months before.
31 Oct, 2021 | 20:14h | UTCInvited Commentary: Boosters appear effective, but are they always needed? – The Lancet
Commentaries on Twitter
Nice analysis of boosters in @TheLancet Fri.: https://t.co/KqXInFa3a9
But I want to highlight one number:
Risk of severe disease w no booster & no coexisting conditions = 1 in 32,000 (3 per 100k).
If you have no other medical problems, this is not an urgent priority. pic.twitter.com/Qwcwsf6LIY
— David Dowdy (@davidwdowdy) October 31, 2021
Study in Israel suggests third dose of BNT162b2 mRNA vaccine effective in protecting individuals against severe COVID-19-related outcomes, compared with receiving only two doses at least 5 months before. https://t.co/g3vFqVFZLI pic.twitter.com/HfbBAPY8qP
— The Lancet (@TheLancet) October 31, 2021
Adding to the body of data for booster shot effectiveness, a new @TheLancet report of over 728,000 people w/ 3 shots vs >728,000 matched controls (2 shots):
93% reduction of Covid hospitalizationshttps://t.co/cVpANpnkHs pic.twitter.com/LlBwWi2Vtw— Eric Topol (@EricTopol) October 30, 2021
Study shows fully vaccinated individuals can still catch SARS-CoV-2 delta variant and efficiently transmit infection in household settings, including to fully vaccinated contacts.
31 Oct, 2021 | 20:16h | UTCCommentaries:
COVID vaccines protect against Delta but don’t fully stop disease spread – CIDRAP
Covid: Double vaccinated can still spread virus at home – BBC
Commentary on Twitter
NEW—#COVID19 vaccines lower the risk of infection with the #DeltaVariant. However, infection can still be passed on in household settings after two doses.
Authors urge unvaccinated to get vaccinated & those eligible to receive a booster. 1/2 https://t.co/jq8DCK69Ww pic.twitter.com/1XzHnKCF01
— The Lancet (@TheLancet) October 28, 2021
Editorial: Safety and efficacy of antivirals against SARS-CoV-2 – “we need evidence not optimism”.
31 Oct, 2021 | 20:11h | UTCSafety and efficacy of antivirals against SARS-CoV-2 – The BMJ
Commentary on Twitter
"Effective antivirals have an obvious appeal, but this must not cloud objective and transparent decision making." @dpsg108 and colleagues on the government's stockpiling of molnupiravir and PF-07321332+ritonavir for covid-19https://t.co/JUj1Y9op3P
— The BMJ (@bmj_latest) October 28, 2021
CDC Study: COVID-19 vaccine associated with 5 times the protection of ‘natural immunity’.
31 Oct, 2021 | 20:09h | UTCCommentaries:
COVID-19 vaccine gives 5 times the protection of ‘natural immunity,’ data show – CIDRAP
COVID shots more protective than past infection, study shows – Associated Press
Commentary on Twitter
⚠️BREAKING—REINFECTION & NATURAL IMMUNITY—new CDC study in hospitalized adults finds: unvaccinated people with prior #COVID19 infection recently were **5 times more likely** to be reinfected / get breakthrough versus people recently fully vaccinated! 🧵 https://t.co/VGmWPmm5lE pic.twitter.com/mlt5fJ3643
— Eric Feigl-Ding (@DrEricDing) October 29, 2021
Cohort Study: Among patients with ST-segment elevation myocardial infarction, a concomitant Covid-19 diagnosis is associated with increased in-hospital mortality.
31 Oct, 2021 | 20:10h | UTCEditorial: Myocardial Infarction During the COVID-19 Pandemic – JAMA
Commentary: STEMI and COVID-19 Often a Lethal Combo, Affirms Largest Study Yet – TCTMD
Commentary from the author on Twitter (thread – click for more)
1/8 It was not unexpected that pts w/ #STEMI would fare worse w/ than w/o #COVID19 https://t.co/B7oWnJunEa
— herbaronowMD (@herbaronowMD) October 29, 2021
Opinion | Is Moderna really better than Pfizer—or is it just a higher dose?
31 Oct, 2021 | 20:06h | UTCIs Moderna Really Better Than Pfizer—Or Is It Just a Higher Dose? – The Atlantic
Commentary on Twitter
Nice piece @theatlantic explores question of: Does Moderna give better protection than Pfizer, which gives better protection than J&J (the data would say yes to both)? And – if so – is it simply a matter of the relative doses? https://t.co/Bqav2pNNi7
— Bob Wachter (@Bob_Wachter) October 30, 2021
NICE Guideline | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management.
31 Oct, 2021 | 20:03h | UTCCommentaries:
Chronic fatigue syndrome advice scraps exercise therapy – BBC
ME exercise therapy guidance scrapped by health watchdog Nice – The Guardian
RCT: Targeting higher intraoperative blood pressures does not reduce adverse cardiovascular events following noncardiac surgery.
31 Oct, 2021 | 20:00h | UTC
Cardiovascular clinical examination: the need for an evidence-based approach.
31 Oct, 2021 | 19:57h | UTC
Commentary on Twitter
Which role for cardiac clinical examination today?
According to new cardiopulse, cardiac physical diagnosis shold be regarded as a science that can be learnt, rather than an art that can only be aspired to.https://t.co/oG1NJusXrS#cardiotwitter, @ESC_Journals, @escardio. pic.twitter.com/B9iUSv0gnj— EHJ Editor-in-Chief (@ehj_ed) October 30, 2021
Study suggests smoking cessation, but not reduction, is associated with reduced risk of cardiovascular disease.
31 Oct, 2021 | 19:59h | UTCSmoking cessation, but not reduction, reduces cardiovascular disease incidence – European Heart Journal (link to abstract – $ for full-text)
Commentary on Twitter
May I just reduce the number of cigarettes? New study shows this is not enough! Smoking cessation, but not reduction, was associated with cardiovascular disease incidence drop.https://t.co/lVgXMwavNs#smoke, #cigarettes, #MI, #cardiotwitter, @ESC_Journals, @escardio. pic.twitter.com/FrqB5V2tx3
— EHJ Editor-in-Chief (@ehj_ed) October 31, 2021
Review: Clinical management of pancreatic premalignant lesions.
31 Oct, 2021 | 19:56h | UTCClinical Management of Pancreatic Premalignant Lesions – Gastroenterology
Imaging of congenital lung diseases presenting in the adulthood: a pictorial review.
31 Oct, 2021 | 19:53h | UTC


