Archives
Does procalcitonin have clinical utility in the management of pediatric community-acquired pneumonia? A PRO/CON debate.
28 Oct, 2021 | 09:54h | UTCPRO: Procalcitonin has clinical utility in children with community-acquired pneumonia
CON: Procalcitonin does not have clinical utility in children with community-acquired pneumonia
RCT: Daratumumab, lenalidomide, and dexamethasone vs. lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma.
28 Oct, 2021 | 09:53h | UTC
Retrospective cohort study: corticosteroid treatment linked to lower odds of surgical drainage among pediatric patients with retropharyngeal and parapharyngeal abscesses.
28 Oct, 2021 | 09:52h | UTC
RCT: A geriatric assessment–driven intervention can reduce chemotherapy-related toxic effects in older adults with cancer.
28 Oct, 2021 | 09:50h | UTCGeriatric Assessment–Driven Intervention (GAIN) on Chemotherapy-Related Toxic Effects in Older Adults With Cancer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentary on Twitter
Randomized trial with 604 older patients with cancer starting a new chemo regimen showed the incidence of grade 3 or higher chemo-related toxic effects was significantly lower in those who underwent a geriatric assessment-driven intervention https://t.co/QtOgmLDRU1
— JAMA Oncology (@JAMAOnc) October 1, 2021
RCT: Extended follow-up of local steroid injection for carpal tunnel syndrome.
28 Oct, 2021 | 09:46h | UTC
Commentary on Twitter
In carpal tunnel syndrome, this randomized trial of local steroid vs placebo injection shows similar symptom severity score improvement but a significant small reduction in rate of and longer time to surgery after steroid. @IsamAtroshi @jonasranstam https://t.co/s5LibRnFaV
— JAMA Network Open (@JAMANetworkOpen) October 22, 2021
Recurrent Glomerular Disease after Kidney Transplantation: Diagnostic and Management Dilemmas.
28 Oct, 2021 | 09:43h | UTC
Commentary on Twitter
Recurrent glomerular disease after kidney transplant remains an important cause of allograft failure. This Review focuses on clinical dilemmas encountered by physicians in managing recurrent glomerular disease https://t.co/QGZOjH7qyP
— CJASN (@CJASN) October 27, 2021
Review: Genome sequencing as a diagnostic test.
28 Oct, 2021 | 09:42h | UTCGenome sequencing as a diagnostic test – Canadian Medical Association Journal
Breakthrough infections occur in those with lower antibody levels.
27 Oct, 2021 | 01:45h | UTCOriginal study: Covid-19 Breakthrough Infections in Vaccinated Health Care Workers – New England Journal of Medicine
FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
27 Oct, 2021 | 01:48h | UTCFDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children – STAT
See also:
Tracking the FDA advisory panel meeting on Covid-19 vaccines for kids – STAT
FDA advisory panel recommends Pfizer vaccine for kids ages 5 to 11 – NPR
Mix-and-match COVID vaccines ace the effectiveness test – “No need for brand loyalty”.
27 Oct, 2021 | 01:42h | UTCMix-and-match COVID vaccines ace the effectiveness test – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Heterologous AstraZeneca/Pfizer vaccination seems to be associated with increased effectiveness against Covid-19 compared to homologous Pfizer/Pfizer vaccination.
27 Oct, 2021 | 01:44h | UTCImmunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
A dose of the AstraZeneca COVID-19 vaccine followed by a dose of the Pfizer/BioNTech vaccine confers better protection against SARS-CoV-2 infection than two doses of the Pfizer vaccine, according to a study in healthcare workers published in @Nature. https://t.co/6hIVkiOLQ1 pic.twitter.com/AmsyVUMpoj
— Nature Portfolio (@NaturePortfolio) October 26, 2021
What game theory can teach us about controlling pandemics.
27 Oct, 2021 | 01:39h | UTCWhat game theory can teach us about controlling pandemics – The BMJ Opinion
Commentary on Twitter
https://twitter.com/glassmanamanda/status/1451498564044136450
COVID super-immunity: one of the pandemic’s great puzzles – “People who have previously recovered from COVID-19 have a stronger immune response after being vaccinated than those who have never been infected. Scientists are trying to find out why”.
27 Oct, 2021 | 01:41h | UTCCOVID super-immunity: one of the pandemic’s great puzzles – Nature
AGA Clinical Practice Update on Endoscopic Management of Perforations in Gastrointestinal Tract.
27 Oct, 2021 | 01:35h | UTC
Bioethics | The suggestion Covid deniers should stay out of Australian public hospitals is appalling.
27 Oct, 2021 | 01:37h | UTC
UEG Consensus on Functional Dyspepsia.
27 Oct, 2021 | 01:32h | UTC
RCT: Elective internal mammary node irradiation does not increase disease-free survival or overall survival in most women with node-positive breast cancer.
27 Oct, 2021 | 01:28h | UTCEffect of Elective Internal Mammary Node Irradiation on Disease-Free Survival in Women With Node-Positive Breast Cancer: A Randomized Phase 3 Clinical Trial – JAMA Oncology (free for a limited period)
Commentary: No Survival Benefit for Internal Mammary Node Irradiation in Breast Cancer — Women with medially or centrally located tumors may be candidates, however, says researcher – MedPage Today (free registration required)
Commentary on Twitter
Phase III randomized study evaluated the role of internal mammary node irradiation (IMNI) in node-positive #breastcancer. IMNI did not improve the DFS in unselected patients, but did improve DFS in patients with medially or centrally located tumors https://t.co/tw4ZrHn5wn pic.twitter.com/34ye3TR9MA
— JAMA Oncology (@JAMAOnc) October 25, 2021
Opinion | We Need to Ground Truth Assumptions about Gene Therapy – “Researchers, practitioners and patients must balance the discipline’s promise with its reality”.
27 Oct, 2021 | 01:21h | UTCWe Need to Ground Truth Assumptions about Gene Therapy – Nature
RCT: Platelet-rich intra-articular plasma injections do not improve symptoms and function in patients with ankle osteoarthritis.
27 Oct, 2021 | 01:26h | UTCEffect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients With Ankle Osteoarthritis: A Randomized Clinical Trial – JAMA (free for a limited period)
Related:
RCT: In critically ill patients, an individualized glucose control targeting an ICU patient’s pre-admission usual glycemia did not demonstrate a survival benefit compared to conventional glucose control (targeting glycemia below 180 mg/dL).
27 Oct, 2021 | 01:17h | UTC
Anticoagulants and diabetes agents are among the most frequent causes of emergency department visits attributed to medication harms.
27 Oct, 2021 | 01:15h | UTCUS Emergency Department Visits Attributed to Medication Harms, 2017-2019 – JAMA (link to abstract – $ for full-text)
Commentaries:
Number of emergency room visits for medication harms increases with age – MedicalResearch.com
Blood thinners, diabetes meds among top causes of drug-related ER visits – UPI
Systematic Review: Antibiotics for the treatment of COVID‐19 – “We are certain that risk of death in hospitalized COVID‐19 patients is not reduced by treatment with azithromycin after 28 days”.
26 Oct, 2021 | 02:07h | UTCAntibiotics for the treatment of COVID‐19 – Cochrane Library
Commentary on Twitter
JUST PUBLISHED – Are #antibiotics an effective treatment for #COVID19 & do they cause unwanted effects? https://t.co/EVHduxmtdD New Cochrane Review looked at evidence from 11 studies: ❌ antibiotic azithromycin is not an effective treatment, 🤔not enough research on other types.
— The Cochrane Library (@CochraneLibrary) October 22, 2021
RCT: Ozanimod as induction and maintenance therapy for ulcerative colitis.
27 Oct, 2021 | 01:19h | UTC
Commentary on Twitter
Visual Abstract: Ozanimod Therapy for Ulcerative Colitis https://t.co/P3XpOvV49P pic.twitter.com/ubqgQX94uW
— NEJM (@NEJM) October 6, 2021
M-A: The efficacy of pharmacotherapies for the treatment of borderline personality disorder is limited.
27 Oct, 2021 | 01:11h | UTC
Podcast: Atopic Dermatitis Pearls.
27 Oct, 2021 | 01:01h | UTCAtopic Dermatitis Pearls – The Cribsiders